Explanipedia

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation Open

Ying Wang, Xinyun Li, Yong Wang, Chongbo Yang, Xiaopei Gao , et al. · 2025

The colonic mucus barrier, dependent on goblet cell‐secreted mucin2 (Muc2), prevents microbial invasion. Compound exocytosis enables the rapid, high‐volume release of mucus from goblet cells; its underlying mechanisms, however, remain uncl…

Identification of target genes of Astragalus mongholicus and Saposhnikovia divaricata extracts in human synoviocytes for potential osteoarthritis treatment Open

Jiarui Zhou, Xiaopei Gao, Xing Liu, Sitong Yang, Zhengren Wei , et al. · 2025

Osteoarthritis (OA) is a leading cause of pain and disability worldwide. Despite extensive research, no curative treatment is currently available. Most therapies focus on symptom relief or disease modification. Traditional Chinese medicine…

Development and Implementation of Checklist Management in Manned Space Medical Rescue Transfer and Handover Open

Jing Li, Guohong Han, Peiming Sun, Xiaopei Gao, Liping Ding , et al. · 2025

Background Medical rescue transfer and handover in manned spaceflight is a critical component of space rescue operations, directly impacting the safety and well-being of astronauts. Objective This study aims to develop a comprehensive chec…

Establishing Pancreatic Cancer Organoids from EUS-Guided Fine-Needle Biopsy Specimens Open

Meijuan Wang, Chao Gao, Xin Huang, Min Wang, Shuai Zhang , et al. · 2025

Pancreatic cancer is a highly malignant digestive system tumor characterized by covert onset and rapid progression, with a 5-year survival rate of less than 10%. Most patients have already reached an advanced or metastatic stage at the tim…

Linking undergraduates’ future work self and employability: a moderated mediation model Open

Yaju Ma, Lingyan Hou, Wenjing Cai, Xiaopei Gao, Lin Jiang · 2024

Background The career intentions of students play a crucial role in shaping the growth of the hospitality and tourism industry. Previous research underlines the significance of future work self in predicting outcomes related to one’s caree…

The application of chatbot in gastroenterology nursing Open

Yang Zhao, Chao Gao, Lu Zhang, Xiaopei Gao, Zheng Zhang · 2023

Objective: The advent of large language models has triggered a wave of technological advancements in the global AI dialogue system, which has been widely adopted in various fields including medical care. This research aims to investigate t…

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury Open

Shiqin Xiong, Zhigang Hong, Long Huang, Yoshikazu Tsukasaki, Saroj Nepal , et al. · 2023

In the original version of Figure 4D, the representative lung histology sections of control and LPS-exposed animals, specifically the Rolipram (5 mg/kg)/PBS, Rolipram (5 mg/kg)/LPS, Rolipram (10 mg/kg)/PBS, and Rolipram (10 mg/kg)/LPS samp…

Future orientation and perceived employability of chinese undergraduates: a moderated mediation model Open

Hao Chen, Yunhong Wu, Lin Jiang, Binfeng Xu, Xiaopei Gao , et al. · 2022

Clinical efficacy of endoscopic antireflux mucosectomy vs. Stretta radiofrequency in the treatment of gastroesophageal reflux disease: a retrospective, single-center cohort study Open

Xinke Sui, Xiaopei Gao, Lu Zhang, Bin Zhang, Changqing Zhong , et al. · 2022

The clinical efficacies of ARMS and SRF 6 months postoperation were equivalent. The results showed that both ARMS and SRF treatment were acceptable for patients with GEFV grades II and III, while ARMS should be selected for patients with G…

How Environmental Leadership Boosts Employees’ Green Innovation Behavior? A Moderated Mediation Model Open

Binfeng Xu, Xiaopei Gao, Wenjing Cai, Lin Jiang · 2022

We examined employees’ green organizational identity as a mediator and green organizational climate as a moderator in the relationship between environmental leadership and follower green innovation behavior. Through collecting data ( N = 3…

Linking Mentoring and Job Search Behavior: A Moderated Mediation Model Open

Ruirui Lian, Wenjing Cai, Kun Chen, Hongru Shen, Xiaopei Gao , et al. · 2021

The present research aims to explore the impact of mentoring relationship on college graduates’ job search behavior among Chinese undergraduate students by examining the mediator of job search intention and the moderator of job search self…

How Can Hotel Employees Produce Workplace Environmentally Friendly Behavior? The Role of Leader, Corporate and Coworkers Open

Shanting Zheng, Lin Jiang, Wenjing Cai, Binfeng Xu, Xiaopei Gao · 2021

Although previous studies have acknowledged that leaders’ such environmental behaviors and environmental issues are becoming critical for long-term development, little research has focused on why, how and when perceived environmentally spe…

Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment Open

Sheng Chen, Feng Du, Changqing Zhong, Caifang Liu, Xiaoying Wang , et al. · 2021

Innovations in endoscopy have brought about some impressive improvements in diagnosing and treating gastroesophageal reflux disease (GERD). GERD, as one of the most prevalent gastrointestinal disorders in the world, has always been on the …

The relationship between KRAS gene mutation and intestinal flora in tumor tissues of colorectal cancer patients Open

Xinke Sui, Yan Chen, Baojun Liu, Lianyong Li, Xin Huang , et al. · 2020

In colorectal cancer, KRAS gene mutation can remarkably affect the survival prognosis and change the composition and abundance of intestinal flora, such as Roseburia, Parabacteroides, Metascardovia, Staphylococcus, and Bacillales, t…

