Xiaoning Bi
YOU?
Author Swipe
View article: Fullerene Gallium Phosphonate Shows Antimycobacterial Effect Against Mycobacterium avium
Fullerene Gallium Phosphonate Shows Antimycobacterial Effect Against Mycobacterium avium Open
Mycobacterium avium complex (MAC) infections present significant therapeutic challenges due to their inherent antibiotic resistance, demanding innovative treatment approaches. This study investigated the antimicrobial and antioxidant poten…
View article: Calpain-2 inhibition or deletion enhances levels of the transcription Factor, MEIS2, and stimulates neurogenesis
Calpain-2 inhibition or deletion enhances levels of the transcription Factor, MEIS2, and stimulates neurogenesis Open
Neurogenesis takes place in the subventricular zone (SVZ) and in the dentate gyrus (DG) of the hippocampus of many adult mammalian species. Recent findings indicate that calpain-2 could participate in neurogenesis regulation through the tr…
View article: Calpain-1 and Calpain-2 in the Brain: What Have We Learned from 45 Years of Research?
Calpain-1 and Calpain-2 in the Brain: What Have We Learned from 45 Years of Research? Open
Although the calcium-dependent proteases, calpains, were discovered more than 60 years ago, we still know very little regarding their functions, mostly because very few studies are addressing questions related to specific members of this r…
View article: Restoration of vascular dysfunction resulting from maternal high-fat diet via modulation of the NLRP3/IL-1β axis
Restoration of vascular dysfunction resulting from maternal high-fat diet via modulation of the NLRP3/IL-1β axis Open
This study investigated the impact of maternal high-fat diet on vascular function and endothelial homeostasis in offspring. We found that offspring exposed to maternal high-fat diet exhibited elevated blood pressure, impaired abdominal aor…
View article: LAMTOR1 regulates dendritic lysosomal positioning in hippocampal neurons through TRPML1 inhibition
LAMTOR1 regulates dendritic lysosomal positioning in hippocampal neurons through TRPML1 inhibition Open
Intracellular lysosomal trafficking and positioning are fundamental cellular processes critical for proper neuronal function. Among the diverse array of proteins involved in regulating lysosomal positioning, the Transient Receptor Potentia…
View article: Alterations of synaptic plasticity in Angelman syndrome model mice are rescued by 5-HT7R stimulation
Alterations of synaptic plasticity in Angelman syndrome model mice are rescued by 5-HT7R stimulation Open
Angelman syndrome (AS) is a severe neurodevelopmental disorder characterized by motor disfunction, seizures, intellectual disability, speech deficits, and autism-like behavior, showing high comorbidity with Autism Spectrum Disorders (ASD).…
View article: Identification and neuroprotective properties of <scp>NA</scp>‐184, a calpain‐2 inhibitor
Identification and neuroprotective properties of <span>NA</span>‐184, a calpain‐2 inhibitor Open
Our laboratory has shown that calpain‐2 activation in the brain following acute injury is directly related to neuronal damage and the long‐term functional consequences of the injury, while calpain‐1 activation is generally neuroprotective …
View article: Revisiting the calpain hypothesis of learning and memory 40 years later
Revisiting the calpain hypothesis of learning and memory 40 years later Open
In 1984, Gary Lynch and Michel Baudry published in Science a novel biochemical hypothesis for learning and memory, in which they postulated that the calcium-dependent protease, calpain, played a critical role in regulating synaptic propert…
View article: Contextual fear memory impairment in Angelman syndrome model mice is associated with altered transcriptional responses
Contextual fear memory impairment in Angelman syndrome model mice is associated with altered transcriptional responses Open
Angelman syndrome (AS) is a rare neurogenetic disorder caused by UBE3A deficiency and characterized by severe developmental delay, cognitive impairment, and motor dysfunction. In the present study, we performed RNA-seq on hippocampal sampl…
View article: Identification and neuroprotective properties of NA-184, a selective calpain-2 inhibitor
Identification and neuroprotective properties of NA-184, a selective calpain-2 inhibitor Open
Our laboratory has shown that calpain-2 activation in the brain following acute injury is directly related to neuronal damage and the long-term functional consequences of the injury, while calpain-1 activation is generally neuroprotective …
View article: Calpain-2 Inhibitors as Therapy for Traumatic Brain Injury
Calpain-2 Inhibitors as Therapy for Traumatic Brain Injury Open
While calpains have long been implicated in neurodegeneration, no calpain inhibitor has been developed for the treatment of neurodegeneration. This is partly due to the lack of understanding of the specific functions of most of the 15 memb…
View article: Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome
Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome Open
Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by severe developmental delay, motor impairment, language and cognition deficits, and often with increased seizure activity. AS is caused by deficiency of UBE3A, wh…
View article: Role of Calpain-1 in Neurogenesis
Role of Calpain-1 in Neurogenesis Open
While calpains have been implicated in neurogenesis for a long time, there is still little information regarding the specific contributions of various isoforms in this process. We took advantage of the availability of mutant mice with comp…
View article: Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death
Calpain-1 and Calpain-2 in the Brain: New Evidence for a Critical Role of Calpain-2 in Neuronal Death Open
Calpains are a family of soluble calcium-dependent proteases that are involved in multiple regulatory pathways. Our laboratory has focused on the understanding of the functions of two ubiquitous calpain isoforms, calpain-1 and calpain-2, i…
View article: Calpain-2 as a therapeutic target in repeated concussion–induced neuropathy and behavioral impairment
Calpain-2 as a therapeutic target in repeated concussion–induced neuropathy and behavioral impairment Open
A selective calpain-2 inhibitor represents a potential therapeutic treatment for concussion.
View article: PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome
PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome Open
The ubiquitin ligase, Ube3a, plays important roles in brain development and functions, since its deficiency results in Angelman Syndrome (AS) while its over-expression increases the risk for autism. We previously showed that the lack of Ub…
View article: Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer’s Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain
Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer’s Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain Open
Calpains represent a family of calcium-dependent proteases participating in a multitude of functions under physiological or pathological conditions. Calpain-1 is one of the most studied members of the family, is ubiquitously distributed in…
View article: UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity Open
Accumulating evidence indicates that the lysosomal Ragulator complex is essential for full activation of the mechanistic target of rapamycin complex 1 (mTORC1). Abnormal mTORC1 activation has been implicated in several developmental neurol…
View article: UBE3A–mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity
UBE3A–mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity Open
Accumulating evidence indicates that the lysosomal Ragulator complex is essential for full activation of the mechanistic target of rapamycin complex 1 (mTORC1). Abnormal mTORC1 activation has been implicated in several developmental neurol…
View article: Calpain-2 as a therapeutic target for acute neuronal injury
Calpain-2 as a therapeutic target for acute neuronal injury Open
Calpains represent a family of neutral, calcium-dependent proteases, which modify the function of their target proteins by partial truncation. These proteases have been implicated in numerous cell functions, including cell division, prolif…
View article: Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice
Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice Open
Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. The calcium-dependent protease, calpain, has been shown to be involved in TBI-induced neuronal death. However, whereas various calpain inhibitors have been te…
View article: Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction
Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction Open
Recent studies indicate that calpain-1 is required for the induction of long-term potentiation (LTP) elicited by theta-burst stimulation in field CA1 of hippocampus. Here we determined the contribution of calpain-1 in another type of synap…