Xiaoli Yao
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View article: Molecular Epidemiology of Drug-Resistant Tuberculosis in Shantou, China: Associations between Drug Resistance and Genotypic Variation
Molecular Epidemiology of Drug-Resistant Tuberculosis in Shantou, China: Associations between Drug Resistance and Genotypic Variation Open
Background Drug-resistant tuberculosis (DR-TB) is a major global health threat, particularly in resource-limited regions. Understanding lineage-specific mutations is critical for improving diagnostics and guiding precision treatment. Metho…
View article: Construction and validation of a novel prognostic model for postoperative patients with stage I intrahepatic cholangiocarcinoma: a population-based study
Construction and validation of a novel prognostic model for postoperative patients with stage I intrahepatic cholangiocarcinoma: a population-based study Open
The prognostic nomogram of postoperative patients diagnosed with stage I ICC performs well. This novel nomogram may help clinicians make individualized predictions of postsurgical outcomes for patients with stage I ICC and provide new pers…
View article: Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy
Isoginkgetin antagonizes ALS pathologies in its animal and patient iPSC models via PINK1-Parkin-dependent mitophagy Open
Damaged mitochondria initiate mitochondrial dysfunction-associated senescence, which is considered to be a critical cause for amyotrophic lateral sclerosis (ALS). Thus, mitophagic elimination of damaged mitochondria provides a promising st…
View article: TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer
TRIM39-mediated deubiquitination upregulates RNF168 to evade autophagy-ferroptosis in triple-negative breast cancer Open
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and due to the lack of robust therapeutic targets, treatment options remain limited to conventional cytotoxic chemotherapy and surgical resection. Autoph…
View article: Rural, urban and suburban differences in the prevalence of metabolic syndrome in individuals aged ≥50 years in Northwest China
Rural, urban and suburban differences in the prevalence of metabolic syndrome in individuals aged ≥50 years in Northwest China Open
Background Metabolic syndrome (MetS) is a significant risk factor for type 2 diabetes and cardiovascular disease. The aim of this study was to identify the characteristics of MetS in northwest China. Methods Three thousand and one adults w…
View article: Predicting brain amyloid load with digital and blood-based biomarkers
Predicting brain amyloid load with digital and blood-based biomarkers Open
View article: Effectiveness of tetramethylpyrazine nitrone in amyotrophic lateral sclerosis: A randomized clinical trial
Effectiveness of tetramethylpyrazine nitrone in amyotrophic lateral sclerosis: A randomized clinical trial Open
View article: Assessment of soil microbial communities and diversity in typical coastal wetlands along a succession gradient: Implications for reconstructing the long-term evolution of coastal wetlands
Assessment of soil microbial communities and diversity in typical coastal wetlands along a succession gradient: Implications for reconstructing the long-term evolution of coastal wetlands Open
View article: Administration practices of and adherence to nusinersen in children with spinal muscular atrophy: a multicenter disease registry study in China
Administration practices of and adherence to nusinersen in children with spinal muscular atrophy: a multicenter disease registry study in China Open
View article: Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis
Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis Open
Importance Tetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Objective To evaluate the safety and efficacy of orally adm…
View article: ToolHop: A Query-Driven Benchmark for Evaluating Large Language Models in Multi-Hop Tool Use
ToolHop: A Query-Driven Benchmark for Evaluating Large Language Models in Multi-Hop Tool Use Open
Effective evaluation of multi-hop tool use is critical for analyzing the understanding, reasoning, and function-calling capabilities of large language models (LLMs). However, progress has been hindered by a lack of reliable evaluation data…
View article: Downregulation of Translation Accounts for Reduced Muscle Hypertrophy in the Early Stage of Big-Eye Mandarin Fish
Downregulation of Translation Accounts for Reduced Muscle Hypertrophy in the Early Stage of Big-Eye Mandarin Fish Open
View article: ToolHop: A Query-Driven Benchmark for Evaluating Large Language Models in Multi-Hop Tool Use
ToolHop: A Query-Driven Benchmark for Evaluating Large Language Models in Multi-Hop Tool Use Open
View article: Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology
Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology Open
Objective The objective of this study is to investigate the presence of astrocyte antibodies in patients, excluding aquaporin‐4 or glial fibrillary acidic protein (GFAP) antibodies, while evaluating associated biomarkers and pathologies. M…
View article: Nusinersen effectiveness and safety in pediatric patients with 5q-spinal muscular atrophy: a multi-center disease registry in China
Nusinersen effectiveness and safety in pediatric patients with 5q-spinal muscular atrophy: a multi-center disease registry in China Open
View article: Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications
Variability in SOD1-associated amyotrophic lateral sclerosis: geographic patterns, clinical heterogeneity, molecular alterations, and therapeutic implications Open
View article: Characterization of sexual size dimorphism in mandarin fish and association with igfbp-5a/b regulation
