Li Chen
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View article: Blood neurofilament light chain as a predictive biomarker for functional outcome of acute ischemic stroke: a systematic review and meta-analysis
Blood neurofilament light chain as a predictive biomarker for functional outcome of acute ischemic stroke: a systematic review and meta-analysis Open
Aim: Ischemic stroke continues to be a significant contributor to mortality and disability on a global scale. The blood neurofilament light chain (bNfL) as a prognostic indicator for stroke functional outcomes is a topic of ongoing debate.…
View article: The bittersweet link between glucose metabolism, cellular microenvironment and viral infection
The bittersweet link between glucose metabolism, cellular microenvironment and viral infection Open
Viral particles and proteins released during infection profoundly reshape the cellular microenvironment by disrupting host signaling, triggering inflammation, and modulating immune responses. Glucose metabolism, a critical hub for energy p…
View article: Identification of hub genes and prediction of the ceRNA network in adult sepsis
Identification of hub genes and prediction of the ceRNA network in adult sepsis Open
Background Sepsis refers to a dysregulated host immune response to infection. It carries a high risk of morbidity and mortality, and its pathogenesis has yet to be fully elucidated. The main aim of this study was to identify prognostic hub…
View article: Fear of cancer recurrence and associated factors in Chinese patients with colorectal cancer: a cross-sectional study
Fear of cancer recurrence and associated factors in Chinese patients with colorectal cancer: a cross-sectional study Open
FCR is common among postoperative CRC patients and is strongly linked to illness perception and anxiety. These findings underscore the need for routine psychological screening and tailored communication. Interventions addressing maladaptiv…
View article: Comparative morphological and lipidomic profiling of abdominal adipose tissue in Beijing You chickens at different ages and Ross 308 broilers
Comparative morphological and lipidomic profiling of abdominal adipose tissue in Beijing You chickens at different ages and Ross 308 broilers Open
This study aimed to compare fat deposition, muscle tissue structure, and abdominal fat lipid metabolism among 150-day-old Beijing You chickens, 450-day-old Beijing You chickens, and 150-day-old Ross 308 broilers. Slaughter performance anal…
View article: The Predictive Value of Peripheral Blood CD4+/CD8+ Ratio and NLR for Short-term Efficacy of Neoadjuvant Chemotherapy Combined with Immunotherapy in Locally Advanced Esophageal Cancer
The Predictive Value of Peripheral Blood CD4+/CD8+ Ratio and NLR for Short-term Efficacy of Neoadjuvant Chemotherapy Combined with Immunotherapy in Locally Advanced Esophageal Cancer Open
The neutrophil-to-lymphocyte ratio (NLR) and peripheral blood lymphocyte subpopulations are indicators that can reflect the immune status and the degree of chronic inflammation in the human body. This study aims to investigate the predicti…
View article: Signal mining and risk analysis of the over-indications use of bevacizumab
Signal mining and risk analysis of the over-indications use of bevacizumab Open
Objective To dig deeper into the Adverse events(ADEs) signal generated by bevacizumab in the past decade, and to compare and summarize the clinical characteristics and medication risks of the over-indications use of bevacizumab. Methods “B…
View article: Combining recombinant human endostatin with third-generation EGFR-TKIs in advanced EGFR-sensitive mutant non-small cell lung cancer
Combining recombinant human endostatin with third-generation EGFR-TKIs in advanced EGFR-sensitive mutant non-small cell lung cancer Open
In this real-world study, the combination of recombinant human endostatin and third-generation EGFR-TKIs significantly improved the ORR, PFS, and OS in previously untreated advanced EGFR-mutant NSCLC patients and thus represents a promisin…
View article: Safety and efficacy of the neuroform EZ stent for treating intracranial atherosclerotic stenosis in the posterior circulation: a comparative study of pre-procedure and post-procedure outcomes
Safety and efficacy of the neuroform EZ stent for treating intracranial atherosclerotic stenosis in the posterior circulation: a comparative study of pre-procedure and post-procedure outcomes Open
The Neuroform EZ stent is a safe and effective treatment approach for ICAS in the posterior circulation.
