Xiaomei Yan
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View article: Unravelling Ligand Conjugation Performance in Extracellular Vesicles: A Quantitative Assessment of Lipid, Protein, and Membrane Modifications
Unravelling Ligand Conjugation Performance in Extracellular Vesicles: A Quantitative Assessment of Lipid, Protein, and Membrane Modifications Open
Surface functionalization is an effective approach for enhancing the cancer‐targeting efficiency of extracellular vesicles (EVs). However, the lack of direct comparisons between functionalization strategies has hindered the rational design…
View article: Isolation and Characterization of Vancomycin-Resistant Enterococcus faecium from Cattle: Antimicrobial Resistance, Virulence Genes, and Pathogenicity
Isolation and Characterization of Vancomycin-Resistant Enterococcus faecium from Cattle: Antimicrobial Resistance, Virulence Genes, and Pathogenicity Open
This study aimed to investigate the antimicrobial resistance, virulence gene profile, and pathogenicity of Enterococcus faecium isolated from a large-scale cattle farm in Xinjiang, China, to provide a scientific basis for the prevention an…
View article: Detection of Staphylococcus Enterotoxin sea and seb in Milk Samples by Duplex Droplet Digital PCR
Detection of Staphylococcus Enterotoxin sea and seb in Milk Samples by Duplex Droplet Digital PCR Open
This study sought to develop a method to accurately and quantitatively measure the staphylococcal enterotoxin genes sea and seb in milk samples using duplex droplet digital polymerase chain reaction (ddPCR). Specific primers and probes wer…
View article: Genomic epidemiology of dominant lineages of Streptococcus pyogenes emm types between 1993-2020, in China
Genomic epidemiology of dominant lineages of Streptococcus pyogenes emm types between 1993-2020, in China Open
Streptococcus pyogenes infections such as scarlet fever have increased in China since 2011. The genomic drivers of this increase are not known. The temporal clonal shifts within dominant emm12 and emm1 populations are unknown due to limite…
View article: Co-host ncRNA MIR503HG/miR-503-5p antagonistically interfere with the crosstalk between fibroblasts and microvascular endothelial cells by affecting the production of LMW FGF2 in pterygium
Co-host ncRNA MIR503HG/miR-503-5p antagonistically interfere with the crosstalk between fibroblasts and microvascular endothelial cells by affecting the production of LMW FGF2 in pterygium Open
AIM: To explore the effect of co-host non-coding RNA (ncRNA) MIR503HG/miR-503-5p on the angiogenesis of pterygium. METHODS: MIR503HG/miR-503-5p/fibroblast growth factor 2 (FGF2) expression levels in pterygium tissues, control conjunctival …
View article: A Foodborne Outbreak Associated with ST59-<i>spa</i> t441-SCC<i>mec</i> IVa Methicillin-resistant <i>Staphylococcus aureus</i> Producing Enterotoxins A and B — Puyang City, Henan Province, China, September 2024
A Foodborne Outbreak Associated with ST59-<i>spa</i> t441-SCC<i>mec</i> IVa Methicillin-resistant <i>Staphylococcus aureus</i> Producing Enterotoxins A and B — Puyang City, Henan Province, China, September 2024 Open
The identification of foodborne clones of ST59 CA-MRSA in this outbreak underscores the prevalence and transmission risks associated with this hypervirulent lineage. These findings highlight the critical need to strengthen surveillance mea…
View article: A GWO-GA-EL Neural Network Approach for Predicting the Laminar Burning Velocity of RP-3 Aviation Kerosene and Its Blends
A GWO-GA-EL Neural Network Approach for Predicting the Laminar Burning Velocity of RP-3 Aviation Kerosene and Its Blends Open
View article: Detection of ferrous ions in extracellular vesicles at the single-particle level by nano-flow cytometry
Detection of ferrous ions in extracellular vesicles at the single-particle level by nano-flow cytometry Open
Single-EV Fe 2+ profiling via nano-flow cytometry and chemosensor Ac-FluNox identifies vesicular iron export as a compensatory mechanism in ferroptosis, revealing a ferroportin-independent iron homeostasis pathway.
View article: LPItabformer: Enhancing generalization in predicting lncRNA-protein interactions via a tabular Transformer
LPItabformer: Enhancing generalization in predicting lncRNA-protein interactions via a tabular Transformer Open
Long-noncoding RNAs (LncRNAs) play important roles in physiological and pathological processes. Accurately predicting lncRNA-protein interactions (LPIs) is vital strategy for clarify functions and pathogenic mechanisms of lncRNAs. Current …
View article: Amino acid deletions at positions 893 and 894 of cytotoxin-associated gene A protein affect <i>Helicobacter pylori</i> gastric epithelial cell interactions
Amino acid deletions at positions 893 and 894 of cytotoxin-associated gene A protein affect <i>Helicobacter pylori</i> gastric epithelial cell interactions Open
BACKGROUND Helicobacter pylori (H. pylori ) persistently colonizes the human gastric mucosa in more than 50% of the global population, leading to various gastroduodenal diseases ranging from chronic gastritis to gastric carcinoma. Cytotoxi…
View article: Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine
Consensus statement on extracellular vesicles in liquid biopsy for advancing laboratory medicine Open
Extracellular vesicles (EVs) represent a diverse class of nanoscale membrane vesicles actively released by cells. These EVs can be further subdivided into categories like exosomes and microvesicles, based on their origins, sizes, and physi…
View article: Construction and Validation of Chicken Immune scFv Antibody Library against Helicobacter pylori
Construction and Validation of Chicken Immune scFv Antibody Library against Helicobacter pylori Open
Accurate diagnostic techniques and effective therapeutic methods are required to treat H. pylori. The application of chicken single-chain variable fragment (scFv) antibodies may diagnose and treat H. pylori. This study used the phage displ…
View article: Nano-flow cytometry unveils mitochondrial permeability transition process and multi-pathway cell death induction for cancer therapy
Nano-flow cytometry unveils mitochondrial permeability transition process and multi-pathway cell death induction for cancer therapy Open
View article: Corrigendum to ‘Characterization of lipid-based nanomedicines at the single-particle level’ [Fundamental Research 3 (2023) 488–504]
Corrigendum to ‘Characterization of lipid-based nanomedicines at the single-particle level’ [Fundamental Research 3 (2023) 488–504] Open
[This corrects the article DOI: 10.1016/j.fmre.2022.09.011.].
