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View article: The ABC-14 regimen (Azacitidine, Venetoclax, and Chidamide) as a bridge to allogeneic hematopoietic stem cell transplantation for Acute Myeloid Leukemia: A single-center experience
The ABC-14 regimen (Azacitidine, Venetoclax, and Chidamide) as a bridge to allogeneic hematopoietic stem cell transplantation for Acute Myeloid Leukemia: A single-center experience Open
Background: The combination of azacitidine, venetoclax, and chidamide (ABC-14 regimen) has demonstrated efficacy comparable to “3+7” intensive chemotherapy (IC) with a favorable tolerability profile in newly diagnosed AML. However, its rol…
View article: Effect of different heat treatments on physicochemical properties and antioxidant characteristics of black beans
Effect of different heat treatments on physicochemical properties and antioxidant characteristics of black beans Open
This study systematically evaluated the effects of four thermal processing methods-boiling, steaming, extrusion, and roasting-on the physicochemical properties and in vitro antioxidant activity of black beans. Notably, ash content decrease…
View article: 3D surface profiling via photonic integrated geometric sensor
3D surface profiling via photonic integrated geometric sensor Open
Measurements of microscale surface patterns are essential for process and quality control in industries across semiconductors, micro-machining, and biomedicines. However, the development of miniaturized and intelligent profiling systems re…
View article: Optimizing olverembatinib dose in chronic phase chronic myeloid leukemia
Optimizing olverembatinib dose in chronic phase chronic myeloid leukemia Open
Optimizing olverembatinib dose in people with chronic phase chronic myeloid leukemia (CML) is important to increase safety without compromising efficacy. We designed a multi-center retrospective study comparing safety and efficacy of olver…
View article: Comparison of the efficacy of transumbilical single-port laparoscopy and traditional laparoscopy for type II/III cesarean scar pregnancy
Comparison of the efficacy of transumbilical single-port laparoscopy and traditional laparoscopy for type II/III cesarean scar pregnancy Open
TSPLS had better cosmetic effects than traditional multi-port laparoscopy, without surgical results and postoperative recovery difference, making it valuable for clinical application.
View article: Correlation between ultrasound-measured inferior vena cava diameter and peripherally inserted central catheter measured central venous pressure in low birth weight infants
Correlation between ultrasound-measured inferior vena cava diameter and peripherally inserted central catheter measured central venous pressure in low birth weight infants Open
Birth weight, SD, S/L ratio, and CVP are significant factors affecting PICC placement in LBWI. There is a notable correlation between ultrasound-measured IVC SD and S/L ratio and PICC-measured CVP in LBWIs.
View article: Preparation of Black Soybean (<i>Glycine max</i> (L.) Merr.) Components by Supercritical Carbon Dioxide (SC‐CO<sub>2</sub>) Extraction: A Box–Behnken Process Optimization, Component, and Oxidation Resistance Analysis
Preparation of Black Soybean (<i>Glycine max</i> (L.) Merr.) Components by Supercritical Carbon Dioxide (SC‐CO<sub>2</sub>) Extraction: A Box–Behnken Process Optimization, Component, and Oxidation Resistance Analysis Open
Black soybeans have a long history in China, with rich nutrition and efficacy. The extraction of its active ingredients is mostly focused on methods such as ultrasound, microwave, Soxhlet extraction, and distillation. These methods rely he…
View article: Azacitidine, Venetoclax Combined with Chidamide (ABC-14 Regimen) As an Induction Therapy for Newly Diagnosed AML: A Real-World Retrospective Analysis By the ABC-14 Collaboration Group
Azacitidine, Venetoclax Combined with Chidamide (ABC-14 Regimen) As an Induction Therapy for Newly Diagnosed AML: A Real-World Retrospective Analysis By the ABC-14 Collaboration Group Open
Background: The “3+7” chemotherapy regimen is the standard for newly diagnosed acute myeloid leukemia (ND-AML). New therapeutic agents have made exploring alternative intensive chemotherapy (IC) regimens viable. The VIALE-A study explored …
View article: MRD-Driven Prophylactic or Pre-Emptive Intervention with Chidamide-Based Treatment for High-Risk AML Relapse Post-Transplantation: A Real-World Experience from a Chinese Single Center
MRD-Driven Prophylactic or Pre-Emptive Intervention with Chidamide-Based Treatment for High-Risk AML Relapse Post-Transplantation: A Real-World Experience from a Chinese Single Center Open
Background: The persistence of measurable residual disease (MRD) at the time of transplantation or post-transplantation is widely recognized as the most significant risk factor for relapse and poor outcomes in patients with acute myeloid l…
View article: Induction Chemotherapy‐Related Covert Cardiac Remodeling in Pre‐Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma: A Retrospective Observational Study
Induction Chemotherapy‐Related Covert Cardiac Remodeling in Pre‐Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma: A Retrospective Observational Study Open
Background Autologous hematopoietic stem cell transplantation (ASCT) has emerged as a cornerstone in multiple myeloma (MM) management, offering the prospect of prolonged disease control. However, the induction chemotherapy drugs required p…
View article: Phase 3 study of gilteritinib versus salvage chemotherapy in predominantly Asian patients with relapsed/refractory FLT3-mutated acute myeloid leukemia
Phase 3 study of gilteritinib versus salvage chemotherapy in predominantly Asian patients with relapsed/refractory FLT3-mutated acute myeloid leukemia Open
