Xiaolei Tang
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View article: FUT3-B3GNT3 Interaction Promotes Pancreatic Cancer Progression and Chemoresistance via NF-κB signaling Mediated Autophagy
FUT3-B3GNT3 Interaction Promotes Pancreatic Cancer Progression and Chemoresistance via NF-κB signaling Mediated Autophagy Open
Pancreatic ductal adenocarcinoma (PDAC) is prone to drug resistance and a role for fucosyltransferase 3 (FUT3) is increasingly recognized. The current study investigated the mechanisms by which FUT3 contributes to PDAC. FUT3 expression was…
View article: Mannose‐binding lectin insufficiency is associated with airway <i>Haemophilus</i> colonization and a higher risk of post‐RSV bronchiolitis recurrent wheezing
Mannose‐binding lectin insufficiency is associated with airway <i>Haemophilus</i> colonization and a higher risk of post‐RSV bronchiolitis recurrent wheezing Open
Objective To investigate whether mannose‐binding lectin (MBL) insufficiency influences the airway microbiota composition and development of subsequent recurrent wheezing in infants with severe respiratory syncytial virus (RSV) bronchioliti…
View article: Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer’s disease
Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer’s disease Open
View article: Research on Emergency Nursing Strategies for Patients with Acute Myocardial Infarction
Research on Emergency Nursing Strategies for Patients with Acute Myocardial Infarction Open
Background: Acute myocardial infarction (AMI) demands timely and effective intervention to prevent severe complications and improve patient outcomes. However, differences in emergency nursing protocols can affect the success of treatment. …
View article: Lymphatic malformations involving the thorax in children: a retrospective cohort study
Lymphatic malformations involving the thorax in children: a retrospective cohort study Open
View article: Calycosin Inhibits Cell Proliferation and Induces Apoptosis in Bladder Cancer T24 Cells
Calycosin Inhibits Cell Proliferation and Induces Apoptosis in Bladder Cancer T24 Cells Open
View article: USP14/S100A11 axis promote colorectal cancer progression by inhibiting cell senescence
USP14/S100A11 axis promote colorectal cancer progression by inhibiting cell senescence Open
The aberrant expression of S100A11 has been identified in various malignancies but its functional roles and underlying mechanisms in colorectal cancer (CRC) have not been fully elucidated. Therefore, this study was designed to investigate …
View article: Therapeutic Applications of Vitamin D
Therapeutic Applications of Vitamin D Open
View article: Curcumin-copper complex nanoparticles as antioxidant nanozymes for acute kidney injury alleviation
Curcumin-copper complex nanoparticles as antioxidant nanozymes for acute kidney injury alleviation Open
View article: Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway Open
Dendrobium huoshanense has received special attention for its advantages in the treatment of lung cancer, but the underlying molecular mechanisms are not yet well understood. First, we obtained 8 active ingredients and 159 effective action…
View article: Research diversity in infectious and immunological diseases at Long Island University College of Veterinary Medicine
Research diversity in infectious and immunological diseases at Long Island University College of Veterinary Medicine Open
View article: MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis
MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis Open
View article: Clinical features and risk factors for development of post-infectious bronchiolitis obliterans in children
Clinical features and risk factors for development of post-infectious bronchiolitis obliterans in children Open
View article: 1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5+ Intestinal Stem Cells In Vitro and In Vivo
1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5+ Intestinal Stem Cells In Vitro and In Vivo Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines without a cure. Current therapies suppress inflammation to prevent further intestinal damage. However, healing already damaged intestinal epithelia is st…
View article: Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction
Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction Open
Objective To investigate the clinical significance of the creatine kinase (CK)-MB/total CK ratio, neutrophil/lymphocyte ratio (NLR) and red blood cell distribution width in acute myocardial infarction (AMI). Methods A retrospective analysi…
View article: Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis
Hepatocellular carcinoma cells downregulate NADH:Ubiquinone Oxidoreductase Subunit B3 to maintain reactive oxygen species homeostasis Open
Background: HCC is a leading cause of cancer-related death. The role of reactive oxygen species (ROS) in HCC remains elusive. Since a primary ROS source is the mitochondrial electron transport chain complex Ι and the NADH:ubiquinone Oxidor…
View article: Fluorescein-Modified Nitrogen-Doped Carbon Quantum Dots Prepared as Triple-Emission Ratiometric Fluorescent Probes for the Detection of Roxithromycin in Human Serum Samples
Fluorescein-Modified Nitrogen-Doped Carbon Quantum Dots Prepared as Triple-Emission Ratiometric Fluorescent Probes for the Detection of Roxithromycin in Human Serum Samples Open
View article: Enhancing Human Treg Cell Induction through Engineered Dendritic Cells and Zinc Supplementation
