Xiaojing Gu
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View article: The impact of internet usage preferences on secondary students’ mathematical literacy
The impact of internet usage preferences on secondary students’ mathematical literacy Open
View article: Genetically Predict Diet‐derived Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study
Genetically Predict Diet‐derived Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study Open
Background The incidence of neurodegenerative disorders (NDDs) is increasing, and currently, there are no curative treatments available for these conditions. The potential benefits of supplementation with diet‐derived antioxidants and thei…
View article: Quantitative scale validation of the Dimensional Anhedonia Rating Scale in the treatment of Chinese patients with major depressive disorder
Quantitative scale validation of the Dimensional Anhedonia Rating Scale in the treatment of Chinese patients with major depressive disorder Open
Background The patient-reported Dimensional Anhedonia Rating Scale (DARS) has been adapted into Chinese, so there is a need to evaluate its measurement properties in a Chinese population. Aims To evaluate the reliability and validity of th…
View article: Ke-Vum: Knowledge-Enhanced Video Understanding Model for Fine-Grained Movie Description
Ke-Vum: Knowledge-Enhanced Video Understanding Model for Fine-Grained Movie Description Open
View article: Transformer-Enhanced Intelligent Microgrid Self-Healing: Integrating Large Language Models and Adaptive Optimization for Real-Time Fault Detection and Recovery
Transformer-Enhanced Intelligent Microgrid Self-Healing: Integrating Large Language Models and Adaptive Optimization for Real-Time Fault Detection and Recovery Open
View article: Quantifying the split-elbow sign: a comprehensive study in amyotrophic lateral sclerosis
Quantifying the split-elbow sign: a comprehensive study in amyotrophic lateral sclerosis Open
Purpose The split-elbow sign (SES), characterized by preferential dysfunction of the biceps brachii compared to the triceps, is a clinical feature observed in amyotrophic lateral sclerosis (ALS). However, the quantified SES index has not b…
View article: Application of “Internet +” continuous emotion management training in patients with depression
Application of “Internet +” continuous emotion management training in patients with depression Open
Objective Explore the application effects of “Internet +” continuous emotional management training in depression patients and analyze the feasibility of innovative rehabilitation training methods. Methods Conveniently selected 100 discharg…
View article: Systematic druggable genome‐wide Mendelian randomization identifies therapeutic targets for sarcopenia
Systematic druggable genome‐wide Mendelian randomization identifies therapeutic targets for sarcopenia Open
Background There are no effective pharmacological treatments for sarcopenia. We aim to identify potential therapeutic targets for sarcopenia by integrating various publicly available datasets. Methods We integrated druggable genome data, c…
View article: Integrated full-length transcriptome and metabolome analysis reveals the defense response of melon to gummy stem blight
Integrated full-length transcriptome and metabolome analysis reveals the defense response of melon to gummy stem blight Open
Gummy stem blight (GSB), a severe and widespread disease causing great losses to cucurbit production, is a major threat to melon production. However, the melon-GSB interaction remains largely unknown, which significantly impedes the geneti…
View article: Causal association and mediating effect of blood biochemical metabolic traits and brain image-derived endophenotypes on Alzheimer's disease
Causal association and mediating effect of blood biochemical metabolic traits and brain image-derived endophenotypes on Alzheimer's disease Open
View article: TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro Open
Background There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment. Methods To identify therapeutic targe…
View article: Humans Create, Ai Evaluates: How Do People Perform and Feel When Their Creativity Would Be Judged by an Ai Partner?