Characterization of sexual size dimorphism in mandarin fish and association with igfbp-5a/b regulation Open
Mandarin fish (Siniperca chuatsi) is an important cultured fish in East Asia that shows sexual size dimorphism (SSD), with females growing faster than males when reaching marketable size. However, the regulatory mechanism of SSD is not cle…
View article: Drug Screening and Validation Targeting TDP-43 Proteinopathy for Amyotrophic Lateral Sclerosis
Drug Screening and Validation Targeting TDP-43 Proteinopathy for Amyotrophic Lateral Sclerosis Open
Amyotrophic lateral sclerosis (ALS) stands as a rare, yet severely debilitating disorder marked by the deterioration of motor neurons (MNs) within the brain and spinal cord, which is accompanied by degenerated corticobulbar/corticospinal t…
View article: PCDHA9 as a candidate gene for amyotrophic lateral sclerosis
PCDHA9 as a candidate gene for amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify additional genetic factors, we analyzed exome sequences in a large cohort of Chinese ALS patients and found a homozygous variant (p.L700P) in PCDHA…
View article: Genome-wide identification of igfbp genes and their different growth expression patterns of mandarin fish
Genome-wide identification of igfbp genes and their different growth expression patterns of mandarin fish Open
The igfbp family proteins are key regulators of the biological activities of igfs, which play a pivotal role in controlling growth. Growth is highly variable between different fish species and even between growth stages and sexes within th…
View article: Togcn Analysis Offers New Insights into the Accelerated Skeletal Muscle Growth of Mandarin Fish Relative to Big-Eye Mandarin Fish
Togcn Analysis Offers New Insights into the Accelerated Skeletal Muscle Growth of Mandarin Fish Relative to Big-Eye Mandarin Fish Open
View article: Functional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis
Functional identification of protocadherin alpha 9 (PCDHA9) as a candidate causative gene for amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. To identify additional genetic contributors to ALS, we analyzed exome sequences in a large cohort of Chinese ALS patients. We found a homozygous variant (p.L70…
View article: A multicenter, randomized, double blind, placebo-controlled clinical trial of DL-3-n-butylphthalide in treatment of amyotrophic lateral sclerosis
A multicenter, randomized, double blind, placebo-controlled clinical trial of DL-3-n-butylphthalide in treatment of amyotrophic lateral sclerosis Open
To the Editor: DL-3-n-butylphthalide (NBP) is a synthetic drug based on a component extracted from seeds of Apium graveolens Linn. (Chinese celery). It reportedly has protective effects in amyotrophic lateral sclerosis (ALS) model mice.[1]…
View article: DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling
DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling Open
Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response to stress without first requiring nuclear feedback. In this study, we ide…
View article: Analysing the influencing factors on caregivers’ burden among amyotrophic lateral sclerosis patients in China: a cross-sectional study based on data mining
Analysing the influencing factors on caregivers’ burden among amyotrophic lateral sclerosis patients in China: a cross-sectional study based on data mining Open
Objectives There is significant burden on caregivers of patients with amyotrophic lateral sclerosis (ALS). However, only a few studies have focused on caregivers, and traditional research methods have obvious shortcomings in dealing with m…
View article: Identification of TARDBP Gly298Ser as a founder mutation for amyotrophic lateral sclerosis in Southern China
Identification of TARDBP Gly298Ser as a founder mutation for amyotrophic lateral sclerosis in Southern China Open
Background Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by predominant impairment of upper and lower motor neurons. Over 50 TARDBP mutations have been reported in both familial (FALS) and spo…
View article: [Retracted] MicroRNA‑744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain‑derived neurotrophic factor
[Retracted] MicroRNA‑744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain‑derived neurotrophic factor Open
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell migration assay data shown in Fig. 2D were strikingly similar to data that had appeared in different form in oth…
View article: Fertility Does Not Alter Disease Progression in ALS Patients of Childbearing Age: A Three Centers Retrospective Analysis in Southern China
Fertility Does Not Alter Disease Progression in ALS Patients of Childbearing Age: A Three Centers Retrospective Analysis in Southern China Open
Background Limited data exists on the clinical features of patients with amyotrophic lateral sclerosis (ALS) during reproductive ages. Objective Our study characterized the clinical features of ALS and the effects of pregnancy on disease p…
View article: Development of a Slow Loris Computer Vision Detection Model
Development of a Slow Loris Computer Vision Detection Model Open
The slow loris (Genus Nycticebus) is a group of small, nocturnal and venomous primates with a distinctive locomotion mode. The detection of slow loris plays an important role in the subsequent individual identification and behavioral recog…
View article: Identification of TARDBP Gly298Ser as a Founder Mutation for Amyotrophic Lateral Sclerosis in Southern China
Identification of TARDBP Gly298Ser as a Founder Mutation for Amyotrophic Lateral Sclerosis in Southern China Open
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by predominant impairment of upper and lower motor neurons. Over 50 TARDBP mutations have been reported in both familial (FALS) and sp…