Explanipedia

756 Developing a flexible cell profiling platform to qualify raw cellular materials and final therapeutics Open

Xueying Sun, Jingjing Liu, Shi Bai, Tingting Fan, Tianfu Zhang , et al. · 2025

1048 Rapid mycoplasma detection technologies: enhancing biopharmaceutical safety and efficiency Open

Lisa Chou, Xueying Sun, Jingjing Liu, Shi Bai, Tingting Fan , et al. · 2025

165 | LINPERLISIB PLUS CHOP FOR NEWLY DIAGNOSED PERIPHERAL T‐CELL LYMPHOMA: A SINGLE‐ARM, OPEN‐LABLE, MULTI‐CENTER PHASE IB/II STUDY (LINCH TRIAL) Open

Qingqing Cai, Y. Xia, He Huang, Yuting Zhao, H. Tong , et al. · 2025

Acidic Tumor Microenvironments and Emerging Therapeutic Strategies for Cancer Therapy Open

Yongzhi Zhuang, Liquan Tong, Xueying Sun · 2025

Hypoxia and acidity represent two distinct properties of tumor microenvironments (TMEs). Tumor acidity was initially proposed to be a "by-product" of hypoxia, which results from abnormal vasculature and excessive oxygen demands. It is now …

Atorvastatin inhibits glioma glycolysis and immune escape by modulating the miR-125a-5p/TXLNA axis Open

Kang Gao, Tao Zhou, Ying-Chun Yin, Xueying Sun, Heping Jiang , et al. · 2024

Background Conventional treatments, including surgery, radiotherapy and chemotherapy, have many limitations in the prognosis of glioma patients. Atorvastatin (ATOR) has a significant inhibitory effect on glioma malignancy. Thus, ATOR may p…

Is 26S proteasome non-ATPase regulatory subunit 6 a potential molecular target for intrahepatic cholangiocarcinoma? Open

Yongzhi Zhuang, Li-Quan Tong, Xueying Sun · 2024

In this editorial we comment on the article by Tang et al published in the recent issue of World Journal of Hepatology . Drug therapy of intrahepatic cholangiocarcinoma (iCCA) poses an enormous challenge since only a small proportion of pa…

Identification of a novel prognostic model for gastric cancer utilizing glutamine-related genes Open

Weidong Li, Qixing Zhong, Naisheng Deng, Haitao Wang, Jun Ouyang , et al. · 2024

[Corrigendum] T7 peptide inhibits angiogenesis via downregulation of angiopoietin‑2 and autophagy Open

Fuhai Wang, Xiaofeng Dong, Peng Xiu, Jingtao Zhong, Honglong Wei , et al. · 2024

Following the publication of this article, an interested reader drew to the authors' attention that two pairs of protein bands featured in the western blots in Fig. 3A and 5D on p. 679 and 681 respectively appeared to be strikingly similar…

Identification of adipokine-related gene-based molecular subtypes of colon cancer and prognostic characteristics Open

Weidong Li, Jincheng Xu, Zhengchao Wen, Qixing Zhong, Naisheng Deng , et al. · 2024

STAC3 as a poor prognostic biomarker in renal clear cell carcinoma: relationship with immune infiltration Open

Yingnan Zhang, Jingtao Li, Luwen Feng, Yue Cheng, Linlin Shi , et al. · 2024

Calcium ions (Ca²⁺) are crucial in tumorigenesis and progression, with their elevated levels indicating a negative prognosis in Kidney Renal Clear Cell Carcinoma (KIRC). The influence of genes regulating calcium ions on the surv…

Mapping the immunological battlefield in gastric cancer: prognostic implications of an immune gene expression signature Open

Xianhong Meng, Daxiu Wang, Xueying Sun, Jiangfeng Yuan, Jiwu Han · 2023

Background Gastric cancer (GC) is a heterogeneous malignancy with variable clinical outcomes. The immune system has been implicated in GC development and progression, highlighting the importance of immune-related gene expression patterns a…

[Strengthening the development and application of precision burn medicine]. Open

Gaoxing Luo, Xueying Sun, J Wu · 2023

In recent years, precision medicine in various clinical disciplines has made great progress. However, the progress and practice of precision medicine in burn surgery at present have lagged far behind other disciplines due to various reason…

Retraction Notice to: Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/β-Catenin Signaling Pathway in GC Open

Zhengtian Li, Xu Zhang, Dawei Wang, Jun Xu, Ke-Jian Kou , et al. · 2022

[This retracts the article DOI: 10.1016/j.omtn.2019.09.034.].

MicroRNA-128-3p Mediates Lenvatinib Resistance of Hepatocellular Carcinoma Cells by Downregulating c-Met Open

Xin Xu, Wenjing Jiang, Peng Han, Jingyan Zhang, Liquan Tong , et al. · 2022

Xin Xu,1,2 Wenjing Jiang,1 Peng Han,1 Jingyan Zhang,3 Liquan Tong,3 Xueying Sun1 1Hepatosplenic Surgery Center, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China; 2Department of General …

Role of Vesical Imaging–Reporting and Data System in predicting muscle‐invasive bladder cancer: A diagnostic meta‐analysis Open

Baorui Yuan, Lingkai Cai, Qiang Cao, Qikai Wu, Juntao Zhuang , et al. · 2021

The objective of this study is to systematically evaluate the diagnostic performance of the Vesical Imaging–Reporting and Data System for predicting muscle‐invasive bladder cancer. Embase, PubMed and Web of Science were systematically sear…

Correction to: LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells Open

Weidong Li, Xuesong Dong, Changjun He, Gang Tan, Ziyi Li , et al. · 2021

D-serine supplement ameliorates MPP+-induced neurotoxicity via attenuating DAPK1-associated pathway in Parkinson's disease models Open

