Xiaoling Qian
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View article: Salidroside alleviates fluoride induced pyroptosis and developmental neurotoxicity through P2X7R/NF-κB/NLRP3 pathway
Salidroside alleviates fluoride induced pyroptosis and developmental neurotoxicity through P2X7R/NF-κB/NLRP3 pathway Open
Fluoride can cause damage to neurons, but the specific mechanisms remain unclear. Neuronal pyroptosis is associated with cognitive dysfunction, but previous studies mainly focused on hippocampal impairments. This study aimed to whether the…
View article: Patients’ knowledge, attitude, and practice toward stroke rehabilitation: a web-based cross-sectional study
Patients’ knowledge, attitude, and practice toward stroke rehabilitation: a web-based cross-sectional study Open
Objective The objective of this research was to comprehensively assess how well patients understand stroke rehabilitation, their perceptions of it, and their inclination to participate. Methods This web-based cross-sectional study was cond…
View article: Artesunate inhibits hepatocellular carcinoma cell migration and invasion through OGA-mediated <i>O</i>-GlcNAcylation of ZEB1
Artesunate inhibits hepatocellular carcinoma cell migration and invasion through OGA-mediated <i>O</i>-GlcNAcylation of ZEB1 Open
Metastasis remains a major challenge to improve the survival of patients with hepatocellular carcinoma (HCC). Artesunate is an antimalarial drug that also has anti-cancer properties. Additionally, O -GlcNAcylation has been implicated in ca…
View article: LDHA exacerbates myocardial ischemia-reperfusion injury through inducing NLRP3 lactylation
LDHA exacerbates myocardial ischemia-reperfusion injury through inducing NLRP3 lactylation Open
Myocardial ischemia-reperfusion (I/R) injury caused by revascularization treatment is the leading cause of cardiac damage aggravation in ischemic heart disease. Increasing evidence has unraveled the crucial role of pyroptosis in myocardial…
View article: Rapamycin Rescues Learning and Memory Impairment Caused by Co-Exposure to Fluorine and Aluminium by Antagonizing Mir-183/96/182 Cluster-Triggered Neuronal Apoptosis in Vivo and in Vitro
Rapamycin Rescues Learning and Memory Impairment Caused by Co-Exposure to Fluorine and Aluminium by Antagonizing Mir-183/96/182 Cluster-Triggered Neuronal Apoptosis in Vivo and in Vitro Open
View article: <scp>HS</scp>‐10352 in hormone receptor‐positive, <scp>HER2</scp>‐negative advanced breast cancer: A phase 1 dose‐escalation trial
<span>HS</span>‐10352 in hormone receptor‐positive, <span>HER2</span>‐negative advanced breast cancer: A phase 1 dose‐escalation trial Open
Background Approximately 40% of patients with hormone receptor (HR)‐positive and human epidermal growth factor receptor 2 (HER2)‐negative advanced breast cancer (ABC) exhibit PIK3CA mutations. Aims This study aims to evaluate the safety, t…
View article: Coal Gangue Recognition during Coal Preparation Using an Adaptive Boosting Algorithm
Coal Gangue Recognition during Coal Preparation Using an Adaptive Boosting Algorithm Open
The recognition of coal and gangue is the premise and foundation of coal gangue intelligent sorting. Adaptive boosting (AdaBoost) algorithm-based coal gangue identification has not been studied in depth. This paper proposed a coal gangue i…
View article: Intrarenal Doppler approaches in hemodynamics: A major application in critical care
Intrarenal Doppler approaches in hemodynamics: A major application in critical care Open
The treatment of severe cases usually requires multimodality hemodynamic monitoring approaches, particularly for tissue and organ perfusion tracking. Currently, only a few studies have investigated renal perfusion status at the bedside. Ul…
View article: Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Prediction Models for Conversion From Mild Cognitive Impairment to Alzheimer’s Disease: A Systematic Review and Meta-Analysis Open
Background and Purpose Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no cure, and available treatments are only able to postpone the progression of the disease. Mild cognitive impairment (MCI) is considered to b…
View article: Combined effect of hydrotherapy and transcranial direct-current stimulation on children with cerebral palsy
Combined effect of hydrotherapy and transcranial direct-current stimulation on children with cerebral palsy Open
Background: Cerebral palsy (CP) is a neurodevelopmental disorder caused by a brain injury resulting in poor coordination and motor control deficits, which is one of the most common physical disabilities in children. CP brings a heavy burde…
View article: Efficacy of Chinese herbal prescriptions containing Ejiao or Velvet antler for management of uterine fibroids: a systematic review and meta-analysis of randomized controlled trials
Efficacy of Chinese herbal prescriptions containing Ejiao or Velvet antler for management of uterine fibroids: a systematic review and meta-analysis of randomized controlled trials Open
TCM prescriptions containing E/VA seemed superior to the control group in shrinking the volume of uterine fibroids and uterus, improving related symptoms, and reducing non-menopausal women's E2 and P levels, with lower incidence of AEs.
