Xiaoman Yang
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View article: The complete chloroplast genome sequence of <i>Populus</i> × <i>deltoides</i> L. ‘Jinheiyang’
The complete chloroplast genome sequence of <i>Populus</i> × <i>deltoides</i> L. ‘Jinheiyang’ Open
Northwest China's stress-resistant, high-yield poplar Populus × deltoides L. 'Jinheiyang' (JHP) has an unreported chloroplast genome. This study sequenced it: 157,084 bp circular genome with quadripartite structure, 123 genes (83 protein-c…
View article: Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody
Tricin selectively combats KRAS-mutant non-small cell lung cancer by inhibiting the PDGF-BB-induced SRC/MAPK/AP-1/PD-L1 signaling pathway and potentiating the antitumor effect of an anti-PD-1 antibody Open
Background KRAS is a commonly mutated gene that is present in approximately 30% of NSCLC patients. Currently, the identification of effective therapies for KRAS-mutant NSCLC is difficult for reasons of the structural and biochemical charac…
View article: Protective Effect of Semaglutide on Obesity-Induced Renal Disease and Obesity-Induced Kidney Renal Clear Cell Carcinoma
Protective Effect of Semaglutide on Obesity-Induced Renal Disease and Obesity-Induced Kidney Renal Clear Cell Carcinoma Open
Semaglutide could regulate the development of KIRC by up-adjusting the expression of Man1a1 and Ntn4.
View article: Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression
Alpha-synuclein Fibrils Inhibit Activation of the BDNF/ERK Signaling Loop in the mPFC to Induce Parkinson's Disease-like Alterations with Depression Open
Depression (Dep) is one of the most common concomitant symptoms of Parkinson's disease (PD), but there is a lack of detailed pathologic evidence for the occurrence of PD-Dep. Currently, the management of symptoms from both conditions using…
View article: The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway
The tubulin polymerization inhibitor gambogenic acid induces myelodysplastic syndrome cell apoptosis through upregulation of Fas expression mediated by the NF-κB signaling pathway Open
The development of an effective treatment for myelodysplastic syndrome (MDS) is needed due to the insufficient efficacy of current therapies. Gambogenic acid (GNA) is a xanthone constituent of gamboge, a resin secreted by Garcinia hanburyi…
View article: Identification and experimental validation of m7G-related molecular subtypes, immune signature, and feature genes in Alzheimer's disease
Identification and experimental validation of m7G-related molecular subtypes, immune signature, and feature genes in Alzheimer's disease Open
To the best of our knowledge, this is the first study to reveal close correlations among m7G RNA modification, the immune microenvironment, and the pathogenesis of AD. We also identified five feature genes associated with AD, further contr…
View article: Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease
Analysis and experimental validation of necroptosis-related molecular classification, immune signature and feature genes in Alzheimer’s disease Open
Necroptosis, a programmed cell death pathway, has been demonstrated to be activated in Alzheimer’s disease (AD). However, the precise role of necroptosis and its correlation with immune cell infiltration in AD remains unclear. In this stud…
View article: AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia
AMPK-mediated autophagy pathway activation promotes ΔFosB degradation to improve levodopa-induced dyskinesia Open
In conclusion, our results suggest that long-term metformin treatment could promote ΔFosB degradation and thus attenuate the development of LID through activating the AMPK-mediated autophagy pathway. Overall, our results support the AMPK-m…
View article: The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products
The influence of simulated weightlessness on the composition and function of gut microbiota and bile acid metabolism products Open
The aim of this study was to investigate the effects of simulated weightlessness on gut microbiota, bile acid metabolism, and inflammatory cytokines compared to the control group. The study compared the changes in gut microbiota at the phy…
View article: Magnetic chitin beads (MCB) coated with <i>Vibrio cholerae</i> reveals transcriptome dynamics in adult mice with a complex gut microbiota
Magnetic chitin beads (MCB) coated with <i>Vibrio cholerae</i> reveals transcriptome dynamics in adult mice with a complex gut microbiota Open
Vibrio cholerae adapts to the host environment by altering gene expression. Because of the complexity of the gut microbiome, current in vivo V. cholerae transcriptome studies have focused on microbiota-undeveloped conditions, neglecting th…
View article: Clinical progress of anti-angiogenic targeted therapy and combination therapy for gastric cancer
Clinical progress of anti-angiogenic targeted therapy and combination therapy for gastric cancer Open
The incidence of gastric cancer is increasing year by year. Most gastric cancers are already in the advanced stage with poor prognosis when diagnosed, which means the current treatment is not satisfactory. Angiogenesis is an important link…
View article: Identification and Validation of Metabolism-Related Genes in Alzheimer’s Disease
Identification and Validation of Metabolism-Related Genes in Alzheimer’s Disease Open
