Xiaolin Fan
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View article: CCDC 2518257: Experimental Crystal Structure Determination
CCDC 2518257: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synchronized nutrition fertilizer improves soil microbial diversity and sugarcane yield through agrochemical and enzymatic regulation
Synchronized nutrition fertilizer improves soil microbial diversity and sugarcane yield through agrochemical and enzymatic regulation Open
Introduction The new type of synchronized nutrition fertilizers (SNFert) has been popularized and applied in agro-production in northern China. However, the impacts of the SNFert on soil microbial diversity and sugarcane growth have not ye…
View article: LRRC15 Promotes the Development of Breast Cancer by Regulating Autophagy through the PI3K/AKT/mTOR Signaling Pathway
LRRC15 Promotes the Development of Breast Cancer by Regulating Autophagy through the PI3K/AKT/mTOR Signaling Pathway Open
LRRC15 regulates autophagy-induced proliferation and other biological activities of breast cancer cells through the PI3K/AKT/mTOR signaling pathway.
View article: Fracture Evolution Mechanisms and Roof Failure Assessment in Shallow-Buried Soft Coal Seams Under Fully Mechanized Caving Mining
Fracture Evolution Mechanisms and Roof Failure Assessment in Shallow-Buried Soft Coal Seams Under Fully Mechanized Caving Mining Open
To address the challenges in the collaborative control of strong mine pressure and surface damage during fully mechanized shallow soft coal seam top-coal caving mining, this study takes the 22,031 working face of Xindeng (Zhengzhou, China)…
View article: Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders
Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders Open
Dysfunction of the lysosome and autophagy–lysosome pathway is closely associated with various diseases, such as neurodegenerative diseases, non-alcoholic fatty liver disease (NAFLD), etc. Additionally, chloroquine is a clinically widely us…
View article: AVP-AP: Self-Supervised Automatic View Positioning in 3D Cardiac CT via Atlas Prompting
AVP-AP: Self-Supervised Automatic View Positioning in 3D Cardiac CT via Atlas Prompting Open
Automatic view positioning is crucial for cardiac computed tomography (CT) examinations, including disease diagnosis and surgical planning. However, it is highly challenging due to individual variability and large 3D search space. Existing…
View article: Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation
Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation Open
Mutp53 level is widely variable among individual cancer cells in tumor tissues, and within cells a higher level of mutp53 is usually observed in the nucleus as compared to the cytoplasm. This spatial heterogeneity in mutp53 expression has …
View article: Investigation of the Current Situation of Innovation Ability Education of Vocational College Students Under the Guidance of Ideological and Political Education
Investigation of the Current Situation of Innovation Ability Education of Vocational College Students Under the Guidance of Ideological and Political Education Open
Innovation ability is the ability to continuously provide new ideas, theories, methods, and inventions with economic, social, and ecological values in the fields of technology and various practical activities. The ideological and political…
View article: <scp>ScY</scp>@<i>C</i><sub>3<i>v</i></sub>(8)‐<scp>C<sub>82</sub></scp>:<scp>Metal‐Metal</scp>σ<sup>2</sup>Bond in Mixed<scp>Rare‐Earth</scp>Di‐metallofullerenes<sup>†</sup>
<span>ScY</span>@<i>C</i><sub>3<i>v</i></sub>(8)‐<span>C<sub>82</sub></span>:<span>Metal‐Metal</span>σ<sup>2</sup>Bond in Mixed<span>Rare‐Earth</span>Di‐metallofullerenes<sup>†</sup> Open
Comprehensive Summary The experimental investigation of rare‐earth metal‐metal bonds remains a challenge in the study of chemical bonds. Herein, we report the synthesis and characterization of a novel heteronuclear di‐metallofullerene, ScY…
View article: Screening co-expressed target genes in rats and goats of blast lung injury through comparative transcriptomic analysis
Screening co-expressed target genes in rats and goats of blast lung injury through comparative transcriptomic analysis Open
Background Blast lung injury (BLI) has been one of the most threat for human beings with the frequent occurrence of local wars, terrorist attacks and industrial explosions. The underlying mechanisms remains unclear. In this paper, transcri…
View article: Response of alkaline functional fertilizer on Cd absorption and transportation in soil-rice system
Response of alkaline functional fertilizer on Cd absorption and transportation in soil-rice system Open
Reduction of cadmium accumulation in rice grain is of great significance for food safety. The purposes of this study were to investigate the efficacy and mechanism of alkaline functional fertilizer (AFF) on soil acid, available cadmium (Cd…
View article: Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme–substrate binding
Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme–substrate binding Open
Transition state stabilization and ground state destabilization utilize the same molecular mechanism when lowering the free energy barriers (Δ G ‡ s) of reactions, but differ in achieving the requirement for Δ G ‡ reduction.
