Xiaojing Liu
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View article: Pan-genome identification and expression analysis of the ARF gene family in potato
Pan-genome identification and expression analysis of the ARF gene family in potato Open
Our findings revealed the function of the auxin response-factor family members in biological processes in potato, and provide a new theoretical reference for drought resistance-breeding in this important crop species.
View article: Clinical efficacy of COMBO endoscopy of oropharyngeal airways in elderly patients undergoing painless gastroenteroscopy under anaesthesia: a randomized controlled trial protocol
Clinical efficacy of COMBO endoscopy of oropharyngeal airways in elderly patients undergoing painless gastroenteroscopy under anaesthesia: a randomized controlled trial protocol Open
View article: Clinical and pathological characteristics of NELL-1-positive membranous nephropathy: a case series study
Clinical and pathological characteristics of NELL-1-positive membranous nephropathy: a case series study Open
Objective This study aimed to comprehensively characterize the clinical and pathological features, treatment strategies, and outcomes of patients with neural epidermal growth factor-like 1 protein (NELL-1)-positive membranous nephropathy (…
View article: Cross-calibration of the energy response of the gamma-ray detectors on board GECAM-B
Cross-calibration of the energy response of the gamma-ray detectors on board GECAM-B Open
Context . The Gravitational-wave high-energy Electromagnetic Counterpart All-sky Monitor (GECAM) was primarily designed to detect gamma-ray bursts (GRBs), particularly those associated with gravitational-wave events. The energy response of…
View article: A meta-analysis of the effects of proton pump inhibitors on the risk of gastric cancer
A meta-analysis of the effects of proton pump inhibitors on the risk of gastric cancer Open
Background: Proton pump inhibitors (PPIs) are commonly prescribed drugs in clinical practice, mainly for the treatment of Helicobacter pylori infection and gastroesophageal reflux disease (GERD). With the application of PPIs, doctors have …
View article: <i>Polygonatum sibiricum</i> polysaccharide alleviates liver fibrosis through the TGF‑β/Smad signaling pathway and reduces collagen
<i>Polygonatum sibiricum</i> polysaccharide alleviates liver fibrosis through the TGF‑β/Smad signaling pathway and reduces collagen Open
Liver fibrosis (LF) is a liver condition that represents a serious health risk to humans, and effective therapeutic options are limited. Polygonatum sibiricum polysaccharide (PSP), derived from the roots of P. sibiricum Red, …
View article: Integrated analysis of myeloperoxidase in gastric health and cancer: associations with pepsinogen levels, immune regulation, and prognosis in a large healthy population-based and TCGA cohorts
Integrated analysis of myeloperoxidase in gastric health and cancer: associations with pepsinogen levels, immune regulation, and prognosis in a large healthy population-based and TCGA cohorts Open
Background Myeloperoxidase (MPO) is a key enzyme involved in immune responses and oxidative stress, yet its roles in gastric physiology and gastric cancer remain incompletely understood. This study comprises two independent analyses: (1) t…
View article: Discovery of non-covalent rhinovirus 3Cpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses
Discovery of non-covalent rhinovirus 3Cpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses Open
Human rhinovirus 14 (HRV-14) is a leading cause of the common cold, with its 3C protease (3Cpro) playing a crucial role in viral replication by cleaving polyproteins into functional proteins and enzymes. This makes 3Cpro a promising target…
View article: Clinical Efficacy of COMBO endoscopy oropharyngeal airway in Elderly Patients Undergoing Painless Gastroenteroscopy Under Anesthesia: A Randomized Controlled Trial Protocol
Clinical Efficacy of COMBO endoscopy oropharyngeal airway in Elderly Patients Undergoing Painless Gastroenteroscopy Under Anesthesia: A Randomized Controlled Trial Protocol Open
Background Respiratory depression and airway obstruction are the most common respiratory adverse reactions in elderly patients undergoing gastroenteroscopy under sedation. Additionally, sharing the airway with endoscopists can complicate a…