Background：Due to its heterogeneity, the pathogenic mechanisms underlying Alzheimer's disease (AD) are not yet fully elucidated. Emerging evidence has demonstrated the critical role of metabolism in the pathophysiology of AD. This study ex…
View article: Cross-Platform Transcriptomic Data Integration, Profiling, and Mining in <i>Vibrio cholerae</i>
Cross-Platform Transcriptomic Data Integration, Profiling, and Mining in <i>Vibrio cholerae</i> Open
We used two techniques to integrate RNA-seq data for laboratory studies with clinical microarray data for the first time. The interactions between V. cholerae genes were obtained from a global perspective, as well as comparing the similari…
View article: Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review
Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review Open
Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological …
View article: Dps-dependent in vivo mutation enhances long-term host adaptation in Vibrio cholerae
Dps-dependent in vivo mutation enhances long-term host adaptation in Vibrio cholerae Open
As one of the most successful pathogenic organisms, Vibrio cholerae ( V . cholerae ) has evolved sophisticated regulatory mechanisms to overcome host stress. During long-term colonization by V . cholerae in adult mice, many spontaneous non…
View article: Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α–Syn and tau fragments
Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α–Syn and tau fragments Open
Introduction Accurate demonstration of phosphorylated α-synuclein aggregation and propagation, progressive nigrostriatal degeneration and motor deficits will help further research on elucidating the mechanisms of Parkinson’s Disease. α-syn…
View article: Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut
Antibiotic-Induced Primary Biles Inhibit SARS-CoV-2 Endoribonuclease Nsp15 Activity in Mouse Gut Open
The gut microbiome profile of COVID-19 patients was found to correlate with a viral load of SARS-CoV-2, COVID-19 severity, and dysfunctional immune responses, suggesting that gut microbiota may be involved in anti-infection. In order to in…
View article: mcr-1-Mediated In Vitro Inhibition of Plasmid Transfer Is Reversed by the Intestinal Environment
mcr-1-Mediated In Vitro Inhibition of Plasmid Transfer Is Reversed by the Intestinal Environment Open
Colistin is regarded as an antibiotic of last resort against multidrug-resistant Gram-negative bacteria, including Klebsiella pneumoniae and Escherichia coli. Colistin resistance is acquired by microorganisms via chromosome-mediated mutati…
View article: Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease
Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease Open
The aim of our study was to investigate differences in whole brain connectivity at different levels between drug-naïve individuals with early Parkinson’s disease (PD) and healthy controls (HCs). Resting-state functional magnetic resonance …
View article: Transcranial Magnetic Stimulation Alleviates Levodopa-Induced Dyskinesia in Parkinson's Disease and the Related Mechanisms: A Mini-Review
Transcranial Magnetic Stimulation Alleviates Levodopa-Induced Dyskinesia in Parkinson's Disease and the Related Mechanisms: A Mini-Review Open
After long-term use of levodopa, Parkinson's patients almost inevitably develop dyskinesia, a kind of drug side effect manifesting as uncontrollable choreic movements and dystonia, which could be crippling yet have limited therapeutic opti…
View article: Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry
Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry Open
Long-term therapy with levodopa (L-DOPA) in patients with Parkinson’s disease (PD) often triggers motor complications termed as L-DOPA-induced dyskinesia (LID). However, few studies have explored the pathogenesis of LID from the perspectiv…
View article: CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB
CBS-derived H2S facilitates host colonization of Vibrio cholerae by promoting the iron-dependent catalase activity of KatB Open
Sensing and resisting oxidative stress is critical for Vibrio cholerae to survive in either the aquatic environment or the gastrointestinal tract. Previous studies mainly focused on the mechanisms of oxidative stress response regulation th…
View article: Genetic and Chemical Engineering of Phages for Controlling Multidrug-Resistant Bacteria
Genetic and Chemical Engineering of Phages for Controlling Multidrug-Resistant Bacteria Open
Along with the excessive use of antibiotics, the emergence and spread of multidrug-resistant bacteria has become a public health problem and a great challenge vis-à-vis the control and treatment of bacterial infections. As the natural pred…
View article: Crosstalks Between Gut Microbiota and Vibrio Cholerae
Crosstalks Between Gut Microbiota and Vibrio Cholerae Open
Vibrio cholerae, the causative agent of cholera, could proliferate in aquatic environment and infect humans through contaminated food and water. Enormous microorganisms residing in human gastrointestinal tract establish a special microecol…
View article: Rho GTPase Regulators and Effectors in Autism Spectrum Disorders: Animal Models and Insights for Therapeutics
Rho GTPase Regulators and Effectors in Autism Spectrum Disorders: Animal Models and Insights for Therapeutics Open
The Rho family GTPases are small G proteins that act as molecular switches shuttling between active and inactive forms. Rho GTPases are regulated by two classes of regulatory proteins, guanine nucleotide exchange factors (GEFs) and GTPase-…