Xiaoyu Zhi
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View article: Research on Static-Dynamic Indicator System and Data Requirements for Digital Transformation of Traffic Safety Facilities
Research on Static-Dynamic Indicator System and Data Requirements for Digital Transformation of Traffic Safety Facilities Open
The digital transformation of highway infrastructure is advancing under China’s “A country with strong transportation network” strategy and “New Infrastructure” initiative, supported by technologies like 5G, IoT, and AI. While progress has…
View article: MDDM: A Multi-view Discriminative Enhanced Diffusion-based Model for Speech Enhancement
MDDM: A Multi-view Discriminative Enhanced Diffusion-based Model for Speech Enhancement Open
With the development of deep learning, speech enhancement has been greatly optimized in terms of speech quality. Previous methods typically focus on the discriminative supervised learning or generative modeling, which tends to introduce sp…
View article: Overexpression of the <i>GmERF071</i> gene confers resistance to soybean cyst nematode in soybean
Overexpression of the <i>GmERF071</i> gene confers resistance to soybean cyst nematode in soybean Open
Soybean cyst nematode (SCN) is one of the most harmful pests, causing major reductions in soybean yield globally. The validation and functional characterization of SCN resistance genes are crucial to improving soybean yield worldwide. Here…
View article: TTC7A Variants Results in Gastrointestinal Defects and Immunodeficiency Syndrome: Case Series and Literature Review
TTC7A Variants Results in Gastrointestinal Defects and Immunodeficiency Syndrome: Case Series and Literature Review Open
Gastrointestinal Defects and Immunodeficiency Syndrome-1 (GIDID-1), caused by abnormalities in TTC7A, is an autosomal recessive disorder characterized by multiple gastrointestinal malformations and immune deficiencies, often accompanied by…
View article: Immunological characteristics of peripheral T cells as prognostic markers for Camrelizumab and Apatinib combination therapy in advanced squamous non-small-cell lung cancer
Immunological characteristics of peripheral T cells as prognostic markers for Camrelizumab and Apatinib combination therapy in advanced squamous non-small-cell lung cancer Open
Our findings suggest that peripheral blood circulating CD4+ CXCR3+ CD137+ cells serve as biomarkers of response to combined immunotherapy and anti-angiogenic therapy in patients with advanced squamous NSCLC, providing potential guidance fo…
View article: Correlation of lung immune prognostic index with the efficacy of immune checkpoint inhibitors in Chinese patients with advanced non-small cell lung cancer
Correlation of lung immune prognostic index with the efficacy of immune checkpoint inhibitors in Chinese patients with advanced non-small cell lung cancer Open
Purpose Treatment with immune checkpoint inhibitors (ICIs) improves the prognoses of patients with non-small cell lung cancer (NSCLC) but is ineffective in some patients. The lung immune prognostic index (LIPI) can predict response to ICIs…
View article: Hypothalamic proteome analysis of insomnia rats treated by abdominal massage
Hypothalamic proteome analysis of insomnia rats treated by abdominal massage Open
Objective: To analyze differential protein expression in the hypothalamus of insomnia rats treated by abdominal massage using proteomic assays. Methods: The insomnia model was established by single intraperitoneal injection of p-chlorophen…
View article: Hypothalamic proteome analysis of insomnia rats treated by abdominal massage
Hypothalamic proteome analysis of insomnia rats treated by abdominal massage Open
Objective: To analyze differential protein expression in the hypothalamus of insomnia rats treated by abdominal massage using proteomic assays. Methods: The insomnia model was established by single intraperitoneal injection of p-chlorophen…
View article: Acupuncture with or without acupoint application for primary dysmenorrhea: protocol for a systematic review and meta-analysis
Acupuncture with or without acupoint application for primary dysmenorrhea: protocol for a systematic review and meta-analysis Open
Introduction Dysmenorrhea is the most common gynaecological symptom reported by women. Ninety percent of women presenting for primary care experience some menstrual pain. Population surveys suggest that, although prevalence rates vary cons…
View article: First‐line <scp>PD</scp>‐1/<scp>PD‐L1</scp> inhibitors plus chemotherapy versus bevacizumab plus chemotherapy for advanced non‐squamous non‐small cell lung cancer: A Bayesian network meta‐analysis of randomized controlled trials
First‐line <span>PD</span>‐1/<span>PD‐L1</span> inhibitors plus chemotherapy versus bevacizumab plus chemotherapy for advanced non‐squamous non‐small cell lung cancer: A Bayesian network meta‐analysis of randomized controlled trials Open