View article: 18 Sputum induction procedure in isolation wards
18 Sputum induction procedure in isolation wards Open
View article: Pan-genome identification and expression analysis of the auxin response gene family in potato
Pan-genome identification and expression analysis of the auxin response gene family in potato Open
Background The auxin response factor plays an important role in plant growth and development, and stress resistance. In this study, the auxin response factor family was identified based on 47 high-quality potato pan-genomes. Results There …
View article: Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease
Pathogenesis and therapeutic applications of microglia receptors in Alzheimer’s disease Open
Microglia, the resident immune cells of the central nervous system, continuously monitor the brain’s microenvironment through their array of specific receptors. Once brain function is altered, microglia are recruited to specific sites to p…
View article: Identification of novel inhibitors of dengue viral NS5 RNA-dependent RNA polymerase through molecular docking, biological activity evaluation and molecular dynamics simulations
Identification of novel inhibitors of dengue viral NS5 RNA-dependent RNA polymerase through molecular docking, biological activity evaluation and molecular dynamics simulations Open
The DENV-NS5 RNA-dependent RNA polymerase (RdRp) is essential for viral replication, and one of the targets of anti-virus. In this study, the Uni-VSW module was used to virtual screen 1.6 million compounds in the ChemDiv and TargetMol (USA…
View article: Spatiotemporally Resolved Transcriptomics of Developing Placenta Reveals Mechanisms of Embryonic Lethality
Spatiotemporally Resolved Transcriptomics of Developing Placenta Reveals Mechanisms of Embryonic Lethality Open
View article: Study on the prediction of prognosis of patients with acute liver failure treated with artificial liver by serum NLR and IL-6 levels
Study on the prediction of prognosis of patients with acute liver failure treated with artificial liver by serum NLR and IL-6 levels Open
Background: To observe the relationship between the expression of serum interleukin-6 (IL-6) and neutrophil/lymphocyte ratio (NLR) and the prognosis of patients with acute liver failure (ALF) treated with artificial liver. Methods: 80 pati…
View article: Identification of novel SARS-CoV-2 3CLpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses
Identification of novel SARS-CoV-2 3CLpro inhibitors by molecular docking, in vitro assays, molecular dynamics simulations and DFT analyses Open
Introduction SARS-CoV-2 pandemic has presented a significant threat to global health and the economy, necessitating urgent efforts to develop effective antiviral drugs. The main protease (3CLpro) of SARS-CoV-2 is a critical target for anti…
View article: Ground calibration and network of the first CATCH pathfinder
Ground calibration and network of the first CATCH pathfinder Open
The Chasing All Transients Constellation Hunters (CATCH) space mission is focused on exploring the dynamic universe via X-ray follow-up observations of various transients. The first pathfinder of the CATCH mission, CATCH-1, was launched on…
View article: A Comparative Study Recognizing the Expression of Information Between Elderly Individuals and Young Individuals
A Comparative Study Recognizing the Expression of Information Between Elderly Individuals and Young Individuals Open
The findings confirmed that young participants have better facial expression recognition performance than elderly participants, which may be related more to perceptual degradation than to decreased attention to informative areas of the fac…
View article: Plasmonic trimers designed as SERS-active chemical traps for subtyping of lung tumors
Plasmonic trimers designed as SERS-active chemical traps for subtyping of lung tumors Open
View article: A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy
A novel H‑tert immortalized human sebaceous gland cell line (XL-i-20) for the investigation of photodynamic therapy Open
We have developed an h‑tert immortalized sebocyte cell line from an Asian population. The cell line, XL-i-20, maintains the essential characteristics of its parent primary sebocytes. Moreover, XL-i-20 sebocyte exhibited a significant respo…
