Xiaohui Zheng
YOU?
Author Swipe
View article: A Local Pareto Front Guided Microscale Search Algorithm for Multi-Modal Multi-Objective Optimization
A Local Pareto Front Guided Microscale Search Algorithm for Multi-Modal Multi-Objective Optimization Open
Multimodal multiobjective optimization problems, characterized by multiple solutions mapping to identical objective vectors, are ubiquitous in real-world applications. Despite their prevalence, most existing multimodal multiobjective evolu…
View article: Synergistic enhancement of microstructure and properties in 304/TC4 cold metal transfer joints via laser pre-melting of FeCoNiCr medium-entropy alloys
Synergistic enhancement of microstructure and properties in 304/TC4 cold metal transfer joints via laser pre-melting of FeCoNiCr medium-entropy alloys Open
View article: Genome-Wide Identification of Luffa Sucrose Synthase Genes Reveals LaSUS1-Mediated Sugar Metabolism Boosting Drought Tolerance
Genome-Wide Identification of Luffa Sucrose Synthase Genes Reveals LaSUS1-Mediated Sugar Metabolism Boosting Drought Tolerance Open
Luffa (Luffa acutangula) serves as an important edible, medicinal, and industrial crop. Sucrose synthase (SUS, EC 2.4.1.13) catalyzes sucrose metabolism and facilitates the entry of photosynthetically derived sucrose into metabolic pathway…
View article: The potential biological function of STARD8 in prostate cancer: A bioinformatic and experimental validation study
The potential biological function of STARD8 in prostate cancer: A bioinformatic and experimental validation study Open
This study identifies STARD8 as a critical tumor suppressor with significant roles in regulating cell proliferation, migration, immune evasion, and drug sensitivity in tumors.
View article: Development of a non-derivatized LC-MS/MS method for simultaneous quantification of ten neurotransmitters in five neuroinflammatory mouse models
Development of a non-derivatized LC-MS/MS method for simultaneous quantification of ten neurotransmitters in five neuroinflammatory mouse models Open
Sensitive and comprehensive measurement of systemic metabolites of Trp, Phe and Glu in biological samples is effective for understanding the pathogenesis of pain, anxiety, depression, PTSD and other neurological diseases. This study develo…
View article: Determination of Equilibrium Solubility and Octanol-Water Partition Coefficient of α-asaronol
Determination of Equilibrium Solubility and Octanol-Water Partition Coefficient of α-asaronol Open
Objective: The objective of this study was to ascertain the equilibrium solubility and oil-water partition coefficient (lgP) of α-fine-octanol in disparate media, thereby establishing a theoretical foundation for the examination of α-fine-…
View article: Research on the Emotional Expression and Usage Path Specification of Chinese National Flag Logo in Clothing
Research on the Emotional Expression and Usage Path Specification of Chinese National Flag Logo in Clothing Open
This study focuses on the application of the Chinese national flag logo in clothing, and the researcher analyses its significance at the individual, social and national levels from the level of emotional expression, such as the manifestati…
View article: Synergistic Strengthening of Tc4/304 Weld Through Laser Pre-Melted Tib2 and V Intermediate Layer
Synergistic Strengthening of Tc4/304 Weld Through Laser Pre-Melted Tib2 and V Intermediate Layer Open
View article: Synergistic Strengthening of Tc4/304 Weld Through Laser Pre-Melted Tib₂
Synergistic Strengthening of Tc4/304 Weld Through Laser Pre-Melted Tib₂ Open
View article: Synergistic strengthening of microstructure and properties in TC4/304 laser weld through laser pre-melted TiB2 and V intermediate layer
Synergistic strengthening of microstructure and properties in TC4/304 laser weld through laser pre-melted TiB2 and V intermediate layer Open
View article: A Comparative Study on the Corrosion Resistance Mechanisms of Ni-Cr-Mo-Nb Alloy Coatings by Laser Cladding, Cold Metal Transition and Pulsed Melting Inert Gas Surfacing
A Comparative Study on the Corrosion Resistance Mechanisms of Ni-Cr-Mo-Nb Alloy Coatings by Laser Cladding, Cold Metal Transition and Pulsed Melting Inert Gas Surfacing Open
View article: Advancement in the development of single chain antibodies using phage display technology
Advancement in the development of single chain antibodies using phage display technology Open
Phage display technology has become an important research tool in biological research, fundamentally changing the traditional monoclonal antibody preparation process, and has been widely used in the establishment of antigen-antibody librar…