Wenli Zhang, Xueying Sun, Jun Liu, Yuanwen Peng, Yuanhua Qin , et al. · 2021

Background: D-serine is reported to modulate neurotransmission via regulating the activation of N-methyl-D-aspartate receptor 1 (NMDAR1) in a narrow range, and dysfunction or dysregulation of NMDAR1 contributes to the pathophysiology of Pa…

Title: GPC3 in the Exosomes from Hepatocellular Carcinoma HepG2 Cells Open

Chunwen Pu, Qi Wang, Aijun Sun, Ping Sun, Hui Huang , et al. · 2021

Background Exosomes play an important role in regulating the growth in normal and abnormal cells. Exosomes secreted from tumor cells are also involved in regulating the growth behaviors of normal cells and tumor cells. Methods HepG2 cells,…

Disulfiram Synergizes with SRC Inhibitors to Suppress the Growth of Pancreatic Ductal Adenocarcinoma Cells <i>in Vitro</i> and <i>in Vivo</i> Open

Ziyi Li, Xiangjun Xie, Gang Tan, Fangyu Xie, Nianjiao Liu , et al. · 2021

Disulfiram (DSF), an old anti-alcoholism drug, has emerged as a candidate for drug repurposing in oncology. In exploratory studies on its therapeutic effects, we unexpectedly discovered that DSF increased the phosphorylation of SRC, a prot…

Characterization of Mixed Urinary Stone Compositions with Dual-Source Dual-Energy Computed Tomography in Vivo Compared to Infrared Spectroscopy Open

Xianghu Meng, Xueying Sun, Rong Cong, Liang Qi, Zengjun Wang , et al. · 2021

Background: Most previous studies have demonstrated the possibility of using dual-source dual-energy computed tomography (DSDECT) to distinguish pure stones with high accuracy. While stones are usually composed of a mixture of substances, …

Recent progress in SRC targeted therapy for pancreatic cancer Open

Ziyi Li, Xueying Sun · 2021

The miR-124-3p/Neuropilin-1 Axis Contributes to the Proliferation and Metastasis of Triple-Negative Breast Cancer Cells and Co-Activates the TGF-β Pathway Open

Jiayang Zhang, Xuesong Zhang, Ziyi Li, Qingshan Wang, Yan Shi , et al. · 2021

Triple-negative breast cancer (TNBC) accounts for 90% of breast cancer-associated mortality. Neuropilin-1 (NRP-1) acts as a non-tyrosine kinase receptor for several cellular signaling pathways involved in the proliferation and metastasis o…

LncRNA TTN-AS1 promotes the progression of cholangiocarcinoma via the miR-320a/neuropilin-1 axis Open

Huaqiang Zhu, Bo Zhai, Changjun He, Ziyi Li, Hengjun Gao , et al. · 2020

Neuropilin-1 regulated by miR-320a participates in the progression of cholangiocarcinoma by serving as a co-receptor that activates multiple signaling pathways. The present study sought to investigate upstream lncRNAs that control the expr…

Non-Coding RNAs Operate in the Crosstalk Between Cancer Metabolic Reprogramming and Metastasis Open

Ziyi Li, Xueying Sun · 2020

Metastasis, the spread of cancer cells from a primary tumor to a secondary site, represents one of the hallmarks of malignancies and the leading cause of cancer-related death. The process of metastasis is a result of the interaction of gen…

Research on Penetration Behavior and after effects of Coated Reactive Fragments Impacting Steel targets Open

Jiang-Zhou Peng, Binfang Yuan, Xueying Sun, Y J Chen, H Chen · 2020

For research the behavior and after effects which had been resulted from the coated reactive fragments impacting the steel targets, the 14.5mm ballistic rifle had been adopted to complete the experiments that the 6mm Q235A steel targets wa…

Identification of a robust functional subpathway signature for pancreatic ductal adenocarcinoma by comprehensive and integrated analyses Open

Ping Wang, Chunlong Zhang, Weidong Li, Bo Zhai, Xian Jiang , et al. · 2020

Identification of a robust functional subpathway signature for pancreatic ductal adenocarcinoma by comprehensive and integrated analyses Open

Ping Wang, Chunlong Zhang, Weidong Li, Bo Zhai, Xian Jiang , et al. · 2020

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy and its mortality continues to rise globally. Because of its high heterogeneity and complex molecular landscapes, published gene signatures have demonstrated…

RETRACTED: Overexpressed lncRNA GATA6-AS1 Inhibits LNM and EMT via FZD4 through the Wnt/β-Catenin Signaling Pathway in GC Open

Zhengtian Li, Xu Zhang, Dawei Wang, Jun Xu, Ke-Jian Kou , et al. · 2019

Identification of a robust functional subpathway signature for pancreatic ductal adenocarcinoma by comprehensive and integrated analyses Open

Ping Wang, Chunlong Zhang, Weidong Li, Bo Zhai, Xian Jiang , et al. · 2019

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy and its mortality continues to rise globally. Because of its high heterogeneity and complex molecular landscapes, published gene signatures have shown low sp…

The miR-141/neuropilin-1 axis is associated with the clinicopathology and contributes to the growth and metastasis of pancreatic cancer Open

Lixin Ma, Bo Zhai, Huaqiang Zhu, Weidong Li, Wenjing Jiang , et al. · 2019

Background Neuropilin-1 (NRP-1) is a non-tyrosine kinase receptor interacting with multiple signaling pathways that underpin the biological behavior and fate of cancer cells. However, in pancreatic cancer, the mechanisms underlying the fun…

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