View article: Interventions for muscles spasticity of children with cerebral palsy: Protocol for a systematic review and network meta-analysis
Interventions for muscles spasticity of children with cerebral palsy: Protocol for a systematic review and network meta-analysis Open
Review question / Objective: The aim of this study is to perform a network meta-analysis to evaluate the effectiveness of d i ff e r e n t n o n -p h a r m a c o l o g i c a l interventions to treat muscle spasticity of children with spast…
View article: Clinical observation of Shengxuebao Mixture in treating anemia after concurrent chemoradiotherapy for cervical cancer
Clinical observation of Shengxuebao Mixture in treating anemia after concurrent chemoradiotherapy for cervical cancer Open
View article: Progress research on non-drug therapy in cancer-related fatigue
Progress research on non-drug therapy in cancer-related fatigue Open
View article: Rab5a suppresses autophagy to promote drug resistance in cancer cells.
Rab5a suppresses autophagy to promote drug resistance in cancer cells. Open
Cancers are huge problems that need to be investigated thoroughly. Rab5a plays an important part in the regulation of intracellular membrane trafficking. However, its role in cancer and autophagy has not been fully determined. In this stud…
View article: Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer
Enolase 1 stimulates glycolysis to promote chemoresistance in gastric cancer Open
Chemotherapy is the major choice for the cancer treatment of early and advanced stages. However, intrinsic or acquired drug resistance significantly restricts the clinical efficacy of chemotherapy. It is critical to develop novel approache…
View article: Reliability and Validity of a Chinese Version of the Stroke Action Test: A New Instrument for Assessment of Stroke Knowledge and Response.
Reliability and Validity of a Chinese Version of the Stroke Action Test: A New Instrument for Assessment of Stroke Knowledge and Response. Open
The C-STAT is an intelligible and brief psychometrical tool to assess individuals' knowledge of the appropriate responses to stroke symptoms in Chinese populations. It could also be used by health care providers to assess educational progr…
View article: <i>Defective Pollen Wall 2</i> (<i>DPW2</i>) Encodes an Acyl Transferase Required for Rice Pollen Development
<i>Defective Pollen Wall 2</i> (<i>DPW2</i>) Encodes an Acyl Transferase Required for Rice Pollen Development Open
Aliphatic and aromatic lipids are both essential structural components of the plant cuticle, an important interface between the plant and environment. Although cross links between aromatic and aliphatic or other moieties are known to be as…
View article: Regulatory Role of a Receptor-Like Kinase in Specifying Anther Cell Identity
Regulatory Role of a Receptor-Like Kinase in Specifying Anther Cell Identity Open
In flowering plants, sequential formation of anther cell types is a highly ordered process that is essential for successful meiosis and sexual reproduction. Differentiation of meristematic cells and cell-cell communication are proposed to …
View article: Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer development.
Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer development. Open
Post-translational modifications (PTMs) are critical molecular events which alter protein conformation after their synthesis and diversity protein properties by modulating their stability, localization, interacting partners or the activity…