Xiaopei Cui
YOU?
Author Swipe
View article: Pulmonary function impairment and its relationship with target therapy response in patients with pulmonary arterial hypertension
Pulmonary function impairment and its relationship with target therapy response in patients with pulmonary arterial hypertension Open
Introduction Patients with pulmonary arterial hypertension (PAH) exhibit exertional dyspnea and decreased exercise capacity, which are not solely attributable to right heart dysfunction. Numerous studies have aimed to elucidate pulmonary f…
View article: Noninvasive assessment of pulmonary vascular resistance: a synergistic approach using computed tomography pulmonary angiography and echocardiography in pulmonary hypertension
Noninvasive assessment of pulmonary vascular resistance: a synergistic approach using computed tomography pulmonary angiography and echocardiography in pulmonary hypertension Open
The integration of BSA-adjusted morphological markers from CTPA with hemodynamic parameters derived from TTE provides a promising noninvasive method for predicting PVR and demonstrates significant prognostic value in evaluating heart failu…
View article: Pterostilbene mitigates experimental pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition
Pterostilbene mitigates experimental pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition Open
Background The natural compound pterostilbene (PTE) has multiple cardiovascular protective effects. However, its effects on pulmonary arterial hypertension (PAH)-associated vascular remodeling remain to be elucidated. This study investigat…
View article: The Diagnostic Value of Transthoracic Echocardiography Parameters Under the New Diagnostic Criteria for Pulmonary Hypertension
The Diagnostic Value of Transthoracic Echocardiography Parameters Under the New Diagnostic Criteria for Pulmonary Hypertension Open
Background In 2022, new guidelines for the diagnosis and treatment of pulmonary hypertension (PH) revised the hemodynamic definition, reducing the mean pulmonary artery pressure threshold from ≥ 25 to > 20 mmHg. The optimal threshold of tr…
View article: Impedance Cardiography Is a Potent Non-Invasive Method in Cardiac Output Measurement and Pulmonary Arterial Hypertension Risk Assessment
Impedance Cardiography Is a Potent Non-Invasive Method in Cardiac Output Measurement and Pulmonary Arterial Hypertension Risk Assessment Open
Impedance cardiography measured CO and SV presented an acceptable correlation with RHC in PAH patients. Stroke volume index and cardiac index measured by ICG is potent to identify the low-risk status and predict clinical deterioration in P…
View article: Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency
Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potency Open
Antibody drugs targeting single inflammatory cytokines have revolutionized the treatment of immune-mediated inflammatory diseases. To investigate whether dual targeting interleukin-17 (IL-17) and IL-36 enhances anti-inflammatory activity, …
View article: Quadricuspid pulmonary valve with pulmonary hypertension: a case report
Quadricuspid pulmonary valve with pulmonary hypertension: a case report Open
Background The quadricuspid pulmonary valve (QPV) is a relatively rare heart congenital anomaly. It is usually asymptomatic and incidentally detected. Case summary A 52-year-old woman presented with paroxysmal palpitations and chest tightn…
View article: Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells
Molecular basis of CX-5461-induced DNA damage response in primary vascular smooth muscle cells Open
Our previous studies have shown that the novel selective RNA polymerase I inhibitor CX-5461 suppresses proliferation of vascular smooth muscle cells, mainly by inducing DNA damage response (DDR), including activations of ataxia telangiecta…
View article: The management pattern and outcomes of chronic thromboembolic pulmonary hypertension: rationale and design for a Chinese real-world study
The management pattern and outcomes of chronic thromboembolic pulmonary hypertension: rationale and design for a Chinese real-world study Open
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive pulmonary vascular disorder with substantial morbidity and mortality, also a disease underdiagnosed and undertreated. It is potentially curable by pulmonary …
View article: Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities
Identification of a distinct cluster of GDF15high macrophages induced by in vitro differentiation exhibiting anti-inflammatory activities Open
Introduction Macrophage-mediated inflammatory response may have crucial roles in the pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a cytokine of the transforming growth factor-β superfamily, with …
View article: Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension
Optimal combination of right ventricular functional parameters using echocardiography in pulmonary arterial hypertension Open
Aims Novel echocardiographic parameters of right ventricular (RV) function, including speckle‐tracking‐derived, three‐dimensional, and RV–pulmonary artery coupling parameters, have emerged for the evaluation of pulmonary arterial hypertens…
View article: CX‑5461 potentiates imatinib‑induced apoptosis in K562 cells by stimulating <i>KIF1B</i> expression
CX‑5461 potentiates imatinib‑induced apoptosis in K562 cells by stimulating <i>KIF1B</i> expression Open
The selective RNA polymerase I inhibitor CX-5461 has been shown to be effective in treating some types of leukemic disorders. Emerging evidence suggests that combined treatments with CX-5461 and other chemotherapeutic agents may achieve en…
View article: Identification of a distinct cluster of GDF15<sup>high</sup>macrophages exhibiting anti-inflammatory activities
Identification of a distinct cluster of GDF15<sup>high</sup>macrophages exhibiting anti-inflammatory activities Open
Macrophage-mediated inflammatory response may have crucial roles in the pathogenesis of a variety of human diseases. Growth differentiation factor 15 (GDF15) is a cytokine of the transforming growth factor-β superfamily, with potential ant…
