Abstract Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformation, resulting in significant risks of life‐threatening seizures and strokes. The current absence of specific treatments underscores the need to define the molecular and cellular mechanisms that drive the progression of SWS. Here, the transcriptome of 119 446 cells isolated from both malformed tissues and peri‐lesion tissues from the brains of patients with SWS is examined. This comprehensive analysis finds a complex landscap…

Background: Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder marked by impaired interactions and restricted interests, the pathophysiology of which is not fully understood. The current study explored the potential therapeutic effects of transcranial direct current stimulation (tDCS) on the neurophysiological aspects of ASD, specifically focusing on the brain’s excitatory/inhibitory (E/I) balance and behavioral outcomes, providing scientific guidance for ASD intervention. Methods: Forty-…

The findings suggest that PTEN could play a key role in enhancing the efficacy of NPC radiotherapy and immunotherapy. By shedding light on PTEN's impact on tumor growth and the immune microenvironment, this study lays the groundwork for future personalized therapeutic strategies in NPC treatment.

Abstract The TWIK-related K + channel (TREK-1), a member of the two-pore domain potassium(K2P) family, is characterized as a “leaky potassium channel” and is integral to the maintenance of the resting membrane potential. As the most abundant cell type in the central nervous system, astrocytes play important roles in the development of epilepsy by regulating the release of glutamate and the function of potassium channels. Previous studies have revealed that TREK-1 is involved in a range of neurological diseases, in…