Xiaoxin Hao
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View article: Current status of multi‐target therapeutics for diabetic macular oedema: Mechanisms and outcomes from clinical trials
Current status of multi‐target therapeutics for diabetic macular oedema: Mechanisms and outcomes from clinical trials Open
Diabetic macular oedema (DME) remains a major cause of vision loss globally, with a growing population leading to a substantial economic burden. Characterised by complex and intricately interconnected pathogenic pathways, DME presents subo…
View article: Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment
Comparative analysis of the efficacy and safety of antibody‑drug conjugates, radionuclide‑drug conjugates and their combination targeting claudin 18.2 in gastric cancer treatment Open
Gastric cancer (GC) is one of the most common types of cancer worldwide, with limited therapeutic options available for patients with advanced‑stage disease. Claudin 18.2 (CLDN18.2) has emerged as a popular target for the diagnosis and tre…
View article: Distribution patterns and determinants of the lens thickness-to-anterior chamber depth ratio in cataract patients
Distribution patterns and determinants of the lens thickness-to-anterior chamber depth ratio in cataract patients Open
Background The lens thickness-to-anterior chamber depth (LT/ACD) ratio remains underexplored, despite its significance in optimizing cataract surgical outcomes and stratifying the risk of potential complications in aging populations. Aim T…
View article: Distribution and determinants of lens biometrics in cataract patients: Insights from biometrics and implications for surgical precision
Distribution and determinants of lens biometrics in cataract patients: Insights from biometrics and implications for surgical precision Open
Distributions of lens-specific biometrics varied with sex, age, and AL, and the lens-specific biometrics were correlated to similar but also distinct determinants in bilateral eyes. Our study provides a better understanding of the signific…
View article: Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows
Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows Open
Allopolyploidy involves the fusion of genomes from different lineages through hybridization and chromosome doubling. However, detecting early allopolyploidy events and understanding the specific subgenomic evolution that contributes to the…
View article: Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration
Identification and validation of integrated stress-response-related genes as biomarkers for age-related macular degeneration Open
Background Age-related macular degeneration (AMD) is a prevalent ocular condition associated with aging, serving as a significant contributor to vision loss among middle-aged and older individuals. Studies have shown that AMD and integrate…
View article: Interocular agreement and differences of ocular growth in cataract patients
Interocular agreement and differences of ocular growth in cataract patients Open
We performed this study to investigate the interocular agreement and differences of ocular growth in cataract patients. Ocular biometrics in both eyes of 715 cataract patients were measured by Lenstar LS-900 and retrospectively collected. …
View article: Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization
Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization Open
Bone is a common site for metastasis of solid cancers. The diversity of histological and molecular characteristics of bone metastases (BMs) remains poorly studied. Here, we performed single-cell RNA sequencing on 42 BMs from eight cancer t…
View article: Data from Bone-Induced HER2 Promotes Secondary Metastasis in HR<sup>+</sup>/HER2<sup>−</sup> Breast Cancer
Data from Bone-Induced HER2 Promotes Secondary Metastasis in HR<sup>+</sup>/HER2<sup>−</sup> Breast Cancer Open
Bone metastases can disseminate to secondary sites and promote breast cancer progression, creating additional clinical challenges. The mechanisms contributing to secondary metastasis are barely understood. Here, we evaluate the prediction …
View article: Supplementary Figures from Bone-Induced HER2 Promotes Secondary Metastasis in HR<sup>+</sup>/HER2<sup>−</sup> Breast Cancer
Supplementary Figures from Bone-Induced HER2 Promotes Secondary Metastasis in HR<sup>+</sup>/HER2<sup>−</sup> Breast Cancer Open
Supplementary Figure 1 Shows the distribution of ERBB2 mutations among metastatic cancer patients, survival outcomes according to metastatic sites (bone vs visceral), and detailed CTC counts from HR+/Her2- MBC patients. Supplementary Figur…
View article: CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer
CREB-binding protein/P300 bromodomain inhibition reduces neutrophil accumulation and activates antitumor immunity in triple-negative breast cancer Open
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB-binding protein (CBP)/P…
View article: BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression
BIGH3 mediates apoptosis and gap junction failure in osteocytes during renal cell carcinoma bone metastasis progression Open
Renal cell carcinoma (RCC) bone metastatis progression is driven by crosstalk between tumor cells and the bone microenvironment, which includes osteoblasts, osteoclasts, and osteocytes. RCC bone metastases (RCCBM) are predominantly osteoly…
View article: Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization
Single cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization Open
SUMMARY Bone represents congenial soil for metastatic seeds and is frequently affected by metastasis of multiple cancer types. The histological and molecular characteristics of bone metastases (BMs) are diverse but poorly understood. Herei…
View article: Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization
Unbiased metastatic niche-labeling identifies estrogen receptor-positive macrophages as a barrier of T cell infiltration during bone colonization Open
SUMMARY Microenvironment niches determine cellular fates of metastatic cancer cells. However, robust and unbiased approaches to identify niche components and their molecular profiles are lacking. We established Sortase A-Based Microenviron…
View article: CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC
CBP/P300 BRD Inhibition Reduces Neutrophil Accumulation and Activates Antitumor Immunity in TNBC Open
Tumor-associated neutrophils (TANs) have been shown to promote immunosuppression and tumor progression, and a high TAN frequency predicts poor prognosis in triple-negative breast cancer (TNBC). Dysregulation of CREB binding protein (CBP)/P…
View article: Supplementary Video 3 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Supplementary Video 3 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
Supplemantary Video 3, LLC1 cells cocultured with NG2- BMSCs
View article: Supplementary Figure S1-S7 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Supplementary Figure S1-S7 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
Supplementary figures and corresponding figure legends
View article: Supplementary Video 2 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Supplementary Video 2 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
Supplemantary Video 2, LLC1 cells under monoculture
View article: Supplementary Figure S1-S7 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Supplementary Figure S1-S7 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
Supplementary figures and corresponding figure legends
View article: Supplementary Raw Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Supplementary Raw Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
summarized excel file containing the quantitative raw data and processed values in the manuscript
View article: Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Data from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
The bone microenvironment is dynamic and undergoes remodeling in normal and pathologic conditions. Whether such remodeling affects disseminated tumor cells (DTC) and bone metastasis remains poorly understood. Here, we demonstrated that pat…
View article: Supplementary Video 2 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Supplementary Video 2 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
Supplemantary Video 2, LLC1 cells under monoculture
View article: Supplementary Video 1 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells
Supplementary Video 1 from Bone Metastasis Initiation Is Coupled with Bone Remodeling through Osteogenic Differentiation of NG2<sup>+</sup> Cells Open
Supplemantary Video 1, LLC1 cells cocultured with NG2+ BMSCs