Xuemei Tang
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View article: A Public Mid-Density Genotyping Platform for Lettuce (Lactuca sativa L.)
A Public Mid-Density Genotyping Platform for Lettuce (Lactuca sativa L.) Open
View article: The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma
The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma Open
FOXA1 upregulates PYCR1 expression, activates autophagy in LUAD cells, and dampens CD8+ T cell antitumor immune response. Targeting FOXA1/PYCR1 may be a potential approach to improve LUAD immunotherapy.
View article: A Public Mid-Density Genotyping Platform For Cultivated Cranberry (Vaccinium macrocarpon Aiton)
A Public Mid-Density Genotyping Platform For Cultivated Cranberry (Vaccinium macrocarpon Aiton) Open
View article: Innexin DNA-binding domains regulate Microplitis bicoloratus bracoviral transcription in symbiotic wasps
Innexin DNA-binding domains regulate Microplitis bicoloratus bracoviral transcription in symbiotic wasps Open
View article: Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinib
Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinib Open
Progression of myeloproliferative neoplasms (MPNs) to secondary acute myeloid leukemia (sAML) is a lethal transition lacking reliable early biomarkers and effective therapies. Integrating multi-omics analyses, a cohort of 240 patient biops…
View article: Sentrin/SUMO-specific protease 1 contributes to drug resistance in melanoma by mediating the deSUMOylation of Yes-associated protein
Sentrin/SUMO-specific protease 1 contributes to drug resistance in melanoma by mediating the deSUMOylation of Yes-associated protein Open
This study suggests that there is a positive correlation between the ubiquitin-specific protease SENP1 and drug resistance in melanoma. Its up-regulation may lead to changes in the deSUMOylation of YAP, activate the Hippo signalling pathwa…
View article: A chromosome-level genome assembly of the legume pod borer, Maruca vitrata Fabricius (Lepidoptera: Crambidae)
A chromosome-level genome assembly of the legume pod borer, Maruca vitrata Fabricius (Lepidoptera: Crambidae) Open
View article: Chromosome-level genome assembly and annotation of the Rhabdophis nuchalis (Hubei keelback)
Chromosome-level genome assembly and annotation of the Rhabdophis nuchalis (Hubei keelback) Open
View article: Fruit ripening and postharvest changes in very early–harvested tomatoes
Fruit ripening and postharvest changes in very early–harvested tomatoes Open
It is well known that if a fruit is harvested extremely early its development and function are interrupted, and it may never attain full maturity and optimal quality. Reports revealing insights regarding the alterations of maturation, ripe…
View article: A single-centre study on abnormal antinuclear antibodies in children caused by intravenous infusion of gamma globulin
A single-centre study on abnormal antinuclear antibodies in children caused by intravenous infusion of gamma globulin Open
Objective To clarify the impact of intravenous infusion of gamma globulin (IVIg) on antinuclear antibodies (ANAs) in children. Methods A retrospective analysis was performed on the data of children with nonspecific autoantibody-related dis…
View article: Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area
Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area Open
View article: Endosonography Elastography and Magnetic Resonance Imaging in the Restaging and Response Assessment of Rectal Cancer After Neoadjuvant Therapy
Endosonography Elastography and Magnetic Resonance Imaging in the Restaging and Response Assessment of Rectal Cancer After Neoadjuvant Therapy Open
The objective of this academic research is to assess the efficacy of conventional endorectal ultrasound (ERUS), ultrasonic shear wave elastography (SWE), and magnetic resonance imaging (MRI) techniques in evaluating the impact of neoadjuva…
View article: Diagnostic value of cerebrospinal fluid human epididymis protein 4 for leptomeningeal metastasis in lung adenocarcinoma
Diagnostic value of cerebrospinal fluid human epididymis protein 4 for leptomeningeal metastasis in lung adenocarcinoma Open
Background The diagnosis of lung adenocarcinoma (LUAD) leptomeningeal metastasis (LM) remains a clinical challenge. Human epididymis protein 4 (HE4) functions as a novel tumor biomarker for cancers. This study aimed to assess the diagnosti…
View article: Identification of QTL associated with resistance to Phytophthora fruit rot in cucumber (Cucumis sativus L.)
