Zhenhao Li
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View article: Renal cell carcinoma organoids for precision medicine: bridging the gap between models and patients
Renal cell carcinoma organoids for precision medicine: bridging the gap between models and patients Open
Renal cell carcinoma (RCC) poses significant challenges to precision oncology due to its pronounced molecular heterogeneity and complex tumor microenvironment (TME). Traditional two-dimensional (2D) cultures and animal models fall short in…
View article: Macrophage bibliometric study and visualization in myocardial ischemia–reperfusion
Macrophage bibliometric study and visualization in myocardial ischemia–reperfusion Open
Macrophages have emerged as a key area of focus in myocardial IRI research in recent years. This is the first bibliometric study to comprehensively analyze the research landscape on macrophages and myocardial IRI, providing valuable insigh…
View article: Renal epidermoid cyst mimicking renal tuberculous abscess: a case report
Renal epidermoid cyst mimicking renal tuberculous abscess: a case report Open
Renal epidermoid cysts (RECs) are exceedingly rare benign cystic lesions, with only 15 histologically confirmed cases reported worldwide to date. Due to their non-specific clinical and radiological features, they are often misdiagnosed pre…
View article: Biomimetic gene delivery system coupled with extracellular vesicle–encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory microenvironment
Biomimetic gene delivery system coupled with extracellular vesicle–encapsulated AAV for improving diabetic wound through promoting vascularization and remodeling of inflammatory microenvironment Open
Adeno-associated virus (AAV)-mediated gene transfer has demonstrated potential in effectively promoting re-epithelialization and angiogenesis. AAV vector has a safety profile; however, the relatively low delivery efficacy in chronic wound …
View article: Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy
Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy Open
Lysosomes is emerging as a promising therapeutic target for improving immunotherapy, which dysfunction would trigger lysosomal membrane permeabilization increase and subsequent leakage of reduced iron, which contributed to ferroptosis thro…
View article: Molecular identification and quality evaluation of commercial Ganoderma
Molecular identification and quality evaluation of commercial Ganoderma Open
Ganoderma has long been renowned in oriental countries as a prominent medicinal and edible supplement, with the products holding a substantial market demand. However, there remains a lack of systematic and comprehensive studies on the qual…
View article: Discovery of Timeline and Crowd Reaction of Software Vulnerability Disclosures
Discovery of Timeline and Crowd Reaction of Software Vulnerability Disclosures Open
Reusing third-party libraries increases productivity and saves time and costs for developers. However, the downside is the presence of vulnerabilities in those libraries, which can lead to catastrophic outcomes. For instance, Apache Log4J …
View article: Study on the time-frequency linkages between China’s economic policy uncertainty and the carbon emission trading market (Central China)—evidence from partial wavelet coherence analysis
Study on the time-frequency linkages between China’s economic policy uncertainty and the carbon emission trading market (Central China)—evidence from partial wavelet coherence analysis Open
In the context of carbon neutrality, the economic policy uncertainty (EPU) in various countries is constantly rising, and the carbon emission trading market (CET market) is constantly changing. This study uses the wavelet analysis to analy…
View article: Knockdown of Thitarodes host genes influences dimorphic transition of Ophiocordyceps sinensis in the host hemolymph
Knockdown of Thitarodes host genes influences dimorphic transition of Ophiocordyceps sinensis in the host hemolymph Open
The Chinese cordyceps, a unique parasitic complex of Thitarodes / Hepialus ghost moths and Ophiocordyceps sinensis fungus in the Tibetan Plateau, is a highly valuable biological resource for medicine and health foods in Asian countries. Ef…
View article: rAAV-ENO1mAb-5 inhibits cell proliferation and migration by suppressing glycolysis in cervical cancer
rAAV-ENO1mAb-5 inhibits cell proliferation and migration by suppressing glycolysis in cervical cancer Open
α-enolase (ENO1), as a plasminogen receptor and a key enzyme of glycolysis, is highly expressed in cervical cancer, Inhibition of ENO1 activity can further inhibit the migration and invasion of tumor cells by inhibiting glycolsis, and inhi…