View article: Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction
Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction Open
Aims Left ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. The aim of this study was to investigate the possible predictive value of blood urea nitrogen‐to‐albumin ratio (BAR) for the LVA formation in…
View article: Discovery of Pyrimidine-2,4-Diamine Analogues as Efficiency Anticancer Drug by Targeting Gtse1
Discovery of Pyrimidine-2,4-Diamine Analogues as Efficiency Anticancer Drug by Targeting Gtse1 Open
View article: The Design of Phugoid Mode Stabilization in Angle of Attack Protection Control Law
The Design of Phugoid Mode Stabilization in Angle of Attack Protection Control Law Open
To achieve the requirement of maintaining the angle of attack, the design of the angle of attack (AOA) protection control law often causes instability in the pitch attitude and generates phugoid mode oscillations. Conversely, adding a damp…
View article: Citrus hystrix: A review of phytochemistry, pharmacology and industrial applications research progress
Citrus hystrix: A review of phytochemistry, pharmacology and industrial applications research progress Open
Citrus hystrix DC, also known as kaffir lime, is a species of lime native to Southeast Asia and the southern China. So far, 78 components have been characterized from C. hystrix. The main constituents of these compounds include coumarins, …
View article: Design and synthesis of ligustrazine derivatives as potential anti-Alzheimer’s agents
Design and synthesis of ligustrazine derivatives as potential anti-Alzheimer’s agents Open
A novel series of ligustrazine derivatives was designed, synthesized, and evaluated as acetylcholinesterase (AChE) and butylcholinesterase (BuChE) inhibitors for the treatment of Alzheimer’s disease (AD). In vitro studies displayed …
View article: Alpha-asaronol promoted oligodendrocyte precursor cell differentiation and improved myelination as an activator PPARγ
Alpha-asaronol promoted oligodendrocyte precursor cell differentiation and improved myelination as an activator PPARγ Open
Preterm white matter injury (PWMI), characterized by oligodendrocyte precursor cell (OPC) differentiation disorder and dysmyelination, is a prevalent demyelinating disease of the central nervous system in premature infants, necessitating t…
View article: Supplementary Fig. S1-S8 from LIN28/<i>let-7</i>/PD-L1 Pathway as a Target for Cancer Immunotherapy
Supplementary Fig. S1-S8 from LIN28/<i>let-7</i>/PD-L1 Pathway as a Target for Cancer Immunotherapy Open
Figure S1.Inverse correlation between let-7e and PD-L1 expression. Figure S2.Let-7 suppresses PD-L1 expression. Figure S3.LIN28 mediates PD-L1 expression and does not directly promote PD-L1 transcription. Figure S4.C1632 suppresses PD-L1 e…
View article: Supplementary Fig. S1-S8 from LIN28/<i>let-7</i>/PD-L1 Pathway as a Target for Cancer Immunotherapy
Supplementary Fig. S1-S8 from LIN28/<i>let-7</i>/PD-L1 Pathway as a Target for Cancer Immunotherapy Open
Figure S1.Inverse correlation between let-7e and PD-L1 expression. Figure S2.Let-7 suppresses PD-L1 expression. Figure S3.LIN28 mediates PD-L1 expression and does not directly promote PD-L1 transcription. Figure S4.C1632 suppresses PD-L1 e…
View article: Data from LIN28/<i>let-7</i>/PD-L1 Pathway as a Target for Cancer Immunotherapy
Data from LIN28/<i>let-7</i>/PD-L1 Pathway as a Target for Cancer Immunotherapy Open
The immunocheckpoint protein PD-1/PD-L1 is considered a promising target for cancer immunotherapeutics. However, the objective response rate using antibodies that block the interaction between PD-1 and PD-L1 was less than 40%, and the mech…
View article: A Practical, Tandem and Protecting-Group-Free Synthesis of (+)-Rosmarinic Acid and its Analogues
A Practical, Tandem and Protecting-Group-Free Synthesis of (+)-Rosmarinic Acid and its Analogues Open
View article: Advances and perspectives on perylenequinone biosynthesis
Advances and perspectives on perylenequinone biosynthesis Open
Under illumination, the fungal secondary metabolites, perylenequinones (PQs) react with molecular oxygen to generate reactive oxygen species (ROS), which, in excess can damage cellular macromolecules and trigger apoptosis. Based on this pr…
View article: microRNA-181c-5p stimulates the development of coronary artery disease by targeting SIRT1
microRNA-181c-5p stimulates the development of coronary artery disease by targeting SIRT1 Open
Downregulation of miR-181c-5p may ameliorate myocardial pathological changes and cardiomyocyte apoptosis in CAD by upregulating SIRT1 expression and decreasing acetylated p65 levels.
