Xiaotong Fan
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View article: Specific Marker Gene Analysis for Primary Central Nervous System Lymphoma Based on Methylation Difference and Development of Detection Primers
Specific Marker Gene Analysis for Primary Central Nervous System Lymphoma Based on Methylation Difference and Development of Detection Primers Open
Background Primary central nervous system lymphoma (PCNSL) is a central nervous system disease with high mortality, wide variation in symptoms, and difficult diagnosis. The development of molecular markers for PCNSL is still in its initial…
View article: Mapping grey matter and network abnormalities in seizure-onset patterns via stereotactic EEG
Mapping grey matter and network abnormalities in seizure-onset patterns via stereotactic EEG Open
This study identifies distinct SOP-related morphological and network abnormalities in MTLE and suggests that IDSCN may offer valuable insights into personalized treatment planning and prognostic evaluation, supporting further exploration o…
View article: Clinical characteristics of patients with pulsatile tinnitus accompanied by ethmoid sinus lesions and high jugular bulb
Clinical characteristics of patients with pulsatile tinnitus accompanied by ethmoid sinus lesions and high jugular bulb Open
PT patients are predominantly affected on the right side, primarily manifested as intermittent tinnitus. The severity of hearing loss and the presence of ESL + HJB are independent factors affecting the prognosis of PT patients.
View article: Delineating structural and metabolic abnormalities in amygdala and hippocampal subfields for different seizure‐onset patterns via stereotactic electroencephalography
Delineating structural and metabolic abnormalities in amygdala and hippocampal subfields for different seizure‐onset patterns via stereotactic electroencephalography Open
Aims We aimed to investigate mesial temporal lobe abnormalities in mesial temporal lobe epilepsy (MTLE) patients with hypersynchronous (HYP) and low‐voltage fast rhythms (LVF) onset identified by stereotactic electroencephalography (SEEG) …
View article: Aberrant individual structure covariance network in patients with mesial temporal lobe epilepsy
Aberrant individual structure covariance network in patients with mesial temporal lobe epilepsy Open
Objective Mesial temporal lobe epilepsy (mTLE) is a complex neurological disorder that has been recognized as a widespread global network disorder. The group-level structural covariance network (SCN) could reveal the structural connectivit…
View article: Thyroid function and epilepsy: a two-sample Mendelian randomization study
Thyroid function and epilepsy: a two-sample Mendelian randomization study Open
Background Thyroid hormones (THs) play a crucial role in regulating various biological processes, particularly the normal development and functioning of the central nervous system (CNS). Epilepsy is a prevalent neurological disorder with m…
View article: Misdirection due to early magnetoencephalographic presentation and management in Rasmussen encephalitis: a case report
Misdirection due to early magnetoencephalographic presentation and management in Rasmussen encephalitis: a case report Open
Rasmussen encephalitis is a rare and unexplained chronic brain hemispheric inflammatory disease. We report a case of epilepsy in which magnetoencephalography showed dipoles localized only in the operculum. Because the patient’s clinical pr…
View article: The alteration of cortical microstructure similarity in drug-resistant epilepsy correlated with mTOR pathway genes
The alteration of cortical microstructure similarity in drug-resistant epilepsy correlated with mTOR pathway genes Open
The National Natural Science Foundation of China, the Ministry of Science and Technology of the People's Republic of China, and the Beijing Municipal Health Commission.
