Xiaoni Zhang
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View article: High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study
High-Concordance Validation of Droplet Digital PCR and Next-Generation Sequencing for EGFR Mutation Detection Across Diverse Biospecimens in a Large-scale NSCLC Cohort Study Open
Backgrounds Next-generation sequencing (NGS) and droplet digital PCR (ddPCR) are both established methods for detecting EGFR mutations in non-small cell lung cancer (NSCLC). However, comprehensive validation of their concordance in mutatio…
View article: Development of a chemotactic SynCom bioorganic fertilizer for biocontrol of bacterial wilt in tobacco fields
Development of a chemotactic SynCom bioorganic fertilizer for biocontrol of bacterial wilt in tobacco fields Open
View article: Baduanjin for alleviating anxiety symptoms in elderly cancer patients: An intervention survey study
Baduanjin for alleviating anxiety symptoms in elderly cancer patients: An intervention survey study Open
This study aimed to evaluate the effect of the Baduanjin intervention on alleviating anxiety symptoms in elderly cancer patients. Methods: Participants were randomly assigned to either the experimental group or the control group using a ra…
View article: Digital Contingency Management for Substance Use Disorder Treatment: 12-Month Quasi-Experimental Design
Digital Contingency Management for Substance Use Disorder Treatment: 12-Month Quasi-Experimental Design Open
Background Although contingency management has shown some efficacy in substance use disorder treatment, digital contingency management (DCM) needs more evidence supporting its value in treating substance misuse. Objective This study aimed …
View article: Synthesis of a Novel Freestanding Atomic Sheet and Study of the Dirac Nodal Semimetal
Synthesis of a Novel Freestanding Atomic Sheet and Study of the Dirac Nodal Semimetal Open
View article: Digital Contingency Management for Substance Use Disorder Treatment: A 12-Month Quasi-Experimental Design (Preprint)
Digital Contingency Management for Substance Use Disorder Treatment: A 12-Month Quasi-Experimental Design (Preprint) Open
BACKGROUND Although contingency management (CM) has shown some efficacy in substance use disorder treatment, digital contingency management (DCM) needs more evidence supporting its value in treating substance misuse. OBJECTIVE This stud…
View article: Unleashing the power of urine‑based biomarkers in diagnosis, prognosis and monitoring of bladder cancer (Review)
Unleashing the power of urine‑based biomarkers in diagnosis, prognosis and monitoring of bladder cancer (Review) Open
Bladder cancer (BCa) is a prevalent malignant neoplasm of the urinary tract with high incidence rate, frequent recurrence and rapid disease progression. Conventional approaches for diagnosing, prognosticating and monitoring BCa often rely …
View article: Interspecific hybridization in <i>Brassica</i> species leads to changes in agronomic traits through the regulation of gene expression by chromatin accessibility and DNA methylation
Interspecific hybridization in <i>Brassica</i> species leads to changes in agronomic traits through the regulation of gene expression by chromatin accessibility and DNA methylation Open
Interspecific hybridization is a common method in plant breeding to combine traits from different species, resulting in allopolyploidization and significant genetic and epigenetic changes. However, our understanding of genome-wide chromati…
View article: Straw Return with Biodegradable Film Mulch: A Synergistic Cultivation Measure with Environmental and Economic Benefits Based on Life Cycle Assessment
Straw Return with Biodegradable Film Mulch: A Synergistic Cultivation Measure with Environmental and Economic Benefits Based on Life Cycle Assessment Open
Straw return and plastic film mulching are two critical management measures that not only maintain high and stable crop yields, but also have a significant impact on the ecological environment. However, there is still a lack of research on…
View article: Metabolomic and transcriptomic analyses provide insight into the variation of floral scent and molecular regulation in different cultivars and flower development of <i>Curcuma alismatifolia</i>
Metabolomic and transcriptomic analyses provide insight into the variation of floral scent and molecular regulation in different cultivars and flower development of <i>Curcuma alismatifolia</i> Open
Curcuma alismatifolia is an important ornamental plant of significant economic value, while the floral fragrance has been rarely investigated, leading to a lack of knowledge about the floral scent. By performing metabolomic and transcripto…
View article: The tissue and circulating cell‐free DNA‐derived genetic landscape of premalignant colorectal lesions and its application for early diagnosis of colorectal cancer