View article: Factors determining the enzyme catalytic power caused by noncovalent interactions: Charge alterations in enzyme active sites
Factors determining the enzyme catalytic power caused by noncovalent interactions: Charge alterations in enzyme active sites Open
Understanding the origin of the enormous catalytic power of enzymes is very important. Electrostatic interactions and desolvation are the phenomena that are most proposed to explain the catalysis of enzymes; however, they also decelerate e…
View article: Effectiveness of Acupuncture in Treatment of Simple Obesity in Animal Models: A Systematic Review and Meta-Analysis
Effectiveness of Acupuncture in Treatment of Simple Obesity in Animal Models: A Systematic Review and Meta-Analysis Open
Background. Simple obesity has become a global risk to health of human beings. Acupuncture, as one of traditional Chinese medicine therapies, has been widely used in obesity treatment in recent years. However, the individual heterogeneity …
View article: Hierarchical Self-Assembly of Amino Acid Derivatives into Enzyme-Responsive Luminescent Gel
Hierarchical Self-Assembly of Amino Acid Derivatives into Enzyme-Responsive Luminescent Gel Open
In this study, a novel three-component hydrogel has been designed and fabricated via hierarchical self-assembly by amino acid derivative (NPPD), riboflavin (RF) and α-cyclodextrin (α-CD). These molecules were aggregated to form some fibrou…
View article: Direct vinylogous oxidative cross-dehydrogenative coupling of 4-nitroisoxazoles with N-aryl tetrahydroisoquinolines in water under air conditions
Direct vinylogous oxidative cross-dehydrogenative coupling of 4-nitroisoxazoles with N-aryl tetrahydroisoquinolines in water under air conditions Open
Using water as the solvent and air as the oxidant, a direct catalytic vinylogous cross-dehydrogenative coupling reaction was developed.
View article: A near-infrared phosphorescent iridium(<scp>iii</scp>) complex for imaging of cysteine and homocysteine in living cells and <i>in vivo</i>
A near-infrared phosphorescent iridium(<span>iii</span>) complex for imaging of cysteine and homocysteine in living cells and <i>in vivo</i> Open
A novel NIR-emitting iridium(iii) complex was developed to detect Cys/Hcy levels in vitro and in vivo.
View article: Photocatalytic direct C–S bond formation: facile access to 3-sulfenylindoles via metal-free C-3 sulfenylation of indoles with thiophenols
Photocatalytic direct C–S bond formation: facile access to 3-sulfenylindoles via metal-free C-3 sulfenylation of indoles with thiophenols Open
An efficient and convenient photocatalytic direct C-3 sulfenylation of indoles with thiophenols has been developed for the construction of 3-sulfenylations.
View article: A Smart pH-Responsive Three Components Luminescent Hydrogel
A Smart pH-Responsive Three Components Luminescent Hydrogel Open
In this study, we report a novel three-component luminescent hydrogel, which is composed of amino acid derivatives (N,N′-di valine-3,4,9,10-perylenetetracarboxylic acid, NVPD), riboflavin (RF), and melamine (MM). The three-component hydrog…
View article: Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae Open
A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-as…