View article: Glyco-signatures in patients with advanced lung cancer during anti-PD-1/PD-L1 immunotherapy
Glyco-signatures in patients with advanced lung cancer during anti-PD-1/PD-L1 immunotherapy Open
Immune checkpoint inhibitors (ICIs) targeting programmed cell death 1/programmed cell death ligand-1 (PD-1/PD-L1) have significantly prolonged the survival of advanced/metastatic patients with lung cancer. However, only a small proportion …
View article: Spatiotemporally resolved transcriptome atlas of developing mouse placenta reveals mechanisms of embryonic lethality
Spatiotemporally resolved transcriptome atlas of developing mouse placenta reveals mechanisms of embryonic lethality Open
Summary Proper placentation is essential for embryonic growth and viability, yet the spatial organization and interactions of placental cell types remain incompletely understood. Here, we present a spatiotemporal transcriptomic atlas of th…
View article: NLRC5 promotes endometrial carcinoma progression by regulating NF-κB pathway-mediated mismatch repair gene deficiency
NLRC5 promotes endometrial carcinoma progression by regulating NF-κB pathway-mediated mismatch repair gene deficiency Open
The innate immune molecule NLR family CARD domain-containing 5 (NLRC5) plays a significant role in endometrial carcinoma (EC) immunosurveillance. However, NLRC5 also plays a protumor role in EC cells. Mismatch repair gene deficiency (dMMR)…
View article: Early identification of macrophage activation syndrome secondary to systemic lupus erythematosus with machine learning
Early identification of macrophage activation syndrome secondary to systemic lupus erythematosus with machine learning Open
View article: The worsening effect of paroxysmal atrial fibrillation on left ventricular function and deformation in type 2 diabetes mellitus patients: a 3.0 T cardiovascular magnetic resonance feature tracking study
The worsening effect of paroxysmal atrial fibrillation on left ventricular function and deformation in type 2 diabetes mellitus patients: a 3.0 T cardiovascular magnetic resonance feature tracking study Open
View article: Simulation studies for the first pathfinder of the CATCH space mission
Simulation studies for the first pathfinder of the CATCH space mission Open
View article: Efficacy and Influencing Factors of Sangju Cough Mixture in the Adjuvant Treatment of Adult Patients with Mycoplasma pneumoniae Infection: A Retrospective Study
Efficacy and Influencing Factors of Sangju Cough Mixture in the Adjuvant Treatment of Adult Patients with Mycoplasma pneumoniae Infection: A Retrospective Study Open
Sangju cough mixture can improve symptoms, accelerate the negative conversion time of MP-IgM antibody, and promote rehabilitation of the patients.
View article: Predictive Value of D-Dimer for In-Hospital Mortality in Non-Diabetic Patients with Non-ST-segment Elevation Myocardial Infarction
Predictive Value of D-Dimer for In-Hospital Mortality in Non-Diabetic Patients with Non-ST-segment Elevation Myocardial Infarction Open
Elevated circulating D-dimer levels have been shown to be a predictor of in-hospital mortality in a variety of diseases; however, the relationship between D-dimer and the in-hospital prognosis of non-ST-segment elevation myocardial infarct…
View article: Regulating Oncogenic lncRNA VPS9D1-AS1 with Cholesterol-Modified siRNA for Esophageal Squamous Cell Carcinoma Therapy
Regulating Oncogenic lncRNA VPS9D1-AS1 with Cholesterol-Modified siRNA for Esophageal Squamous Cell Carcinoma Therapy Open
Esophageal carcinoma is the tenth most common cancer in the world. long non-coding RNA (lncRNA) is a type of RNA molecule that has no or limited coding ability. Many studies have found that it plays an important role in the occurrence and …
View article: Interaction between mitochondrial homeostasis and barrier function in lipopolysaccharide‐induced endothelial cell injury
Interaction between mitochondrial homeostasis and barrier function in lipopolysaccharide‐induced endothelial cell injury Open
This study aimed to investigate the effects of mitochondrial homeostasis on lipopolysaccharide (LPS)‐induced endothelial cell barrier function and the mechanisms that underlie these effects. Cells were treated with LPS or oligomycin (mitoc…