Xin Chen
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View article: Association between waist-to-height ratio and cardiovascular events in patients with chronic obstructive pulmonary disease: the mediating effect of prognostic nutritional index
Association between waist-to-height ratio and cardiovascular events in patients with chronic obstructive pulmonary disease: the mediating effect of prognostic nutritional index Open
Objectives To explore the relationship between waist-to-height ratio (WHtR) and the risk of cardiovascular disease (CVD) in patients with chronic obstructive pulmonary disease (COPD), and to analyze the mediating role of prognostic nutriti…
View article: Efficacy of traditional Chinese exercise for stroke patients with hemiplegia: A systematic review and meta-analysis of randomized controlled trials
Efficacy of traditional Chinese exercise for stroke patients with hemiplegia: A systematic review and meta-analysis of randomized controlled trials Open
Background: A comprehensive assessment of its effectiveness and evidence base is lacking. Therefore, this systematic review and meta-analysis attempts to systematically investigate the therapeutic effect of traditional Chinese exercises (T…
View article: Comparative Transcriptomic Analysis Reveals Molecular Mechanisms Underlying Scale Adhesion Differences Between Carassius auratus indigentiaus and Carassius auratus gibelio
Comparative Transcriptomic Analysis Reveals Molecular Mechanisms Underlying Scale Adhesion Differences Between Carassius auratus indigentiaus and Carassius auratus gibelio Open
Scale adhesion strength is a key trait in aquaculture, directly influencing disease resistance, survival, and commercial value. The Dongting crucian carp (Carassius auratus indigentiaus, hereafter CaDT) is valued for its rapid growth and s…
View article: Validation of the efficacy of the GPSS questionnaire for screening obstructive sleep apnea
Validation of the efficacy of the GPSS questionnaire for screening obstructive sleep apnea Open
Objective This study aimed to compare the screening performance of a newly developed questionnaire for obstructive sleep apnea (OSA), the General Practice Sleep Scale (GPSS), with four commonly used screening questionnaires (NoSAS, Berlin,…
View article: Advances in mild photothermal hydrogel-based therapies for bone and soft tissue injuries
Advances in mild photothermal hydrogel-based therapies for bone and soft tissue injuries Open
Bone and soft tissue injuries resulting from trauma, metabolic disorders, and tumors pose a serious threat to public health, and their treatment faces numerous challenges, including infection, chronic inflammation, and impaired vasculariza…
View article: Exposure to volatile organic compounds and suicidal ideation: Insights from a U.S. population-based study
Exposure to volatile organic compounds and suicidal ideation: Insights from a U.S. population-based study Open
This study provides the first epidemiological evidence of an association between mVOCs exposure and SI. CYMA was identified as the most critical mVOCs influencing SI. The findings suggest that the link between mVOCs exposure and SI does no…
View article: Reduced Modulation of Theta and Beta Oscillations Mediates Empathy Impairment in Parkinson's Disease
Reduced Modulation of Theta and Beta Oscillations Mediates Empathy Impairment in Parkinson's Disease Open
Background Empathy is an inaccessible part of advanced social cognitive functions in humans. Impairment of empathy greatly affects the quality of life of patients with Parkinson's disease (PD) but the underlying neurophysiologic mechanisms…
View article: Impacts of blended learning with BOPPPS model on Chinese medical undergraduate students: a comprehensive systematic review and meta-analysis of 44 studies
Impacts of blended learning with BOPPPS model on Chinese medical undergraduate students: a comprehensive systematic review and meta-analysis of 44 studies Open
The study underscored that the blended BOPPPS teaching mode could effectively improve the comprehensive quality of students. The subjective scores also indicated that students generally preferred this novel teaching mode.
View article: May Measurement Month 2021: an analysis of blood pressure screening results from China
May Measurement Month 2021: an analysis of blood pressure screening results from China Open
We reported findings from participants screened during the May Measurement Month 2021 in China, which aimed to raise awareness of raised blood pressure (BP), and to investigate the risk factors of BP. The study participants were adults (≥1…
View article: Only bioactive forms of PTH (n-oxPTH and Met18(ox)-PTH) inhibit synthesis of sclerostin – evidence from in vitro and human studies
Only bioactive forms of PTH (n-oxPTH and Met18(ox)-PTH) inhibit synthesis of sclerostin – evidence from in vitro and human studies Open
Sclerostin (SOST) is produced by osteocytes and is known as a negative regulator of bone homeostasis. Parathyroid hormone (PTH) regulates calcium, phosphate as well as vitamin D metabolism, and is a strong inhibitor of SOST synthesis in vi…
View article: Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression
Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression Open
Objective The comorbid relationship between migraine and depression has been well recognized, but its underlying pathophysiology is unclear. Here, we aimed to explore the structural changes of the amygdala and the abnormal functional conne…
View article: Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson’s disease
Altered connectivity between frontal cortex and supplementary motor area in various types of Parkinson’s disease Open
Decreases in the left DLSFG-SMA connectivity may be a key feature of the PIGD subtype, while reduced VN-AUD connectivity may characterize the TD subtype.
View article: Vertebral bone quality different in magnetic resonance imaging parameters
Vertebral bone quality different in magnetic resonance imaging parameters Open
Objective This was a single-center retrospective study that aimed to measure the vertebral bone quality (VBQ) in people of all ages and compare changes in VBQ across ages. Differences in VBQ under various MRI parameters were compared. Meth…
View article: Does acupuncture therapy affect peripheral inflammatory cytokines of major depressive disorder? A protocol for the systematic review and meta-analysis
Does acupuncture therapy affect peripheral inflammatory cytokines of major depressive disorder? A protocol for the systematic review and meta-analysis Open
Background Acupuncture is widely used as adjuvant therapy for major depressive disorder (MDD). There is robust evidence that inflammation is closely associated with MDD. To date, only a few numbers of studies have investigated the potentia…
View article: A meta-analysis of clinical effects of microscopic unilateral laminectomy bilateral decompression (ULBD) versus biportal endoscopic ULBD for lumbar canal stenosis
A meta-analysis of clinical effects of microscopic unilateral laminectomy bilateral decompression (ULBD) versus biportal endoscopic ULBD for lumbar canal stenosis Open
Osbjective Several studies have shown that both microscopic unilateral laminotomy bilateral decompression (ULBD) and unilateral biportal endoscopic (UBE) ULBD are effective for treating lumbar canal stenosis (LCS). However, there are diffe…
View article: Transcranial Magnetic Stimulation for Improving Dysphagia After Stroke: A Meta-Analysis of Randomized Controlled Trials
Transcranial Magnetic Stimulation for Improving Dysphagia After Stroke: A Meta-Analysis of Randomized Controlled Trials Open
Background Rehabilitation of post-stroke dysphagia is an urgent clinical problem, and repetitive transcranial magnetic stimulation (rTMS) has been widely used in the study of post-stroke function. However, there is no reliable evidence-bas…
View article: Severity of COVID-19 and adverse long-term outcomes: a retrospective cohort study based on a US electronic health record database
Severity of COVID-19 and adverse long-term outcomes: a retrospective cohort study based on a US electronic health record database Open
Objective To identify potential risk factors for adverse long-term outcomes (LTOs) associated with COVID-19, using a large electronic health record (EHR) database. Design Retrospective cohort study. Patients with COVID-19 were assigned int…
View article: The Design and Evaluation of Clinical Pathway for Disease Management to Maximize Public Health Benefit
The Design and Evaluation of Clinical Pathway for Disease Management to Maximize Public Health Benefit Open
As an implementation strategy, the actual functional scope of clinical pathway (CPW) can be mastered is the basis for evaluating and improving CPW management, which is very important for bridging the evidence-to-practice gap. Here, we prop…
View article: Identifying Functional Brain Abnormalities in Migraine and Depression Comorbidity
Identifying Functional Brain Abnormalities in Migraine and Depression Comorbidity Open
Background: Migraine and major depressive disorder (MDD) are both high prevalence brain disorders and often comorbidity. However, the neural mechanisms underlying the migraine and depression comorbidity are largely unknown. We aimed to exp…
View article: Risk Scoring Systems Including Electrolyte Disorders for Predicting the Incidence of Acute Kidney Injury in Hospitalized Patients
Risk Scoring Systems Including Electrolyte Disorders for Predicting the Incidence of Acute Kidney Injury in Hospitalized Patients Open
The risk scoring systems involving electrolyte disorders were established and validated adequately efficient to predict AKI and severe AKI in hospitalized patients. Electrolyte imbalance needs to be carefully monitored and corrections shou…
View article: Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer
Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer Open
Background. Multiple studies have reported the significance of the systemic immune-inflammation index (SII) in the prognosis of colorectal cancer (CRC), but no consensus has yet been reached. The purpose of this study was to systematically…
View article: Abnormal serum carbohydrate antigen 19-9 levels in a patient with splenic retiform haemangioendothelioma concomitant with hepatic amyloidosis: A case report
Abnormal serum carbohydrate antigen 19-9 levels in a patient with splenic retiform haemangioendothelioma concomitant with hepatic amyloidosis: A case report Open
We describe a rare case of splenic retiform haemangioenthelioma concomitant with hepatic amyloidosis. Physicians should note abnormal serum CA 19-9 levels with early symptoms of fatigue and unintentional weight loss.
View article: KangFuXin Liquid in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis
KangFuXin Liquid in the Treatment of Diabetic Foot Ulcer: A Systematic Review and Meta-Analysis Open
Background . Diabetic foot ulcer (DFU) is one of the most common complications of diabetes mellitus, with the wound not healing as expected and healing slowly. Poor control can develop into gangrene and even amputation. Currently, the exis…
View article: May Measurement Month 2017: an analysis of blood pressure screening results in China—East Asia
May Measurement Month 2017: an analysis of blood pressure screening results in China—East Asia Open
Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. May Measurement Month (MMM) is a global initiative aimed at raising awareness of high BP and to act as a temporary solution to the lac…
View article: Studies on Serum Pharmacochemistry of Effective positions for Anti-gastric ulcer of Modified Xiaochaihutang
Studies on Serum Pharmacochemistry of Effective positions for Anti-gastric ulcer of Modified Xiaochaihutang Open
Background: Chronic gastritis and gastric ulcer are very prevalent digestive tract disease throughout all ages in the world, and are considered to be a global health problem.Usually they are resulting in an imbalance between the protective…