Xiaoyun Ding
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View article: Acoustic Probing of New Biomarkers for Rapid Sickle Cell Disease Screening
Acoustic Probing of New Biomarkers for Rapid Sickle Cell Disease Screening Open
Sickle cell disease (SCD) remains a critical global health issue, with high child mortality in low-resource regions. Early screening and diagnosis is essential for improving health outcomes, but conventional screening methods are unsuitabl…
View article: Extracellular Vesicles in Skin: Biological Function and Therapeutic Potential
Extracellular Vesicles in Skin: Biological Function and Therapeutic Potential Open
Extracellular vesicles (EVs) are nanoscale, lipid bilayer-enclosed particles containing bioactive molecules that play crucial roles in tissue homeostasis. These vesicles regulate cellular functions via delivery of protein, lipid, and nucle…
View article: Editorial: Interaction between genes and the environment in skin aging
Editorial: Interaction between genes and the environment in skin aging Open
View article: Adaptive Analysis of Ecosystem Stability in China to Soil Moisture Variations: A Perspective Based on Climate Zoning and Land Use Types
Adaptive Analysis of Ecosystem Stability in China to Soil Moisture Variations: A Perspective Based on Climate Zoning and Land Use Types Open
In this study, we investigate the impact of soil moisture at varying depths on the stability of Chinese ecosystems, with ecosystem stability assessed using the Enhanced Vegetation Index (EVI) and Gross Primary Productivity (GPP). A multi-p…
View article: A Study of Explainable Machine Learning Method to Explore Grassland Resilience in the Arid Ecosystem
A Study of Explainable Machine Learning Method to Explore Grassland Resilience in the Arid Ecosystem Open
View article: High-throughput mechanical nuclear envelope rupture and the intracellular dynamics of massive wound repair
High-throughput mechanical nuclear envelope rupture and the intracellular dynamics of massive wound repair Open
The dynamics of nuclear envelope rupture and wound repair are critical biological processes that play essential roles in cell homeostasis. Previous studies on nuclear envelope repair dynamics have mainly focused on small ruptures induced b…
View article: Investigating agricultural water sustainability in arid regions with Bayesian network and water footprint theories
Investigating agricultural water sustainability in arid regions with Bayesian network and water footprint theories Open
Water scarcity is a significant constraint in agricultural ecosystems of arid regions, necessitating sustainable development of agricultural water resources. This study innovatively combines Bayesian theory and Water Footprint (WF) to cons…
View article: Investigating the Effect of Climate Change on Drought Propagation in the Tarim River Basin Using Multi-Model Ensemble Projections
Investigating the Effect of Climate Change on Drought Propagation in the Tarim River Basin Using Multi-Model Ensemble Projections Open
Recent studies on China’s arid and semi-arid regions, particularly the Tarim River Basin (TRB), have shown an increase in the intensity and frequency of extreme weather events. This research examines the link between meteorological drought…
View article: Microfluidic pumps for cell sorting
Microfluidic pumps for cell sorting Open
Microfluidic cell sorting has shown promising advantages over traditional bulky cell sorting equipment and has demonstrated wide-reaching applications in biological research and medical diagnostics. The most important characteristics of a …
View article: Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in <i>C. elegans</i>
Acoustic streaming enabled moderate swimming exercise reduces neurodegeneration in <i>C. elegans</i> Open
Regular physical exercise has been shown to delay and alleviate neurodegenerative diseases. Yet, optimum physical exercise conditions that provide neuronal protection and exercise-related factors remain poorly understood. Here, we create a…
View article: Photoacoustic Vaporization of Endoskeletal Droplets Loaded with Zinc Naphthalocyanine
Photoacoustic Vaporization of Endoskeletal Droplets Loaded with Zinc Naphthalocyanine Open
Vaporizable endoskeletal droplets are solid hydrocarbons in liquid fluorocarbon droplets in which melting of the hydrocarbon phase leads to the vaporization of the fluorocarbon phase. In prior work, vaporization of the endoskeletal droplet…
View article: Surface Acoustic Wave Integrated Microfluidics for Repetitive and Reversible Temporary Immobilization of <i>C. elegans</i>
Surface Acoustic Wave Integrated Microfluidics for Repetitive and Reversible Temporary Immobilization of <i>C. elegans</i> Open
Caenorhabditis elegans is an important genetic model for neuroscience studies due to its unique combination of genetics, transparency, complete synaptic connectome, and well-characterized behaviors. These factors, in turn, enable analyses …
View article: Acoustically manipulating internal structure of disk-in-sphere endoskeletal droplets
Acoustically manipulating internal structure of disk-in-sphere endoskeletal droplets Open
View article: Influence of Highly Asymmetric Pore Structure on Capillary Bonding of Porous Membranes
Influence of Highly Asymmetric Pore Structure on Capillary Bonding of Porous Membranes Open
View article: Surface acoustic wave microfluidics for repetitive and reversible temporary immobilization of <i>C. elegans</i>
Surface acoustic wave microfluidics for repetitive and reversible temporary immobilization of <i>C. elegans</i> Open