View article: Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions
Evidence of a large current of transcranial alternating current stimulation directly to deep brain regions Open
Deep brain regions such as hippocampus, insula, and amygdala are involved in neuropsychiatric disorders, including chronic insomnia and depression. Our recent reports showed that transcranial alternating current stimulation (tACS) with a c…
View article: Advances in hypothalamic hamartoma research over the past 30 years (1992–2021): a bibliometric analysis
Advances in hypothalamic hamartoma research over the past 30 years (1992–2021): a bibliometric analysis Open
Background Hypothalamic hamartoma (HH) is a rare intracranial disease whose manifestations include gelastic seizures and precocious puberty. The diagnosis and treatment of HH have changed substantially over the past three decades as medica…
View article: Integrative roles of human amygdala subdivisions: Insight from direct intracerebral stimulations via stereotactic <scp>EEG</scp>
Integrative roles of human amygdala subdivisions: Insight from direct intracerebral stimulations via stereotactic <span>EEG</span> Open
Substantial studies of human amygdala function have revealed its importance in processing emotional experience, autonomic regulation, and sensory information; however, the neural substrates and circuitry subserving functions have not been …
View article: Assessing structural integrity of the pyramidal tracts with diffusion spectrum imaging to predict postoperative motor function in pediatric epilepsy patients with hemispherectomy
Assessing structural integrity of the pyramidal tracts with diffusion spectrum imaging to predict postoperative motor function in pediatric epilepsy patients with hemispherectomy Open
Background Hemispherectomy is an effective treatment option for patients with drug-resistant epilepsy caused by hemispheric lesions. However, patients often have deterioration of their motor functions postoperatively. Diffusion spectrum im…
View article: Prophylactic administration of tranexamic acid combined with thromboelastography-guided hemostatic algorithm reduces allogeneic transfusion requirements during pediatric resective epilepsy surgery: A randomized controlled trial
Prophylactic administration of tranexamic acid combined with thromboelastography-guided hemostatic algorithm reduces allogeneic transfusion requirements during pediatric resective epilepsy surgery: A randomized controlled trial Open
Background: Intraoperative bleeding and allogeneic transfusion remain common problems in pediatric resective epilepsy surgery. Tranexamic acid (TXA) is a widely recommended antifibrinolytic drug that reduces blood loss and transfusion requ…
View article: Functional Connectivity Alterations Based on Hypometabolic Region May Predict Clinical Prognosis of Temporal Lobe Epilepsy: A Simultaneous 18F-FDG PET/fMRI Study
Functional Connectivity Alterations Based on Hypometabolic Region May Predict Clinical Prognosis of Temporal Lobe Epilepsy: A Simultaneous 18F-FDG PET/fMRI Study Open
(1) Background: Accurate localization of the epileptogenic zone and understanding the related functional connectivity (FC) alterations are critical for the prediction of clinical prognosis in patients with temporal lobe epilepsy (TLE). We …
View article: ADIRF Suppresses Tumor Progression And Involves Keratinocyte Differentiation In Esophageal Squamous Cell Carcinoma
ADIRF Suppresses Tumor Progression And Involves Keratinocyte Differentiation In Esophageal Squamous Cell Carcinoma Open
Background and Aim: Adipogenesis regulatory factor (ADIRF) regulates fat cell development and promotes adipogenic differentiation, but the role in esophageal squamous cell carcinoma (ESCC) is unknow. We aimed to interpret the regulatory ef…
View article: ADIRF expression reversely correlates with stage progression and involves keratinocyte differentiation in esophageal squamous cell carcinoma
ADIRF expression reversely correlates with stage progression and involves keratinocyte differentiation in esophageal squamous cell carcinoma Open
Background: Aberrant differentiation in esophageal mucosa was crucial for the carcinogenesis and development of esophageal squamous cell carcinoma (ESCC). However, few evidences elucidated the regulatory molecule during ESCC differentiatio…
View article: Effect of Pronase Premedication on Increasing Detection Rate of Early Esophageal Squamous Cell Carcinoma: A Prospective, Double Blinded, Randomized, Controlled Trial
Effect of Pronase Premedication on Increasing Detection Rate of Early Esophageal Squamous Cell Carcinoma: A Prospective, Double Blinded, Randomized, Controlled Trial Open
View article: Cortactin Expression Identifies Invasion Depth in Superficial Esophageal Squamous Cell Carcinoma
Cortactin Expression Identifies Invasion Depth in Superficial Esophageal Squamous Cell Carcinoma Open
View article: Stereotactic EEG-guided radiofrequency thermocoagulation versus anterior temporal lobectomy for mesial temporal lobe epilepsy with hippocampal sclerosis: study protocol for a randomised controlled trial
Stereotactic EEG-guided radiofrequency thermocoagulation versus anterior temporal lobectomy for mesial temporal lobe epilepsy with hippocampal sclerosis: study protocol for a randomised controlled trial Open
Introduction In this report, we aim to describe the design for the randomised controlled trial of Stereotactic electroencephalogram (EEG)-guided Radiofrequency Thermocoagulation versus Anterior Temporal Lobectomy for Mesial Temporal Lobe E…
View article: Stereotactic-EEG Guided Radiofrequency Thermocoagulation Versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: Study protocol for a randomized controlled trial
Stereotactic-EEG Guided Radiofrequency Thermocoagulation Versus Anterior Temporal Lobectomy for Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis: Study protocol for a randomized controlled trial Open
Introduction: In this report, we aim to describe the design for the randomized controlled trial of Stereotactic-electroencephalogram (EEG) guided Radiofrequency Thermocoagulation versus Anterior Temporal Lobectomy for Mesial Temporal Lobe …
View article: How can the accuracy of SEEG be increased?—an analysis of the accuracy of multilobe-spanning SEEG electrodes based on a frameless stereotactic robot-assisted system
How can the accuracy of SEEG be increased?—an analysis of the accuracy of multilobe-spanning SEEG electrodes based on a frameless stereotactic robot-assisted system Open
Head holder choice, use of a predrill procedure and angular deviation are the primary influencing factors of the accuracy of multilobe-spanning SEEG electrode placement. The Leksell frame and a predrill procedure can be used to increase th…
View article: Lateralizing the affected side of hippocampal sclerosis with quantitative high angular resolution diffusion scalars: a preliminary approach validated by diffusion spectrum imaging
Lateralizing the affected side of hippocampal sclerosis with quantitative high angular resolution diffusion scalars: a preliminary approach validated by diffusion spectrum imaging Open
The quantitative diffusion scalars of the DSI, especially TDI of the FORX and the PHCR, are sensitive indices to define the ipsilateral side for MTLE patients. For preliminary exploration, the use of quantitative DSI scalars may help to im…
View article: Glucose Metabolism Characteristics of Extra-Hypothalamic Cortex in Patients With Hypothalamic Hamartomas (HH) Undergoing Epilepsy Evaluation: A Retrospective Study of 16 Cases
Glucose Metabolism Characteristics of Extra-Hypothalamic Cortex in Patients With Hypothalamic Hamartomas (HH) Undergoing Epilepsy Evaluation: A Retrospective Study of 16 Cases Open
Purpose: There are few studies on the glucose metabolic characteristics of the extra-hypothalamic cortex in the hypothalamic hamartomas (HH). A comprehensive understanding of pathogenic progression of the disease is required from the persp…
View article: Electrophysiological properties and seizure networks in hypothalamic hamartoma
Electrophysiological properties and seizure networks in hypothalamic hamartoma Open
Objective Little is known about the intrinsic electrophysiological properties of hypothalamic hamartoma (HH) in vivo and seizure network since only few cases using stereoelectroencephalography (SEEG) electrodes exploring both cortex and HH…
View article: Stereo-crossed ablation guided by stereoelectroencephalography for epilepsy: comprehensive coagulations <i>via</i> a network of multi-electrodes
Stereo-crossed ablation guided by stereoelectroencephalography for epilepsy: comprehensive coagulations <i>via</i> a network of multi-electrodes Open
Background: Introducing multiple different stereoelectroencephalography electrodes in a three-dimensional (3D) network to create a 3D-lesioning field or stereo-crossed radiofrequency thermocoagulation (scRF-TC) might create larger lesionin…
View article: Automatic labeling of the fanning and curving shape of Meyer’s loop for epilepsy surgery: an atlas extracted from high-definition fiber tractography
Automatic labeling of the fanning and curving shape of Meyer’s loop for epilepsy surgery: an atlas extracted from high-definition fiber tractography Open
View article: Clinical Value of Hybrid TOF-PET/MR Imaging–Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy
Clinical Value of Hybrid TOF-PET/MR Imaging–Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy Open
PET/MR imaging-based multiparametric imaging involving arterial spin-labeling may increase the clinical value of localizing the epileptogenic zone by providing concordant and complementary information in patients with MR imaging-negative t…
View article: Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma
Expression and prognostic value of cell-cycle-associated genes in gastric adenocarcinoma Open
View article: Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG
Comparison between simultaneously acquired arterial spin labeling and 18F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG Open
View article: Combined Application of Tranexamic Acid and Thrombelastography in Pediatric Epilepsy Surgery
Combined Application of Tranexamic Acid and Thrombelastography in Pediatric Epilepsy Surgery Open
Background: Pediatric patients undergoing epilepsy surgeries are under high risks of bleeding, hemodynamic instability and complications related to transfusions. This study aimed to investigate whether combined application of tranexamic ac…