Xiaoman Bi
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Integrative Transcriptomic Analysis Decodes the Interplay Between Aging, Senescence, and Cancer Open
Cancer risk increases with age, and cellular senescence may be a major contributor to cellular carcinogenesis. Enormous efforts have been made to investigate the interrelation between aging and tumors, but little is known about the compara…
View article: Lymph nodes molecular subtypes unravel lymph nodes heterogeneity and clinical implications in colorectal cancer
Lymph nodes molecular subtypes unravel lymph nodes heterogeneity and clinical implications in colorectal cancer Open
Lymph nodes (LNs) play a pivotal role in colorectal cancer (CRC) progression and immunity, yet their molecular and functional diversity remains poorly understood. By analyzing 630 LNs and 88 primary tumors from 200 CRC patients across four…
Activation of the hypoxia response in the aging cerebrovasculature protects males against cognitive impairment Open
Alzheimer's disease (AD) is a neurodegenerative disorder with a distinct sex bias. Age‐related vascular alterations, a hallmark of AD onset and progression, are consistently associated with sexual dimorphism. Here, we conducted an integrat…
View article: Single‐cell transcriptomic landscape reveals distinct tumourigenesis and immune microenvironments in secondary radiation‐exposed rectal cancer
Single‐cell transcriptomic landscape reveals distinct tumourigenesis and immune microenvironments in secondary radiation‐exposed rectal cancer Open
Dear Editor, Radiation therapy is a common treatment option for pelvic cancer patients1 and can induce secondary radiation-exposed rectal cancers (SRCs).2 However, compared with those of primary rectal cancers (PRCs), the molecular charact…
Development of an m6A‐Related lncRNAs Signature Predicts Tumor Stemness and Prognosis for Low‐Grade Glioma Patients Open
Background . Growing evidence has revealed that m6A modification of long noncoding RNAs (lncRNAs) dynamically controls tumor stemness and tumorigenesis‐related processes. However, the prognostic significance of m6A‐related lncRNAs and thei…
Pan‐cancer analyses reveal multi‐omic signatures and clinical implementations of the forkhead‐box gene family Open
Background Forkhead box (FOX) proteins belong to one of the largest transcription factor families and play crucial roles in the initiation and progression of cancer. Prior research has linked several FOX genes, such as FOXA1 and FOXM1, to …
Enhanced insulin‐regulated phagocytic activities support extreme health span and longevity in multiple populations Open
The immune system plays a central role in many processes of age‐related disorders and it remains unclear if the innate immune system may play roles in shaping extreme longevity. By an integrated analysis with multiple bulk and single cell …
Epigenetically regulated lncRNAs dissect the intratumoural heterogeneity and facilitate immune evasion of glioblastomas Open
Background: Glioblastomas are the most common and malignant central nervous system (CNS) tumors that occupied a highly heterogeneous tumor microenvironment (TIME). Long noncoding RNAs (lncRNAs), whose expression can be modified by DNA meth…
Identification and functional analysis of <span>N6</span>‐methyladenine (<span>m<sup>6</sup>A</span>)‐related <span>lncRNA</span> across 33 cancer types Open
Background N6‐methyladenosine (m 6 A) plays an essential role in tumorigenesis and cancer progression. Long noncoding RNAs (lncRNAs) are discovered to be important targets of m 6 A modification, and they play fundamental roles in diverse b…
How Placenta Promotes the Successful Reproduction in High-Altitude Populations: A Transcriptome Comparison between Adaptation and Acclimatization Open
As the best adapted high altitude population, Tibetans feature a relatively high offspring survival rate. Genome-wide studies have identified hundreds of candidate SNPs related to high altitude adaptation of Tibetans, although most of them…
View article: Prognostic Implications and Immune Infiltration Characteristics of Chromosomal Instability-Related Dysregulated CeRNA in Lung Adenocarcinoma
Prognostic Implications and Immune Infiltration Characteristics of Chromosomal Instability-Related Dysregulated CeRNA in Lung Adenocarcinoma Open
An accumulating body of research indicates that long-noncoding RNAs (lncRNAs) regulate the target genes and act as competitive endogenous RNAs (ceRNAs) playing an indispensable role in lung adenocarcinoma (LUAD). LUAD is frequently accompa…
Comprehensive Analysis of the Carcinogenic Process, Tumor Microenvironment, and Drug Response in HPV-Positive Cancers Open
Human papillomavirus (HPV) is a common virus, and about 5% of all cancers worldwide is caused by persistent high-risk HPV infections. Here, we reported a comprehensive analysis of the molecular features for HPV-related cancer types using T…
Additional file 2 of NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis Open
Additional file 2: Supplementary tables S1 to S7.
HCDT: an integrated highly confident drug–target resource Open
Drug–target association plays an important role in drug discovery, drug repositioning, drug synergy prediction, etc. Currently, a lot of drug-related databases, such as DrugBank and BindingDB, have emerged. However, these databases are sep…
The synergistic interaction landscape of chromatin regulators reveals their epigenetic regulation mechanisms across five cancer cell lines Open
Chromatin regulators (CRs) regulate the gene transcription process through combinatorial patterns, which currently remain obscure for pan-cancer. This study identified the interaction of CRs and constructed CR-CR interaction networks acros…
A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors Open
Cystatin E/M (CST6), a representative cysteine protease inhibitor, plays both tumor-promoting and tumor-suppressing functions and is pursued as an epigenetically therapeutic target in special cancer types. However, a comprehensive and syst…
Effective Measures Coping with COVID-19 Pandemic Based on fsQCA: Evidence from China Open
Background: Faced with the global outbreak and spread of COVID-19 pandemic, the government of each country has adopted different emergency measures, but the effectiveness assessment of these emergency measures is still lacked. This paper a…
An NIR-emitting lysosome-targeting probe with large Stokes shift via coupling cyanine and excited-state intramolecular proton transfer Open
A NIR-emitting probe with a large Stokes shift (Δλ ≈ 234 nm) can selectively show lysosome organelles without exhibiting “an alkalinizing effect”.