Xiaokun Geng
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View article: γ-Oryzanol-Loaded PLGA nanoparticles: enhanced drug delivery and therapeutic efficacy for breast cancer therapy
γ-Oryzanol-Loaded PLGA nanoparticles: enhanced drug delivery and therapeutic efficacy for breast cancer therapy Open
Introduction Breast cancer treatment is plagued by systemic toxicity and drug resistance, prompting the search for better drug delivery systems, with oryzanol, a natural compound with anti-tumor potential but poor water solubility, emergin…
View article: Developing an Explainable Prognostic Model for Acute Ischemic Stroke: Combining Clinical and Inflammatory Biomarkers With Machine Learning
Developing an Explainable Prognostic Model for Acute Ischemic Stroke: Combining Clinical and Inflammatory Biomarkers With Machine Learning Open
Background Predicting the prognosis of patients with acute cerebral infarction (ACI) is crucial for clinical decision‐making and personalized treatment. However, existing models often lack the comprehensive integration of clinical and biol…
View article: Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke
Efficacy and procedural efficiency of mechanical thrombectomy devices in posterior circulation stroke Open
Background and purpose Posterior circulation stroke patients have worse outcomes after mechanical thrombectomy (MT) and higher mortality than anterior circulation acute ischemic stroke (AIS) patients due to large vessel occlusions (LVOs). …
View article: An Efficient Hydrodynamic Force Calculation Method for Pile Caps with Arbitrary Cross-Sections Under Earthquake Based on Finite Element Method
An Efficient Hydrodynamic Force Calculation Method for Pile Caps with Arbitrary Cross-Sections Under Earthquake Based on Finite Element Method Open
The pile group-pile cap structure is a key foundation form for deep-water bridges. However, current effective methods for calculating the earthquake-induced hydrodynamic forces on pile caps with arbitrary cross-sections remain insufficient…
View article: Chronic mental stress and ischemic injury: Mechanisms and implications – A mini review
Chronic mental stress and ischemic injury: Mechanisms and implications – A mini review Open
Ischemic stroke is a leading cause of mortality and disability worldwide. Emerging evidence has highlighted a strong link between genetically predisposed risk factors, such as depression and chronic mental stress, and worsens stroke outcom…
View article: Evaluating the safety and feasibility of remote ischemic conditioning for slowing cognitive decline in mild Alzheimer’s dementia
Evaluating the safety and feasibility of remote ischemic conditioning for slowing cognitive decline in mild Alzheimer’s dementia Open
Objective Alzheimer’s disease (AD) is characterized by complex pathological mechanisms involving neuroinflammation, oxidative stress, and vascular dysfunction. Remote Ischemic Conditioning (RIC) has shown potential in addressing these path…
View article: Effect of asymptomatic vestibular dysfunction on insomnia
Effect of asymptomatic vestibular dysfunction on insomnia Open
Objectives: Insomnia is a common condition with limitations in treatment through cognitive behavioral or pharmacological therapies, including variable efficacy, side effects, and time commitment. Given the close association between the ves…
View article: Vestibular rehabilitation in patients with stroke: A comprehensive review of past and current evidence
Vestibular rehabilitation in patients with stroke: A comprehensive review of past and current evidence Open
In 2016, the American Physical Therapy Association Neurology Section published clinical practice guidelines titled “Vestibular Rehabilitation (VR) for Peripheral Vestibular Hypofunction.” These guidelines recommend that physicians should p…
View article: Long-term exposure to PM2.5 exacerbates dopaminergic neuronal loss through CpG hypermethylation induced down-regulation of PINK1 and DJ-1 genes
Long-term exposure to PM2.5 exacerbates dopaminergic neuronal loss through CpG hypermethylation induced down-regulation of PINK1 and DJ-1 genes Open
To investigate whether airborne particle (PM2.5) aggravates Parkinson's disease (PD) and alter expression of key PD-related genes by DNA methylation. Two groups of rats were exposed to either clean air or polluted air for 3, 6, and 12 mont…
View article: Associations Between Sleep Duration and Activity of Daily Living Disability Among Older Adults in China: Cross-Sectional Study
Associations Between Sleep Duration and Activity of Daily Living Disability Among Older Adults in China: Cross-Sectional Study Open
Background China has the largest elderly population globally; the growth rate of the aged tendency of the population was higher than that of Western countries. Given the distinctions in historical, ethnic, and economic status as well as so…
View article: Endothelial Cells and the Blood–Brain Barrier: Critical Determinants of Ineffective Reperfusion in Stroke
Endothelial Cells and the Blood–Brain Barrier: Critical Determinants of Ineffective Reperfusion in Stroke Open
Ineffective reperfusion remains a critical challenge in neurointerventional treatment following ischemic stroke, with the integrity of the blood–brain barrier (BBB) being a key determinant of patient outcomes. This review explores the dist…
View article: Changes in symptomatic intracranial atherosclerotic plaques and perforating arteries under medical treatment using high-resolution magnetic resonance imaging
Changes in symptomatic intracranial atherosclerotic plaques and perforating arteries under medical treatment using high-resolution magnetic resonance imaging Open
Objectives: Follow-up observation of changes in intracranial plaques and lenticulostriate arteries (LSAs) under the standard medical treatment can help further observe treatment effects. This study aims to observe the changes in symptomati…
View article: The link between sleep duration and stroke risk
The link between sleep duration and stroke risk Open
In this review paper, we explore the complex relationship between sleep duration and stroke risk, outlining the association of both insufficient sleep and excessive sleep with an increased risk of cerebrovascular diseases. We explore a U-s…
