Xiaoling Cai
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View article: Intensive blood pressure reduction but an increased risk of peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials
Intensive blood pressure reduction but an increased risk of peripheral arterial disease: a systematic review and meta-analysis of randomized controlled trials Open
Our meta-analysis revealed that intensive reductions in SBP mediated by BP-lowering agents conferred increase the risk of PAD in patients with cardiometabolic risk factors. A gradual and moderate BP reduction as well as regular BP monitori…
View article: Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion
Morning spot urinary cortisol-to-creatinine ratio: a novel screening tool for assessing excess cortisol secretion Open
Context Current screening methods for hypercortisolism face limitations in clinical practice. Objective Our study proposes and validates a novel biomarker, the morning spot urinary cortisol-to-creatinine ratio (UCCR), as a simpler alternat…
View article: Anti-diabetic medications and cancer: links beyond glycemic and body weight control
Anti-diabetic medications and cancer: links beyond glycemic and body weight control Open
Cancer is becoming one of the leading causes of death among patients with diabetes. Hyperglycemia and obesity, two key characteristics of type 2 diabetes, modify the risks of cancer in patients with type 2 diabetes. However, recent studies…
View article: PCSK9 Inhibitor and Potential Decreased Risk of Neoplasms, Especially in Females: A Meta-Analysis
PCSK9 Inhibitor and Potential Decreased Risk of Neoplasms, Especially in Females: A Meta-Analysis Open
Background: Proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) has been reported to exhibit anti-neoplasm effects. However, the specific impacts remain uncertain. This study aims to evaluate the association between PCSK9i and…
View article: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications
Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications Open
Significant weight regain occurred 8 weeks after discontinuation of AOMs and was sustained through 20 weeks. Different weight regain was observed in subjects with different characteristics. Studies with longer follow-up duration are requir…
View article: Cardiovascular and brain effects of liraglutide in transthyretin amyloidosis (ATTR) mice models
Cardiovascular and brain effects of liraglutide in transthyretin amyloidosis (ATTR) mice models Open
Aim: The effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in hereditary transthyretin amyloidosis (ATTRv) remain uncertain. This study aims to investigate whether liraglutide interacts with transthyretin protein (TTR) and th…
View article: Glucagon‐like peptide‐1 receptor agonist treatment associated weight fluctuation and influencing factors in patients with overweight or obesity
Glucagon‐like peptide‐1 receptor agonist treatment associated weight fluctuation and influencing factors in patients with overweight or obesity Open
Objective To characterize the weight fluctuation and explore its influencing factors after glucagon‐like peptide 1 receptor agonist (GLP‐1RA) treatment in patients with overweight or obesity. Methods This retrospective cohort study enrolle…
View article: Developing CGMap: Characterizing Continuous Glucose Monitoring Data in Patients with Type 2 Diabetes
Developing CGMap: Characterizing Continuous Glucose Monitoring Data in Patients with Type 2 Diabetes Open
Objectives: This study will characterize continuous glucose monitoring (CGM) data in patients with type 2 diabetes in China, and assess the relationship between CGM-derived indicators and diabetes-related clinical parameters. Methods: The …
View article: Comparison of glucose fluctuation between metformin combined with acarbose or sitagliptin in Chinese patients with type 2 diabetes: A multicenter, randomized, active-controlled, open-label, parallel design clinical trial
Comparison of glucose fluctuation between metformin combined with acarbose or sitagliptin in Chinese patients with type 2 diabetes: A multicenter, randomized, active-controlled, open-label, parallel design clinical trial Open
Background: Alpha-glucosidase inhibitors or dipeptidyl peptidase-4 inhibitors are both hypoglycemia agents that specifically impact on postprandial hyperglycemia. We compared the effects of acarbose and sitagliptin add on to metformin on t…
View article: Prevalence and Clinical Characteristics of <scp>NEUROD1</scp>‐<scp>MODY</scp> in Chinese Early‐Onset Type 2 Diabetes Mellitus and a Literature Review
Prevalence and Clinical Characteristics of <span>NEUROD1</span>‐<span>MODY</span> in Chinese Early‐Onset Type 2 Diabetes Mellitus and a Literature Review Open
Background Maturity‐onset diabetes of the young resulting from mutations of the NEUROD1 gene (NEUROD1‐MODY) is a rare form of diabetes and has not been well studied. We aimed to estimate its prevalence in Chinese patients with early‐onset …
View article: Clinical characteristics and unique presentations of immune checkpoint inhibitor induced type 1 diabetes in Chinese patients from a single institution
Clinical characteristics and unique presentations of immune checkpoint inhibitor induced type 1 diabetes in Chinese patients from a single institution Open
Immune checkpoint inhibitor-induced type 1 diabetes (ICI-T1D) is a rare immune-related adverse event (irAE) of immune checkpoint inhibitors (ICIs). This retrospective study aimed to characterize the clinical features and glucose patterns o…
View article: Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM)
Metabolic syndrome in type 1 diabetes: higher time above range and glycemic variability revealed by continuous glucose monitoring (CGM) Open
Our findings suggested that in T1D participants, metabolic syndrome was associated with higher glucose level and glycemic variability. Personalized diabetes education including optimal meal planning and sufficient physical activity should …
View article: Congenital muscular dystrophies and myopathies: the leading cause of genetic muscular disorders in eleven Chinese families
Congenital muscular dystrophies and myopathies: the leading cause of genetic muscular disorders in eleven Chinese families Open
Not applicable.
