Xin Ge
YOU?
Author Swipe
View article: Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival
Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival Open
Hexokinases (HKs) are essential enzymes in sugar metabolism, but their mitochondrial release also reflects cellular status in disease. Mycobacterium bovis (M. bovis), the causative agent of bovine and human tuberculosis, infects macrophage…
View article: Bifurcations and Ca2+ oscillations dynamics in a reduced Tsodyks-IP3-Li-Rinzel astrocyte network
Bifurcations and Ca2+ oscillations dynamics in a reduced Tsodyks-IP3-Li-Rinzel astrocyte network Open
A tripartite synapse always links two neuronsand an astrocyte, while this astrocyte regulatessynaptic signal transmission between neurons by modulatingthe release of neurotransmitters through the oscillationof intracellular calcium ion (Ca…
View article: Value of serum NT-IGFBP-4 for non-invasive risk stratification of coronary heart disease and predictive efficiency for complexity of coronary artery lesions
Value of serum NT-IGFBP-4 for non-invasive risk stratification of coronary heart disease and predictive efficiency for complexity of coronary artery lesions Open
Background We aimed to explore the value of serum N-terminal insulin-like growth factor-binding protein 4 (NT-IGFBP-4) in the non-invasive risk stratification of coronary heart disease and its predictive efficiency for the complexity of co…
View article: Genome-Wide Identification, Phylogeny and Expressional Profiles of Mitogen Activated Protein Kinase Gene Family in Blakeslea trispora
Genome-Wide Identification, Phylogeny and Expressional Profiles of Mitogen Activated Protein Kinase Gene Family in Blakeslea trispora Open
In eukaryotes, the mitogen-activated protein kinase (MAPK) cascade pathway is a highly conserved cell signaling mechanism that is essential for stress response, growth, and development. MAPK cascade genes have currently been identified and…
View article: Bridging electronic health literacy and health-related quality of life in China: the role of health self-management behaviors (Preprint)
Bridging electronic health literacy and health-related quality of life in China: the role of health self-management behaviors (Preprint) Open
BACKGROUND Electronic health literacy (eHL) has been increasingly associated with health-related quality of life (HRQoL). However, the underlying mechanisms, especially in the general population, remain insufficiently explored. OBJECTIV…
View article: Recombinant Detoxified Holotoxin as a Potent Candidate Vaccine Against Botulism
Recombinant Detoxified Holotoxin as a Potent Candidate Vaccine Against Botulism Open
Vaccination may represent a suitable strategy for preventing botulism. The recombinant expression of toxin functional domains can induce effective immune responses against botulism. This study aims to develop a safe and effective recombina…
View article: Distinct roles of mTORC2 in excitatory and inhibitory neurons in inflammatory and neuropathic pain
Distinct roles of mTORC2 in excitatory and inhibitory neurons in inflammatory and neuropathic pain Open
This scientific commentary refers to ‘Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain’ by Wong et al. (https://doi.org/10.1093/brain/awae275).
View article: De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries
De novo functional discovery of peptide-MHC restricted CARs from recombinase-constructed large-diversity monoclonal T cell libraries Open
Chimeric antigen receptors (CAR) that mimic T cell receptors (TCR) on eliciting peptide-major histocompatibility complex (pMHC) specific T cell responses hold great promise in the development of immunotherapies against solid tumors, infect…
View article: DDEL-14. NOVEL BLOOD BRAIN BARRIER PENETRATING BI-SPECIFIC ANTIBODY THERAPY FOR BREAST CANCER BRAIN METASTASIS
DDEL-14. NOVEL BLOOD BRAIN BARRIER PENETRATING BI-SPECIFIC ANTIBODY THERAPY FOR BREAST CANCER BRAIN METASTASIS Open
Breast cancer is the second leading cause for brain metastasis after lung cancer. While Her2 +ve tumors respond to her2 targeted antibody therapy, these antibodies are unable to cross the blood brain tumor barrier to effectively target met…
View article: Fc engineering by monoclonal mammalian cell display for improved affinity and selectivity towards FcγRs
Fc engineering by monoclonal mammalian cell display for improved affinity and selectivity towards FcγRs Open
Fc optimization can significantly enhance therapeutic efficacy of monoclonal antibodies. However, existing Fc engineering approaches are sub-optimal with noted limitations, such as inappropriate glycosylation, polyclonal libraries, and uti…
View article: Large T antigen mediated target gene replication improves site-specific recombination efficiency
Large T antigen mediated target gene replication improves site-specific recombination efficiency Open
With advantages of high-fidelity, monoclonality and large cargo capacity, site-specific recombination (SSR) holds great promises for precise genomic modifications. However, broad applications of SSR have been hurdled by low integration eff…