Identification of QTL associated with resistance to Phytophthora fruit rot in cucumber (Cucumis sativus L.) Open
Phytophthora fruit rot (PFR) caused by the soilborne oomycete pathogen, Phytophthora capsici , can cause severe yield loss in cucumber. With no resistant variety available, genetic resources are needed to develop resistant varieties. The g…
View article: Exploration of the development path of university thinking and political education in the background of Internet
Exploration of the development path of university thinking and political education in the background of Internet Open
The effective development of Civic Education work in colleges and universities can promote the cultivation of high-quality talents. Starting from Internet information technology, this paper constructs a digital platform for Civic Education…
View article: Chromosome-Level Genome Assembly of Protosalanx chinensis and Response to Air Exposure Stress
Chromosome-Level Genome Assembly of Protosalanx chinensis and Response to Air Exposure Stress Open
Protosalanx chinensis is a suitable particular species for genetic studies on nearly scaleless skin, transparency and high sensitivity to hypoxia stress. Here, we generated a high-quality chromosome-level de novo assembly of P. chinensis. …
View article: The characteristics of cerebrospinal fluid tumor microenvironment in a patient with leptomeningeal metastases from cancer of unknown primary
The characteristics of cerebrospinal fluid tumor microenvironment in a patient with leptomeningeal metastases from cancer of unknown primary Open
View article: Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy
Inhibitory Potential of Resveratrol in Cancer Metastasis: From Biology to Therapy Open
Cancer metastasis is a significant challenge in cancer treatment, and most existing drugs are designed to inhibit tumor growth but are often ineffective in treating metastatic cancer, which is the leading cause of cancer-related deaths. Re…
View article: Time series analysis revealed prognostic value of continuous nasopharyngeal SARS-CoV-2 nucleic acid quantification for COVID-19: A retrospective study of >3000 COVID-19 patients from 2 centers
Time series analysis revealed prognostic value of continuous nasopharyngeal SARS-CoV-2 nucleic acid quantification for COVID-19: A retrospective study of >3000 COVID-19 patients from 2 centers Open
View article: Comparative transcriptome revealed potential genes related with drug resistance in Melanoma
Comparative transcriptome revealed potential genes related with drug resistance in Melanoma Open
Chemotherapy remains a relatively ineffective and unsatisfactory treatment because of drug resistance in melanoma (whether due to intrinsic resistance or the use of cytostatic drugs). In order to explore the genes and signaling pathways re…
View article: CuGenDBv2: an updated database for cucurbit genomics
CuGenDBv2: an updated database for cucurbit genomics Open
The Cucurbitaceae (cucurbit) family consists of about 1,000 species in 95 genera, including many economically important and popular fruit and vegetable crops. During the past several years, reference genomes have been generated for >20 …
View article: <scp>CEACAM6</scp> serves as a biomarker for leptomeningeal metastasis in lung adenocarcinoma
<span>CEACAM6</span> serves as a biomarker for leptomeningeal metastasis in lung adenocarcinoma Open
Background and aims Diagnosis of leptomeningeal metastasis (LM) is challenging. In our previous study, CEACAM6 mRNA was found to be highly expressed in the circulating tumor cells of cerebrospinal fluid (CSF) from patients with lung adenoc…
View article: Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety
Design, Synthesis, and Bioactivities of Novel Trifluoromethyl Pyrimidine Derivatives Bearing an Amide Moiety Open
Twenty-three novel trifluoromethyl pyrimidine derivatives containing an amide moiety were designed and synthesized through four-step reactions and evaluated for their antifungal, insecticidal, and anticancer properties. Bioassay results in…
View article: Synthesis, bioactivity and preliminary mechanism of action of novel trifluoromethyl pyrimidine derivatives
Synthesis, bioactivity and preliminary mechanism of action of novel trifluoromethyl pyrimidine derivatives Open
In this study, a series of trifluoromethyl pyrimidine derivatives 5a-5v were designed and synthesized. All synthetic compounds were original. Bioassay results showed that some of the target compounds were proved to have higher antiviral an…
View article: Interaction of Microbiota between Fish and the Environment of an In-Pond Raceway System in a Lake
Interaction of Microbiota between Fish and the Environment of an In-Pond Raceway System in a Lake Open
Due to its ability to collect and remove aquaculture waste, an in-pond raceway system (IPRS) has been used to decrease the uncontrolled waste discharge in the traditional cage aquaculture method in large water bodies. However, when applied…
View article: Comparison of COVID-19 Induced Respiratory Failure and Typical ARDS: Similarities and Differences
Comparison of COVID-19 Induced Respiratory Failure and Typical ARDS: Similarities and Differences Open
Coronavirus disease 2019 (COVID-19) is a predominantly respiratory infectious disease caused by novel coronavirus infection (SARS-CoV-2), respiratory failure is the main clinical manifestation and the leading cause of death. Even though it…
View article: Transcriptome Sequencing Analysis Reveals Dynamic Changes in Major Biological Functions during the Early Development of Clearhead Icefish, Protosalanx chinensis
Transcriptome Sequencing Analysis Reveals Dynamic Changes in Major Biological Functions during the Early Development of Clearhead Icefish, Protosalanx chinensis Open
Early development, when many important developmental events occur, is a critical period for fish. However, research on the early development of clearhead icefish is very limited, especially in molecular research. In this study, we aimed to…
View article: Research on Ethnic Traditional Sports Integration and School Physical Education Teaching
Research on Ethnic Traditional Sports Integration and School Physical Education Teaching Open
The change of the concept of physical education in today's world gives the physical education curriculum more flexibility, and it has more autonomy and construction space in selecting teaching content, organizing teaching process and teach…
View article: Synthesis of novel antibacterial and antifungal quinoxaline derivatives
Synthesis of novel antibacterial and antifungal quinoxaline derivatives Open
Structure of some commercial agents.
View article: lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression
lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression Open
lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified GAU1 as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexp…