Xiaolin Ji
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View article: Biomimetic nanovesicle with tri-pronged immune amplification for efficient photo-immunotherapy against triple-negative breast cancer
Biomimetic nanovesicle with tri-pronged immune amplification for efficient photo-immunotherapy against triple-negative breast cancer Open
View article: Sarcopenic obesity and risk of falls: findings in Middle-aged and older Chinese population from CHARLS
Sarcopenic obesity and risk of falls: findings in Middle-aged and older Chinese population from CHARLS Open
Sarcopenic obesity is associated with an increased risk of falls among middle-aged and older adults, especially in longitudinal analyses. Age-stratified results suggest that the impact of SO on falls may be more pronounced in the middle-ag…
View article: Impact of type 2 diabetes mellitus on hematoma expansion and clinical outcomes in patients with spontaneous intracranial hematoma
Impact of type 2 diabetes mellitus on hematoma expansion and clinical outcomes in patients with spontaneous intracranial hematoma Open
Background and purpose Spontaneous intracerebral hemorrhage (sICH) significantly affects patient outcomes. Diabetes mellitus (DM) is a common comorbidity associated with sICH; however, the influence of DM on hematoma expansion (HE) and cli…
View article: Accelerated brain age in Moyamoya disease patients: a deep learning approach and correlation with disease severity
Accelerated brain age in Moyamoya disease patients: a deep learning approach and correlation with disease severity Open
Introduction This study aims to utilize a DenseNet based deep learning framework to predict brain age in patients with Moyamoya disease (MMD), examining the relationship between brain age and disease severity to enhance diagnostic and prog…
View article: Risk of postoperative major adverse cerebrovascular events in patients with spontaneous intracranial hematoma stratified by type 2 diabetes mellitus
Risk of postoperative major adverse cerebrovascular events in patients with spontaneous intracranial hematoma stratified by type 2 diabetes mellitus Open
Background and purpose Diabetes Mellitus (DM) is a common concomitant disease of spontaneous intracranial hemorrhage (ICH). Postoperative major adverse cerebrovascular events (post-MACEs) may diminish the surgical benefits of patients with…
View article: How Do Personalized Recommendations Influence Purchasing Intent?
How Do Personalized Recommendations Influence Purchasing Intent? Open
View article: Exazerbation der atopischen Dermatitis nach Behandlungsabbruch und prädiktive Faktoren für die Exazerbation: JAK1‐Inhibitoren versus Dupilumab
Exazerbation der atopischen Dermatitis nach Behandlungsabbruch und prädiktive Faktoren für die Exazerbation: JAK1‐Inhibitoren versus Dupilumab Open
Zusammenfassung Hintergrund und Ziele Beim klinischen Management der atopischen Dermatitis (AD) kommt es häufig zu Behandlungsabbrüchen und in der Folge zu Exazerbationen der Erkrankung. Das Verstehen von Rezidivmustern nach einem Behandlu…
View article: Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles
Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles Open
View article: GZMA silencing inhibits JAK2/STAT1 pathway and improves allergic rhinitis
GZMA silencing inhibits JAK2/STAT1 pathway and improves allergic rhinitis Open
Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory disorder. This study attempts to identify AR-related differential expressed genes (DEGs) and determine potential targets for AR. We employed bioinformatics analysis …
View article: Nocturnal Hypoxemia and Daytime Sleepiness in Epilepsy With Obstructive Sleep Apnea‐Hypopnea Syndrome: A Case–Control Polysomnography Study
Nocturnal Hypoxemia and Daytime Sleepiness in Epilepsy With Obstructive Sleep Apnea‐Hypopnea Syndrome: A Case–Control Polysomnography Study Open
Sleep disorders are common in patients with epilepsy, affecting their quality of life. In this study, we aimed to explore the sleep structure of adult patients with epilepsy and determine its correlation with different degrees of obstructi…
View article: Machine learning-based phenogroups and prediction model in patients with functional gastrointestinal disorders to reveal distinct disease subsets associated with gas production
Machine learning-based phenogroups and prediction model in patients with functional gastrointestinal disorders to reveal distinct disease subsets associated with gas production Open
Background and Objectives Symptom-based subtyping for functional gastrointestinal disorders (FGIDs) has limited value in identifying underlying mechanisms and guiding therapeutic strategies. Small intestinal dysbiosis is implicated in the …
View article: Duration of N1 sleep is a factor for excessive daytime sleepiness in epilepsy patients with interictal epileptiform discharges: A polysomnographic study
Duration of N1 sleep is a factor for excessive daytime sleepiness in epilepsy patients with interictal epileptiform discharges: A polysomnographic study Open
View article: A polysomnographic study of slow-wave sleep loss in elderly patients with epilepsy
A polysomnographic study of slow-wave sleep loss in elderly patients with epilepsy Open
Elderly patients with epilepsy exhibit higher levels of ODI and spontaneous arousal index. Our findings indicate that OSAHS could be a contributing factor to slow-wave sleep loss in this population. The incidence of slow-wave sleep loss wa…
View article: Biomimetic Polydopamine Loaded with Janus Kinase Inhibitor for Synergistic Vitiligo Therapy via Hydrogel Microneedles
Biomimetic Polydopamine Loaded with Janus Kinase Inhibitor for Synergistic Vitiligo Therapy via Hydrogel Microneedles Open
Background Both oxidative stress and autoimmune responses play crucial roles in the development of vitiligo. Under oxidative stress, the apoptotic melanocytes exposure self-antigens and release high mobility group box 1 (HMGB1), triggering…
View article: Insulin resistance-related features are associated with cognitive decline: a cross-sectional study in adult patients with type 1 diabetes