View article: Therapeutic Effect of Brucea Javanica Oil Emulsion in Mice with Irinotecan-Induced Delayed Diarrhea
Therapeutic Effect of Brucea Javanica Oil Emulsion in Mice with Irinotecan-Induced Delayed Diarrhea Open
BJOE effectively mitigated inflammation and preserved intestinal barrier function, at least partially, via inhibiting cGAS-STING pathway in irinotecan-induced delayed diarrhea. Active components, long-term safety and pharmacokinetics studi…
View article: Comprehensive auricular therapy combined with Hufu copper scraping in the treatment of cough following mycoplasma pneumonia: A case study of Traditional Chinese Medicine nursing
Comprehensive auricular therapy combined with Hufu copper scraping in the treatment of cough following mycoplasma pneumonia: A case study of Traditional Chinese Medicine nursing Open
This article summarizes the experience of integrated Traditional Chinese and Western medicine nursing care for a patient with post-mycoplasma pneumonia cough. Based on the concept of Traditional Chinese Medicine syndrome differentiation, n…
View article: Implementation and effectiveness of advance care planning in hospitalized older adults with chronic heart failure: a mixed-methods systematic review and meta-analysis
Implementation and effectiveness of advance care planning in hospitalized older adults with chronic heart failure: a mixed-methods systematic review and meta-analysis Open
Objectives This study aims to integrate the data on the effects of a pre-established medical care program on hospitalized older adults with chronic heart failure (CHF). Method A comprehensive systematic review incorporating mixed research …
View article: Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population
Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population Open
Impaired central, but not peripheral sensitivity to thyroid hormones was associated with increased body fat mass/muscle mass ratio (F/M), this association was obvious in males, individuals with age < 65 years and BMI ≥ 25 kg/m2,…
View article: Targeting PD-1 post-translational modifications for improving cancer immunotherapy
Targeting PD-1 post-translational modifications for improving cancer immunotherapy Open
View article: The Evolution of Ischemia‐Reperfusion Injury Research in Ischemic Stroke: Insights From a Two‐Decade Bibliometric Analysis
The Evolution of Ischemia‐Reperfusion Injury Research in Ischemic Stroke: Insights From a Two‐Decade Bibliometric Analysis Open
Background Ischemic stroke is a complex disease with high mortality and disability rates. Ischemia‐reperfusion injury is a common aftermath. There have been significant advancements in understanding ischemia‐reperfusion injury in ischemic …
View article: Public participation willingness in out-of-hospital cardiopulmonary resuscitation: A systematic review and meta-analysis
Public participation willingness in out-of-hospital cardiopulmonary resuscitation: A systematic review and meta-analysis Open
View article: Joint association of sleep onset time and sleep duration with depression in patients with chronic kidney disease: Insights from the NHANES 2015–2020
Joint association of sleep onset time and sleep duration with depression in patients with chronic kidney disease: Insights from the NHANES 2015–2020 Open
View article: Comparison of short-term outcomes following minimally invasive (endoscopic/robotic) vs open thyroidectomy for patients with thyroid cancer
Comparison of short-term outcomes following minimally invasive (endoscopic/robotic) vs open thyroidectomy for patients with thyroid cancer Open
Background Selection between open thyroidectomy (OT) and minimally invasive (endoscopic/robotic) thyroidectomy for patients with thyroid cancer has been a subject of considerable debate. Comprehensive analysis of the short-term outcomes of…
View article: Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review)
Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review) Open
Signal transducer and activator of transcription 3 (STAT3), a crucial transcription factor, exerts a notable influence by hyperactivating or acquiring functional mutations in the occurrence and progression of cancers. Hyperactive STAT3 is …
View article: EGFR-mutant lung adenocarcinoma transformed into small cell Lung cancer: A case report and literatures review
EGFR-mutant lung adenocarcinoma transformed into small cell Lung cancer: A case report and literatures review Open
View article: Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader
Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader Open
Poly (ADP-ribose) polymerase 1 (PARP1) catalyzes poly (ADP) ribosylation reaction, one of the essential post-translational modifications of proteins in eukaryotic cells. Given that PARP1 inhibition can lead to synthetic lethality in cells …
View article: Penehyclidine hydrochloride activates PARK2 and modulates ubiquitination of AIFM1 to rescue renal tubular injury in diabetic kidney disease
Penehyclidine hydrochloride activates PARK2 and modulates ubiquitination of AIFM1 to rescue renal tubular injury in diabetic kidney disease Open
PHC activated Nrf2 to up-regulate PARK2 transcription to induce mitophagy and inhibit apoptosis mediated by nuclear translocation of AIFM1 through promoting non-degradative ubiquitination of AIFM1, ultimately rescuing RTI in DN.
View article: Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study
Development and Validation of a Novel Classification System and Prognostic Model for Open Traumatic Brain Injury: A Multicenter Retrospective Study Open
The implementation of our proposed OTBI classification system and its use alongside the other prognostic factors identified here may improve the prediction of patient prognosis and aid in the selection of the most suitable treatment strate…
View article: Can the digital economy contribute to rural revitalization? A case of from China?
Can the digital economy contribute to rural revitalization? A case of from China? Open
This study establishes a multi-dimensional evaluation index system for measuring digital economy and rural revitalization. It explores the impact of digital economy on China’s rural revitalization and its mechanism using dynamic balanced p…
View article: Exploring cuproptosis-related molecular clusters and immunological characterization in ischemic stroke through machine learning
Exploring cuproptosis-related molecular clusters and immunological characterization in ischemic stroke through machine learning Open
View article: IFI-16 inhibition attenuates myocardial remodeling following myocardial infarction
IFI-16 inhibition attenuates myocardial remodeling following myocardial infarction Open
View article: Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer
Stability and variability of molecular subtypes: comparative analysis of primary and metastatic triple-negative breast cancer Open
Objective: Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive cancer. Although our previous study classified primary TNBC into four subtypes, comprehensive longitudinal investigations are lacking. Methods: We assembled …
View article: The role of coagulopathy and subdural hematoma thickness at admission in predicting the prognoses of patients with severe traumatic brain injury: a multicenter retrospective cohort study from China
The role of coagulopathy and subdural hematoma thickness at admission in predicting the prognoses of patients with severe traumatic brain injury: a multicenter retrospective cohort study from China Open
Background: Traumatic brain injury (TBI) is one of the diseases with high disability and mortality worldwide. Recent studies have shown that TBI-related factors may change the complex balance between bleeding and thrombosis, leading to coa…
View article: Endovascular treatment versus standard medical treatment in patients with established large infarct: a cohort study
Endovascular treatment versus standard medical treatment in patients with established large infarct: a cohort study Open
Background: Previous trials confirmed the benefit of endovascular treatment (EVT) in acute large core stroke, but the effect of EVT on outcomes in these patients based on noncontrast computed tomography (NCCT) in real-world clinical practi…
View article: Ultrasound‐activated in situ click chemistry to trigger autophagosome tracking for enhanced autophagy blockade and synergistic cancer therapy
Ultrasound‐activated in situ click chemistry to trigger autophagosome tracking for enhanced autophagy blockade and synergistic cancer therapy Open
The blockade of cytoprotective autophagy has been demonstrated to effectively enhance the efficacy of sonodynamic therapy (SDT). However, the limited recognition of antiautophagy agents for autophagosomes impedes the clinical application o…