Xiaopeng Zhao
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View article: Integrating network pharmacology, transcriptomics, molecular docking and in vitro experiments to investigate the material basis and mechanism of Liuwei Dihuang Pills for treating diabetic nephropathy
Integrating network pharmacology, transcriptomics, molecular docking and in vitro experiments to investigate the material basis and mechanism of Liuwei Dihuang Pills for treating diabetic nephropathy Open
Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Liuwei Dihuang Pills (LW) has significant clinical efficacy in the treatment of DN, but its pharmacological mechanism and material basis remain poorl…
View article: Neurofeedback-Enhanced Working Memory Training: A Proof-of-Concept for Reversing Age-Related Neural Slowing in Older Adults
Neurofeedback-Enhanced Working Memory Training: A Proof-of-Concept for Reversing Age-Related Neural Slowing in Older Adults Open
Specific electrophysiological (EEG) brain patterns may serve as neural biomarkers of aging, predicting Mild Cognitive Impairment (MCI) in older adults, while other patterns are more closely associated with preserved brain health, such as i…
View article: Trust-Region Method for Optimization of Set-Valued Maps Given by Finitely Many Functions
Trust-Region Method for Optimization of Set-Valued Maps Given by Finitely Many Functions Open
In this article, we develop a trust-region technique to find critical points of unconstrained set optimization problems with the objective set-valued map defined by finitely many twice continuously differentiable functions. The technique i…
View article: A Quasi-Newton Method to Solve Uncertain Multiobjective Optimization Problems with Uncertainty Set of Finite Cardinality
A Quasi-Newton Method to Solve Uncertain Multiobjective Optimization Problems with Uncertainty Set of Finite Cardinality Open
In this article, we derive an iterative scheme through a quasi-Newton technique to capture robust weakly efficient points of uncertain multiobjective optimization problems under the upper set less relation. It is assumed that the set of un…
View article: Risk assessment and early prediction of intraventricular hemorrhage in extremely preterm infants
Risk assessment and early prediction of intraventricular hemorrhage in extremely preterm infants Open
This study aimed to identify the risk factors associated with intraventricular hemorrhage (IVH) in extremely preterm infants (EPIs), focusing on early-stage prediction to improve clinical outcomes. A retrospective cohort study was conducte…
View article: On well-posedness and decay of Active model B
On well-posedness and decay of Active model B Open
We study the well-posedness and decay estimates of Cauchy problem for Active model B in R3. First, based on the higher-order norm estimates of solutions and the mollifier technique, we obtain the local existence of unique strong solution. …
View article: VOYAGER: an international consortium investigating the role of human papilloma virus and genetics in oral and oropharyngeal cancer risk and survival
VOYAGER: an international consortium investigating the role of human papilloma virus and genetics in oral and oropharyngeal cancer risk and survival Open
Head and neck cancer (HNC) is the sixth most common cancer globally. Incidence and survival rates vary significantly across geographic regions and tumor subsites. This is partly due to differences in risk factor exposure, which includes to…
View article: Risk factors for early periventricular intraventricular hemorrhage in extremely low birth weight infants: a retrospective study
Risk factors for early periventricular intraventricular hemorrhage in extremely low birth weight infants: a retrospective study Open
View article: Sex Differences in the Impact of Vascular Risk and Apoe Genotype on Cognitive Decline and Dementia: Evidence from a U.S. Longitudinal Study
Sex Differences in the Impact of Vascular Risk and Apoe Genotype on Cognitive Decline and Dementia: Evidence from a U.S. Longitudinal Study Open
View article: Survey on Human-Vehicle Interactions and AI Collaboration for Optimal Decision-Making in Automated Driving
Survey on Human-Vehicle Interactions and AI Collaboration for Optimal Decision-Making in Automated Driving Open
The capabilities of automated vehicles are advancing rapidly, yet achieving full autonomy remains a significant challenge, requiring ongoing human cognition in decision-making processes. Incorporating human cognition into control algorithm…
View article: User Perceptions of a Robot‐based Music Intervention System for Dementia Care
User Perceptions of a Robot‐based Music Intervention System for Dementia Care Open
Background To address the rapid increase in the number of persons with Alzheimer’s disease or related dementia (PwADRD), we seek to combine the benefits of music intervention with the adaptability of social robotics. Our system, the Music …
View article: Nutritional influences on Alzheimer’s disease: Insights from transformer models and explainable AI
Nutritional influences on Alzheimer’s disease: Insights from transformer models and explainable AI Open
Background This study utilizes transformer‐based machine learning models and explainable AI (XAI) techniques to investigate the complex relationship between various nutritional factors and AD mortality. Drawing data from the Third National…
View article: Advancing Dementia Care: AI Simulations in Managing Everyday Challenges
Advancing Dementia Care: AI Simulations in Managing Everyday Challenges Open
Background The prevalence of Alzheimer’s disease and related dementias (ADRD) presents a growing public health challenge. This study introduces an innovative approach to dementia care through the development of AI agents that simulate the …
View article: Associations between Cardiovascular‐Kidney‐Metabolic Health and the Risk of Cognitive Decline and Alzheimer’s Disease Mortality in a Multiethnic Cohort Study
Associations between Cardiovascular‐Kidney‐Metabolic Health and the Risk of Cognitive Decline and Alzheimer’s Disease Mortality in a Multiethnic Cohort Study Open
Background Cardiovascular‐kidney‐metabolic (CKM) health, a term recently defined by the American Heart Association, encompasses the interplay among metabolic, chronic kidney, and cardiovascular risk factors. We aimed to investigate the pre…
View article: Using Social Robots and AI to Perform Genetic Risk Assessment for Cancer
Using Social Robots and AI to Perform Genetic Risk Assessment for Cancer Open
Genetic risk assessment (GRA) and genetic counseling have become integral to optimal patient care for patients with cancer. At present, there is a limited number of qualified healthcare providers who provide this service. To assist profess…
