Xiaolin Shi
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View article: The prevalence of sarcopenia and risk factors in the older adult in China: a systematic review and meta-analysis
The prevalence of sarcopenia and risk factors in the older adult in China: a systematic review and meta-analysis Open
Background Understanding the epidemiological information of a certain disease is the first step in related prevention and control work. This article aims to understand the prevalence and associated risk factors of sarcopenia among the olde…
View article: The intervention of OPG/RANKL/RANK signaling pathway by QGYKL mediated complement C3 and succinylation process on osteoporosis
The intervention of OPG/RANKL/RANK signaling pathway by QGYKL mediated complement C3 and succinylation process on osteoporosis Open
Introduction: Qiangguyin Keli(QGYKL)is a traditional Chinese medicine formula used in the clinical treatment of osteoporosis for over 20 years. The specific protective mechanism of QGYKL against osteoporosis is still unclear. Previous stud…
View article: A machine learning–Based model to predict early death among bone metastatic breast cancer patients: A large cohort of 16,189 patients
A machine learning–Based model to predict early death among bone metastatic breast cancer patients: A large cohort of 16,189 patients Open
Purpose: This study aims to develop a prediction model to categorize the risk of early death among breast cancer patients with bone metastases using machine learning models. Methods: This study examined 16,189 bone metastatic breast cancer…
View article: A novel nomogram to stratify quality of life among advanced cancer patients with spinal metastatic disease after examining demographics, dietary habits, therapeutic interventions, and mental health status
A novel nomogram to stratify quality of life among advanced cancer patients with spinal metastatic disease after examining demographics, dietary habits, therapeutic interventions, and mental health status Open
Background It would be very helpful to stratify patients and direct patient selection if risk factors for quality of life were identified in a particular population. Nonetheless, it is still challenging to forecast the health-related quali…
View article: Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease
Quality of Life and Mental Health Status Among Cancer Patients With Metastatic Spinal Disease Open
This study aimed to investigate the quality of life and mental health status and further to identify relevant risk factors among advanced cancer patients with spine metastases. This study prospectively included and analyzed 103 advanced ca…
View article: Increased level of Complement C3 in patients with osteoporosis and enhanced osteogenic ability in osteoblasts with Complement component 3 knockdown
Increased level of Complement C3 in patients with osteoporosis and enhanced osteogenic ability in osteoblasts with Complement component 3 knockdown Open
Objective(s) :Complement C3 has the potential to impact bone homeostasis. The purpose of this study is to determine the difference in serum Complement C3 levels between osteoporosis patients and non-osteoporosis patients, as well as how Co…
View article: Increased level of Complement C3 in patients with osteoporosis and enhanced osteogenic ability in osteoblasts with Complement component 3 knockdown
Increased level of Complement C3 in patients with osteoporosis and enhanced osteogenic ability in osteoblasts with Complement component 3 knockdown Open
Objective(s) :Complement C3 has the potential to impact bone homeostasis. The purpose of this study is to determine the difference in serum Complement C3 levels between osteoporosis patients and non-osteoporosis patients, as well as how Co…
View article: The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1
The effect of QiangGuYin on osteoporosis through the AKT/mTOR/autophagy signaling pathway mediated by CKIP-1 Open
Osteoporosis is a systemic bone disease characterized by decreased bone mass and deterioration of bone microstructure, which leads to increased bone fragility and increased risk of fractures. Casein kinase 2 interacting protein 1 (CKIP-1, …
View article: Percutaneous Vertebroplasty Combined with Zoledronic Acid in Treatment and Prevention of Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis of Comparative Studies
Percutaneous Vertebroplasty Combined with Zoledronic Acid in Treatment and Prevention of Osteoporotic Vertebral Compression Fractures: A Systematic Review and Meta-Analysis of Comparative Studies Open
Vertebroplasty combined with ZOL was superior to vertebroplasty alone in terms of BMD, bone metabolism makers, refracture rate, pain and function.
View article: Internal Fixation <i>versus</i> Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fractures in the Elderly: A Systematic Review and <scp>Meta‐Analysis</scp>
Internal Fixation <i>versus</i> Hemiarthroplasty in the Treatment of Unstable Intertrochanteric Fractures in the Elderly: A Systematic Review and <span>Meta‐Analysis</span> Open
Objective To evaluate the clinical efficacy of internal fixation versus hemiarthroplasty in the treatment of unstable intertrochanteric fractures in the elderly. Methods A search was conducted in PubMed, Web of Science, Embase, and Cochran…
View article: Ubiquitylomes Analysis of the Whole blood in Postmenopausal Osteoporosis Patients and healthy Postmenopausal Women
Ubiquitylomes Analysis of the Whole blood in Postmenopausal Osteoporosis Patients and healthy Postmenopausal Women Open
Objectives To determine the mechanisms of ubiquitination in postmenopausal osteoporosis and investigate the ubiquitinated spectrum of novel targets between healthy postmenopausal women and postmenopausal osteoporosis patients, we performed…
View article: Discovery and Identification of Serum Succinyl‐Proteome for Postmenopausal Women with Osteoporosis and Osteopenia
Discovery and Identification of Serum Succinyl‐Proteome for Postmenopausal Women with Osteoporosis and Osteopenia Open
Objective For the purpose of providing evidence for the treatment of osteoporosis and osteopenia, this study retrospectively identified succinylation‐modified sites and proteins in postmenopausal women, and bioinformatics analysis were per…
View article: Study on Zoledronic Acid Reducing Acute Bone Loss and Fracture Rates in Elderly Postoperative Patients with Intertrochanteric Fractures
Study on Zoledronic Acid Reducing Acute Bone Loss and Fracture Rates in Elderly Postoperative Patients with Intertrochanteric Fractures Open
Objective To observe the effect of zoledronic acid on the reduction of acute bone loss and fracture rate in elderly postoperative patients with intertrochanteric fracture. Methods From August 2012 to January 2015, a total of 482 patients w…
View article: Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer partially via the inhibition of Wnt/&beta;-catenin signaling
Berbamine suppresses cell proliferation and promotes apoptosis in ovarian cancer partially via the inhibition of Wnt/β-catenin signaling Open
Ovarian cancer is a common and lethal cancer affecting women globally. Berbamine is a natural compound from the plant Berberis amurensis, which is used in Chinese traditional medicine. Recent studies have shown the anti-tumor effects of be…
View article: Intravenous Zoledronic Acid 5 mg on Bone Turnover Markers and Bone Mineral Density in East China Subjects with Newly Diagnosed Osteoporosis: A 24‐month Clinical Study
Intravenous Zoledronic Acid 5 mg on Bone Turnover Markers and Bone Mineral Density in East China Subjects with Newly Diagnosed Osteoporosis: A 24‐month Clinical Study Open
Objective This randomized, double‐blind, placebo‐controlled study assessed the necessity of early intervention, safety and efficacy of intravenous zoledronic acid 5 mg/year in East China women with newly diagnosed osteoporosis at high risk…
View article: Effect of Traditional Chinese Medicine Product, QiangGuYin, on Bone Mineral Density and Bone Turnover in Chinese Postmenopausal Osteoporosis
Effect of Traditional Chinese Medicine Product, QiangGuYin, on Bone Mineral Density and Bone Turnover in Chinese Postmenopausal Osteoporosis Open
Introduction . The aim of this study was to investigate the efficacy of herbal formula QiangGuYin (QGY) in postmenopausal women. Materials and Methods . A total of 240 participants from six clinical centers were randomly to receive alendro…
View article: Weak cation exchange magnetic beads coupled with matrix-assisted laser desorption ionization-time of flight-mass spectrometry in screening serum protein markers in osteopenia
Weak cation exchange magnetic beads coupled with matrix-assisted laser desorption ionization-time of flight-mass spectrometry in screening serum protein markers in osteopenia Open
The present study aimed at investigating the weak cation magnetic separation technology and matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) in screening serum protein markers of osteopenia from t…
View article: Effects of Electroacupuncture at Gb Points on Markers of Osteoporosis and Bodyweight in Ovariectomised Rats
Effects of Electroacupuncture at Gb Points on Markers of Osteoporosis and Bodyweight in Ovariectomised Rats Open
Background Based on a description of acupuncture to treat a bone disease resembling osteoporosis in the ancient text of Huangdi Neijing, we aimed to assess the effects of electroacupuncture (EA) at GB points in ovariectomised (OVX) rats. M…
View article: SET8 expression is associated with overall survival in gastric cancer
SET8 expression is associated with overall survival in gastric cancer Open
SET8, a member of the SET domain-containing methyl-transferase, has been implicated in various biological processes. In this study, SET8 was immunostained in 100 samples of gastric cancer tissues and semi-quantified using the HSCORE method…
View article: Weak cation magnetic separation technology and MALDI-TOF-MS in screening serum protein markers in primary type I osteoporosis
Weak cation magnetic separation technology and MALDI-TOF-MS in screening serum protein markers in primary type I osteoporosis Open
We investigated weak cation magnetic separation technology and matrix-assisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) in screening serum protein markers of primary type I osteoporosis. We selected 16 po…