Explanipedia

BACE1 Expression Is Required for Proper Synaptic Vesicle Dynamics in the Hippocampus Open

Srdjan D. Antic, Brati Das, Tran Do Hoang Nhu, Xiangyou Hu, Rafael Fernández‐Chacón , et al. · 2025

BACE1 is an indispensable enzyme for the production of β‐amyloid peptides by initiating the cleavage of amyloid precursor protein at the β‐secretase site. Targeting BACE1 inhibition is therefore a therapeutic strategy for treating patients…

Downregulation of Nrf2 deteriorates cognitive impairment in APP/PS1 mice by inhibiting mitochondrial biogenesis through the PPARγ/PGC1α signaling pathway Open

Weigang Luo, Wei Bu, Guisong Zhang, Yujuan Dong, Yuling Wang , et al. · 2025

Nrf2 can directly regulate PGC1α transcription, and can also regulate PPARγ followed by binding to the PGC1α protein, thereby modulating mitochondrial biogenesis.Nrf2 downregulation reduces the expression of PPARγ and PGC1α proteins, there…

The Effect of Topical Ketoconazole and Topical Miconazole Nitrate in Modulating the Skin Microbiome and Mycobiome of Patients With Tinea Pedis Open

Yen Tan, Yakun Shao, Tingting Li, Xiangyou Hu, Wang Xiaowen , et al. · 2025

Background Tinea pedis is a type of dermatophytosis that affects the superficial layers of the skin on feet. Limited data are available on the skin microbiome composition in affected patients and its changes following topical antifungal th…

Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects Open

Cheemala Ashok, Amy L. Kimble, Emily N. Burrage, Stephen B. Helming, Jordan D. Tyburski , et al. · 2025

Mutations in the TARDBP gene encoding TDP-43 protein are linked to loss of function in neurons and familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We recently identified reduced nuclear TDP-43 in capillary e…

Circadian Control of Sleep by Melatonin via MT1-Dependent Activation of BK Channels in the Suprachiasmatic Nucleus Open

Kiranmayi Vedantham, Adeel Ahmad, Longgang Niu, Yuan Shui, Fouad Lemtiri‐Chlieh , et al. · 2025

Melatonin promotes sleep through mechanisms that have remained elusive. Here, we identify a molecular pathway by which melatonin promotes sleep by activating BK channels (Slo1) via MT 1 receptors in the suprachiasmatic nucleus (SCN), the b…

Thonningianin A ameliorates acetaminophen-induced liver injury by activating GPX4 and modulating endoplasmic reticulum stress Open

Shanglei Lai, Yingyan Ye, Qinchao Ding, Xiangyou Hu, Ai Fu , et al. · 2025

Introduction Acetaminophen (APAP) is widely used as an analgesic and antipyretic. However overdose APAP can lead to acute liver injury (ALI), representing a significant challenge for public health due to limited treatment options. Current …

Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease Open

Akihiro Ishii, Joseph Pathoulas, Omar M. Omar, Yingying Ge, Annie Y. Yao , et al. · 2024

IRAK4 is an immunological checkpoint in neuropsychiatric systemic lupus erythematosus Open

Antoine Ménoret, Federica Agliano, Timofey A. Karginov, Xiangyou Hu, Anthony T. Vella · 2024

Loss of Endothelial TDP-43 Leads to Blood Brain Barrier Defects in Mouse Models of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Open

Cheemala Ashok, Amy L. Kimble, Jordan D. Tyburski, Nathan K. Leclair, Aamir Zuberi , et al. · 2023

Loss of nuclear TDP-43 occurs in a wide range of neurodegenerative diseases, and specific mutations in the TARDBP gene that encodes the protein are linked to familial Frontal Temporal Lobar Dementia (FTD), and Amyotrophic Lateral Sclerosis…

Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep–wake Disturbances in AD Mice Open

Annie Y. Yao, Philip F. Halloran, Yingying Ge, Neeraj Singh, John Zhou , et al. · 2023

Alzheimer’s disease (AD) increases the risk for seizures and sleep disorders. We show here that germline deletion of β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) in neurons, but not in astrocytes, increased epileptiform…

Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development Open

John Zhou, Qi Shi, Ying Y Ge, Wanxia He, Xiangyou Hu , et al. · 2023

Reticulon (RTN) proteins are a family of proteins biochemically identified for shaping tubular endoplasmic reticulum, a subcellular structure important for vesicular transport and cell-to-cell communication. In our recent study of mice wit…

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides Open

John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu , et al. · 2023

Additional file 1 of BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides Open

John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu , et al. · 2023

Additional file 1: Supplemental Figure S1. Quality control measure of Bace1-/- and Bace1+/+ scRNAseq. (A) Violin plots of data set quality control measurement for nFeature_RNA, nCount_RNA, and percent.mt generated from each ACSA2+-enriched…

Postnatal neuronalBace1deletion impairs neuroblast and oligodendrocyte maturation Open

Marc Benoit, Mabintou Darboe, Brati Das, Yingying Ge, John Zhou , et al. · 2022

Beta amyloid cleaving enzyme 1 (BACE1) is largely expressed by neurons and is the sole β-secretase for initiating the production of neuronal β-amyloid peptides (Aβ). To fully understand the physiological functions of neuronal BACE1, we use…