Humans Create, Ai Evaluates: How Do People Perform and Feel When Their Creativity Would Be Judged by an Ai Partner? Open
View article: Author Correction: Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients
Author Correction: Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients Open
View article: Roles of mir155hg and TNF-α in evaluation of prognosis of patients with systemic lupus erythematosus
Roles of mir155hg and TNF-α in evaluation of prognosis of patients with systemic lupus erythematosus Open
Background: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease characterized by multi-organ multi-system inflammation, causing severe damage to various organs or systems. Recent studies have shown that miR-155 …
View article: Expanding causal genes for Parkinson’s disease via multi-omics analysis
Expanding causal genes for Parkinson’s disease via multi-omics analysis Open
Genome‑wide association studies (GWASs) have revealed numerous loci associated with Parkinson’s disease (PD). However, some potential causal/risk genes were still not revealed and no etiological therapies are available. To find potential c…
View article: Factors influencing cognitive function in patients with Huntington's disease from China: A cross‐sectional clinical study
Factors influencing cognitive function in patients with Huntington's disease from China: A cross‐sectional clinical study Open
Background and aim Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. Cognitive decline contributes to the loss of daily activity in manifest HD. We aimed to examine the…
View article: Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients
Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients Open
View article: Differential Roles of Highly Expressed PFKFB4 across Stages in Colon Adenocarcinoma Patients
Differential Roles of Highly Expressed PFKFB4 across Stages in Colon Adenocarcinoma Patients Open
Colon adenocarcinoma (COAD) is a common malignant tumor, and the role of the protein PFKFB4 in glycolysis and pentose phosphate pathways is crucial. Researchers investigated the clinical significance of PFKFB4 in COAD by studying its expre…
View article: Genetically predict diet-derived Antioxidants and risk of Neurodegenerative diseases among individuals of European descent: a Mendelian randomization study
Genetically predict diet-derived Antioxidants and risk of Neurodegenerative diseases among individuals of European descent: a Mendelian randomization study Open
Background The prevalence of neurodegenerative disorders (NDDs) is increasing, and there is no cure for any of these diseases. Antioxidants have been associated with several diseases in observational studies. However, the relationship betw…
View article: Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer’s disease
Systematic druggable genome-wide Mendelian randomisation identifies therapeutic targets for Alzheimer’s disease Open
Background Alzheimer’s disease (AD) is the leading cause of dementia. Currently, there are no effective disease-modifying treatments for AD. Mendelian randomisation (MR) has been widely used to repurpose licensed drugs and discover novel t…
View article: A PREDICTIVE MODEL FOR ULTRA‐HIGH RISK IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: A SINGLE‐CENTER STUDY IN CHINA
A PREDICTIVE MODEL FOR ULTRA‐HIGH RISK IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: A SINGLE‐CENTER STUDY IN CHINA Open
Introduction: Although novel therapies have significantly improved the prognosis of multiple myeloma (MM) patients, there are still a subgroup of MM patients experienced early relapse or disease progression. To early identify the patients …
View article: Risk factors of amyotrophic lateral sclerosis: a global meta-summary
Risk factors of amyotrophic lateral sclerosis: a global meta-summary Open
Background The etiology of amyotrophic lateral sclerosis (ALS) remains largely unknown. This study aimed to summarize the relationship between ALS and its genetic and non-genetic risk factors. Method A search of relevant literature from Pu…
View article: Protective effect of antihypertensive drugs on the risk of Parkinson’s disease lacks causal evidence from mendelian randomization
Protective effect of antihypertensive drugs on the risk of Parkinson’s disease lacks causal evidence from mendelian randomization Open
Background: Evidence from observational studies concerning the causal role of blood pressure (BP) and antihypertensive medications (AHM) on Parkinson’s disease (PD) remains inconclusive. A two-sample Mendelian randomization (MR) study was …
View article: Signature of miRNAs derived from the circulating exosomes of patients with amyotrophic lateral sclerosis
Signature of miRNAs derived from the circulating exosomes of patients with amyotrophic lateral sclerosis Open
Background Amyotrophic lateral sclerosis (ALS) is a progressive, fatal neurodegenerative disorder (NDS) with unclear pathophysiology and few therapeutic options. Mutations in SOD1 and C9orf72 are the most common in Asian and Caucasian pati…
View article: Identifying novel proteins underlying loneliness by integrating GWAS summary data with human brain proteomes
Identifying novel proteins underlying loneliness by integrating GWAS summary data with human brain proteomes Open
View article: Genetically Predict Circulating Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study
Genetically Predict Circulating Antioxidants and Risk of Neurodegenerative Diseases Among Individuals of European Descent: A Mendelian Randomization Study Open
View article: TBK1, a Novel Drug Repurposing Target for Amyotrophic Lateral Sclerosis: Evidence from Druggable Genome Mendelian Randomization and Pharmacological Verification <i>in Vitro</i>
TBK1, a Novel Drug Repurposing Target for Amyotrophic Lateral Sclerosis: Evidence from Druggable Genome Mendelian Randomization and Pharmacological Verification <i>in Vitro</i> Open
View article: Additional file 1 of Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data
Additional file 1 of Identifying novel proteins underlying schizophrenia via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data Open
Additional file 1: Table S1. Cohort information. Table S2. Demographics of the participants included in the pQTL analyses. Table S3. IVs used in the MR analysis. Table S4. Phennoscanner results for the IVs. Table S5. MR results of proteins…
View article: Prediction of early-wheelchair dependence in multiple system atrophy based on machine learning algorithm: A prospective cohort study
Prediction of early-wheelchair dependence in multiple system atrophy based on machine learning algorithm: A prospective cohort study Open
View article: The Comprehensive Analysis of Motor and Neuropsychiatric Symptoms in Patients with Huntington’s Disease from China: A Cross-Sectional Study
The Comprehensive Analysis of Motor and Neuropsychiatric Symptoms in Patients with Huntington’s Disease from China: A Cross-Sectional Study Open
Huntington’s disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. There is a paucity of comprehensive clinical analysis in Chinese HD patients due to the low prevalence of HD in Asia. …