The tissue and circulating cell‐free DNA‐derived genetic landscape of premalignant colorectal lesions and its application for early diagnosis of colorectal cancer Open
Colorectal adenomas (CRAs) represent precancerous lesions that precede the development of colorectal cancer (CRC). Regular monitoring of CRAs can hinder the progression into carcinoma. To explore the utility of tissue DNA and circulating c…
View article: Health Use Cases of AI Chatbots: Identification and Analysis of ChatGPT Prompts in Social Media Discourses
Health Use Cases of AI Chatbots: Identification and Analysis of ChatGPT Prompts in Social Media Discourses Open
The popularity of ChatGPT has raised questions surrounding AI’s potential for health use cases. Since the release of ChatGPT in 2022, social media users have shared their prompts and ChatGPT responses on different topics such as health. De…
View article: Signaling roles of sphingolipids in the ischemic brain and their potential utility as therapeutic targets
Signaling roles of sphingolipids in the ischemic brain and their potential utility as therapeutic targets Open
Sphingolipids comprise a class of lipids, which are composed of a sphingoid base backbone and are essential structural components of cell membranes. Beyond their role in maintaining cellular integrity, several sphingolipids are pivotally i…
View article: Fermi Edge of Semimetallic Borophane Sheets and its Reduction by a Porous Structure
Fermi Edge of Semimetallic Borophane Sheets and its Reduction by a Porous Structure Open
Theoretically predicted materials are often synthesized in low yields, and unexpected relationships are often encountered between the target materials and byproducts. Recently, two-dimensional boron materials proposed on the basis of model…
View article: Unveiling the role of KRAS in Chinese colorectal cancer patients: a positive influence on tumor mutational burden
Unveiling the role of KRAS in Chinese colorectal cancer patients: a positive influence on tumor mutational burden Open
The TMB driven by KRAS co-mutations may have the potential to be used as a key biomarker for prediction of treatment outcomes of immune checkpoint inhibitors (ICIs) in patients with CRC, especially with APC co-mutation.
View article: Arterial specification precedes microvascular restitution in the peri-infarct cortex that is driven by small microvessels
Arterial specification precedes microvascular restitution in the peri-infarct cortex that is driven by small microvessels Open
Evaluation of microvascular networks was impeded until recently by the need of histological tissue sectioning, which precluded 3D analyses. Using light-sheet microscopy, we investigated microvascular network characteristics in the peri-inf…
View article: Siderophore interactions drive the ability of <i>Pseudomonas</i> spp<i>.</i> consortia to protect tomato against <b> <i>Ralstonia solanacearum</i> </b>
Siderophore interactions drive the ability of <i>Pseudomonas</i> spp<i>.</i> consortia to protect tomato against <b> <i>Ralstonia solanacearum</i> </b> Open
The soil-borne bacterial pathogen Ralstonia solanacearum causes significant losses in Solanaceae crop production worldwide, including tomato, potato, and eggplant. To efficiently prevent outbreaks, it is essential to understand the complex…
View article: Effects of applying blended learning based on the ADDIE model in nursing staff training on improving theoretical and practical operational aspects
Effects of applying blended learning based on the ADDIE model in nursing staff training on improving theoretical and practical operational aspects Open
Objective To assess the impact of blended learning, based on the ADDIE model, on theoretical and practical aspects of nursing staff training. Methods Retrospective analysis of data from 87 nursing staff members in Xi’an Qinhuang Hospital d…
View article: Haplotype-resolved genome assembly of the diploid Rosa chinensis provides insight into the mechanisms underlying key ornamental traits
Haplotype-resolved genome assembly of the diploid Rosa chinensis provides insight into the mechanisms underlying key ornamental traits Open
Roses are consistently ranked at the forefront in cut flower production. Increasing demands of market and changing climate conditions have resulted in the need to further improve the diversity and quality of traits. However, frequent hybri…
View article: Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota
Aloin ameliorates cecal ligation and puncture-induced sepsis in mice by attenuating inflammation and modulating gut microbiota Open
Most Aloe species are used as new food or functional food ingredient. Even though widely known for its health benefits, the anti-inflammatory effects and underlying mechanisms of Aloin (Alo), an anthraquinone compound isolated from plant s…
