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View article: CORM-2 attenuates red blood cell-mediated inflammation by upregulating phagocytic capacity of cerebral microglial cells of the neonatal rat in vitro
CORM-2 attenuates red blood cell-mediated inflammation by upregulating phagocytic capacity of cerebral microglial cells of the neonatal rat in vitro Open
View article: The role of D-dimer in intracerebral haemorrhage outcomes
The role of D-dimer in intracerebral haemorrhage outcomes Open
View article: Blood–Brain Barrier (<scp>BBB</scp>) Dysfunction in <scp>CNS</scp> Diseases: Paying Attention to Pericytes
Blood–Brain Barrier (<span>BBB</span>) Dysfunction in <span>CNS</span> Diseases: Paying Attention to Pericytes Open
Background Dysfunction of the blood–brain barrier (BBB) is an important pathological mechanism in central nervous system (CNS) diseases and can trigger a series of pathological reactions, such as neuroinflammatory responses, oxidative stre…
View article: Advances in 3D printing combined with tissue engineering for nerve regeneration and repair
Advances in 3D printing combined with tissue engineering for nerve regeneration and repair Open
The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative…
View article: SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system
SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system Open
View article: The neuroprotective effects of normobaric oxygen therapy after stroke
The neuroprotective effects of normobaric oxygen therapy after stroke Open
Background Stroke, including ischemic and hemorrhagic stroke, is a severe and prevalent acute cerebrovascular disease. The development of hypoxia following stroke can trigger a cascade of pathological events, including mitochondrial dysfun…
View article: Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms
Current evidence of synaptic dysfunction after stroke: Cellular and molecular mechanisms Open
Background Stroke is an acute cerebrovascular disease in which brain tissue is damaged due to sudden obstruction of blood flow to the brain or the rupture of blood vessels in the brain, which can prompt ischemic or hemorrhagic stroke. Afte…
View article: Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects
Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects Open
Alzheimer's and Parkinson's diseases are two of the most frequent neurological diseases. The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly manifests as motor dysfunction such as limb tremors, muscle …
View article: High-resolution magnetic resonance vessel wall imaging provides new insights into Moyamoya disease
High-resolution magnetic resonance vessel wall imaging provides new insights into Moyamoya disease Open
Moyamoya disease (MMD) is a rare condition that affects the blood vessels of the central nervous system. This cerebrovascular disease is characterized by progressive narrowing and blockage of the internal carotid, middle cerebral, and ante…
View article: Normobaric hyperoxia alleviates complement <scp>C3</scp>‐mediated synaptic pruning and brain injury after intracerebral hemorrhage
Normobaric hyperoxia alleviates complement <span>C3</span>‐mediated synaptic pruning and brain injury after intracerebral hemorrhage Open
Background Intracerebral hemorrhage (ICH) is a common cerebrovascular disease, and the complement cascade exacerbates brain injury after ICH. As the most abundant component of the complement system, complement component 3 (C3) plays essent…
View article: The Role of the Complement System in Synaptic Pruning after Stroke
The Role of the Complement System in Synaptic Pruning after Stroke Open
Stroke is a serious disease that can lead to local neurological dysfunction and cause great harm to the patient's health due to blood cerebral circulation disorder. Synaptic pruning is critical for the normal development of the human brain…
View article: Mechanisms and therapeutic targets of mitophagy after intracerebral hemorrhage
Mechanisms and therapeutic targets of mitophagy after intracerebral hemorrhage Open
Mitochondria are dynamic organelles responsible for cellular energy production. In addition to regulating energy homeostasis, mitochondria are responsible for calcium homeostasis, clearance of damaged organelles, signaling, and cell surviv…
View article: Research progress of mitophagy in chronic cerebral ischemia
Research progress of mitophagy in chronic cerebral ischemia Open
Chronic cerebral ischemia (CCI), a condition that can result in headaches, dizziness, cognitive decline, and stroke, is caused by a sustained decrease in cerebral blood flow. Statistics show that 70% of patients with CCI are aged > 80 y…
View article: Epigenetic regulation of synaptic disorder in Alzheimer’s disease
Epigenetic regulation of synaptic disorder in Alzheimer’s disease Open
Synapses are critical structures involved in neurotransmission and neuroplasticity. Their activity depends on their complete structure and function, which are the basis of learning, memory, and cognitive function. Alzheimer’s disease (AD) …
View article: The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases Open
View article: The Comprehensive Neural Mechanism of Oxytocin in Analgesia
The Comprehensive Neural Mechanism of Oxytocin in Analgesia Open
