Xuebing Cao
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View article: Subcutaneous Schwannoma on the leg with hemorrhagic cystic degeneration:a case report
Subcutaneous Schwannoma on the leg with hemorrhagic cystic degeneration:a case report Open
View article: Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling
Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling Open
View article: Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons
Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons Open
Taltirelin, an orally effective thyrotropin-releasing hormone analog, significantly improves motor impairments in rat models of Parkinson's disease (PD) and enhances dopamine release within the striatum. However, the underlying mechanism r…
View article: Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression Open
Depression (Dep) is one of the most common concomitant symptoms of Parkinson's disease (PD), but there is a lack of detailed pathologic evidence for the occurrence of PD-Dep. Currently, the management of symptoms from both conditions using…
View article: Identification and experimental validation of m7G-related molecular subtypes, immune signature, and feature genes in Alzheimer's disease
Identification and experimental validation of m7G-related molecular subtypes, immune signature, and feature genes in Alzheimer's disease Open
To the best of our knowledge, this is the first study to reveal close correlations among m7G RNA modification, the immune microenvironment, and the pathogenesis of AD. We also identified five feature genes associated with AD, further contr…
View article: Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease
Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease Open
Necroptosis, a programmed cell death pathway, has been demonstrated to be activated in Alzheimer’s disease (AD). However, the precise role of necroptosis and its correlation with immune cell infiltration in AD remains unclear. In this stud…
View article: AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia
AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia Open
In conclusion, our results suggest that long-term metformin treatment could promote ΔFosB degradation and thus attenuate the development of LID through activating the AMPK-mediated autophagy pathway. Overall, our results support the AMPK-m…
View article: Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease
Identification of metabolism-related subtypes and feature genes in Alzheimer’s disease Open
View article: Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies Open
View article: Clinical characteristics and reaction to dopaminergic treatment of drug-naïve patients with Parkinson's disease in central China: A cross sectional study
Clinical characteristics and reaction to dopaminergic treatment of drug-naïve patients with Parkinson's disease in central China: A cross sectional study Open
The motor symptoms of patients with early PD were mild but virous. They also suffered from different non-motor symptoms. In ALCT, about two thirds of patients (54/80) with early PD showed good response to levodopa. Among four aspects of mo…
View article: Issue Information
Issue Information Open
Aims and ScopeAsia Pacific Journal of Human Resources is an applied, peer-reviewed journal which aims to communicate the development and practice of the field of human resources within the Asia Pacific region.The journal publishes the resu…
View article: Identification and Validation of Metabolism-Related Genes in Alzheimer’s Disease
Identification and Validation of Metabolism-Related Genes in Alzheimer’s Disease Open
Background：Due to its heterogeneity, the pathogenic mechanisms underlying Alzheimer's disease (AD) are not yet fully elucidated. Emerging evidence has demonstrated the critical role of metabolism in the pathophysiology of AD. This study ex…
View article: Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review
Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review Open
Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological …
View article: Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α–Syn and tau fragments
Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α–Syn and tau fragments Open
Introduction Accurate demonstration of phosphorylated α-synuclein aggregation and propagation, progressive nigrostriatal degeneration and motor deficits will help further research on elucidating the mechanisms of Parkinson’s Disease. α-syn…
View article: Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease Open
The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson’s disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance …
View article: Transcranial Magnetic Stimulation Alleviates Levodopa-Induced Dyskinesia in Parkinson's Disease and the Related Mechanisms: A Mini-Review
Transcranial Magnetic Stimulation Alleviates Levodopa-Induced Dyskinesia in Parkinson's Disease and the Related Mechanisms: A Mini-Review Open
After long-term use of levodopa, Parkinson's patients almost inevitably develop dyskinesia, a kind of drug side effect manifesting as uncontrollable choreic movements and dystonia, which could be crippling yet have limited therapeutic opti…
View article: Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry
Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry Open
Long-term therapy with levodopa (L-DOPA) in patients with Parkinson’s disease (PD) often triggers motor complications termed as L-DOPA-induced dyskinesia (LID). However, few studies have explored the pathogenesis of LID from the perspectiv…
View article: Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction Open
Neurofibrillary tangles composed of hyperphosphorylated tau and synaptic dysfunction are characteristics of Alzheimer’s disease (AD). However, the underlying molecular mechanisms remain poorly understood. Here, we identified Amphiphysin I …
View article: Author response: Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
Author response: Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction Open
View article: Prevalence and Clinical Features of FOG in Chinese PD Patients, a Multicenter and Cross-Sectional Clinical Study
Prevalence and Clinical Features of FOG in Chinese PD Patients, a Multicenter and Cross-Sectional Clinical Study Open
Objectives: Freezing of gait (FOG) is generally considered as an independent symptom of Parkinson's disease (PD) with a complex pathophysiology. There is a wide range of associated clinical features of FOG reported from different studies w…
View article: Characteristic of Parkinson’s disease with severe COVID-19: a study of 10 cases from Wuhan
Characteristic of Parkinson’s disease with severe COVID-19: a study of 10 cases from Wuhan Open
Information about Parkinson’s disease (PD) patients with severe COVID-19 is scarce. We aimed to analyze the clinical characteristics, outcomes, and risk factors affecting the prognosis of PD patients with severe COVID-19 infection. Clinica…
View article: Evaluation of Wearable Sensor Devices in Parkinson’s Disease: A Review of Current Status and Future Prospects
Evaluation of Wearable Sensor Devices in Parkinson’s Disease: A Review of Current Status and Future Prospects Open
Parkinson’s disease (PD) decreases the quality of life of the affected individuals. The incidence of PD is expected to increase given the growing aging population. Motor symptoms associated with PD render the patients unable to self-care a…
View article: LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP
LY354740 Reduces Extracellular Glutamate Concentration, Inhibits Phosphorylation of Fyn/NMDARs, and Expression of PLK2/pS129 α-Synuclein in Mice Treated With Acute or Sub-Acute MPTP Open
Glutamate overactivity in basal ganglia critically contributes to the exacerbation of dopaminergic neuron degeneration in Parkinson's disease (PD). Activation of group II metabotropic glutamate receptors (mGlu2/3 receptors), whi…
View article: Distinct anti-dyskinetic effects of amantadine and group II metabotropic glutamate receptor agonist LY354740 in a rodent model: An electrophysiological perspective
Distinct anti-dyskinetic effects of amantadine and group II metabotropic glutamate receptor agonist LY354740 in a rodent model: An electrophysiological perspective Open
L-DOPA-induced dyskinesia (LID) is a major complication of long-term dopamine replacement therapy in Parkinson's disease. Characteristic neural oscillation and abnormal activity of striatal projection neurons (SPNs) are typical pathologica…
View article: Clinical Features and Outcomes of Parkinson's Disease with Coronavirus Disease 2019 (COVID-19) in Wuhan: A Single Center, Retrospective, Observational Study
Clinical Features and Outcomes of Parkinson's Disease with Coronavirus Disease 2019 (COVID-19) in Wuhan: A Single Center, Retrospective, Observational Study Open
View article: Initiation of Parkinson’s disease from gut to brain by δ-secretase
Initiation of Parkinson’s disease from gut to brain by δ-secretase Open
View article: The Rodent Models of Dyskinesia and Their Behavioral Assessment
The Rodent Models of Dyskinesia and Their Behavioral Assessment Open
Dyskinesia, a major motor complication resulting from dopamine replacement treatment, manifests as involuntary hyperkinetic or dystonic movements. This condition poses a challenge to the treatment of Parkinson's disease. So far, several be…
View article: The gut-brain axis in the pathogenesis of Parkinson’s disease
The gut-brain axis in the pathogenesis of Parkinson’s disease Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Its pathological markers include Lewy bodies and Lewy neuritis, which primarily affect the substantia nigra. However, in recent years, mounting evidence suggests…
View article: The gut-brain axis in the pathogenesis of Parkinson’s disease
The gut-brain axis in the pathogenesis of Parkinson’s disease Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Its pathological markers include Lewy bodies and Lewy neuritis, which primarily affect the substantia nigra. However, in recent years, mounting evidence suggests…
View article: Involvement of p38 mitogen‐activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes
Involvement of p38 mitogen‐activated protein kinase in altered expressions of AQP1 and AQP4 after carbon monoxide poisoning in rat astrocytes Open
Cerebral oedema is a major pathological change of acute carbon monoxide (CO) poisoning, the pathogenesis of which is still unclear. In the aquaporin (AQP) water channel family, AQP1 and AQP4 play critical roles in the progress of cerebral …