View article: Intrinsic variability of fluorescence calibrators impacts the assignment of MESF or ERF values to nanoparticles and extracellular vesicles by flow cytometry
Intrinsic variability of fluorescence calibrators impacts the assignment of MESF or ERF values to nanoparticles and extracellular vesicles by flow cytometry Open
Flow cytometry allows to characterize nanoparticles (NPs) and extracellular vesicles (EVs) but results are often expressed in arbitrary units of fluorescence. We evaluated the precision and accuracy of molecules of equivalent soluble fluor…
View article: Genomic diversity and taxonomic marker for Arcobacter species
Genomic diversity and taxonomic marker for Arcobacter species Open
Arcobacter was recognized as an emerging enteropathogen and controversies regarding its classification persisted. This study aimed to reevaluate the taxonomy of Arcobacter utilizing the 16S rRNA gene, 23S rRNA gene, single-copy orthologous…
View article: Rapid, Selective Extraction of Silver from Complex Water Matrices with a Metal–Organic Framework/Oligomer Composite Constructed via Supercritical CO<sub>2</sub>
Rapid, Selective Extraction of Silver from Complex Water Matrices with a Metal–Organic Framework/Oligomer Composite Constructed via Supercritical CO<sub>2</sub> Open
Every year vast quantities of silver are lost in various waste streams; this, combined with its limited, diminishing supply and rising demand, makes silver recovery of increasing importance. Thus, herein, we report a controllable, green pr…
View article: JA-mediated MYC2/LOX/AOS feedback loop regulates osmotic stress response in tea plant
JA-mediated MYC2/LOX/AOS feedback loop regulates osmotic stress response in tea plant Open
Osmotic stress caused by low-temperature, drought and salinity was a prevalent abiotic stress in plant that severely inhibited plant development and agricultural yield, particularly in tea plant. Jasmonic acid (JA) is an important phytohor…
View article: Quantitative assessment of lipophilic membrane dye‐based labelling of extracellular vesicles by nano‐flow cytometry
Quantitative assessment of lipophilic membrane dye‐based labelling of extracellular vesicles by nano‐flow cytometry Open
Although lipophilic membrane dyes (LMDs) or probes (LMPs) are widely used to label extracellular vesicles (EVs) for detection and purification, their labelling performance has not been systematically characterized. Through concurrent side …
View article: Linezolid-Resistant Enterococcus faecalis of Chicken Origin Harbored Chromosome-Borne <i>optrA</i> and Plasmid-Borne <i>cfr</i> , <i>cfr</i> (D), and <i>poxtA2</i> Genes
Linezolid-Resistant Enterococcus faecalis of Chicken Origin Harbored Chromosome-Borne <i>optrA</i> and Plasmid-Borne <i>cfr</i> , <i>cfr</i> (D), and <i>poxtA2</i> Genes Open
In this study, the simultaneous occurrence of four acquired oxazolidinone resistance genes [ optrA , cfr , cfr (D), and poxtA2 ] was identified in an E. faecalis isolate of chicken origin. The association of the cfr gene with a novel pseud…
View article: Supp Table 3 from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy
Supp Table 3 from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy Open
qPCR primers
View article: Data from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Data from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes Open
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic disorders that are incurable with conventional therapy. Their incidence is increasing with global population aging. Although many genetic, epigenetic, splicing, and metabolic …
View article: Data from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy
Data from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy Open
Natural killer (NK) cells and T cells are key effectors of antitumor immune responses and major targets of checkpoint inhibitors. In multiple cancer types, we find that the expression of Wnt signaling potentiator R-spondin genes (e.g., …
View article: Supp Table 3 from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy
Supp Table 3 from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy Open
qPCR primers
View article: Data from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy
Data from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy Open
Natural killer (NK) cells and T cells are key effectors of antitumor immune responses and major targets of checkpoint inhibitors. In multiple cancer types, we find that the expression of Wnt signaling potentiator R-spondin genes (e.g., …
View article: Supplementary Figure S1-13 and Supplementary Table S1,3 from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Supplementary Figure S1-13 and Supplementary Table S1,3 from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes Open
Figure S1-13 and Table S1,3
View article: Supplementary Figures from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy
Supplementary Figures from Tumor Microenvironment–Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy Open
Supplementary Figures
View article: Supplementary Methods from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Supplementary Methods from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes Open
Supplementary Methods
View article: Supplementary Methods from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Supplementary Methods from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes Open
Supplementary Methods
View article: Supplementary Figure S1-13 and Supplementary Table S1,3 from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Supplementary Figure S1-13 and Supplementary Table S1,3 from Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes Open
Figure S1-13 and Table S1,3