The angiocrine Rspondin3 instructs interstitial macrophage transition via metabolic–epigenetic reprogramming and resolves inflammatory injury Open

Bisheng Zhou, Lissette Magana, Zhigang Hong, Long Shuang Huang, Sreeparna Chakraborty , et al. · 2020

Selective Nanotherapeutic Targeting of the Neutrophil Subset Mediating Inflammatory Injury Open

Kurt Bachmaier, Andrew Stuart, Zhigang Hong, Yoshikazu Tsukasaki, Abhalaxmi Singh , et al. · 2020

Inflammatory tissue injury such as acute lung injury (ALI) is a disorder that leads to respiratory failure, a major cause of morbidity and mortality worldwide. Excessive neutrophil influx is a critical pathogenic factor in the development …

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury Open

Kwong Tai Cheng, Shiqin Xiong, Zhiming Ye, Zhigang Hong, Anke Di , et al. · 2020

Acute lung injury is a leading cause of death in bacterial sepsis due to the wholesale destruction of the lung endothelial barrier, which results in protein-rich lung edema, influx of proinflammatory leukocytes, and intractable hypoxemia. …

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury Open

Shiqin Xiong, Zhigang Hong, Long Shuang Huang, Yoshikazu Tsukasaki, Saroj Nepal , et al. · 2020

Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury remain largely unknown. Here we showed that bacterial endotox…

How Servant Leadership Leads to Employees’ Customer-Oriented Behavior in the Service Industry? A Dual-Mechanism Model Open

Mengru Yuan, Wenjing Cai, Xiaopei Gao, Jingtao Fu · 2020

Although servant leadership has been acknowledged as an important predictor of employees’ behavioral outcomes in the service industry, there is still no cohesive understanding of the positive association between servant leadership and empl…

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury Open

Long Shuang Huang, Zhigang Hong, Wei Wu, Shiqin Xiong, Ming Zhong , et al. · 2020

Reflux finding score is associated with gastroesophageal flap valve status in patients with laryngopharyngeal reflux disease: a retrospective study Open

Wei Wu, Lianyong Li, Changmin Qu, Min Wang, Shuwen Liang , et al. · 2019

Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier Open

Ming Zhong, Wei Wu, Hojin Kang, Zhigang Hong, Shiqin Xiong , et al. · 2019

Disruption of alveolar-capillary barriers is a major complication of high-volume mechanical ventilation referred to as "ventilator-induced lung injury." The stretching force in alveoli is transmitted to endothelial cells, increasing the te…

A Tie2-Notch1 signaling axis regulates regeneration of the endothelial bone marrow niche Open

Lijian Shao, Kilian Sottoriva, Karol Palasiewicz, Jizhou Zhang, James Hyun , et al. · 2019

Loss-of-function studies have determined that Notch signaling is essential for hematopoietic and endothelial development. By deleting a single allele of the Notch1 transcriptional activation domain we generated viable, post-natal mice exhi…

Research on the Science and Technology Policy Coordination of China’s Yangtze River Delta Open

Binfeng Xu, Wei Song, Xiaopei Gao, Yu Zhang · 2019

Science and technology innovation policies have been considered as effective policy tools in promoting regional innovation. This paper used content analysis method to analyze 321 pieces of science and technology policies published from 200…

Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury Open

Kwong Tai Cheng, Shiqin Xiong, Zhiming Ye, Zhigang Hong, Anke Di , et al. · 2017

Acute lung injury is a leading cause of death in bacterial sepsis due to the wholesale destruction of the lung endothelial barrier, which results in protein-rich lung edema, influx of proinflammatory leukocytes, and intractable hypoxemia. …

Role of the phagosomal redox-sensitive TRP channel TRPM2 in regulating bactericidal activity of macrophages Open

Anke Di, Tomohiro Kiya, Haixia Gong, Xiaopei Gao, Asrar B. Malik · 2017

Acidification of macrophage phagosomes serves an important bactericidal function. We show here that the redox-sensitive transient receptor potential (TRP) cation channel TRPM2 is expressed in the phagosomal membrane and regulates macrophag…

Oxidant Sensing by TRPM2 Inhibits Neutrophil Migration and Mitigates Inflammation Open

Gang Wang, Luyang Cao, Xiaowen Liu, Nathan A. Sieracki, Anke Di , et al. · 2016

Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells Open

Liangtang Wu, Kishore K. Wary, Sergei Revskoy, Xiaopei Gao, Kitman Tsang , et al. · 2015

Novel Role of Reactive Oxygen Species–Activated <i>trp</i> Melastatin Channel-2 in Mediating Angiogenesis and Postischemic Neovascularization Open

Manish Mittal, Norifumi Urao, Claudie Hecquet, Min Zhang, Sudhahar Varadarajan , et al. · 2015

Objective— Transient receptor potential melastatin-2 (TRPM2) channel is a nonselective cation channel that mediates influx of Ca 2+ and Na + with relative permeability of P Ca: P Na ≈0.6 in response to cellular oxidative stress. As angioge…

Mapping and Evaluating Regional University-Industry Knowledge Flow through Patent Licensing Open

Xiaopei Gao, Yuming Chen, Wei Song, Xiaobao Peng, Xiaoyan Song · 2015

Different regions had various kinds of academic resources and industries competitors. The knowledge and innovation output generated by researchers in academy had been transferred into industries through patent licensing. Using the patent l…

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