View article: General anesthesia is an independent predictor for worse maternal outcome in pregnant pulmonary arterial hypertension patients without cardiac shunt but not for those with shunt
General anesthesia is an independent predictor for worse maternal outcome in pregnant pulmonary arterial hypertension patients without cardiac shunt but not for those with shunt Open
Background Although pregnancy imposes extra risk in patients with pulmonary arterial hypertension (PAH), hemodynamic characteristics vary between PAH patients with and without cardiac shunts. However, previous studies did not take hemodyna…
View article: Potential impact of specific therapy on pregnant women with pulmonary arterial hypertension without cardiac shunt: a descriptive study in northern China
Potential impact of specific therapy on pregnant women with pulmonary arterial hypertension without cardiac shunt: a descriptive study in northern China Open
Background Pregnancy in women with pulmonary arterial hypertension (PAH) is a fatal condition, despite the effectiveness of PAH-specific therapies. The coverage status and effect of specific therapies in pregnant patients with PAH without …
View article: Co-engagement of TIGIT<sup>+</sup>immune cells to PD-L1<sup>+</sup>tumours by a bispecific antibody potentiates T-cell response and tumour control
Co-engagement of TIGIT<sup>+</sup>immune cells to PD-L1<sup>+</sup>tumours by a bispecific antibody potentiates T-cell response and tumour control Open
Co-targeting PD-1/PD-L1 and TIGIT/CD226 is being pursued to broaden the efficacy of current immunotherapy. Here we demonstrate that a bispecific antibody (BsAb) targeting PD-L1 and TIGIT, HB0036, shows major advantages over the combination…
View article: Molecular events leading to CX-5461-induced DNA damage response in vascular smooth muscle cells
Molecular events leading to CX-5461-induced DNA damage response in vascular smooth muscle cells Open
Background Our previous studies have shown that the novel selective RNA polymerase I inhibitor CX-5461 suppresses proliferation of vascular smooth muscle cells, mainly via induction of activations of ataxia telangiectasia mutated (ATM)/ATM…
View article: Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer
Ferroptosis-related lncRNA model based on CFAP58-DT for predicting prognosis and immunocytes infiltration in endometrial cancer Open
Overall, we identified a prognostic ferroptosis-related lncRNA model based on CFAP58-DT for predicting the prognosis and immune-infiltrating conditions in EC. We concluded that the potential oncogenic role of CFAP58-DT can further guide imm…
View article: A transcriptional program associated with cell cycle regulation predominates in the anti-inflammatory effects of CX-5461 in macrophage
A transcriptional program associated with cell cycle regulation predominates in the anti-inflammatory effects of CX-5461 in macrophage Open
CX-5461, a novel selective RNA polymerase I inhibitor, shows potential anti-inflammatory and immunosuppressive activities. However, the molecular mechanisms underlying the inhibitory effects of CX-5461 on macrophage-mediated inflammation r…
View article: Selexipag-based triple combination therapy improves prognosis in Chinese pulmonary arterial hypertension patients
Selexipag-based triple combination therapy improves prognosis in Chinese pulmonary arterial hypertension patients Open
Aim Selexipag is an oral selective prostacyclin receptor agonist approved for treatment of patients with pulmonary arterial hypertension (PAH). In the present study, we aim to assess the safety and efficacy of selexipag in triple combinati…
View article: Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases
Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases Open
The pro-inflammatory cytokine interleukin-17A (IL-17A) is a key driver of multiple inflammatory and immune disorders. Therapeutic antibodies targeting IL-17A have been proven effective in treating patients with these diseases; however, lar…
View article: A Novel Bispecific Antibody Targeting PD-L1 and VEGF With Combined Anti-Tumor Activities
A Novel Bispecific Antibody Targeting PD-L1 and VEGF With Combined Anti-Tumor Activities Open
Therapeutic monoclonal antibodies (mAbs) blocking immune checkpoints have been mainly used as monotherapy. Recently, combination therapy targeting multiple immune checkpoints has recently been explored to increase anti-cancer efficacy. Par…
View article: Combined transcriptomic and lipidomic analysis of D-4F ameliorating bleomycin-induced pulmonary fibrosis
Combined transcriptomic and lipidomic analysis of D-4F ameliorating bleomycin-induced pulmonary fibrosis Open
It may be that D-4F prevented the BLM-induced pulmonary fibrosis model by inhibiting the expression of pla2g4c. Our findings suggest that D-4F may be a potential treatment of IPF.
View article: Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX‐5461 on pulmonary arterial hypertension and associated vascular remodelling
Therapeutic efficacy of the novel selective RNA polymerase I inhibitor CX‐5461 on pulmonary arterial hypertension and associated vascular remodelling Open
Background and Purpose CX‐5461 is a novel selective RNA polymerase I (Pol I) inhibitor. Previously, we found that CX‐5461 could inhibit pathological arterial remodelling caused by angioplasty and transplantation. In the present study, we e…
View article: Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degeneration
Nucleolar stress induces a senescence-like phenotype in smooth muscle cells and promotes development of vascular degeneration Open
Senescence of smooth muscle cells (SMCs) has a crucial role in the pathogenesis of abdominal aortic aneurysm (AAA), a disease of vascular degeneration. Perturbation of cellular ribosomal DNA (rDNA) transcription triggers nucleolar stress r…
View article: Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury
Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury Open
Myocardial ischaemia reperfusion (I/R) injury is one of the leading causes of coronary artery disease‐associated morbidity and mortality. While different strategies have been used to limit I/R injuries, cardiac functions often do not recov…