Xifeng Dong
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View article: Efficacy and safety of entecavir, peginterferon alfa-2b and GM-CSF combination therapy: the anchor randomized controlled trial
Efficacy and safety of entecavir, peginterferon alfa-2b and GM-CSF combination therapy: the anchor randomized controlled trial Open
Background and aim Functional cure is considered the advanced treatment goal for patients with chronic hepatitis B (CHB). We aimed to evaluate hepatitis B surface antigen (HBsAg) loss rates after combination treatment of entecavir (ETV) an…
View article: Comparative analysis of primary immune thrombocytopenia and immune thrombocytopenia secondary to connective tissue diseases
Comparative analysis of primary immune thrombocytopenia and immune thrombocytopenia secondary to connective tissue diseases Open
Compared with patients in the primary ITP group, those in the CTD-ITP group had more severe conditions, more intense immune disturbances, and greater treatment challenges. Individualized treatment is needed.
View article: Adipocytes regulate monocyte development through the OGT-NEFA-CD36/FABP4 pathway in high-fat diet-induced obesity
Adipocytes regulate monocyte development through the OGT-NEFA-CD36/FABP4 pathway in high-fat diet-induced obesity Open
View article: From severe aplastic anemia with TERT variant to Wilson disease - associations or not
From severe aplastic anemia with TERT variant to Wilson disease - associations or not Open
View article: From Severe Aplastic Anemia with TERT Variant to Wilson Disease - Associations or Not
From Severe Aplastic Anemia with TERT Variant to Wilson Disease - Associations or Not Open
Severe aplastic anemia is a life-threatening ineffective hematopoiesis, arising from inherited or acquired traits. Wilson disease is a rare congenital metabolic disorder with copper accumulation. Here we report a rare case of a 15 year-old…
View article: Identification of a non-inhibitory aptameric ligand to CRL2ZYG11B E3 ligase for targeted protein degradation
Identification of a non-inhibitory aptameric ligand to CRL2ZYG11B E3 ligase for targeted protein degradation Open
View article: Aberrant Hematopoiesis and <scp>CD8</scp><sup>+</sup> T‐Cell Activation in Thymoma‐Associated Pure Red Cell Aplasia
Aberrant Hematopoiesis and <span>CD8</span><sup>+</sup> T‐Cell Activation in Thymoma‐Associated Pure Red Cell Aplasia Open
Background Thymoma‐associated pure red cell aplasia (PRCA) is a rare autoimmune disorder characterized by selective erythroid lineage suppression. However, the underlying immune mechanisms remain unclear. Methods We performed single‐cell R…
View article: Multi-omics in exploring the pathophysiology of diabetic retinopathy
Multi-omics in exploring the pathophysiology of diabetic retinopathy Open
Diabetic retinopathy (DR) is a leading global cause of vision impairment, with its prevalence increasing alongside the rising rates of diabetes mellitus (DM). Despite the retina’s complex structure, the underlying pathology of DR remains i…
View article: CYLD/HDAC6 signaling regulates the interplay between epithelial-mesenchymal transition and ciliary homeostasis during pulmonary fibrosis
CYLD/HDAC6 signaling regulates the interplay between epithelial-mesenchymal transition and ciliary homeostasis during pulmonary fibrosis Open
The primary cilium behaves as a platform for sensing and integrating extracellular cues to control a plethora of cellular activities. However, the functional interaction of this sensory organelle with epithelial-mesenchymal transition (EMT…
View article: [Efficacy and safety of eltrombopag in the treatment of primary immune thrombocytopenia: real-world data from a single medical center].
[Efficacy and safety of eltrombopag in the treatment of primary immune thrombocytopenia: real-world data from a single medical center]. Open
Objective: This study aimed at investigating the efficacy and safety of eltrombopag in the treatment of adult primary immune thrombocytopenia (ITP) and evaluated the factors influencing its efficacy and side effects. Methods:…
View article: Longitudinal genetically detectable minimal residual disease by fluorescence <i>in situ</i> hybridization confers a poor prognosis in myeloma
Longitudinal genetically detectable minimal residual disease by fluorescence <i>in situ</i> hybridization confers a poor prognosis in myeloma Open
Background: Deeper depth of response (DpR) after induction therapy, especially gain of negative minimal residual disease (MRD), has been linked to prolonged survival in multiple myeloma (MM). However, flow-MRD examination focuses on the nu…
View article: Acquired pure red cell aplasia: unraveling the immune pathogenesis
Acquired pure red cell aplasia: unraveling the immune pathogenesis Open
Acquired pure red cell aplasia (aPRCA) is a rare hematological disorder characterized by normochromic, normocytic anemia, reticulocytopenia, and the absence of erythroblasts. The pathogenesis of aPRCA has remained elusive. This review delv…
View article: <scp>HDAC6</scp> deacetylates <scp>IDH1</scp> to promote the homeostasis of hematopoietic stem and progenitor cells
<span>HDAC6</span> deacetylates <span>IDH1</span> to promote the homeostasis of hematopoietic stem and progenitor cells Open
View article: Identification of Plasma Thrombopoietin Level and Its Significance in Patients with Aplastic Anemia and Myelodysplastic Syndrome