Bace1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides Open

Riqiang Yan, John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko , et al. · 2022

Background : Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1 to reduce Aβ production is therefore being explored for the treatment …

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance Open

Neeraj Singh, Brati Das, John Zhou, Xiangyou Hu, Riqiang Yan · 2022

Abnormal accumulation of β-amyloid (Aβ) peptides is a culprit in Alzheimer’s disease (AD); blocking Aβ generation is therefore being explored as a logical approach for AD treatment. Here, we demonstrate that targeted inhibition of β-site a…

BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1 Open

Neeraj Singh, Marc Benoit, John Zhou, Brati Das, José Dávila-Velderrain , et al. · 2022

BACE-1 is required for generating β-amyloid (Aβ) peptides in Alzheimer’s disease (AD). Here, we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature. BACE-1 deficie…

Loss of Awareness or Urinary Dysfunction? Investigating Amyloidosis and Urinary Physiology in a Transgenic Mouse Open

Cara Hardy, Ramalakshmi Ramasamy, Dawn Rosenberg, Philip J. Scarpa, Xiangyou Hu , et al. · 2021

Alzheimer’s disease (AD) is a devastating disorder primarily affecting older adults and is the most common neurodegenerative disease in the US. More than one in three AD patients experience AD-associated urinary dysfunction (ADUD), which d…

BACE1 controls synaptic function through modulating release of synaptic vesicles Open

Brati Das, Neeraj Singh, Annie Y. Yao, John Zhou, Wanxia He , et al. · 2021

Deletion of neuronal BACE1 causes mice memory deficits Open

Xiangyou Hu, Mabintou Darboe, Riqiang Yan · 2020

Background The β‐site APP cleaving enzyme 1 (BACE1) was initially identified as a transmembrane aspartyl protease cleaving amyloid precursor protein. Methods Behavioral test (open field, water maze, Y‐maze and fear conditioning test), west…

Alzheimer’s Disease-Associated Pathology in a Transgenic Mouse Model Results in Altered Voiding Function Open

Cara Hardy, Dawn Rosenberg, Ramalakshmi Ramasamy, Xiangyou Hu, Phillip P. Smith · 2020

Alzheimer’s disease (AD) is a devastating disorder primarily affecting older adults and is the most common neurodegenerative disease in the US. More than one in three AD patients experience AD-associated urinary dysfunction (ADUD), which d…

Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction Open

Qingyuan Fan, Wanxia He, Manoshi Gayen, Marc Benoit, Xiaoyang Luo , et al. · 2019

Neurofibrillary tangles likely cause neurodegeneration in Alzheimer's disease (AD). We demonstrate that the CX3CL1 C-terminal domain can upregulate neurogenesis, which may ameliorate neurodegeneration. Here we generated transgenic (Tg-CX3C…

Dystrophic neurites labelled by pre-autophagosomal proteins in Alzheimer’s brains Open

Md Golam Sharoar, Xiangyou Hu, Xin‐Ming Ma, Xiongwei Zhu, Riqiang Yan · 2019

Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains Open

Md Golam Sharoar, Xiangyou Hu, Xin‐Ming Ma, Xiongwei Zhu, Riqiang Yan · 2019

Characteristics of the salivary microbiota in cheilitis granulomatosa Open

Y Liu, Qingbin Zhang, Xiangyou Hu, Feng Chen, Hong Hua · 2019

The composition and structure of bacterial communities in CG patients were different from HC. Most of the genera observed in CG patients were associated with periodontitis and pulp infection. These findings might be helpful in understandin…

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions Open

Xiangyou Hu, Brati Das, Hailong Hou, Wanxia He, Riqiang Yan · 2018

BACE1 initiates the generation of the β-amyloid peptide, which likely causes Alzheimer’s disease (AD) when accumulated abnormally. BACE1 inhibitory drugs are currently being developed to treat AD patients. To mimic BACE1 inhibition in adul…

RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer’s brains Open

Qi Shi, Yingying Ge, Wanxia He, Xiangyou Hu, Riqiang Yan · 2017

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus Open

Hailong Hou, Qingyuan Fan, Wanxia He, Hoonkyo Suh, Xiangyou Hu , et al. · 2017

BACE1 is validated as Alzheimer's β-secretase and a therapeutic target for Alzheimer's disease. In examining BACE1-null mice, we discovered that BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive…

Neurological dysfunctions associated with altered BACE1‐dependent Neuregulin‐1 signaling Open

Xiangyou Hu, Qingyuan Fan, Hailong Hou, Riqiang Yan · 2015

Inhibition of BACE 1 is being pursued as a therapeutic target to treat patients suffering from Alzheimer's disease because BACE 1 is the sole β‐secretase that generates β‐amyloid peptide. Knowledge regarding other cellular functions of BAC…

Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves Open

Xiangyou Hu, Jinxuan Hu, Lu Dai, Bruce D. Trapp, Riqiang Yan · 2015

Inhibition of β-site APP cleaving enzyme 1 (BACE1) is being pursued as a therapeutic target for treating patients with Alzheimer's disease because BACE1 is the sole β-secretase for generating β-amyloid peptide. Knowledge regarding the othe…

Xiangyou Hu YOU? Author Swipe