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View article: Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases
Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases Open
Neurodegenerative diseases present significant therapeutic challenges, primarily due to the restrictive nature of the blood–brain barrier (BBB), which limits drug delivery to the brain. While the BBB is crucial for protecting the brain fro…
View article: Predator-prey dynamics with competitive attachment and Beddington-DeAngelis response under Allee effect
Predator-prey dynamics with competitive attachment and Beddington-DeAngelis response under Allee effect Open
Predator-prey systems constraint to specific spatiotemporal exhibit complex dynamic coexistence patterns characterized by intricate ecological interdependence and competitive antagonism. Accurately characterizing these nonlinear interactio…
View article: Colorectal Cancer Cells Promote <i>de novo</i> Glycine Synthesis for Collagen Production in Cancer‐Associated Fibroblasts by Secreting TGF‐β1
Colorectal Cancer Cells Promote <i>de novo</i> Glycine Synthesis for Collagen Production in Cancer‐Associated Fibroblasts by Secreting TGF‐β1 Open
Metabolic reprogramming of cancer‐associated fibroblasts (CAFs) plays an important role in colorectal cancer (CRC) progression. However, the mechanisms by which dysfunctional amino acid metabolism in CAFs contributes to cancer progression …
View article: Sea Squirt-Derived Peptide WLP Mitigates OKA-Induced Alzheimer’s Disease-like Phenotypes in Human Cerebral Organoid
Sea Squirt-Derived Peptide WLP Mitigates OKA-Induced Alzheimer’s Disease-like Phenotypes in Human Cerebral Organoid Open
Alzheimer’s disease (AD), a prevalent neurodegenerative disorder in the elderly, poses significant humanistic and economic burdens worldwide. Previously, we identified Trp-Leu-Pro (WLP), a novel antioxidant peptide derived from the sea squ…
View article: LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice
LUZP1 Regulates Dendritic Spine Maturation and Synaptic Plasticity in the Hippocampal Dentate Gyrus of Mice Open
Leucine zipper protein 1 (LUZP1) functions in the maintenance and dynamics of the cytoskeleton by interacting with actin and microtubules. Deficiency or mutation of LUZP1 is associated with brain developmental disorders; however, its preci…
View article: Mapping the chromothripsis landscape in urothelial carcinoma unravels great intratumoral and intertumoral heterogeneity
Mapping the chromothripsis landscape in urothelial carcinoma unravels great intratumoral and intertumoral heterogeneity Open
Chromothripsis, a hallmark of cancer, is characterized by extensive and localized DNA rearrangements involving one or a few chromosomes. However, its genome-wide frequency and characteristics in urothelial carcinoma (UC) remain largely unk…
View article: A high-fat plus high-sucrose diet induces age-related macular degeneration in an experimental rabbit model
A high-fat plus high-sucrose diet induces age-related macular degeneration in an experimental rabbit model Open
Age-related macular degeneration (AMD) is a leading cause of blindness. Metabolic disorders and diets are risk factors. We compared lipid profiles and retinal phenotypes with long-term feeding of four diets in male Chinchilla rabbits. Anim…
View article: Anatomical and Micro-CT measurement analysis of ocular volume and intraocular volume in adult Bama Miniature pigs, New Zealand rabbits, and Sprague-Dawley rats
Anatomical and Micro-CT measurement analysis of ocular volume and intraocular volume in adult Bama Miniature pigs, New Zealand rabbits, and Sprague-Dawley rats Open
Aim Utilizing a combination of micro-computed tomography (micro-CT) and anatomical techniques for the volumetric assessment of the eyeball and its constituents in Bama Miniature Pigs, New Zealand rabbits, and Sprague-Dawley (SD) rats. Meth…
View article: Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition
Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition Open
The Bin/Amphiphysin/Rvs (BAR) domain protein FAM92A1 is a multifunctional protein engaged in regulating mitochondrial ultrastructure and ciliogenesis, but its physiological role in the brain remains unclear. Here, we show that FAM92A1 is e…
View article: Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation
Pyruvate dehydrogenase complex E1 subunit α crotonylation modulates cocaine-associated memory through hippocampal neuron activation Open
Neuronal activation is required for the formation of drug-associated memory, which is critical for the development, persistence, and relapse of drug addiction. Nevertheless, the metabolic mechanisms underlying energy production for neurona…
View article: Tumor biomarkers for diagnosis, prognosis and targeted therapy
Tumor biomarkers for diagnosis, prognosis and targeted therapy Open
Tumor biomarkers, the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, progno…