Identification of Plasma Thrombopoietin Level and Its Significance in Patients with Aplastic Anemia and Myelodysplastic Syndrome Open
Objective Our objective was to investigate the concentration of plasma thrombopoietin (TPO) in patients with aplastic anemia (AA) and myelodysplastic syndrome (MDS), as well as its relationship with patients' responses to recombined human …
View article: VEXAS Syndrome—Review
VEXAS Syndrome—Review Open
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly defined refractory adult-onset autoinflammatory syndrome caused by somatic mutations in the ubiquitin-like modifier-activating enzyme 1 (UBA1) gene in hem…
View article: Phenotype Molding of Monocytes in the Multiple Myeloma Microenvironment
Phenotype Molding of Monocytes in the Multiple Myeloma Microenvironment Open
View article: Pim-2 Kinase Regulates Energy Metabolism in Multiple Myeloma
Pim-2 Kinase Regulates Energy Metabolism in Multiple Myeloma Open
Pim-2 kinase is overexpressed in multiple myeloma (MM) and is associated with poor prognosis in patients with MM. Changes in quantitative metabolism, glycolysis, and oxidative phosphorylation pathways are reportedly markers of all tumor ce…
View article: The Role of T Lymphocytes in the Pathogenesis of Paroxysmal Nocturnal Hemoglobinuria
The Role of T Lymphocytes in the Pathogenesis of Paroxysmal Nocturnal Hemoglobinuria Open
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell genetic mutation disease that causes defective erythrocyte membrane hemolysis. Its pathologic basis is the mutation of the PIG-A gene, whose product is necess…
View article: Single whole‐genome sequencing analysis of metastatic biopsy is sufficient for investigational treatment opportunities in cancer
Single whole‐genome sequencing analysis of metastatic biopsy is sufficient for investigational treatment opportunities in cancer Open
Cancer is the second leading cause of death worldwide, accounting for an estimated 9.96 million deaths in 2020 [1]. The global cancer burden is dominated by China, which has the largest population size worldwide [2, 3]. Cancer is a group o…
View article: Pembrolizumab provides long‐term survival benefits in advanced non‐small cell lung cancer: The 5‐year outcomes of the <scp>KEYNOTE</scp>‐024 trial
Pembrolizumab provides long‐term survival benefits in advanced non‐small cell lung cancer: The 5‐year outcomes of the <span>KEYNOTE</span>‐024 trial Open
Lung cancer is one of the most frequently diagnosed cancers in the world with more than 2 million new cases diagnosed every year.1 As the largest developing country worldwide, China has more lung cancer diagnoses and fatalities than any ot…
View article: Primary mediastinal large <scp>B</scp> cell lymphoma
Primary mediastinal large <span>B</span> cell lymphoma Open
Primary mediastinal large B cell lymphoma (PMBCL) is an aggressive large B cell lymphoma originating in the mediastinum, that mainly expresses B cell surface molecules, such as CD19, CD20, CD22, andCD79a. Clinically, they are characterized…
View article: Targeting De Novo Lipogenesis and Cholesterol Biosynthesis Simultaneously is a Novel Therapeutic Option for Hepatocellular Carcinoma
Targeting De Novo Lipogenesis and Cholesterol Biosynthesis Simultaneously is a Novel Therapeutic Option for Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is one of the most common and serious types of cancer in the world. Currently, the treatment options for patients with HCC are limited. Lipid metabolic alterations are being recognized as a therapeutic target…
View article: Nuclear glycogenolysis modulates histone acetylation: a novel mechanism of epigenetic regulation in cancer
Nuclear glycogenolysis modulates histone acetylation: a novel mechanism of epigenetic regulation in cancer Open
View article: GDF11 is increased in patients with aplastic anemia
GDF11 is increased in patients with aplastic anemia Open
Serum GDF11 levels were increased and negatively correlated with Hb levels and reticulocyte counts in AA patients. This suggests an impaired GDF11 response contributing to anemia in AA patients.
View article: Hippocampal-Sparing Prophylactic Cranial Irradiation in Small Cell Lung Cancer: A Phase II Clinical Trial
Hippocampal-Sparing Prophylactic Cranial Irradiation in Small Cell Lung Cancer: A Phase II Clinical Trial Open
View article: Research Progress on Infectious Inflammation Markers in Blood
Research Progress on Infectious Inflammation Markers in Blood Open
Acute phase protein (APP) is a type of special protein closely related to infection inflammation. In recent years, a large number of studies have shown that multiple positive and negative APPs, including C-reactive protein, serum amyloid A…
View article: Meta-analysis of the diagnostic yield and safety of electromagnetic navigation bronchoscopy for lung nodules.
Meta-analysis of the diagnostic yield and safety of electromagnetic navigation bronchoscopy for lung nodules. Open
ENB is an effective and safe procedure in diagnosing peripheral lung lesions.
View article: A meta-analysis comparing hyperfractionated vs. conventional fractionated radiotherapy in non-small cell lung cancer.
A meta-analysis comparing hyperfractionated vs. conventional fractionated radiotherapy in non-small cell lung cancer. Open
The results of the present meta-analysis showed that HRT was not significantly better to conventional radiotherapy in NSCLC treatment.