Xiaoke Gu
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View article: Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response
Design and Synthesis of Triazole-Containing HDAC Inhibitors That Induce Antitumor Effects and Immune Response Open
Histone deacetylase (HDAC) is an epigenetic antitumor drug target, but most existing HDAC inhibitors show limited antitumor activity and their use is often accompanied by serious adverse effects. To overcome these problems, we designed and…
View article: Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V<sub>2</sub> Receptor in <i>In Vitro</i>, Ex Vivo, and In Vivo Models of ADPKD
Optical-Controlled Kinetic Switch: Fine-Tuning of the Residence Time of an Antagonist Binding to the Vasopressin V<sub>2</sub> Receptor in <i>In Vitro</i>, Ex Vivo, and In Vivo Models of ADPKD Open
The pharmacological activity of a small-molecule ligand is linked to its receptor residence time. Therefore, precise control of the duration for which a ligand binds to its receptor is highly desirable. Herein, we designed photoswitchable …
View article: Assessment of a bifendate derivative bearing a 6,7-dihydro-dibenzo[<i>c</i>,<i>e</i>]azepine scaffold as a potential anti-metastatic agent
Assessment of a bifendate derivative bearing a 6,7-dihydro-dibenzo[<i>c</i>,<i>e</i>]azepine scaffold as a potential anti-metastatic agent Open
4i exhibited significant anti-metastatic activity in MDA-MB-231 cells via inhibiting MMP-2/9 activity and expression.
View article: Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound
Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound Open
Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon species. It exhibits inhibitory activities against a variety of tumor cells, and pharmacological study shows that oridonin could inhibit cell prolif…
View article: Anticancer efficacy of a nitric oxide‐modified derivative of bifendate against multidrug‐resistant cancer cells
Anticancer efficacy of a nitric oxide‐modified derivative of bifendate against multidrug‐resistant cancer cells Open
The development of multidrug resistance ( MDR ) not only actively transports a wide range of cytotoxic drugs across drug transporters but is also a complex interaction between a number of important cellular signalling pathways. Nitric oxid…
View article: CCDC 1450999: Experimental Crystal Structure Determination
CCDC 1450999: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …