Xiaoqi Wang
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View article: Application of the image-based measurement triaxial fluid-solid coupling experimental platform
Application of the image-based measurement triaxial fluid-solid coupling experimental platform Open
View article: ROCK 2 inhibition with belumosudil for the treatment of chronic graft-versus-host disease: a narrative review
ROCK 2 inhibition with belumosudil for the treatment of chronic graft-versus-host disease: a narrative review Open
Chronic graft-versus-host disease (cGVHD) is a potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). The global incidence of cGVHD remains high, despite prophylactic regimens for patients undergoing H…
View article: Study on the Spatial Coupling Coordination of Public Service Facilities Around Large Comprehensive Hospitals in Beijing from a Supply–Demand Perspective
Study on the Spatial Coupling Coordination of Public Service Facilities Around Large Comprehensive Hospitals in Beijing from a Supply–Demand Perspective Open
With the development of urban construction and the improvement of residents’ quality of life, the focus of governance has shifted to a people-centered approach. In the core area of Beijing, there is a mismatch between the existing large co…
View article: Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation
Enhance the therapeutic efficacy of human umbilical cord-derived mesenchymal stem cells in prevention of acute graft-versus-host disease through CRISPLD2 modulation Open
View article: The emerging functions and clinical implications of circRNAs in acute myeloid leukaemia
The emerging functions and clinical implications of circRNAs in acute myeloid leukaemia Open
Acute myeloid leukaemia (AML) is a prevalent haematologic malignancy characterized by significant heterogeneity. Despite the application of aggressive therapeutic approaches, AML remains associated with poor prognosis. Circular RNAs (circR…
View article: Sequential Infusion of Mesenchymal Stem Cell for Graft-Versus-Host Disease Prevention in Haploidentical Hematopoietic Stem Cell Transplantation: An Open-Label, Multicenter, Randomized Controlled Clinical Trial
Sequential Infusion of Mesenchymal Stem Cell for Graft-Versus-Host Disease Prevention in Haploidentical Hematopoietic Stem Cell Transplantation: An Open-Label, Multicenter, Randomized Controlled Clinical Trial Open
PURPOSE The aim of this open-label, multicenter, randomized controlled trial was to determine the efficacy and safety of sequential umbilical cord–derived mesenchymal stem cell (UC-MSC) infusion for graft-versus-host disease (GVHD) prevent…
View article: Correlation between visceral fat area and cardiac valve calcification in hemodialysis patients
Correlation between visceral fat area and cardiac valve calcification in hemodialysis patients Open
Objective To investigate the relationship between Visceral Fat Area (VFA) and cardiac valve calcification (CVC) in Maintenance Hemodialysis (MHD) patients. Methods This cross-sectional study included MHD patients enrolled at our hospital b…
View article: Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement
Exploring treatment-driven subclonal evolution of prognostic triple biomarkers: Dual gene fusions and chimeric RNA variants in novel subtypes of acute myeloid leukemia patients with KMT2A rearrangement Open
View article: [<i>Danshen</i> Injection inhibits peritoneal dialysis fluid-induced endothelial-mesenchymal transition in HMrSV5 cells by regulating the TGF-β/Smad signaling pathway].
[<i>Danshen</i> Injection inhibits peritoneal dialysis fluid-induced endothelial-mesenchymal transition in HMrSV5 cells by regulating the TGF-β/Smad signaling pathway]. Open
Danshen Injection can suppress peritoneal dialysis fluid-induced EndMT in HMrSV5 cells possibly by regulating the TGF-β/Smad signaling pathway.
View article: Engineering a controllable and reversible switch for CAR-based cellular immunotherapies via a genetic code expansion system
Engineering a controllable and reversible switch for CAR-based cellular immunotherapies via a genetic code expansion system Open
Our study systematically demonstrated that the BOCK-induced genetic code expansion system effectively and precisely regulates CAR protein expression and controls CAR-T cell anti-tumor effects in vitro and in vivo. We conclude that this con…
View article: Long-term survival with donor CD19 CAR-T cell treatment for relapsed patients after allogeneic hematopietic stem cell transplantation
Long-term survival with donor CD19 CAR-T cell treatment for relapsed patients after allogeneic hematopietic stem cell transplantation Open
View article: Recent advances and research progress regarding monoclonal antibodies for chronic graft-versus-host disease
Recent advances and research progress regarding monoclonal antibodies for chronic graft-versus-host disease Open
Chronic graft-versus-host disease (cGVHD) is one of the leading causes of mortality following allogeneic hematopoietic stem cell transplantation (HSCT), with only 50 % of patients responding to conventional corticosteroids with or without …
View article: Effect of low blockage ratio obstacle on explosion characteristic in methane/air mixture
Effect of low blockage ratio obstacle on explosion characteristic in methane/air mixture Open
Methane/air explosion is one of the common hazards in process and mining industries. In this study, the methane explosion propagation is studied, and two-dimensional configuration is considered. The gas phase equations are solved using an …
View article: Exploring the Burden of PM2.5-Related Deaths and Economic Health Losses in Beijing
Exploring the Burden of PM2.5-Related Deaths and Economic Health Losses in Beijing Open
Air pollution is one of the major global public health challenges. Using annual fine particulate matter (PM2.5) concentration data from 2016 to 2021, along with the global exposure mortality model (GEMM), we estimated the multi-year PM2.5-…
View article: Long-Term Follow-Up of Patients Undergoing Thalidomide Therapy for Transfusion-Dependent β-Thalassaemia: A Single-Center Experience
Long-Term Follow-Up of Patients Undergoing Thalidomide Therapy for Transfusion-Dependent β-Thalassaemia: A Single-Center Experience Open
Thalidomide was well tolerated in the long term, while it significantly improved Hb levels and reduced the transfusion burden.
View article: Multi-view graph learning for deciphering the dominant cell communication assembly of downstream functional events from single-cell RNA-seq data
Multi-view graph learning for deciphering the dominant cell communication assembly of downstream functional events from single-cell RNA-seq data Open
Cell-cell communications (CCCs) from multiple sender cells collaboratively affect downstream functional events in receiver cells, thus influencing cell phenotype and function. How to rank the importance of these CCCs and find the dominant …
View article: Multi-Omics Analysis Unravelling Stemness Features Associated with Oncogenic Dedifferentiation in 12 Cancers
Multi-Omics Analysis Unravelling Stemness Features Associated with Oncogenic Dedifferentiation in 12 Cancers Open
View article: Fracture Behavior and Failure Mechanism of Straight Wall Tunnel Lining with Void Defects Using Fem-Czm Method
Fracture Behavior and Failure Mechanism of Straight Wall Tunnel Lining with Void Defects Using Fem-Czm Method Open
View article: Spatiotemporal evolution characteristics of carbon rebound effect in China’s transportation industry and mechanism
Spatiotemporal evolution characteristics of carbon rebound effect in China’s transportation industry and mechanism Open
[Objective] To implement the new development concept and achieve the “dual carbon”, this study reveals the spatiotemporal evolution characteristics of the carbon rebound effect in the transportation industry and its impact mechanism, expan…
View article: Cardioprotective effects of nanoparticles green formulated by <i>Spinacia oleracea</i> extract on isoproterenol-induced myocardial infarction in mice by the determination of PPAR-γ/NF-κB pathway
Cardioprotective effects of nanoparticles green formulated by <i>Spinacia oleracea</i> extract on isoproterenol-induced myocardial infarction in mice by the determination of PPAR-γ/NF-κB pathway Open
We developed a contemporary cardioprotective medication using silver nanoparticles (AgNPs) loaded with Spinacia oleracea to treat isoproterenol (ISO)-induced myocardial infarction in mice, focusing on the PPAR-γ/NF-κB pathway. The physicoc…