The SAW immobilization device facilitates multiplexed, longitudinal analysis of fluorescently tagged glutamatergic receptors and swimming behavior in C. elegans , enabling future studies on how aging affects neural circuits that control lo…
View article: Acoustically excited microstructure for on-demand fouling mitigation in a microfluidic membrane filtration device
Acoustically excited microstructure for on-demand fouling mitigation in a microfluidic membrane filtration device Open
Membrane separation is widely used in food, pharmaceutical and water treatment industries but suffers a longstanding challenge of fouling. In this article, acoustically excited microstructures are demonstrated as a new mechanism to mitigat…
View article: Acoustically Manipulating Internal Structure of Disk-in-Sphere Endoskeletal Droplets
Acoustically Manipulating Internal Structure of Disk-in-Sphere Endoskeletal Droplets Open
Manipulation of micro/nano particles has been well studied and demonstrated by optical, electromagnetic, and acoustic approaches, or their combinations. Manipulation of internal structure of droplet/particle is rarely explored and remains …
View article: Nuclear Stiffness Decreases with Disruption of the Extracellular Matrix in Living Tissues
Nuclear Stiffness Decreases with Disruption of the Extracellular Matrix in Living Tissues Open
Reciprocal interactions between the cell nucleus and the extracellular matrix lead to macroscale tissue phenotype changes. However, little is known about how the extracellular matrix environment affects gene expression and cellular phenoty…
View article: A frugal microfluidic pump
A frugal microfluidic pump Open
A frugal microfluidic pump is a fluid actuation system that is Fully self-sufficient, RobUst, Gravity-Assisted, and Low-cost (FRUGAL). The pump can generate pressure for versatile microfluidic applications.
View article: Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization
Emerging on-chip surface acoustic wave technology for small biomaterials manipulation and characterization Open
Surface acoustic wave microfluidic technology has found great potential in biomaterials science thanks to its advantages in micro/nano manipulation and characterization.
View article: Protein Thermodynamic Stability: On‐Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability (Small 41/2020)
Protein Thermodynamic Stability: On‐Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability (Small 41/2020) Open
In article number 2003506, Xiaoyun Ding and co‐workers present an acousto thermal shift assay (ATSA) utilizing acoustic mechanisms to denature proteins and concentrate protein precipitates for rapid and label‐free assessment of protein the…
View article: On‐Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability
On‐Chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability Open
Thermal shift assays (TSAs) have been extensively used to study thermodynamics of proteins and provide an efficient means to assess protein–ligand binding or protein–protein interactions. However, existing TSAs have limitations, such as be…
View article: Nuclear stiffness decreases with disruption of the extracellular matrix in living tissues
Nuclear stiffness decreases with disruption of the extracellular matrix in living tissues Open
Reciprocal interactions between the cell nucleus and the extracellular matrix lead to macroscale tissue phenotype changes. The extracellular environment is physically linked to the nuclear envelope and provides cues to maintain nuclear str…
View article: Vaporizable endoskeletal droplets via tunable interfacial melting transitions
Vaporizable endoskeletal droplets via tunable interfacial melting transitions Open
Interfacial melting of an internal solid hydrocarbon “skeletal” phase initiates vaporization of liquid fluorocarbon droplets.
View article: Tethering transforming growth factor β1 to soft hydrogels guides vascular smooth muscle commitment from human mesenchymal stem cells
Tethering transforming growth factor β1 to soft hydrogels guides vascular smooth muscle commitment from human mesenchymal stem cells Open
View article: A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing
A review of emerging physical transfection methods for CRISPR/Cas9-mediated gene editing Open
Gene editing is a versatile technique in biomedicine that promotes fundamental research as well as clinical therapy. The development of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) as a genome editing machinery has ac…
View article: Flattening of Diluted Species Profile via Passive Geometry in a Microfluidic Device
Flattening of Diluted Species Profile via Passive Geometry in a Microfluidic Device Open
In recent years, microfluidic devices have become an important tool for use in lab-on-a-chip processes, including drug screening and delivery, bio-chemical reactions, sample preparation and analysis, chemotaxis, and separations. In many su…
View article: Advanced nanostructures for cell membrane poration
Advanced nanostructures for cell membrane poration Open
Nanostructured devices are able to foster the technology for cell membrane poration. With the size smaller than a cell, nanostructures allow efficient poration on the cell membrane. Emerging nanostructures with various physical transductio…
View article: High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption
High-throughput nuclear delivery and rapid expression of DNA via mechanical and electrical cell-membrane disruption Open