View article: Icariside I enhances the effects of immunotherapy in gastrointestinal cancer via targeting TRPV4 and upregulating the cGAS-STING-IFN-I pathway
Icariside I enhances the effects of immunotherapy in gastrointestinal cancer via targeting TRPV4 and upregulating the cGAS-STING-IFN-I pathway Open
Gastrointestinal cancer is among the most common cancers worldwide. Immune checkpoint inhibitor-based cancer immunotherapy has become an innovative approach in cancer treatment; however, its efficacy in gastrointestinal cancer is limited b…
View article: In Vitro Digestion and Fermentation of Different Ethanol-Fractional Polysaccharides from Dendrobium officinale: Molecular Decomposition and Regulation on Gut Microbiota
In Vitro Digestion and Fermentation of Different Ethanol-Fractional Polysaccharides from Dendrobium officinale: Molecular Decomposition and Regulation on Gut Microbiota Open
Polysaccharides from Dendrobium officinale have garnered attention for their diverse and well-documented biological activities. In this study, we isolated three ethanol-fractionated polysaccharides from Dendrobium officinale (EPDO) and inv…
View article: Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a Open
BACKGROUND Knee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immun…
View article: CLINICAL OUTCOMES BY PROGRESSION OF DISEASE WITHIN 24 MONTHS (POD24) IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) FOLLICULAR LYMPHOMA (FL) TREATED WITH LINPERLISIB
CLINICAL OUTCOMES BY PROGRESSION OF DISEASE WITHIN 24 MONTHS (POD24) IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) FOLLICULAR LYMPHOMA (FL) TREATED WITH LINPERLISIB Open
Introduction: Linperlisib, a PI3Kδ inhibitor, has shown clinically efficacy and manageable safety profile as third- or further-line treatment in patients with R/R FL from a multicenter phase 2 trial (NCT04370405). We aimed to perform a sub…
View article: Unveiling the spatial distribution and molecular mechanisms of terpenoid biosynthesis in <i>Salvia miltiorrhiza</i> and <i>S. grandifolia</i> using multi-omics and DESI–MSI
Unveiling the spatial distribution and molecular mechanisms of terpenoid biosynthesis in <i>Salvia miltiorrhiza</i> and <i>S. grandifolia</i> using multi-omics and DESI–MSI Open
Salvia miltiorrhiza and S. grandifolia are rich in diterpenoids and have therapeutic effects on cardiovascular diseases. In this study, the spatial distribution of diterpenoids in both species was analyzed by a combination of metabolomics …
View article: An experimental study on Host Versus Graft Reaction at different stages of autologous or allogeneic transplantation of large-area full-thickness cartilage defects in rats
An experimental study on Host Versus Graft Reaction at different stages of autologous or allogeneic transplantation of large-area full-thickness cartilage defects in rats Open
Objective : To observe the regularity of host-anti-graft reaction in animal model full-thickness cartilage defect after autologous or allogeneic full-thickness cartilage transplantation. Methods : The model of cartilage combined with subch…
View article: USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC
USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC Open
GTPase-activating protein-binding protein 2 (G3BP2) is a key stress granule-associated RNA-binding protein responsible for the formation of stress granules (SGs). Hyperactivation of G3BP2 is associated with various pathological conditions,…
View article: The effects of traditional Chinese medicine and dietary compounds on digestive cancer immunotherapy and gut microbiota modulation: A review
The effects of traditional Chinese medicine and dietary compounds on digestive cancer immunotherapy and gut microbiota modulation: A review Open
Digestive tract-related cancers account for four of the top ten high-risk cancers worldwide. In recent years, cancer immunotherapy, which exploits the innate immune system to attack tumors, has led to a paradigm shifts in cancer treatment.…
View article: GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis
GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis Open
Background and Purpose: Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. Aortic calcification leads to r…
View article: Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma
Aqueous-soluble components of sporoderm-removed Ganoderma lucidum spore powder promote ferroptosis in oral squamous cell carcinoma Open
Our findings demonstrate the therapeutic potential of A-GSP for treating patients with OSCC by targeting ferroptosis.