Xiaolin Pei
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View article: Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus
Inducible engineering precursor metabolic flux for synthesizing hyaluronic acid of customized molecular weight in Streptococcus zooepidemicus Open
Studies on regulating the balance of the HA precursor substances indicate that an oversupply of either UDP-GlcNAc or UDP-GlcUA can reduce HA MW. The hasE gene serves as a crucial regulator for maintaining this balance. Precise regulation o…
View article: Combining Protein Phase Separation and Bio‐orthogonal Linking to Coimmobilize Enzymes for Cascade Biocatalysis
Combining Protein Phase Separation and Bio‐orthogonal Linking to Coimmobilize Enzymes for Cascade Biocatalysis Open
The designed and ordered co‐immobilization of multiple enzymes for vectorial biocatalysis is challenging. Here, a combination of protein phase separation and bioorthogonal linking is used to generate a zeolitic imidazole framework (ZIF‐8) …
View article: Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathway
Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathway Open
Background Lymphangioleiomyomatosis (LAM) is a female‐predominant interstitial lung disease, characterized by progressive cyst formation and respiratory failure. Clinical treatment with the mTORC1 inhibitor rapamycin could relieve partiall…
View article: Disulfiram Exerts anti-pulmonary Fibrosis Effect by Activating PGE2 Synthesis
Disulfiram Exerts anti-pulmonary Fibrosis Effect by Activating PGE2 Synthesis Open
Idiopathic pulmonary fibrosis (IPF) is marked with the replacement of normal alveolar tissue by thicker and harder fibrous material, damaged exchange ability. Currently, nintedanib and pirfenidone, are the only FDA-approved drugs with limi…
View article: Designing an enzyme assembly line for green cascade processes using bio-orthogonal chemistry
Designing an enzyme assembly line for green cascade processes using bio-orthogonal chemistry Open
Linear orderly combi-crosslinked enzymes (O-CLEs) were designed and constructed for green cascade catalysis using bio-orthogonal chemistry.
View article: Targeting estrogen-mediated CYP4F2/CYP4F11-20-HETE metabolic disorder decelerates tumorigenesis in ER+ breast cancer
Targeting estrogen-mediated CYP4F2/CYP4F11-20-HETE metabolic disorder decelerates tumorigenesis in ER+ breast cancer Open
Background The female hormone estrogen (E2) is essential for mammary gland development and unequivocally drives 80% of breast malignancies. The elucidation of molecular events in the E2-estrogen receptor (ER) α signaling pathway in ER + BC…
View article: Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinoma
Inhibition of Polo-like kinase 1 (PLK1) triggers cell apoptosis via ROS-caused mitochondrial dysfunction in colorectal carcinoma Open
Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. Polo-like kinase 1 (PLK1), a member of the serine/threonine kinase PLK family, is the most investigated and essential in the regulation of cell cycle progression, inc…
View article: An efficient microbial-based method for production of high-purity Monascus azaphilones pigments
An efficient microbial-based method for production of high-purity Monascus azaphilones pigments Open
Monascus azaphilones (MAs) are widely used as food colorant in food industry. The MAs mixture, produced by Monascus strains., are traditionally classified into orange MAs (OMAs), yellow MAs (YMAs) and red MAs (RMAs). Each component exhibit…
View article: Pyrotinib Targeted EGFR-STAT3/CD24 Loop-Mediated Cell Viability in TSC
Pyrotinib Targeted EGFR-STAT3/CD24 Loop-Mediated Cell Viability in TSC Open
Pyrotinib is an irreversible pan-ErbB receptor tyrosine kinase inhibitor, designed for the therapy of HER2-positive breast cancers. Inhibition of the epidermal growth factor receptor (EGFR, HER family) efficiently and selectively suppresse…
View article: The anti-tumor effect of a novel agent MCL/ACT001 in pancreatic ductal adenocarcinoma
The anti-tumor effect of a novel agent MCL/ACT001 in pancreatic ductal adenocarcinoma Open
Purpose Pancreatic ductal adenocarcinoma (PDAC) is a major challenge in cancer therapy, there are more than four hundred thousand deaths a year and the 5-year survival rate less than 10%. The incidence continues to rise. Treatment with cla…
View article: Targeting glucose‐6‐phosphate dehydrogenase by <scp>6‐AN</scp> induces <scp>ROS</scp> ‐mediated autophagic cell death in breast cancer
Targeting glucose‐6‐phosphate dehydrogenase by <span>6‐AN</span> induces <span>ROS</span> ‐mediated autophagic cell death in breast cancer Open
Dysregulation of G6PD involved in the pentose phosphate pathway (PPP) is known to promote tumorigenesis. The PPP plays a pivotal role in meeting the anabolic demands of cancer cells. However, the detailed underlying molecular mechanisms of…
View article: Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway
Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway Open
Idiopathic pulmonary fibrosis (IPF) is an interstitial pneumonia characterized by chronic progressive fibrosis, ultimately leading to respiratory failure and early mortality. Although not fully explored, the major causative factors in IPF …
View article: Correction: Controlled chemical assembly of enzymes in cell lysate enabled by genetic-encoded nonstandard amino acids
Correction: Controlled chemical assembly of enzymes in cell lysate enabled by genetic-encoded nonstandard amino acids Open
Correction for ‘Controlled chemical assembly of enzymes in cell lysate enabled by genetic-encoded nonstandard amino acids’ by Jing Zhang et al. , Mater. Chem. Front. , 2022, 6 , 182–193, https://doi.org/10.1039/D1QM01285A.
View article: Putting precision and elegance in enzyme immobilisation with bio-orthogonal chemistry
Putting precision and elegance in enzyme immobilisation with bio-orthogonal chemistry Open
This review focuses on recent advances in the use of elegant bio-orthogonal chemistry in conjunction with rec-DNA to affect highly precise, cost-effective immobilisation of enzymes directly from cell lysate.
View article: Programing a cyanide-free transformation of aldehydes to nitriles and one-pot synthesis of amides through tandem chemo-enzymatic cascades
Programing a cyanide-free transformation of aldehydes to nitriles and one-pot synthesis of amides through tandem chemo-enzymatic cascades Open
A chemo-enzymatic cascade was developed for the cyanide-free synthesis of nitriles from aldehydes and further one-pot transformation into amides.
View article: Disulfiram Regulates Epithelial-Mesenchymal Transition by Activating PGE<sub>2</sub> Biosynthesis to Improve Idiopathic Pulmonary Fibrosis
Disulfiram Regulates Epithelial-Mesenchymal Transition by Activating PGE<sub>2</sub> Biosynthesis to Improve Idiopathic Pulmonary Fibrosis Open
Rationale.Idiopathic pulmonary fibrosis (IPF) is the scariest one with unknown etiology among lung diseases, which is considered as "cancer that is not cancer".IPF is characterized of replacement of normal alveolar tissue by thicker and ha…
View article: Enhancement of Monascus yellow pigments production by activating the cAMP signalling pathway in Monascus purpureus HJ11
Enhancement of Monascus yellow pigments production by activating the cAMP signalling pathway in Monascus purpureus HJ11 Open
Background : Monascus azaphilone pigments (MonAzPs), which were produced by Monascus species, have been used as important food colorant and food supplements for more than one billion people during their daily life. Moreover, MonAzPs recent…
View article: Enhancement of Monascus Azaphilone Pigments Production by Activating the cAMP Signalling Pathway in Monascus Purpureus HJ11
Enhancement of Monascus Azaphilone Pigments Production by Activating the cAMP Signalling Pathway in Monascus Purpureus HJ11 Open
Background: Monascus azaphilone pigments (MonAzPs), which were produced by Monascus species, have been used as important food colorant and food supplements for more than one billion people during their daily life. Moreover, MonAzPs recentl…
View article: Stable immobilization of aldehyde ketone reductase mutants containing nonstandard amino acids on an epoxy resin <i>via</i> strain-promoted alkyne–azide cycloaddition
Stable immobilization of aldehyde ketone reductase mutants containing nonstandard amino acids on an epoxy resin <i>via</i> strain-promoted alkyne–azide cycloaddition Open
Stable immobilization of aldehyde ketone reductase mutants containing non-standard amino acids on an epoxy resin via strain-promoted alkyne–azide cycloaddition.
View article: Effects of replacing inorganic trace minerals with organic trace minerals on the production performance, blood profiles, and antioxidant status of broiler breeders
Effects of replacing inorganic trace minerals with organic trace minerals on the production performance, blood profiles, and antioxidant status of broiler breeders Open
This study was conducted to investigate the effects of replacing inorganic trace minerals (ITMs) with organic trace minerals (OTMs) on the production performance, blood profile, and antioxidative status of broiler breeders. A total of 600 …
View article: Efficient synthesis of vitamin A palmitate in nonaqueous medium using self-assembled lipase TLL@apatite hybrid nanoflowers by mimetic biomineralization
Efficient synthesis of vitamin A palmitate in nonaqueous medium using self-assembled lipase TLL@apatite hybrid nanoflowers by mimetic biomineralization Open
To conveniently prepare the immobilized enzyme for green synthesis of vitamin A palmitate, thermomyces lanuginosus lipase (TLL) was assembled with apatite derived from calcium phosphate in solution to form TLL@apatite hybrid nanoflowers (h…
View article: Dual-cycle immobilization to reuse both enzyme and support by reblossoming enzyme–inorganic hybrid nanoflowers
Dual-cycle immobilization to reuse both enzyme and support by reblossoming enzyme–inorganic hybrid nanoflowers Open
Both enzyme and support can be recycled using dual-cycle immobilization method by reblossoming the enzyme–inorganic hybrid nanoflowers.
View article: Efficient promiscuous Knoevenagel condensation catalyzed by papain confined in Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> nanoflowers
Efficient promiscuous Knoevenagel condensation catalyzed by papain confined in Cu<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> nanoflowers Open
Knoevenagel condensation was catalyzed and enhanced by Cu2+ and papain on hybrid nanoflowers (hNFs) in the promiscuous catalysis.