Xin Hong
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View article: Predictive model for preterm premature rupture of membranes following fetal endoscopy laser coagulation in twin-to-twin transfusion syndrome surgery
Predictive model for preterm premature rupture of membranes following fetal endoscopy laser coagulation in twin-to-twin transfusion syndrome surgery Open
This model, incorporating postoperative amniotic fluid leakage, operation time, intraoperative amniotic fluid reduction rate, preoperative cervical canal length, and Trocar insertion distance, effectively predicts PPROM risk after FLC for …
View article: Uterine arteriovenous malformation (AVM)/Enhanced myometrial vascularity(EMV): Risk Prediction Model for Life-Threatening Major Bleeding - A Multicenter Clinical Study
Uterine arteriovenous malformation (AVM)/Enhanced myometrial vascularity(EMV): Risk Prediction Model for Life-Threatening Major Bleeding - A Multicenter Clinical Study Open
Objective: To develop a risk prediction model for identifying high-risk cases of uterine AVM/EMV. Methods: A retrospective analysis was conducted on 191 patients with uterine AVM/EMV from multiple hospitals in Anhui Province and Qinghai Pr…
View article: Learning Protein-Ligand Binding in Hyperbolic Space
Learning Protein-Ligand Binding in Hyperbolic Space Open
Protein-ligand binding prediction is central to virtual screening and affinity ranking, two fundamental tasks in drug discovery. While recent retrieval-based methods embed ligands and protein pockets into Euclidean space for similarity-bas…
View article: JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance
JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance Open
Adipose tissue inflammation contributes to obesity-induced insulin resistance. However, increasing evidence shows that high BMI (obesity) is not an accurate predictor of poor metabolic health in individuals. The molecular mechanisms regula…
View article: BK channel agonists may affect matrix vesicle secretion and ameliorate vascular calcification via autophagy
BK channel agonists may affect matrix vesicle secretion and ameliorate vascular calcification via autophagy Open
Although our experimental sample size is small, we still speculate that BK channel agonists might inhibit the secretion of MVs by activating autophagy, thereby alleviating VC. BK channels may be applied in clinical practice and become a po…
View article: Predicting the risk of postoperative avascular necrosis in patients with talar fractures based on an interpretable machine learning model
Predicting the risk of postoperative avascular necrosis in patients with talar fractures based on an interpretable machine learning model Open
Purpose This study aims to develop and validate an interpretable machine learning model for predicting avascular necrosis (AVN) following talar fracture, thereby aiding in personalized prevention and treatment. Methods A retrospective coho…
View article: m<sup>6</sup>A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma
m<sup>6</sup>A‐modified EHD1 controls PD‐L1 endosomal trafficking to modulate immune evasion and immunotherapy responses in lung adenocarcinoma Open
Background Eps15 homology domain (EHD) proteins, including EHD1 to EHD4, play vital roles in tumor progression. In this study, we aimed to investigate which specific EHD proteins, if any, are implicated in tumor immune evasion and immunoth…
View article: Predictive Model for Preterm Premature Rupture of Membranes Following Fetal Endoscopy Laser Coagulation in Twin-to-twin Transfusion Syndrome Surgery
Predictive Model for Preterm Premature Rupture of Membranes Following Fetal Endoscopy Laser Coagulation in Twin-to-twin Transfusion Syndrome Surgery Open
Objective To develop a risk prediction model for preterm premature rupture of membranes (PPROM) after fetal endoscopy laser coagulation (FLC) for Twin-to-Twin Transfusion Syndrome (TTTS), identifying related influencing factors. Methods A …
View article: Risk prediction models for discordant growth in dichorionic twins was established based on the logistic regression algorithm and machine learning techniques
Risk prediction models for discordant growth in dichorionic twins was established based on the logistic regression algorithm and machine learning techniques Open
Objective To develop a risk prediction model for discordant growth in dichorionic twins, enabling early identification and screening of high-risk cases. Methods Clinical data from 1,098 dichorionic twin pregnancies delivered at Anhui Mater…
View article: Hierarchically Porous Microgels with Interior Spiral Canals for High‐Efficiency Delivery of Stem Cells in Wound Healing
Hierarchically Porous Microgels with Interior Spiral Canals for High‐Efficiency Delivery of Stem Cells in Wound Healing Open
Chronic wound poses a serious risk to diabetic patients, primarily due to damaged skin microvasculature and prolonged inflammation at the wound site. Mesenchymal stem cell (MSC) therapy utilizing microgels as a cell delivery system has sho…
View article: Targeting piRNA‐137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via <i>De Novo</i> Cholesterol Biosynthesis in Lung Adenocarcinoma
Targeting piRNA‐137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via <i>De Novo</i> Cholesterol Biosynthesis in Lung Adenocarcinoma Open
The important role of PIWI‐interacting RNAs (piRNAs) in tumors has garnered increasing attention. However, research on their role in lung adenocarcinoma (LUAD) remains limited. Elevated levels of piRNA‐137463 have been linked to poor progn…
View article: m<sup>6</sup>A‐Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma
m<sup>6</sup>A‐Modified SNRPA Controls Alternative Splicing of ERCC1 Exon 8 to Induce Cisplatin Resistance in Lung Adenocarcinoma Open
Alternative splicing (AS) generates protein diversity and is exploited by cancer cells to drive tumor progression and resistance to many cancer therapies, including chemotherapy. SNRPA is first identified as a spliceosome‐related gene that…
View article: Circulating tumour cell clusters: isolation, biological significance and therapeutic implications
Circulating tumour cell clusters: isolation, biological significance and therapeutic implications Open
Circulating tumour cells (CTCs) and CTC clusters are considered metastatic precursors due to their ability to seed distant metastasis. However, navigating the bloodstream presents a significant challenge for CTCs, as they must endure fluid…
View article: Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma
Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma Open
Intratumor heterogeneity (ITH) of bladder cancer (BLCA) contributes to therapy resistance and immune evasion affecting clinical prognosis. The molecular and cellular mechanisms contributing to BLCA ITH generation remain elusive. It is foun…
View article: A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression? Open
Metabolic reprogramming is a defining hallmark of cancer metastasis, warranting thorough exploration. The tumor-promoting function of the "Warburg Effect", marked by escalated glycolysis and restrained mitochondrial activity, is widely ack…
View article: Detection and characterization of circulating tumor cells and pre-metastatic cancer cells: Questions 108–109 in the 150 most important questions in cancer research and clinical oncology series
Detection and characterization of circulating tumor cells and pre-metastatic cancer cells: Questions 108–109 in the 150 most important questions in cancer research and clinical oncology series Open
In this article, the authors raise two key questions: 108. Can we develop automated noninvasive detection coupled with single-cell omics technologies that can simultaneously identify and characterize the biological properties of circulatin…
View article: Table S6 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S6 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S6
View article: Supplementary Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Supplementary Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Supplementary Information
View article: Table S2 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S2 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S2
View article: Table S5 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S5 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S5
View article: Supplementary Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Supplementary Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Supplementary Information
View article: Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Data from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from patients with melanoma coordinately upregulate lipogenesis and ir…
View article: Table S3 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S3 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S3
View article: Table S7 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S7 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S7
View article: Table S4 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S4 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S4
View article: Table S6 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S6 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S6
View article: Table S3 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
Table S3 from The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis Open
Table S3