View article: Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients
Association between body mass index and lumbar spine volumetric bone mineral density in diabetic and non-diabetic patients Open
BACKGROUND The association between body mass index (BMI) and bone mineral density (BMD) has shown inconsistent results, varying by sex and skeletal site. Despite normal or elevated bone mass, individuals with type 2 diabetes have an increa…
View article: Effects of Semaglutide and Tirzepatide on Bone Metabolism in Type 2 Diabetic Mice
Effects of Semaglutide and Tirzepatide on Bone Metabolism in Type 2 Diabetic Mice Open
Background/Objectives: Type 2 diabetes and weight loss are associated with detrimental skeletal health. Incretin-based therapies (GLP-1 receptor agonists, and dual GIP/GLP-1 receptor agonists) are used clinically to treat diabetes and obes…
View article: Development and external validation of an algorithm for self‐identification of risk for microvascular complications in patients with type 1 diabetes
Development and external validation of an algorithm for self‐identification of risk for microvascular complications in patients with type 1 diabetes Open
Aims Microvascular complications, such as diabetic retinopathy (DR), diabetic nephropathy (DN) and diabetic peripheral neuropathy (DPN), are common and serious outcomes of inadequately managed type 1 diabetes (T1D). Timely detection and in…
View article: Exon Sequencing of HNF1β in Chinese Patients with Early-Onset Diabetes
Exon Sequencing of HNF1β in Chinese Patients with Early-Onset Diabetes Open
Background: Maturity-onset diabetes of the young (MODY) due to variants of hepatocyte nuclear factor 1-beta (HNF1β) (MODY5) has not been well studied in the Chinese population. This study aimed to estimate its prevalence and evaluate the a…
View article: Prediction of building HVAC energy consumption based on least squares support vector machines
Prediction of building HVAC energy consumption based on least squares support vector machines Open
Air conditioning, as an essential appliance in daily life, has the function of ensuring comfortable room temperature, but it is also accompanied by a large amount of power consumption. Consequently, the study suggests an energy consumption…
View article: Efficacy and safety of visepegenatide as an add-on therapy to metformin in patients with type 2 diabetes: a randomised, double-blind, parallel, placebo-controlled, phase 3 study
Efficacy and safety of visepegenatide as an add-on therapy to metformin in patients with type 2 diabetes: a randomised, double-blind, parallel, placebo-controlled, phase 3 study Open
The study was funded by PegBio Co., Ltd, Suzhou, China.
View article: Mulberry Twig Alkaloids Improved the Progression of Metabolic-Associated Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating the PGC1α/PPARα and KEAP1/NRF2 Pathways
Mulberry Twig Alkaloids Improved the Progression of Metabolic-Associated Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating the PGC1α/PPARα and KEAP1/NRF2 Pathways Open
Background/Objectives: Metabolic-associated fatty liver disease (MAFLD) is one of the most common liver disorders associated with obesity and metabolic syndrome, and poses a significant global health burden with limited effective treatment…
View article: The association between exposure to famine in early life and risks of diabetic complications in adult patients with type two diabetes
The association between exposure to famine in early life and risks of diabetic complications in adult patients with type two diabetes Open
Early-life exposure to famine in patients with type two diabetes might be associated with increased risks of coronary heart disease, cerebrovascular disease, and diabetic retinopathy but a reduced risk of diabetic kidney disease in adultho…
View article: The weight reduction mediated by anti-obesity medication and the cardiovascular outcome
The weight reduction mediated by anti-obesity medication and the cardiovascular outcome Open
The association between anti-obesity medications (AOMs) as well as their weight-loss effects and cardiovascular outcomes need to be comprehensively investigated. We searched PubMed, Embase, the Cochrane Center Register of Controlled Trials…
View article: The Effectiveness of Mixed Food Attractant for Managing Helicoverpa armigera (Hübner) and Agrotis ipsilon (Hufnagel) in Peanut Fields
The Effectiveness of Mixed Food Attractant for Managing Helicoverpa armigera (Hübner) and Agrotis ipsilon (Hufnagel) in Peanut Fields Open
Peanut is one of the widely cultivated oil-bearing and nut crops worldwide, so its stable production is crucial for oil supply and nuts, as well as socioeconomic development. Noctuid pests, such as Helicoverpa armigera (Hübner) and Agrotis…
View article: Overburden of rare ALMS1 deleterious variants in Chinese early‐onset type 2 diabetes with severe insulin resistance
Overburden of rare ALMS1 deleterious variants in Chinese early‐onset type 2 diabetes with severe insulin resistance Open
Aims Alström syndrome (AS) is a rare recessive disorder characterised by diabetes, obesity, insulin resistance (IR), and visual and hearing impairments. Mutations in the ALMS1 gene have been identified as the causative agents of AS. This s…
View article: The opportunities and challenges of the disease-modifying immunotherapy for type 1 diabetes: A systematic review and meta-analysis
The opportunities and challenges of the disease-modifying immunotherapy for type 1 diabetes: A systematic review and meta-analysis Open
There are multiple disease-modifying immunotherapies showing the potential of preventing or delaying the progression of type 1 diabetes (T1D). We designed and performed this systematic review and meta-analysis to gain an overview of what a…