Chemotherapy in combination with immune checkpoint inhibitor (ICI) or bevacizumab has demonstrated a superior effect for non‐squamous non‐small cell lung cancer (NS‐NSCLC). There are still few randomized controlled trials (RCTs) investigat…
View article: Tuina for perimenopausal insomnia
Tuina for perimenopausal insomnia Open
Background: Insomnia in perimenopausal women has a negative impact on quality of life and increases health care costs. With the increasing incidence of the disease, Tuina has been accepted by perimenopausal women. The purpose of this study…
View article: Case Report: Osimertinib Followed by Osimertinib Plus Bevacizumab, Personalized Treatment Strategy for a Lung Cancer Patient With a Novel EGFR Exon 20 Insertion D770_N771insGT and Multiple Brain Metastases
Case Report: Osimertinib Followed by Osimertinib Plus Bevacizumab, Personalized Treatment Strategy for a Lung Cancer Patient With a Novel EGFR Exon 20 Insertion D770_N771insGT and Multiple Brain Metastases Open
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) are the standard of care for non–small cell lung cancer (NSCLC) patients with EGFR exon 19 deletion and L858R mutations. However, no EGFR TKI has been approved …
View article: Efficacy and safety evaluation of acupuncture in the treatment of impaired glucose regulation: a protocol for systematic review and meta-analysis
Efficacy and safety evaluation of acupuncture in the treatment of impaired glucose regulation: a protocol for systematic review and meta-analysis Open
Review question / Objective: To prove the efficacy and safety of acupuncture in the treatment of impaired glucose regulation.
View article: Study on the mechanism of regulating the hypothalamic cortical hormone releasing hormone/corticotropin releasing hormone type I receptor pathway by vibro-annular abdominal massage under the brain–intestine interaction in the treatment of insomnia
Study on the mechanism of regulating the hypothalamic cortical hormone releasing hormone/corticotropin releasing hormone type I receptor pathway by vibro-annular abdominal massage under the brain–intestine interaction in the treatment of insomnia Open
Background: Insomnia is a common disease associated with different nervous system stress response and endocrine disorders. It has been reported previously that abdominal vibration and ring massage therapy can significantly improve the symp…
View article: [Research Progress of Circular RNA in Lung Cancer].
[Research Progress of Circular RNA in Lung Cancer]. Open
Lung cancer is the most common malignant tumor with the highest morbidity and mortality worldwide, and its imposes an insupportable burden on patients due to its poor prognosis. The diagnosis and treatment of lung cancer is under great pre…
View article: Immunotherapy beyond progression in patients with advanced non-small cell lung cancer
Immunotherapy beyond progression in patients with advanced non-small cell lung cancer Open
IBP is associated with longer OS and PFS in patients with aNSCLC. Our findings may suggest new therapeutic options for patients with aNSCLC who experienced disease progression after initial immunotherapy.
View article: Dynamics of Serum Tumor Markers Can Serve as a Prognostic Biomarker for Chinese Advanced Non-small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors
Dynamics of Serum Tumor Markers Can Serve as a Prognostic Biomarker for Chinese Advanced Non-small Cell Lung Cancer Patients Treated With Immune Checkpoint Inhibitors Open
Background: Serum tumor markers carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), cytokeratin 19 fragment (CYFRA21-1) and squamous-cell carcinoma-related antigen (SCC-Ag) are routinely used for monitoring the response to chemothe…
View article: Pretreatment hemoglobin level as a predictor to evaluate the efficacy of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer
Pretreatment hemoglobin level as a predictor to evaluate the efficacy of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer Open
Background: Targeting immune checkpoints represents an immense breakthrough in cancer therapeutics. The prognostic value of hemoglobin (Hb) has been investigated in many malignancies including non-small cell lung cancer (NSCLC). However, t…
View article: [Advances in the Influence of EGFR Mutation on the PD-L1 Expression in Non-small Cell Lung Cancer].
[Advances in the Influence of EGFR Mutation on the PD-L1 Expression in Non-small Cell Lung Cancer]. Open
Researches on the inhibitors of programmed death-1 (PD-1) and programmed death-1 ligand (PD-L1) enjoy considerable breakthroughs in recent years, which has brought relative changes in the therapeutic model of non-small cell lung cancer (NS…