View article: Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition
Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition Open
Background Glyceryl trinitrate (GTN), also known as nitroglycerin, is predominantly recognized as a vasodilator for ischemic heart disease, and its potential neuroprotective properties in acute ischemic stroke remain under exploration. We …
View article: Residual stenosis >30% is an independent predictor of stroke recurrence postendovascular therapy in patients with symptomatic intracranial atherosclerotic stenosis
Residual stenosis >30% is an independent predictor of stroke recurrence postendovascular therapy in patients with symptomatic intracranial atherosclerotic stenosis Open
Objective: The purpose of this study was to investigate the correlation between residual stenosis rate following percutaneous transluminal angioplasty and stenting (PTAS) and the incidence of ischemic stroke recurrence in patients with sym…
View article: Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis
Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis Open
Importance Previous randomized clinical trials did not demonstrate the superiority of endovascular stenting over aggressive medical management for patients with symptomatic intracranial atherosclerotic stenosis (sICAS). However, balloon an…
View article: Prospective randomized controlled trial on the safety and neuroprotective efficacy of remote administration of hypothermia over spleen during acute ischemic stroke with mechanical thrombectomy: rationale, design, and protocol
Prospective randomized controlled trial on the safety and neuroprotective efficacy of remote administration of hypothermia over spleen during acute ischemic stroke with mechanical thrombectomy: rationale, design, and protocol Open
Background Brain inflammation plays a key role in ischemia/reperfusion (I/R) injury and is the main cause of “ineffective or futile recanalization” after successful mechanical thrombectomy (MT) in acute ischemic stroke (AIS). One of the pr…
View article: Immune Alterations in Vestibular Neuritis: A Pilot Study on T and B Lymphocyte Profiles and Cytokine Levels
Immune Alterations in Vestibular Neuritis: A Pilot Study on T and B Lymphocyte Profiles and Cytokine Levels Open
Objectives Vestibular neuritis (VN) etiology remains elusive, with hypotheses suggesting viral infection, non-infectious inflammation, or immune responses. This study aims to assess the T and B lymphocyte subsets and cytokine expressions i…
View article: Modulation of NLRP3 inflammasome-related-inflammation via RIPK1/RIPK3-DRP1 or HIF-1α signaling by phenothiazine in hypothermic and normothermic neuroprotection after acute ischemic stroke
Modulation of NLRP3 inflammasome-related-inflammation via RIPK1/RIPK3-DRP1 or HIF-1α signaling by phenothiazine in hypothermic and normothermic neuroprotection after acute ischemic stroke Open
Hypothermic and normothermic neuroprotection of C + P involve different pathways. The normothermic effect was mediated by HIF-1α, while hypothermic effect was via RIPK1/RIPK3-DRP1 signaling. This provides a theoretical basis for future pre…
View article: Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial
Endovascular therapy in acute ischaemic stroke with large infarction with matched or mismatched clinical-radiological severities: a post-hoc analysis of the ANGEL-ASPECT trial Open
Unrestricted grants from industry [Covidien Healthcare International Trading (Shanghai), Johnson & Johnson MedTech, Genesis MedTech (Shanghai), and Shanghai HeartCare Medical Technology].
View article: Intentional saccadic eye movements in patients with vestibular migraine
Intentional saccadic eye movements in patients with vestibular migraine Open
Objectives: Patients with vestibular migraine (VM) show a significant decrease in gray matter cortical regions associated with pain and vestibular processing, as revealed by head functional magnetic resonance imaging. We predict that these…
View article: Endothelial Cells and Blood-Brain Barrier (BBB): The Key Factors in Ineffective Reperfusion Outcomes
Endothelial Cells and Blood-Brain Barrier (BBB): The Key Factors in Ineffective Reperfusion Outcomes Open
In the realm of neurointerventional treatment after ischemic stroke, ineffective reperfusion represents a significant challenge, with the integrity of the blood-brain barrier (BBB) serving as a pivotal determinant of outcomes. This review …
View article: The Modulatory Role of Hypothermia in Poststroke Brain Inflammation: Mechanisms and Clinical Implications
The Modulatory Role of Hypothermia in Poststroke Brain Inflammation: Mechanisms and Clinical Implications Open
Background: Acute ischemic stroke remains a major contributor to mortality and disability worldwide. The use of hypothermia has emerged as a promising neuroprotective strategy, with proven effectiveness in cardiac arrest and neonatal hypox…
View article: Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa — a case report and literature review
Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa — a case report and literature review Open
Dyskinesia-hyperpyrexia syndrome, a rare medical emergency in Parkinson's disease, is first described in 2010. It is characterized by severe continuous dyskinesia associated with rhabdomyolysis, hyperthermia and subsequent alteration of th…
View article: Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke
Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke Open
Reperfusion strategies such as vascular thrombolysis and thrombectomy are the first-line treatments recommended for acute ischemic stroke. However, only half of these patients achieve functional independence after endovascular reperfusion …
View article: The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression
The Greater Omentum: Multifaceted Interactions in Neurological Recovery and Disease Progression Open
The greater omentum, a unique anatomical structure composed of adipocytes, loose connective tissue, and a dense vascular network. Plays a pivotal role beyond its traditional understanding. It houses specialized immunological units known as…