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View article: Chronic TCR Signaling-Driven Suppression of the FOXO-KLHL6 Axis Promotes T Cell Exhaustion
Chronic TCR Signaling-Driven Suppression of the FOXO-KLHL6 Axis Promotes T Cell Exhaustion Open
No abstract is needed for a brief report.
View article: 364 Systems immunology-guided <i>in vivo</i> CRISPR screens reveal a multifunctional E3 ligase that enhances adoptive T cell therapy for solid tumors
364 Systems immunology-guided <i>in vivo</i> CRISPR screens reveal a multifunctional E3 ligase that enhances adoptive T cell therapy for solid tumors Open
View article: Efficacy and safety of tranexamic acid in cardiac surgery: a systematic review and network meta-analysis
Efficacy and safety of tranexamic acid in cardiac surgery: a systematic review and network meta-analysis Open
View article: Borderline Z-scores in non-invasive prenatal screening: does its presence hold clinical significance?
Borderline Z-scores in non-invasive prenatal screening: does its presence hold clinical significance? Open
Initial NIPT outcomes suggested elevated screening positive rates and a higher incidence of fetal abnormalities among cases with borderline Z-scores compared to the general population. Establishing a defined borderline Z-score threshold in…
View article: Optimized Homologous Sequence Alignment for the Identification of CYP21A2 Variants in 21-Hydroxylase Deficiency Using Next-Generation Sequencing Technology
Optimized Homologous Sequence Alignment for the Identification of CYP21A2 Variants in 21-Hydroxylase Deficiency Using Next-Generation Sequencing Technology Open
In genetic testing, particularly when addressing misalignment challenges associated with highly homologous genes such as CYP21A2, application of the HSA algorithm enables accurate mutation detection using commonly employed short-read seque…
View article: Loss of hepatic carboxylesterase 3 prevents the development of MASLD in mice
Loss of hepatic carboxylesterase 3 prevents the development of MASLD in mice Open
Carboxylesterases (CESs) are essential for metabolizing compounds with ester, thioester, and amide bonds. While the roles of CES1 and CES2 in lipid metabolism have been well established, little is known about the role of CES3 in lipid meta…
View article: Borderline Z-scores in Non-Invasive Prenatal Screening: Does Its Presence Hold Clinical Significance?
Borderline Z-scores in Non-Invasive Prenatal Screening: Does Its Presence Hold Clinical Significance? Open
Background This study aimed to investigate the utility of repeated testing for the detection of fetal cell-free DNA (cfDNA) from maternal peripheral blood in cases with borderline Z-scores, and to analyze the associated pregnancy outcomes.…
View article: Treatment Landscape of Intracranial Aneurysms in Eastern China: A Propensity-Matched Analysis of Technique Adoption and Outcomes (2018–2022)
Treatment Landscape of Intracranial Aneurysms in Eastern China: A Propensity-Matched Analysis of Technique Adoption and Outcomes (2018–2022) Open
This is the first multicenter study on IA treatment in Eastern China, integrating clinical outcomes with socioeconomic factors. Findings suggest EC is increasingly favored, particularly for UIAs, but SC remains essential for complex cases.…
View article: Intelligent identification method of origin for Alismatis Rhizoma based on image and machine learning
Intelligent identification method of origin for Alismatis Rhizoma based on image and machine learning Open
View article: Resolution of tonsillar herniation and syringomyelia after resection of supratentorial large meningioma
Resolution of tonsillar herniation and syringomyelia after resection of supratentorial large meningioma Open
This case shows that supratentorial space-occupying lesions (SOLs) causing acquired Chiari malformation (ACM) and syringomyelia is closely related to the tumor oppresses and increases the pressure of the posterior cranial fossa. Posterior …
View article: 230 Mannose supplementation: a strategy for metabolically driving a stem-like T cell program for improved tumor control
230 Mannose supplementation: a strategy for metabolically driving a stem-like T cell program for improved tumor control Open
View article: Loss of adipose ATF3 promotes adipose tissue lipolysis and the development of MASH
Loss of adipose ATF3 promotes adipose tissue lipolysis and the development of MASH Open
The crosstalk between adipose tissue and the liver is finely controlled to maintain metabolic health. Yet, how adipose tissue controls toxic free fatty acid overflow into the liver remains incompletely understood. Here, we show that adipoc…
View article: Does Screw Number of Zero‐profile Implants in Fusion Segment Influence Intervertebral Stability?