View article: Identification of hub genes in vestibular Schwannoma by bioinformatics analyses and machine learning methods
Identification of hub genes in vestibular Schwannoma by bioinformatics analyses and machine learning methods Open
Background Vestibular Schwannoma (VS) is one of the causes of severe hearing loss with poor therapeutic effect and low quality of life. Lacking effective biomarkers may result in underdiagnosis. Therefore, by exploring the mechanism of sen…
View article: Advances in single-cell RNA sequencing and its applications in cancer research
Advances in single-cell RNA sequencing and its applications in cancer research Open
View article: An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China
An Observational Prospective Cohort Study of Vaccine Effectiveness Against Severe Acute Respiratory Syndrome Coronavirus 2 Infection of an Aerosolized, Inhaled Adenovirus Type 5–Vectored Coronavirus Disease 2019 Vaccine Given as a Second Booster Dose in Guangzhou City, China Open
Using a prospective, observational cohort study during the post–“dynamic COVID-zero” wave in China, we estimated short-term relative effectiveness against Omicron BA.5 infection of inhaled aerosolized adenovirus type 5–vectored ancestral s…
View article: P1259: HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS AMELIORATE ACUTE GRAFT VERSUS HOST DISEASE BY ELEVATING PHYTOSPHINGOSINE
P1259: HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS AMELIORATE ACUTE GRAFT VERSUS HOST DISEASE BY ELEVATING PHYTOSPHINGOSINE Open
Topic: 21. Stem cell transplantation - Experimental Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for malignant hematological diseases. However, acute graft-versus-host disease (aGVHD)…
View article: P522: OFF-THE-SHELF CD33 CAR-NK CELL THERAPY FOR RELAPSE/REFRACTORY AML: FIRST-IN-HUMAN, PHASE I TRIAL
P522: OFF-THE-SHELF CD33 CAR-NK CELL THERAPY FOR RELAPSE/REFRACTORY AML: FIRST-IN-HUMAN, PHASE I TRIAL Open
Background: CD19 CAR-T cell therapy have brough hope to patients with refractory and relapsed (R/R) B cell malignancies. However, the primary result of CAR-T therapy for patients with R/R AML remained modest. One of the main challenges is …
View article: P1275: SAFETY AND EFFICACY OF HUMAN AMNIOTIC EPITHELIAL STEM CELLS EYE DROP IN OCULAR CHRONIC GRAFT-VERSUS-HOST DISEASE
P1275: SAFETY AND EFFICACY OF HUMAN AMNIOTIC EPITHELIAL STEM CELLS EYE DROP IN OCULAR CHRONIC GRAFT-VERSUS-HOST DISEASE Open
Topic: 22. Stem cell transplantation - Clinical Background: Around 50% of patients suffer from ocular chronic GVHD (ocGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which causes serious dryness and visual impai…
View article: P1284: THE TEAR CYTOKINE PANEL IS A USEFUL BIOMARKER FOR EARLY DIAGNOSIS AND SEVERITY-EVALUATING OF OCULAR CHRONIC GRAFT-VERSUS-HOST DISEASE
P1284: THE TEAR CYTOKINE PANEL IS A USEFUL BIOMARKER FOR EARLY DIAGNOSIS AND SEVERITY-EVALUATING OF OCULAR CHRONIC GRAFT-VERSUS-HOST DISEASE Open
Topic: 22. Stem cell transplantation - Clinical Background: Chronic graft-versus-host disease (cGVHD) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), affecting 30–70% of patients after allo-HS…
View article: Donor T cell STAT3 deficiency enables tissue PD-L1–dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity
Donor T cell STAT3 deficiency enables tissue PD-L1–dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity Open
STAT3 deficiency (STAT3-/-) in donor T cells prevents graft-versus-host disease (GVHD), but the impact on graft-versus-leukemia (GVL) activity and mechanisms of GVHD prevention remains unclear. Here, using murine models of GVHD, we show th…
View article: Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases
Differential Roles of Interleukin-6 in Severe Acute Respiratory Syndrome-Coronavirus-2 Infection and Cardiometabolic Diseases Open
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can lead to a cytokine storm, unleashed in part by pyroptosis of virus-infected macrophages and monocytes. Interleukin-6 (IL-6) has emerged as a key participant in this…
View article: Ginsenoside Rg1 improves anti-tumor efficacy of adoptive cell therapy by enhancing T cell effector functions
Ginsenoside Rg1 improves anti-tumor efficacy of adoptive cell therapy by enhancing T cell effector functions Open
Adoptive cell therapy (ACT) has emerged with remarkable efficacies for tumor immunotherapy. Chimeric antigen receptor (CAR) T cell therapy, as one of most promising ACTs, has achieved prominent effects in treating malignant hematological t…