Insulin resistance-related features are associated with cognitive decline: a cross-sectional study in adult patients with type 1 diabetes Open
Background To investigate the associations between insulin resistance (IR)-related features and cognitive function in type 1 diabetes (T1D). Methods A total of 117 adult patients with T1D were recruited in this cross-sectional study. IR-re…
View article: Radionecrosis mimicking pseudo‑progression in a patient with lung cancer and brain metastasis following the combination of anti‑PD‑1 therapy and stereotactic radiosurgery: A case report
Radionecrosis mimicking pseudo‑progression in a patient with lung cancer and brain metastasis following the combination of anti‑PD‑1 therapy and stereotactic radiosurgery: A case report Open
Brain metastases (BMs) usually develop in patients with non-small cell lung cancer. In addition to systemic therapy, radiation therapy and surgery, anti-programmed cell death-ligand 1 (PD-L1) therapy is another promising clinical anticance…
View article: Structured nutrition and advanced carbohydrate counting questionnaire for adult type 1 diabetes
Structured nutrition and advanced carbohydrate counting questionnaire for adult type 1 diabetes Open
To the Editor: Advanced carbohydrate counting (CC) is a recommended dietary strategy and necessary nutritional knowledge for individuals with type 1 diabetes mellitus (T1DM).[1] Evidence supports the positive effects of advanced CC on gluc…
View article: Effects of lateralized interictal epileptiform discharges on the sleep architecture of people with epilepsy: a case-control study
Effects of lateralized interictal epileptiform discharges on the sleep architecture of people with epilepsy: a case-control study Open
Background : Disruption of sleep architecture occurs in patients with epilepsy, with interictal epileptiform discharge (IED) being one possible cause. IED lateralization may exert different effects on sleep architecture, and different type…
View article: Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis
Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis Open
Background Nasopharyngeal carcinoma (NPC) is cancer with high mortality and poor prognosis. Circular RNAs (circRNAs) have been identified in a wide variety of cancers. But the functional mechanism of circ_000285 in NPC remains unclear. Pur…
View article: Bioinformatics analysis reveling prognostic roles of CDK1 in breast cancer
Bioinformatics analysis reveling prognostic roles of CDK1 in breast cancer Open
Background The current treatment of breast cancer (BC) commonly adopts endocrine therapy and immunotherapy. And the acquired resistance to those therapies remains a major challenge. Recent evidences indicate that the alternation in tumor m…
View article: Using Glycated Albumin and Stimulated C-Peptide to Define Partial Remission in Type 1 Diabetes
Using Glycated Albumin and Stimulated C-Peptide to Define Partial Remission in Type 1 Diabetes Open
Objective To propose a new definition of partial remission (PR) for patients with type 1 diabetes (T1D) of all-ages using insulin dose and glycated albumin (GA), and find the optimal cut-off values for stimulated C-peptide to diagnose PR i…
View article: Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis
Asiaticoside Suppresses Gastric Cancer Progression and Induces Endoplasmic Reticulum Stress through the miR-635/HMGA1 Axis Open
Objective. Gastric cancer is a prevalent malignant tumor with high morbidity and poor prognosis. Asiaticoside (AC) has antitumor effects, while its role in gastric cancer is elusive. Thus, this study investigated the effect of AC on gastri…
View article: A D-peptide-based HIV gelatinous combination vaccine improves therapy in ART-delayed macaques of chronic infection
A D-peptide-based HIV gelatinous combination vaccine improves therapy in ART-delayed macaques of chronic infection Open
Improving virus control in HIV-infected individuals without a timely antiretroviral therapy (ART) intervention still remains an important challenge, which is largely due to the lack of a potent means to co-deliver a complex therapeutic sys…
View article: SPP1 overexpression is associated with poor outcomes in ALK fusion lung cancer patients without receiving targeted therapy
SPP1 overexpression is associated with poor outcomes in ALK fusion lung cancer patients without receiving targeted therapy Open
View article: Safety and immunogenicity of COVID-19 vaccination in patients with non-alcoholic fatty liver disease (CHESS2101): A multicenter study
Safety and immunogenicity of COVID-19 vaccination in patients with non-alcoholic fatty liver disease (CHESS2101): A multicenter study Open
View article: Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B
Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B Open
View article: CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques Open
View article: Characterization and expression of <i>dax1</i> during embryonic and gonad development in the carp ( <i>Cyprinus carpio</i> )
Characterization and expression of <i>dax1</i> during embryonic and gonad development in the carp ( <i>Cyprinus carpio</i> ) Open
Objective The purpose of this study is to investigate the role of dax1 , which causes adrenal hypoplasia congenita (AHC) with associated hypogonadotropic hypogonadism (HH) and dosage-sensitive sex reversal (DSS) during carp embryogenesis a…
View article: Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor
Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor Open
View article: Identification of significantly different modules between permanent and deciduous teeth by network and pathway analyses
Identification of significantly different modules between permanent and deciduous teeth by network and pathway analyses Open
The differences in genetic backgrounds between deciduous and permanent teeth might contribute to the differences in developmental processes, histological characteristics, and tooth life cycles. Here, we attempted to identify significantly …