View article: Diagnostic value of stress myocardial perfusion imaging in combination with computed tomography angiography for coronary slow flow
Diagnostic value of stress myocardial perfusion imaging in combination with computed tomography angiography for coronary slow flow Open
Introduction : To date, there are few reports on computed tomography angiography (CTA) in combination with stress myocardial perfusion imaging (SMPI) in the diagnosis of coronary slow flow (CSF). Methods : A total of 62 patients with suspe…
View article: Pain management by chemogenetic control of sensory neurons
Pain management by chemogenetic control of sensory neurons Open
In this study, Perez-Sanchez et al.1 developed a chemogenetic method aimed at alleviating pain in mouse models while dampening excitability in human sensory neurons. This analgesic effect was attained through the introduction of human α7 n…
View article: High-fidelity large-diversity monoclonal mammalian cell libraries by cell cycle arrested recombinase-mediated cassette exchange
High-fidelity large-diversity monoclonal mammalian cell libraries by cell cycle arrested recombinase-mediated cassette exchange Open
Mammalian cells carrying defined genetic variations have shown great potentials in both fundamental research and therapeutic development. However, their full use was limited by lack of a robust method to construct large monoclonal high-qua…
View article: One‐step production of fully biotinylated and glycosylated human <scp>Fc</scp> gamma receptors
One‐step production of fully biotinylated and glycosylated human <span>Fc</span> gamma receptors Open
Initiating and regulating humoral immunity, Fc gamma receptors (FcγRs) have been identified both as therapeutics and as drug targets, and thus production of biologically active FcγRs is highly demanded for biopharmaceutical development. Fo…
View article: Bfra-loaded nanoparticles confer protection against paratuberculosis infection
Bfra-loaded nanoparticles confer protection against paratuberculosis infection Open
Paratuberculosis is a chronic wasting disease of granulomatous enteritis in ruminants caused by Mycobacterium avium subsp. paratuberculosis ( M. paratuberculosis , MAP) resulting in heavy economic losses to dairy industries worldwide. Curr…
View article: Substrate derived sequences act as subsite‐blocking motifs in protease inhibitory antibodies
Substrate derived sequences act as subsite‐blocking motifs in protease inhibitory antibodies Open
Proteases are involved in many physiologic processes, and dysregulated proteolysis is basis of a variety of diseases. Specific inhibition of pathogenetic proteases via monoclonal antibodies therefore holds significant therapeutic promise. …
View article: Supplementary Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
Supplementary Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11 Open
Supplementary Data
View article: Supplementary Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
Supplementary Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11 Open
Supplementary Data
View article: Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11 Open
Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction. Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment. However, such therapeutic strategies show limited efficacy due…
View article: Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11
Data from Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11 Open
Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction. Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment. However, such therapeutic strategies show limited efficacy due…
View article: Antibodies Targeting the Cell Wall Induce Protection against Virulent Mycobacterium bovis Infection
Antibodies Targeting the Cell Wall Induce Protection against Virulent Mycobacterium bovis Infection Open
M. bovis is the causative agent of animal tuberculosis (TB) and human TB. Research on M. bovis is of great public health significance.
View article: Construction of machine learning tools to predict threatened miscarriage in the first trimester based on AEA, progesterone and β-hCG in China: a multicentre, observational, case-control study
Construction of machine learning tools to predict threatened miscarriage in the first trimester based on AEA, progesterone and β-hCG in China: a multicentre, observational, case-control study Open
Background Endocannabinoid anandamide (AEA), progesterone (P4) and β-human chorionic gonadotrophin (β-hCG) are associated with the threatened miscarriage in the early stage. However, no study has investigated whether combing these three ho…
View article: Dual Regulatory Role Exerted by Cyclic Dimeric GMP To Control FsnR-Mediated Bacterial Swimming
Dual Regulatory Role Exerted by Cyclic Dimeric GMP To Control FsnR-Mediated Bacterial Swimming Open
Stenotrophomonas maltophilia has become a great threat to human health because of the high mortality of infected patients. Swimming motility plays a crucial role in regulating bacterial virulence and adaptation.