The phase 3 COMMODORE trial evaluated gilteritinib versus salvage chemotherapy (SC) in a predominantly Asian relapsed/refractory (R/R) FLT3-mutated (FLT3mut+) acute myeloid leukemia (AML) patient population. The primary endpoint was overal…
View article: Long-term outcomes with HLX01 (HanliKang®), a rituximab biosimilar, in previously untreated patients with diffuse large B-cell lymphoma: 5-year follow-up results of the phase 3 HLX01-NHL03 study
Long-term outcomes with HLX01 (HanliKang®), a rituximab biosimilar, in previously untreated patients with diffuse large B-cell lymphoma: 5-year follow-up results of the phase 3 HLX01-NHL03 study Open
HLX01 (HanliKang ® ) is a rituximab biosimilar that showed bioequivalence to reference rituximab in untreated CD20-positive diffuse large B-cell lymphoma (DLBCL) in the phase 3 HLX01-NHL03 study. Here, we report the 5-year follow-up result…
View article: A novel anti‐amyloid‐beta oligomer antibody reduces plaque burden and slows cognitive decline in 5xFAD mice
A novel anti‐amyloid‐beta oligomer antibody reduces plaque burden and slows cognitive decline in 5xFAD mice Open
Background The soluble amyloid‐beta (Aβ) oligomers are the more toxic form of Aβ as compared with monomers and insoluble fibrils. Lecanemab, a humanized monoclonal antibody (mAb) with high affinity for Aβ oligomers, reduced cognitive decli…
View article: A Prediction Model for Early Recurrence after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with CMML: A Nationwide Representative Multicenter Study
A Prediction Model for Early Recurrence after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with CMML: A Nationwide Representative Multicenter Study Open
Introduction: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy. Some patients experience prolonged remission after aggressive chemotherapy, but the only current therapy with proven curative potential is…
View article: Novel Anti-TMPRSS6 Monoclonal Antibody Provides a Potential Therapeutic Approach for the Treatment of Polycythemia Vera
Novel Anti-TMPRSS6 Monoclonal Antibody Provides a Potential Therapeutic Approach for the Treatment of Polycythemia Vera Open
Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) triggered by activating mutations in JAK2, an important kinase in the principal signaling pathway of the erythropoietin receptor. Most of the clinical manifestations of PV are c…
View article: Stem cell-based therapy for COVID-19
Stem cell-based therapy for COVID-19 Open
While The World Health Organization (WHO) has announced that COVID-19 is no longer a public health emergency of international concern(PHEIC), the risk of reinfection and new emerging variants still makes it crucial to study and work toward…
View article: P1277: IMPACT OF A NOVEL PROGNOSTIC MODEL ON ALLOGENEIC HAEMATOPOIETIC STEM CELL TRANSPLANTATION OUTCOMES IN PATIENTS WITH CMML
P1277: IMPACT OF A NOVEL PROGNOSTIC MODEL ON ALLOGENEIC HAEMATOPOIETIC STEM CELL TRANSPLANTATION OUTCOMES IN PATIENTS WITH CMML Open
Topic: 22. Stem cell transplantation - Clinical Background: Chronic myelomonocytic leukaemia (CMML) is a clonal haematopoietic stem cell malignancy, and allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a potentially curat…
View article: Impact of a novel prognostic model on allogeneic hematopoietic stem cell transplantation outcomes in patients with <scp>CMML</scp>
Impact of a novel prognostic model on allogeneic hematopoietic stem cell transplantation outcomes in patients with <span>CMML</span> Open
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the only curable treatment. The outcomes after transplant are influenced by both d…
View article: Supplementary Figure 4 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer
Supplementary Figure 4 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer Open
Supplementary Figure 4. Pano did not enhance the cytotoxicity of CARaMEL cells nor oncolysis of VV-gp100.
View article: Supplementary Figure 2 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer
Supplementary Figure 2 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer Open
Supplementary Figure 2. Pancreatic cells are resistant to VV-gp100 oncolysis but sensitive to CAR T cell-mediated cytotoxicity.
View article: Supplementary Figure 6 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer
Supplementary Figure 6 from A Histone Deacetylase Inhibitor, Panobinostat, Enhances Chimeric Antigen Receptor T-cell Antitumor Effect Against Pancreatic Cancer Open
Supplementary Figure 6. The infiltration of CD8+ cells to the Her2+ non-tumor regions.
View article: Erratum to: Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: Overactivated <scp>WNT</scp>/β‐catenin signalling by parallel <scp>RNA</scp> sequencing and dysfunctional phenotypes
Erratum to: Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: Overactivated <span>WNT</span>/β‐catenin signalling by parallel <span>RNA</span> sequencing and dysfunctional phenotypes Open
British Journal of HaematologyEarly View ERRATUMFree Access Erratum to: Bone marrow mesenchymal stromal cells in chronic myelomonocytic leukaemia: Overactivated WNT/β-catenin signalling by parallel RNA sequencing and dysfunctional phenotyp…
View article: Additional file 8 of Sex-biased molecular differences in lung adenocarcinoma are ethnic and smoking specific
Additional file 8 of Sex-biased molecular differences in lung adenocarcinoma are ethnic and smoking specific Open
Additional file 8: Table S19. The DEGs identified from the comparison between female and male responders to ICB in the GSE135222 dataset.
View article: Additional file 5 of Sex-biased molecular differences in lung adenocarcinoma are ethnic and smoking specific
Additional file 5 of Sex-biased molecular differences in lung adenocarcinoma are ethnic and smoking specific Open
Additional file 5: Table S16. The DEGs identified from the comparison between all female and male LUADs in the TCGA cohort (Non-Asian).