View article: Causal Effects of Tea Intake on Multiple Types of Fractures: A Two-Sample Mendelian Randomization Study
Causal Effects of Tea Intake on Multiple Types of Fractures: A Two-Sample Mendelian Randomization Study Open
Fracture is a global public health disease. Bone health and fracture risk have become the focus of public and scientific attention. Observational studies have reported that tea consumption is associated with fracture risk, but the results …
View article: Alpha-Asaronol Alleviates Dysmyelination by Enhancing Glutamate Transport Through the Activation of PPARγ-GLT-1 Signaling in Hypoxia-Ischemia Neonatal Rats
Alpha-Asaronol Alleviates Dysmyelination by Enhancing Glutamate Transport Through the Activation of PPARγ-GLT-1 Signaling in Hypoxia-Ischemia Neonatal Rats Open
Preterm white matter injury (PWMI) is the most common form of brain damage in premature infants caused by hypoxia-ischemia (HI), inflammation, or excitotoxicity. It is characterized by oligodendrocyte precursor cell (OPC) differentiation d…
View article: Revealing the Antiepileptic Effect of α-Asaronol on Pentylenetetrazole-Induced Seizure Rats Using NMR-Based Metabolomics
Revealing the Antiepileptic Effect of α-Asaronol on Pentylenetetrazole-Induced Seizure Rats Using NMR-Based Metabolomics Open
α-Asaronol from Acorus tatarinowii (known as "Shichangpu" in Traditional Chinese medicine) has been proved to possess more efficient antiepileptic activity and lower toxicity than α-asarone (namely "Xixinnaojiaonang" as an antiepile…
View article: Isopropyl 3-(3, 4-Dihydroxyphenyl)-2-Hydroxypropanoate, A Novel Metabolite From Salvia Miltiorrhiza, Protects Against LPS-Induced Acute Lung Injury in Mice by Attenuating the Canonical and Non-Canonical Inflammatory Pathway of Pyroptosis
Isopropyl 3-(3, 4-Dihydroxyphenyl)-2-Hydroxypropanoate, A Novel Metabolite From Salvia Miltiorrhiza, Protects Against LPS-Induced Acute Lung Injury in Mice by Attenuating the Canonical and Non-Canonical Inflammatory Pathway of Pyroptosis Open
Background: The pathological characteristics of acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are pulmonary edema resulting from pulmonary permeability increasing. The main cause is uncontrolled inflammatory respons…
View article: Applications of chromatography in giant complex drug-organism system
Applications of chromatography in giant complex drug-organism system Open
Chromatography is an important branch of analytical chemistry that focuses on the separation and analysis of complex structures. Following more than 100 years of development and improvement, chromatography theory and technology have gradua…
View article: Pulsatilla chinensis: A review of traditional uses, phytochemistry and pharmacology research progress
Pulsatilla chinensis: A review of traditional uses, phytochemistry and pharmacology research progress Open
This paper is intended to review advances in the botanical, traditional uses, phytochemical and pharmacological studies of the Pulsatilla chinensis. Up to date, 68 kinds of chemical constituents have been isolated and identified from P. ch…