View article: Unveiling the gut microbiota and metabolite profiles in guinea pigs with form deprivation myopia through 16S rRNA gene sequencing and untargeted metabolomics
Unveiling the gut microbiota and metabolite profiles in guinea pigs with form deprivation myopia through 16S rRNA gene sequencing and untargeted metabolomics Open
The findings suggest that the Ruminococcus_Albus and glutamate metabolic pathways play a significant role in myopia development, leading to concurrent alterations in serum VIP and LPS levels in FDM guinea pigs. This underscores the potenti…
View article: Serine promotes the progression of esophageal cancer through regulating one-carbon metabolism
Serine promotes the progression of esophageal cancer through regulating one-carbon metabolism Open
Serine metabolism provides important metabolic intermediates that support rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanisms remains unclear…
View article: GTPBP8 modulates mitochondrial fission through a Drp1-dependent process
GTPBP8 modulates mitochondrial fission through a Drp1-dependent process Open
Mitochondrial fission is a tightly regulated process involving multiple proteins and cell signaling. Despite extensive studies on mitochondrial fission factors, our understanding of the regulatory mechanisms remains limited. This study sho…
View article: Epigenetic regulation in cancer therapy: From mechanisms to clinical advances
Epigenetic regulation in cancer therapy: From mechanisms to clinical advances Open
Epigenetic regulation refers to the alteration of gene expression independent of changes in DNA sequence. It involves chemical modifications such as DNA methylation, histone methylation, and histone acetylation, which are regulated by a co…
View article: Neurodevelopmental defects in human cortical organoids with <i>N</i> -acetylneuraminic acid synthase mutation
Neurodevelopmental defects in human cortical organoids with <i>N</i> -acetylneuraminic acid synthase mutation Open
Biallelic genetic variants in N -acetylneuraminic acid synthase ( NANS ), a critical enzyme in endogenous sialic acid biosynthesis, are clinically associated with neurodevelopmental disorders. However, the mechanism underlying the neuropat…
View article: Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare
Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare Open
Bear bile has been a valuable and effective medicinal material in traditional Chinese medicine (TCM) for over 13 centuries. However, the current practice of obtaining it through bear farming is under scrutiny for its adverse impact on bear…
View article: Discovery and Optimization of Novel <i>h</i>DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease
Discovery and Optimization of Novel <i>h</i>DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease Open
As a key rate-limiting enzyme in the de novo synthesis of pyrimidine nucleotides, human dihydroorotate dehydrogenase (hDHODH) is considered a known target for the treatment of autoimmune diseases, including inflammatory bowel disease (IBD)…
View article: Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres
Methamphetamine exposure drives cell cycle exit and aberrant differentiation in rat hippocampal-derived neurospheres Open
Introduction: Methamphetamine (METH) abuse by pregnant drug addicts causes toxic effects on fetal neurodevelopment; however, the mechanism underlying such effect of METH is poorly understood. Methods: In the present study, we applied three…
View article: Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist
Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist Open
Opiates produce analgesia via G-protein signaling, and adverse effects, such as respiratory depression and decreased bowel motility, by β-arrestin pathway. Oliceridine, a G protein-biased MOR agonist, only presents modest safety advantages…
View article: Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45B
Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45B Open
Lysine‐specific histone demethylase 1 (LSD1) is an attractive target for malignancies therapy. Nevertheless, its role in hepatocellular carcinoma (HCC) progression and the potential of its inhibitor in HCC therapy remains unclear. Here, we…
View article: Morphine Re-Arranges Chromatin Spatial Architecture of Primate Cortical Neurons
Morphine Re-Arranges Chromatin Spatial Architecture of Primate Cortical Neurons Open
The expression of linear DNA sequence is precisely regulated by the three-dimensional (3D) architecture of chromatin. Morphine-induced aberrant gene networks of neurons have been extensively investigated; however, how morphine impacts the …
View article: Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons
Morphine Re-arranges Chromatin Spatial Architecture of Primate Cortical Neurons Open
The expression of linear DNA sequences is precisely regulated by the three–dimensional (3D) architecture of chromatin. Morphine-induced aberrant gene networks of neurons have been extensively investigated; however, how morphine impacts the…