Xiaomeng Jia
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View article: Optimizing endocrine adjuvant therapy in HR+/HER2− breast cancer: supplemental strategies and innovations
Optimizing endocrine adjuvant therapy in HR+/HER2− breast cancer: supplemental strategies and innovations Open
Endocrine therapy (ET) is a cornerstone in adjuvant therapy for hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2−) breast cancer. However, recent research challenges the conventional 5-year adjuva…
View article: Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population
Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population Open
Background The inconclusive associations between thyroid-related hormones and differentiated thyroid cancer (DTC) suggest complex pathophysiologic processes, for which thyroid hormone sensitivity may provide new insights. Methods We retros…
View article: Options after progression on first-line CDK4/6 inhibitors in advanced breast cancer patients
Options after progression on first-line CDK4/6 inhibitors in advanced breast cancer patients Open
Background: There is no recognized optimal second-line treatment option for advanced hormone receptor-positive (HR+) breast cancer patients with CDK4/6 inhibitor (CDK4/6i) resistance. Objectives: This work aims to identify the optimal trea…
View article: Clinical Analysis of the Renal Protective Effect of GLP-1 on Diabetic Patients Based on Edge Detection
Clinical Analysis of the Renal Protective Effect of GLP-1 on Diabetic Patients Based on Edge Detection Open
With the rapid development of IoT technology, it is a new trend to combine edge computing with smart medicine in order to better develop modern medicine, avoid the crisis of information “sibling,” and meet the requirements of timeliness an…
View article: DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis Open
Over the past decades, the incidence of thyroid cancer (TC) rapidly increased all over the world, with the papillary thyroid cancer (PTC) accounting for the vast majority of TC cases. It is crucial to investigate novel diagnostic and thera…
View article: A study on the status of normoalbuminuric renal insufficiency among type 2 diabetes mellitus patients: A multicenter study based on a Chinese population
A study on the status of normoalbuminuric renal insufficiency among type 2 diabetes mellitus patients: A multicenter study based on a Chinese population Open
Background Patients with normoalbuminuria and a reduced estimated glomerular filtration rate (eGFR) account for a considerable proportion of type 2 diabetes patients. The aim of this research was to investigate the epidemiological and clin…
View article: Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing
Association of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol Levels with the Risk of Type 2 Diabetes: A Retrospective Cohort Study in Beijing Open
Background. Previous studies have shown that the ratio of triglyceride to high-density lipoprotein cholesterol level (TG/HDL-C) is a risk factor for type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the nonlinear re…
View article: circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer
circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer Open
Hepatocellular carcinoma (HCC), a common malignant tumor, is one of the main causes of cancer-related deaths worldwide. Circular RNAs (circRNAs), a novel class of non-coding RNA, have been reported to be involved in the etiology of various…
View article: The Coexistence of Genetic Mutations in Thyroid Carcinoma Predicts Histopathological Factors Associated With a Poor Prognosis: A Systematic Review and Network Meta-Analysis
The Coexistence of Genetic Mutations in Thyroid Carcinoma Predicts Histopathological Factors Associated With a Poor Prognosis: A Systematic Review and Network Meta-Analysis Open
In this molecular marker mutation-based systematic review and network meta-analysis, we found that coexistent BRAFV600E + TERT genetic co-mutations predicted poor histopathological prognosis, including progression,…
View article: Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study
Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer Between 2011 and 2015 in Beijing, China: A Retrospective Study Open
The anti-thyroglobulin antibody (TgAb) has been suggested to be more common in patients with papillary thyroid cancer (PTC). Here, we performed a retrospective study investigated the correlation between TgAb level and PTC in Chinese patien…
View article: Quercetin promotes long noncoding RNA lncSHGL expression via estrogen receptor α to suppress type 2 diabetes mellitus in mice
Quercetin promotes long noncoding RNA lncSHGL expression via estrogen receptor α to suppress type 2 diabetes mellitus in mice Open
Background Type 2 diabetes mellitus (T2DM) is the most common type of metabolic disorder involving multiple organ systems. Grape has been reported to improve the symptoms of T2DM, the precise mechanism of its action is unclear. Our study w…
View article: <p>Impacts of <em>CYP2C19</em> Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients</p>
Impacts of <em>CYP2C19</em> Polymorphism and Clopidogrel Dosing on in-Stent Restenosis: A Retrospective Cohort Study in Chinese Patients Open
Increased dose of clopidogrel may reduce the risk of ISR after PCI in CYP2C19 LOF allele(s) carriers. The presence of CYP2C19 LOF allele(s) increases the risk of ISR after stenting, which could be counteracted by the increase…
View article: Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population
Association of obesity with the clinicopathological features of thyroid cancer in a large, operative population Open
We aimed to investigate the association between excess body mass index (BMI) and papillary thyroid cancer (PTC) in an operative population, and the impact of higher BMI on clinicopathological aggressiveness of PTC. Charts of 10,844 consecu…
View article: Unraveling the molecular nature of melanin changes in metastatic cancer
Unraveling the molecular nature of melanin changes in metastatic cancer Open
More people die from melanoma after a stage I diagnosis than after a stage IV diagnosis, because the tools available to clinicians do not readily identify which early-stage cancers will be aggressive. Near-infrared pump-probe microscopy de…
View article: Aminophenols increase proliferation of thyroid tumor cells by inducing the transcription factor activity of estrogen receptor α
Aminophenols increase proliferation of thyroid tumor cells by inducing the transcription factor activity of estrogen receptor α Open