Xiaoqiao Zhang
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View article: Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis
Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis Open
ANGPTL8 aggravates microglial pyroptosis via the PirB/NLRP3 pathway to accelerate the pathogenesis of AD. Targeting high expression of ANGPTL8 in the liver may hold potential for developing therapies for AD.
View article: Influence of surgical start time on the quality of surgery for middle and low rectal cancer: a post hoc analysis of the real trial
Influence of surgical start time on the quality of surgery for middle and low rectal cancer: a post hoc analysis of the real trial Open
Background: Surgical start time is considered to influence the quality of surgery due to surgeon fatigue. High-quality studies on middle and low rectal cancer are lacking. The analysis aims to find out the influence of surgical start time …
View article: An achievement has been made in establishing an induced pluripotent stem cell line (SDPHi005-A) from a healthy Chinese male donor
An achievement has been made in establishing an induced pluripotent stem cell line (SDPHi005-A) from a healthy Chinese male donor Open
Successfully transforming isolated peripheral blood mononuclear cells (PBMCs) from a healthy male into induced pluripotent stem cells (iPSCs) was achieved using non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-X…
View article: MiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis
MiR-483-5p downregulation alleviates ox-LDL induced endothelial cell injury in atherosclerosis Open
Background In light of the abnormal expression of microRNA (miR-483-5p) in patients with atherosclerosis (AS), its role in vascular endothelial cell injury was explored. And the mechanisms related to autophagy were also elucidated. Methods…
View article: MicroRNA-218-5p regulates inflammation response via targeting TLR4 in atherosclerosis
MicroRNA-218-5p regulates inflammation response via targeting TLR4 in atherosclerosis Open
Background To investigate the expression of miR-218-5p in atherosclerosis patients and its effect on ox-LDL induced THP-1-derived macrophage inflammatory response. Methods RT-qPCR detected the expression of serum miR-218-5p, and the diagno…
View article: ANGPTL8 as an Inflammatory Trigger Aggravated Microglial Pyroptosis in the Pathogenesis of Alzheimer’s Disease
ANGPTL8 as an Inflammatory Trigger Aggravated Microglial Pyroptosis in the Pathogenesis of Alzheimer’s Disease Open
Background: Increasing evidence indicates that Alzheimer’s disease (AD) is not only a disease of the brain but also an autoimmune disorder of innate immunity. Pyroptosis-mediated inflammation activates microglia, which are innate immune re…
View article: Baicalein Induces Mitochondrial Autophagy to Prevent Parkinson's Disease in Rats via miR-30b and the SIRT1/AMPK/mTOR Pathway
Baicalein Induces Mitochondrial Autophagy to Prevent Parkinson's Disease in Rats via miR-30b and the SIRT1/AMPK/mTOR Pathway Open
Parkinson's disease (PD) is a prevailing neurodegenerative disorder. Baicalein has neuroprotective effects on PD animals, but its mechanism is not clarified. We explored baicalein effects on PD rats. PD rat models were established by injec…
View article: Baicalein Mediates Mitochondrial Autophagy via miR-30b and the NIX/BNIP3 Signaling Pathway in Parkinson’s Disease
Baicalein Mediates Mitochondrial Autophagy via miR-30b and the NIX/BNIP3 Signaling Pathway in Parkinson’s Disease Open
Parkinson’s disease (PD) is regarded as a severe neurodegenerative disorder. Baicalein is involved in the treatment of PD. This study explored the mechanism of baicalein in PD. The PD rat model was established using 6-hydroxydopamine. The …