: Oxytocin (OXT) is a nine amino acid neuropeptide hormone that has become one of the most intensively studied molecules in the past few decades. The vast majority of OXT is synthesized in the periventricular nucleus and supraoptic nucleus…
View article: Transforming growth factor‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p
Transforming growth factor‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p Open
Intracerebral hemorrhage (ICH) has the highest mortality rate of all stroke subtypes but an effective treatment has yet to be clinically implemented. Transforming growth factor‑β1 (TGF‑β1) has been reported to modulate microglia‑mediated n…
View article: WITHDRAWN: CORM-2 can Attenuate Bleeding-mediated Inflammation by Increasing Phagocytic Capacity of Cerebral Microglial Cells in Neonatal Rat in Vitro
WITHDRAWN: CORM-2 can Attenuate Bleeding-mediated Inflammation by Increasing Phagocytic Capacity of Cerebral Microglial Cells in Neonatal Rat in Vitro Open
Objective: This study aimed to explore the mechanism of CORM-2 on attenuating bleeding-related inflammation. Methods: Microglia were isolated from the neonatal rats (1-2days old) and identified by the CD11b/c anti-body, and some microglia …
View article: Safety and efficacy of normobaric oxygenation on rescuing acute intracerebral hemorrhage-mediated brain damage—a protocol of randomized controlled trial
Safety and efficacy of normobaric oxygenation on rescuing acute intracerebral hemorrhage-mediated brain damage—a protocol of randomized controlled trial Open
View article: LncRNA TUG1 Demethylated by TET2 Promotes NLRP3 Expression, Contributes to Cerebral Ischemia/Reperfusion Inflammatory Injury
LncRNA TUG1 Demethylated by TET2 Promotes NLRP3 Expression, Contributes to Cerebral Ischemia/Reperfusion Inflammatory Injury Open
LncRNA TUG1 has not yet been reported in cerebral ischemia/reperfusion (I/R) injury. Methylcytosine dioxygenase TET2 is involved in ischemic damage. This study aimed to investigate the effects of TUG1 demethylated by TET2 on I/R-induced in…
View article: Targeting miR‐124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model
Targeting miR‐124/Ferroportin signaling ameliorated neuronal cell death through inhibiting apoptosis and ferroptosis in aged intracerebral hemorrhage murine model Open
Incidence of intracerebral hemorrhage (ICH) and brain iron accumulation increases with age. Excess iron accumulation in brain tissues post‐ICH induces oxidative stress and neuronal damage. However, the mechanisms underlying iron deregulati…
View article: Classification mechanism and clinical analysis of perihematomal edema in intracerebral hemorrhage
Classification mechanism and clinical analysis of perihematomal edema in intracerebral hemorrhage Open
The classification and mechanism of perihematomal edema in cerebral hemorrhage are complicated. The edema theory in different periods needs to be unified due to various reasons. Secondary perihematomal edema is the most important cause of …
View article: Flea surveillance on wild mammals in northern region of Xinjiang, northwestern China
Flea surveillance on wild mammals in northern region of Xinjiang, northwestern China Open
View article: Bartonella rochalimae, B. grahamii, B. elizabethae, and Wolbachia spp. in Fleas from Wild Rodents near the China-Kazakhstan Border
Bartonella rochalimae, B. grahamii, B. elizabethae, and Wolbachia spp. in Fleas from Wild Rodents near the China-Kazakhstan Border Open
The Alataw Pass, near the Ebinur Lake Wetland (northwest of China) and Taldykorgan (east of Kazakhstan), is a natural habitat for wild rodents. To date, little has been done on the surveillance of Bartonella spp. and Wolbachia spp. from fl…
View article: MiR‐21‐5p/dual‐specificity phosphatase 8 signalling mediates the anti‐inflammatory effect of haem oxygenase‐1 in aged intracerebral haemorrhage rats
MiR‐21‐5p/dual‐specificity phosphatase 8 signalling mediates the anti‐inflammatory effect of haem oxygenase‐1 in aged intracerebral haemorrhage rats Open
Intracerebral haemorrhage (ICH) is a severe neurological disorder caused by bleeding within the brain tissue. Inflammation has been implicated in ICH pathogenesis and is a potential therapeutic target for ICH. Haemin, an activator of haem …
View article: Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway
Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway Open
SFN may protect PC12 cells from MPP+‑induced damage via activating the Nrf2‑ARE (antioxidant responsive element) pathway.
View article: Chronic Stress Remodels Synapses in an Amygdala Circuit–Specific Manner
Chronic Stress Remodels Synapses in an Amygdala Circuit–Specific Manner Open
View article: Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia
Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia Open
View article: Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits
Acute stress enhances the glutamatergic transmission onto basoamygdala neurons embedded in distinct microcircuits Open
View article: First detection of Candidatus Rickettsia barbariae in the flea Vermipsylla alakurt from north-western China
First detection of Candidatus Rickettsia barbariae in the flea Vermipsylla alakurt from north-western China Open
Our study suggests that: (i) V. alakurt may serve as a carrier for Candidatus R. barbariae; and (ii) Candidatus R. barbariae, previously reported in Israel, is the eighth newly discovered validated Rickettsia species in China. This finding…