View article: Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury
Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury Open
Myeloperoxidase (MPO) plays critical role in the pathology of cerebral ischemia–reperfusion (I/R) injury via producing hypochlorous acid (HOCl) and inducing oxidative modification of proteins. High-mobility group box 1 (HMGB1) oxidation, p…
View article: Activation of <scp>STING</scp> signaling aggravates chronic alcohol exposure‐induced cognitive impairment by increasing neuroinflammation and mitochondrial apoptosis
Activation of <span>STING</span> signaling aggravates chronic alcohol exposure‐induced cognitive impairment by increasing neuroinflammation and mitochondrial apoptosis Open
Aims Chronic alcohol exposure leads to persistent neurological disorders, which are mainly attributed to neuroinflammation and apoptosis. Stimulator of IFN genes (STING) is essential in the cytosolic DNA sensing pathway and is involved in …
View article: Platinum-based neoadjuvant chemotherapy upregulates STING/IFN pathway expression and promotes TILs infiltration in NSCLC
Platinum-based neoadjuvant chemotherapy upregulates STING/IFN pathway expression and promotes TILs infiltration in NSCLC Open
Objectives To evaluate the effects of platinum-based neoadjuvant chemotherapy (NACT) on the STING/IFN pathway and tumor-infiltrating lymphocytes (TILs) in non-small cell lung cancer (NSCLC), as well as clinicopathological factors affecting…
View article: Chronic alcohol exposure induces cerebral microbleeds by TGF-β1/Smad signaling pathway mediated remodeling of cerebral small vessels
Chronic alcohol exposure induces cerebral microbleeds by TGF-β1/Smad signaling pathway mediated remodeling of cerebral small vessels Open
Background Long-term heavy drinking is a major risk factor for cerebral microbleeds(CMBs), which are increasingly gaining attention as a pathological phenotype of cerebral small vessel diseases(CSVD). Under pathological conditions, remodel…
View article: Application of Desulfurization Wastewater and Desulfurization Sludge in Autoclaved Aerated Concrete Blocks: Mechanical Properties, Safety Performance, and Economic Benefits
Application of Desulfurization Wastewater and Desulfurization Sludge in Autoclaved Aerated Concrete Blocks: Mechanical Properties, Safety Performance, and Economic Benefits Open
View article: Optimization of Practical Path of Teaching Reform in Higher Education - Based on Distributed Logistic Model Application
Optimization of Practical Path of Teaching Reform in Higher Education - Based on Distributed Logistic Model Application Open
This study presents a novel approach to the application of distributed logistic modeling for the enhancement of education and teaching in colleges and universities, particularly focusing on the pedagogical goals and curriculum content. Uti…
View article: Immune skeletal dysplasia with neurodevelopmental abnormalities caused by a novel variant of <i>EXTL3</i> gene in a Chinese family
Immune skeletal dysplasia with neurodevelopmental abnormalities caused by a novel variant of <i>EXTL3</i> gene in a Chinese family Open
Background Immune skeletal dysplasia with neurodevelopmental abnormalities (ISDNA) is an extremely rare, autosomal recessive genetic disorder characterized by various skeletal abnormalities, neurodevelopmental deficits, and abnormal immune…
View article: The haplotype-resolved telomere-to-telomere carnation (<i>Dianthus caryophyllus</i>) genome reveals the correlation between genome architecture and gene expression
The haplotype-resolved telomere-to-telomere carnation (<i>Dianthus caryophyllus</i>) genome reveals the correlation between genome architecture and gene expression Open
Carnation (Dianthus caryophyllus) is one of the most valuable commercial flowers, due to its richness of color and form, and its excellent storage and vase life. The diverse demands of the market require faster breeding in carnations. A fu…
View article: Health perceptions and attitudes on mobile health apps in China
Health perceptions and attitudes on mobile health apps in China Open
Since the COVID-19 pandemic, the use of mobile health apps has been increasing significantly. Many have started using mobile health apps to manage their health and well-being. People need to develop healthy habits that will increase their …
View article: Multi-integrated genomic data for Passiflora foetida provides insights into genome size evolution and floral development in Passiflora
Multi-integrated genomic data for Passiflora foetida provides insights into genome size evolution and floral development in Passiflora Open
Passiflora is a plant genus known for its extremely distinctive and colorful flowers and a wide range of genome sizes (over ten-fold variation). However, the relationship between differences in genome size and organization and the variatio…