View article: The PINK1/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia/reperfusion injury
The PINK1/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia/reperfusion injury Open
Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the pathological mechanisms of MIRI have received extensive attention. Oxidative …
View article: Newton Method for Set Optimization Problems with Set-Valued Mapping of Finitely Many Vector-Valued Functions
Newton Method for Set Optimization Problems with Set-Valued Mapping of Finitely Many Vector-Valued Functions Open
In this paper, we propose a Newton method for unconstrained set optimization problems to find its weakly minimal solutions with respect to lower set-less ordering. The objective function of the problem under consideration is given by finit…
View article: Inertial Bregman Golden Ratio Algorithm for Solving Variational Inequalities
Inertial Bregman Golden Ratio Algorithm for Solving Variational Inequalities Open
In this paper, we study a modification of the Golden Ratio Algorithm (GRAAL) for solving monotone variational inequalities. We present an inertial Bregman modification of GRAAL for solving the aforementioned problem. Our proposed algorithm…
View article: Using a Convolutional Neural Network and Explainable AI to Diagnose Dementia Based on MRI Scans
Using a Convolutional Neural Network and Explainable AI to Diagnose Dementia Based on MRI Scans Open
As the number of dementia patients rises, the need for accurate diagnostic procedures rises as well. Current methods, like using an MRI scan, rely on human input, which can be inaccurate. However, the decision logic behind machine learning…
View article: Risk factors for early periventricular intraventricular hemorrhage in extremely low birth weight infants: a retrospective study
Risk factors for early periventricular intraventricular hemorrhage in extremely low birth weight infants: a retrospective study Open
Background This study aimed to explore the risk factors for early periventricular intraventricular hemorrhage (PIVH) in extremely low birth weight infants (ELBWIs), provide guidance for early intervention, and improve the survival rate and…
View article: Association of multiple metabolic and cardiovascular markers with the risk of cognitive decline and mortality in adults with Alzheimer’s disease and AD-related dementia or cognitive decline: a prospective cohort study
Association of multiple metabolic and cardiovascular markers with the risk of cognitive decline and mortality in adults with Alzheimer’s disease and AD-related dementia or cognitive decline: a prospective cohort study Open
Background and objectives There is a scarcity of data stemming from large-scale epidemiological longitudinal studies focusing on potentially preventable and controllable risk factors for Alzheimer’s disease (AD) and AD-related dementia (AD…
View article: Explainable AI and transformer models: Unraveling the nutritional influences on Alzheimer's disease mortality
Explainable AI and transformer models: Unraveling the nutritional influences on Alzheimer's disease mortality Open
View article: Smart Driver Monitoring Robotic System to Enhance Road Safety : A Comprehensive Review
Smart Driver Monitoring Robotic System to Enhance Road Safety : A Comprehensive Review Open
The future of transportation is being shaped by technology, and one revolutionary step in improving road safety is the incorporation of robotic systems into driver monitoring infrastructure. This literature review explores the current land…
View article: Awareness and Acceptance of Emerging Technology and Quadruped Robots in Dementia Care: A Survey Study
Awareness and Acceptance of Emerging Technology and Quadruped Robots in Dementia Care: A Survey Study Open
The rapid increase in the number of persons with Alzheimer’s Disease or related dementia has led many researchers to develop supplemental care to assist caregivers. One such form of care comes in the form of a quadruped robot that can inte…
View article: Real‐time Memory‐related Neurofeedback Training Improves Intrinsic Brain Oscillations in Older Adults
Real‐time Memory‐related Neurofeedback Training Improves Intrinsic Brain Oscillations in Older Adults Open
Background Mild cognitive impairment (MCI), manifesting as working memory deficits for example, is the most common and earliest symptom of Alzheimer’s disease and related dementias (AD/ADRD). To combat the brain aging processes, early inte…
View article: Low‐Frequency Oscillations During Resting and Task Differentially Associate with Working Memory Performance in Older Adults
Low‐Frequency Oscillations During Resting and Task Differentially Associate with Working Memory Performance in Older Adults Open
Background Increased intrinsic slow delta oscillations during resting state are associated with brain aging and increased Alzheimer’s disease/related dementia pathologies, i.e., synaptic network dysfunctions and astrocyte over‐reactivity i…
View article: Causal inference on strategies to increase conversational engagement for socially isolated older adults
Causal inference on strategies to increase conversational engagement for socially isolated older adults Open
Background Social isolation, characterized by a small social network and lack of contact, negatively impact the quality of life. Older adults are at an increased risk for social isolation, which is found to be a risk factor of cognitive de…
View article: Sex differences in serum pigment epithelium-derived factor in healthy individuals
Sex differences in serum pigment epithelium-derived factor in healthy individuals Open
To investigate sexual dimorphism of serum pigment epithelium-derived factor (PEDF) and its influencing factors in healthy individuals. A total of 162 healthy people (69 males, 93 females) who underwent health examinations in our department…
View article: An experimental study of the carbohydrate exchange method combined with aerobic exercise to intervene in the physical health of obese college students
An experimental study of the carbohydrate exchange method combined with aerobic exercise to intervene in the physical health of obese college students Open
The purpose of investigating the carbohydrate exchange method in combination with aerobic exercise for obese college students is to help college students have better bodies to cope with their academic life. This paper introduces the qualit…
View article: Nrf2: a dark horse in doxorubicin-induced cardiotoxicity
Nrf2: a dark horse in doxorubicin-induced cardiotoxicity Open
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven to be a formidable obstacle. Numerous studies are currently devoted to elucidating the path…