Xiaolong Zhu
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View article: Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis
Identification of serum MicroRNAs associated with hepatic immunoinflammatory injury in chronic hepatitis B: implications for non-invasive diagnosis Open
Background and aims Hepatitis B virus (HBV) causes chronic hepatic infection, leading to various advanced liver diseases. Currently, there is still a lack of effective non-invasive biomarkers for evaluating hepatic inflammation and fibrosi…
View article: Research on the Influence of Groundwater Level Dynamic Rising Process on Buildings Based on Numerical Simulation
Research on the Influence of Groundwater Level Dynamic Rising Process on Buildings Based on Numerical Simulation Open
In the North China region, measures such as restricting groundwater extraction and promoting cross-basin water diversion have effectively alleviated the problem of excessive groundwater exploitation. Nevertheless, the continuous rise in gr…
View article: Cardiopulmonary resuscitation knowledge and skills among school teachers in Xinjiang, China: a cross-sectional survey
Cardiopulmonary resuscitation knowledge and skills among school teachers in Xinjiang, China: a cross-sectional survey Open
Background Cardiopulmonary resuscitation (CPR) is a critical, life-saving intervention that is especially important in school settings. This study assessed the levels of CPR knowledge, training, and rescue willingness among school teachers…
View article: Factors influencing rehabilitation costs for stroke inpatients in Shenzhen: a multicenter retrospective study
Factors influencing rehabilitation costs for stroke inpatients in Shenzhen: a multicenter retrospective study Open
The study protocol was registered in the Chinese Clinical Trial Registry (ChiCTR-2000034067, Registration date: 22 June 2020, http://www.chictr.org.cn/showproj.aspx?proj=54770 ).
View article: Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy
Protein modifications in hepatic ischemia-reperfusion injury: molecular mechanisms and targeted therapy Open
Ischemia-reperfusion injury refers to the damage that occurs when blood supply is restored to organs or tissues after a period of ischemia. This phenomenon is commonly observed in clinical contexts such as organ transplantation and cardiac…
View article: Exploration of Umbilical Hernia Incidence and Etiology in 753 Cases of Single-Incision Laparoscopic Surgery: A Retrospective Analysis
Exploration of Umbilical Hernia Incidence and Etiology in 753 Cases of Single-Incision Laparoscopic Surgery: A Retrospective Analysis Open
Purpose The rising popularity of Single Incision Laparoscopic Surgery (SILS) brings concerns regarding a higher incidence of postoperative incisional hernias due to the enlarged umbilical incision compared to conventional laparoscopy. This…
View article: SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis
SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3/SMURF1/PPARγ axis Open
Obesity is a prevalent global disease associated with various metabolic disorders. The expansion of white adipose tissue plays a pivotal role in regulating obesity-related metabolic dysfunctions. This study identified serum-defined colon c…
View article: Extracellular vesicles derived from lung M2 macrophages enhance group 2 innate lymphoid cells function in allergic airway inflammation
Extracellular vesicles derived from lung M2 macrophages enhance group 2 innate lymphoid cells function in allergic airway inflammation Open
Group 2 innate lymphoid cells (ILC2s) promote the recruitment of eosinophils by secreting large amounts of type 2 cytokines (IL-5 and IL-13), thus triggering the main feature of asthma, pathological inflammation. Recent insights from mouse…
View article: Hospitalization costs in patients with stroke in southeastern China: a retrospective population-based cohort study, 2019–2022
Hospitalization costs in patients with stroke in southeastern China: a retrospective population-based cohort study, 2019–2022 Open
Introduction Stroke remains a predominant cause of mortality and accounts for one-third of all stroke-related fatalities worldwide. Increasing expenses associated with stroke are a matter of significant concern; however, this aspect has be…
View article: Comparison of Diagnosis-Related Group Rehabilitation Reimbursement Payments With Those of a Novel Patient Classification-Based Payment System
Comparison of Diagnosis-Related Group Rehabilitation Reimbursement Payments With Those of a Novel Patient Classification-Based Payment System Open
The findings of DIP payment reduced the rehabilitation hospitalization cost would be helpful in developing more effectively and efficiently tailored interventions for rehabilitation health care in China. Furthermore, the results of this st…
View article: Nanomaterial Delivery Vehicles for the Development of Neoantigen Tumor Vaccines for Personalized Treatment
Nanomaterial Delivery Vehicles for the Development of Neoantigen Tumor Vaccines for Personalized Treatment Open
Tumor vaccines have been considered a promising therapeutic approach for treating cancer in recent years. With the development of sequencing technologies, tumor vaccines based on neoantigens or genomes specifically expressed in tumor cells…
View article: SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis
SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis Open
BACKGROUND: Angiogenesis, which plays a critical role in embryonic development and tissue repair, is controlled by a set of angiogenic signaling pathways. As a TF (transcription factor) belonging to the basic helix-loop-helix family, HEY (…
View article: M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2/HIF-1α axis mediated metabolic reprogramming of macrophages
M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2/HIF-1α axis mediated metabolic reprogramming of macrophages Open
Viral myocarditis (VM) is a clinically common inflammatory disease. Accumulating literature has indicated that M2 macrophages protect mice from Coxsackievirus B3 (CVB3)-induced VM. However, mechanisms that underlie M2 macrophages alleviati…
View article: TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes
TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes Open
The endothelium is a major target of the proinflammatory cytokine, tumor necrosis factor alpha (TNFα). Exposure of endothelial cells (EC) to proinflammatory stimuli leads to an increase in mitochondrial metabolism; however, the function an…
View article: Impact of Sea Rice Planting on Enzymatic Activity and Microbial Community of Coastal Soils: Focus on Proteinase
Impact of Sea Rice Planting on Enzymatic Activity and Microbial Community of Coastal Soils: Focus on Proteinase Open
Soil proteinase and proteinase-producing microbial community are closely associated with soil fertility and soil health. Sea rice has been planted in the coastal beach of Jiaozhou Bay, China, in an effort to transform saline-alkali soil in…
View article: Observation of ultra-large Rabi splitting in the plasmon-exciton polaritons at room temperature
Observation of ultra-large Rabi splitting in the plasmon-exciton polaritons at room temperature Open
Modifying the light–matter interactions in the plasmonic structures and the two-dimensional (2D) materials not only advances the deeper understanding of the fundamental studies of many-body physics but also provides the opportunities for e…
View article: Investigating the active chemical constituents and pharmacology of Nanocnide lobata in the treatment of burn and scald injuries
Investigating the active chemical constituents and pharmacology of Nanocnide lobata in the treatment of burn and scald injuries Open
Objective To identify the most effective fraction of Nanocnide lobata in the treatment of burn and scald injuries and determine its bioactive constituents. Methods Chemical identification methods were used to analyze solutions extracted fr…
View article: m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Background Long non-coding RNAs (lncRNAs) play important roles in the progression of glioma. Here, we examined the potential functions of a lncRNA, LINC01003, in glioma and characterized the underlying molecular mechanisms. Methods The GEI…
View article: [M2 macrophage-derived exosomal lncRNA NR_028113.1 promotes macrophage polarization possibly by activating the JAK2/STAT3 signaling pathway].
[M2 macrophage-derived exosomal lncRNA NR_028113.1 promotes macrophage polarization possibly by activating the JAK2/STAT3 signaling pathway]. Open
M2 macrophage-derived exosomal lncRNA NR_028113.1 can significantly promote M2 polarization of macrophages possibly by activating the JAK2/STAT3 signaling pathway.
View article: Additional file 5 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
Additional file 5 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Additional file 5: Table S3. The m6A sites on LINC01003 were predicted by the GEIPA2 database.
View article: Additional file 1 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
Additional file 1 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Additional file 1: Table S1. The DEGs between NC and LINC01003 smart silencer siRNA.
View article: Additional file 2 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma
Additional file 2 of m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma Open
Additional file 2: Table S2. Top 20 KEGG enrichment pathways in the downregulated mRNAs.
View article: FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis
FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis Open
Angiogenesis contributes fundamentally to embryonic development, tissue homeostasis, and wound healing. Basic fibroblast growth factor (FGF2) is recognized as the first proangiogenic molecule discovered, and it facilitates angiogenesis by …