Enhancing Human Treg Cell Induction through Engineered Dendritic Cells and Zinc Supplementation Open
Regulatory T (Treg) cells hold promise for the ultimate cure of immune-mediated diseases. However, how to effectively restore Treg function in patients remains unknown. Previous reports suggest that activated dendritic cells (DCs) de no…
View article: Clinical and genetic analysis of two patients with primary ciliary dyskinesia caused by a novel variant of DNAAF2
Clinical and genetic analysis of two patients with primary ciliary dyskinesia caused by a novel variant of DNAAF2 Open
View article: Pathogens of first-episode pulmonary infection in 141 children with chronic granulomatous disease
Pathogens of first-episode pulmonary infection in 141 children with chronic granulomatous disease Open
To the Editor: Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disease characterized by recurrent life-threatening bacterial or fungal infection and tissue granuloma formation.[1] Pulmonary infection is the mos…
View article: Circular RNA ANKIB1 alleviates hypoxia-induced cardiomyocyte injury by modulating miR-452-5p/SLC7A11 axis
Circular RNA ANKIB1 alleviates hypoxia-induced cardiomyocyte injury by modulating miR-452-5p/SLC7A11 axis Open
This investigation revealed for the first time that circANKIB1 regulated signaling of the miR-452-5p/SLC7A11 axis, thereby ameliorating hypoxia-induced cardiomyocyte injury. These findings suggest that circANKIB1 might be a useful adjunct …
View article: 1,25-Dihydroxy Vitamin D Enhances the Differentiation of Intestinal Stem Cells Ex Vivo and In Vivo
1,25-Dihydroxy Vitamin D Enhances the Differentiation of Intestinal Stem Cells Ex Vivo and In Vivo Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines. Current therapies aim at suppressing inflammation to prevent further damage. However, healing already damaged intestinal epithelia is still an unmet med…
View article: Zinc Treated Engineered Human Dendritic Cells Capable of Synthesizing High Active Vitamin D and Retinoic Acid Concentrations Enhance Gut-homing Regulatory T Cell Induction
Zinc Treated Engineered Human Dendritic Cells Capable of Synthesizing High Active Vitamin D and Retinoic Acid Concentrations Enhance Gut-homing Regulatory T Cell Induction Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the gastrointestinal tract (the Gut). Available IBD therapies can cause severe side effects, and many patients either fail to respond to the treatment or lose therapeut…
View article: Targeting histone deacetylases for cancer therapy: Trends and challenges
Targeting histone deacetylases for cancer therapy: Trends and challenges Open
View article: Association between Serum Homocysteine and Erectile Dysfunction: A Systematic Review and Meta-Analysis
Association between Serum Homocysteine and Erectile Dysfunction: A Systematic Review and Meta-Analysis Open
View article: The prevalence and influencing factors of the oropharyngeal carriage of Haemophilus influenzae in healthy children in a high-altitude area of China: A cross-sectional study
The prevalence and influencing factors of the oropharyngeal carriage of Haemophilus influenzae in healthy children in a high-altitude area of China: A cross-sectional study Open
Haemophilus influenzae is a common commensal organism of the human upper respiratory tract and an important cause of human disease. No data on H influenzae carriage rate has been carried out on the Qinghai-Tibet Plateau of China. This stud…
View article: New clinical aspects of immune dysregulation in atypical severe combined immunodeficiency due to mutations in IL2RG and RAG1
New clinical aspects of immune dysregulation in atypical severe combined immunodeficiency due to mutations in IL2RG and RAG1 Open
Purpose The mild form of severe combined immunodeficiency disease (SCID) is called atypical SCID resulting from hypomorphic mutations in SCID-causing genes. We characterize the new clinical aspects in four atypical SCID children. Methods F…
View article: Expression and significance of FOXO3 and IL-2 in conjunctival epithelial cells and tears of patients with dry eye
Expression and significance of FOXO3 and IL-2 in conjunctival epithelial cells and tears of patients with dry eye Open
AIM: To explore the expression and significance of forkhead box class O3(FOXO3)and interleukin-2(IL-2)in conjunctival epithelial cells and tears of patients with dry eye(DE).METHODS:A perspective study. A total of 106 DE patients who accep…
View article: Ginseng-derived nanoparticles inhibit lung cancer cell epithelial mesenchymal transition by repressing pentose phosphate pathway activity
Ginseng-derived nanoparticles inhibit lung cancer cell epithelial mesenchymal transition by repressing pentose phosphate pathway activity Open
It is unclear whether ginseng-derived nanoparticles (GDNPs) can prevent tumor cell epithelial-mesenchymal transition (EMT). Here, we describe typical characteristics of GDNPs and possible underlying mechanisms for GDNP antitumor activities…
View article: The value of interleukin-27 for differentiating tuberculous pleural effusion from Mycoplasma pneumoniae pneumonic effusion in children
The value of interleukin-27 for differentiating tuberculous pleural effusion from Mycoplasma pneumoniae pneumonic effusion in children Open
Objectives The early diagnosis of tuberculous pleural effusion (TPE) is challenging due to the difficulty of isolating Mycobacterium tuberculosis , and pleural biomarkers are an optional choice. Recent studies showed that interleukin-27 (I…