Does Screw Number of Zero‐profile Implants in Fusion Segment Influence Intervertebral Stability? Open
Objective The unclear clinical outcomes of two different zero‐profile implants with different number of screws in hybrid surgery restricts the choice of patient‐specific implants. This study aims to compare two different implants on its po…
View article: Electroacupuncture improves low-grade duodenal inflammation in FD rats by reshaping intestinal flora through the NF-κB p65/NLRP3 pyroptosis pathway
Electroacupuncture improves low-grade duodenal inflammation in FD rats by reshaping intestinal flora through the NF-κB p65/NLRP3 pyroptosis pathway Open
View article: Krüppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4α-mediated metabolic pathways
Krüppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4α-mediated metabolic pathways Open
View article: Hepatic FOXA3 overexpression prevents Western diet–induced obesity and MASH through TGR5
Hepatic FOXA3 overexpression prevents Western diet–induced obesity and MASH through TGR5 Open
Forkhead transcription factor 3 (FOXA3) has been shown to regulate metabolism and development. Hepatic FOXA3 is reduced in obesity and fatty liver disease. However, the role of hepatic FOXA3 in regulating obesity or steatohepatitis remains…
View article: A statistical investigation of parameters associated with low cell-free fetal DNA fraction in maternal plasma for noninvasive prenatal testing
A statistical investigation of parameters associated with low cell-free fetal DNA fraction in maternal plasma for noninvasive prenatal testing Open
According to our findings based on the OR value, factors associated strongly with LFF include a high BMI and the use of IVF. Factors associated less strongly with LFF include early gestational age and twin pregnancy, while advanced materna…
View article: Co-N-C Catalyst with Single Atom Active Sites for Base-Free Aerobic Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid Under Mild Conditions
Co-N-C Catalyst with Single Atom Active Sites for Base-Free Aerobic Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid Under Mild Conditions Open
View article: Efficacy of benfotiamine plus donepezil treatment for patients with mild‐to‐moderate Alzheimer’s disease: multicenter, randomized, phase II clinical trial
Efficacy of benfotiamine plus donepezil treatment for patients with mild‐to‐moderate Alzheimer’s disease: multicenter, randomized, phase II clinical trial Open
Background To assess the efficacy of benfotiamine plus donepezil treating mild‐to‐moderate Alzheimer’s disease (AD). Method Design: Multicenter, randomised, double‐blind, phase II clinical trial. Setting: 21 cognitive clinics of tertiary h…
View article: Adipocyte retinoic acid receptor α prevents obesity and steatohepatitis by regulating energy expenditure and lipogenesis
Adipocyte retinoic acid receptor α prevents obesity and steatohepatitis by regulating energy expenditure and lipogenesis Open
Objective The adipose tissue–liver axis is a major regulator of the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Retinoic acid signaling plays an important role in development and metabolism. However, little is known about the…
View article: Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats
Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats Open
This experiment was designed to explore the effect and mechanism of electroacupuncture (EA) for hyperlipidemia and hepatic cholesterol synthesis in rats. Liver and adipose tissues were assessed histologically, and body and liver weight, se…
View article: Hepatocyte Sirtuin 6 Protects against Atherosclerosis and Steatohepatitis by Regulating Lipid Homeostasis
Hepatocyte Sirtuin 6 Protects against Atherosclerosis and Steatohepatitis by Regulating Lipid Homeostasis Open
Histone deacetylase Sirtuin 6 (SIRT6) regulates many biological processes. SIRT6 is known to regulate hepatic lipid metabolism and inhibit the development of nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the role of hep…
View article: Risk Factors of Nonfusion after Anterior Cervical Decompression and Fusion in the Early Postoperative Period: A Retrospective Study
Risk Factors of Nonfusion after Anterior Cervical Decompression and Fusion in the Early Postoperative Period: A Retrospective Study Open
Objective Although high fusion rates have been reported for anterior cervical decompression and fusion (ACDF) in the medium and long term, the risk of nonfusion in the early period after ACDF remains substantial. This study investigates ea…
View article: Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating <i>Itgav</i> expression
Runx2 activates hepatic stellate cells to promote liver fibrosis via transcriptionally regulating <i>Itgav</i> expression Open
Backgrounds and aims As a central event during liver fibrosis, hepatic stellate cells (HSC) have been thought to be a potential therapeutic target for liver fibrosis. Previous studies have shown that runt‐related transcription factor 2 (Ru…
View article: A comparison of the five-minute cognitive test with the mini-mental state examination in the elderly for cognitive impairment screening
A comparison of the five-minute cognitive test with the mini-mental state examination in the elderly for cognitive impairment screening Open
The five-minute cognitive test (FCT) is a novel cognitive screening method with the quick and reliable merit for detecting cognitive impairment at an early stage. The diagnostic power of FCT in differentiating subjects with cognitive impai…
View article: Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model
Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model Open
Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally plasmablasts, that express B cell receptors (BCRs) on their cell surface. Despite the impo…
View article: Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer
Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer Open
Epidermal growth factor receptor (EGFR) is one of the most studied drug targets for the treatment of non-small-cell lung cancer (NSCLC). Here, we report the identification, structure optimization, and structure-activity relationship studie…
View article: The Effect of the JAK-inhibitor Tofacitinib on Chondrocyte Autophagy in Osteoarthritis
The Effect of the JAK-inhibitor Tofacitinib on Chondrocyte Autophagy in Osteoarthritis Open
Osteoarthritis (OA) is a multifactorial disease of the whole joint that has a complex pathogenesis. There is currently no cure for OA. Tofacitinib is a broad JAK inhibitor that can have an anti-inflammatory effect. The objective of this st…
View article: IL-17 in osteoarthritis: A narrative review
IL-17 in osteoarthritis: A narrative review Open
Osteoarthritis (OA) is a painful joint disease that is common among the middle-aged and elderly populations, with an increasing prevalence. Therapeutic options for OA are limited, and the pathogenic mechanism of OA remains unclear. The rol…
View article: Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology
Physiological Roles of β-amyloid in Regulating Synaptic Function: Implications for AD Pathophysiology Open