Xiaoqun Yang
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View article: Translation Strategy Study on the Functional Equivalence Theory: Taking Translations of Security: A Framework for the Study of Unwanted Futures (Chapter 1) as an Example
Translation Strategy Study on the Functional Equivalence Theory: Taking Translations of Security: A Framework for the Study of Unwanted Futures (Chapter 1) as an Example Open
This study applies Nida’s Functional Equivalence Theory to translating Chapter 1 of Translations of Security: A Framework for the Study of Unwanted Futures, a conceptually dense academic text. To bridge the English-Chinese typological gaps…
View article: Merlin‐deficient renal cell carcinoma often exhibits high‐grade cytology, admixed architectural patterns, sclerotic and mucinous stroma, inflammatory infiltrates and calcifications
Merlin‐deficient renal cell carcinoma often exhibits high‐grade cytology, admixed architectural patterns, sclerotic and mucinous stroma, inflammatory infiltrates and calcifications Open
Aims Recent studies have enhanced our understanding of NF2 ‐mutated renal neoplasms, particularly the emerging entity of biphasic hyalinizing psammomatous renal cell carcinoma (BHP RCC) characterised by biphasic features and NF2 alteration…
View article: Eosinophilic vacuolated tumor of the kidney can have distant metastasis: a histo-molecular case study
Eosinophilic vacuolated tumor of the kidney can have distant metastasis: a histo-molecular case study Open
Eosinophilic vacuolated tumor (EVT) is an emerging renal entity and further studies are required to characterize this neoplasm. EVT is considered generally indolent because metastasis or death from the disease has never been reported. Here…
View article: Germline Mutations in Renal Neoplasms and Their Clinicopathological Correlations
Germline Mutations in Renal Neoplasms and Their Clinicopathological Correlations Open
Introduction . Germline mutations have been described in multiple renal neoplasm entities in the fifth edition of the World Health Organization Classification of Urinary and Male Genital Systems. However, our knowledge of renal neoplasms w…
View article: Cepharanthine inhibits African swine fever virus replication by suppressing AKT-associated pathways through disrupting Hsp90-Cdc37 complex
Cepharanthine inhibits African swine fever virus replication by suppressing AKT-associated pathways through disrupting Hsp90-Cdc37 complex Open
African swine fever (ASF) represents one of the most economically important viral infectious diseases in the swine industry worldwide. Presently, there is an absence of commercially available therapeutic drugs and safe vaccines. Cepharanth…
View article: Fangchinoline Inhibits African Swine Fever Virus Replication by Suppressing the AKT/mTOR/NF-κB Signaling Pathway in Porcine Alveolar Macrophages
Fangchinoline Inhibits African Swine Fever Virus Replication by Suppressing the AKT/mTOR/NF-κB Signaling Pathway in Porcine Alveolar Macrophages Open
African swine fever (ASF), caused by the African swine fever virus (ASFV), is one of the most important infectious diseases that cause high morbidity and mortality in pigs and substantial economic losses to the pork industry of affected co…
View article: Dynamic changes of SCGN expression imply different phases of clear cell renal cell carcinoma progression
Dynamic changes of SCGN expression imply different phases of clear cell renal cell carcinoma progression Open
The secretagogin (SCGN) was originally identified as a secreted calcium-binding protein present in the cytoplasm. Recent studies have found that SCGN has a close relationship with cancer. However, its role in the occurrence, progression, a…
View article: Construction and validation of a mutation-related model in papillary renal cell carcinoma and associated immune infiltration
Construction and validation of a mutation-related model in papillary renal cell carcinoma and associated immune infiltration Open
Background: To improve the clinical evaluation of the prognosis of papillary renal cell carcinoma (PRCC), we screened a model to predict the survival of patients with mutations in related genes. Methods: We downloaded RNA sequencing inform…
View article: Fumarate Hydratase–Deficient Renal Cell Carcinoma With Predominant Tubulocystic Features Mimics Tubulocystic Renal Cell Carcinoma
Fumarate Hydratase–Deficient Renal Cell Carcinoma With Predominant Tubulocystic Features Mimics Tubulocystic Renal Cell Carcinoma Open
Context.— Fumarate hydratase (FH)–deficient renal cell carcinoma (RCC) rarely exhibits a predominant tubulocystic architecture with few other components. RCC with pure tubules and cysts lined by eosinophilic tumor cells with prominent nucl…
View article: Acquired cystic disease-associated renal cell carcinoma with PTCH1 mutation: a case report
Acquired cystic disease-associated renal cell carcinoma with PTCH1 mutation: a case report Open
Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is an extremely rare kidney tumor seen mainly in patients with end-stage renal disease. Currently, there are few reports on this type of tumor. We describe the case of a 58-…
View article: Machine Learning-Based Pathomics Model to Predict the Prognosis in Clear Cell Renal Cell Carcinoma
Machine Learning-Based Pathomics Model to Predict the Prognosis in Clear Cell Renal Cell Carcinoma Open
Clear cell renal cell carcinoma (ccRCC) is a highly lethal urinary malignancy with poor overall survival (OS) rates. Integrating computer vision and machine learning in pathomics analysis offers potential for enhancing classification, prog…
View article: Long non-coding RNA HIF1A-AS2 promotes carcinogenesis by enhancing Gli1-mediated HIF1α expression in clear cell renal cell carcinoma
Long non-coding RNA HIF1A-AS2 promotes carcinogenesis by enhancing Gli1-mediated HIF1α expression in clear cell renal cell carcinoma Open
lncRNA HIF1A-AS2 affects ccRCC development by regulating HIF1a expression through Gli1.
View article: Clinicopathological and molecular analysis of microsatellite instability in prostate cancer: a multi-institutional study in China
Clinicopathological and molecular analysis of microsatellite instability in prostate cancer: a multi-institutional study in China Open
Background Microsatellite instability (MSI), or mismatch repair-deficiency (dMMR), is rare in prostate cancers (PCas). The histological and molecular features of PCas with MSI/dMMR are incompletely described. Thus, we sought to identify th…
View article: The heterogeneity and clonal evolution analysis of the advanced prostate cancer with castration resistance
The heterogeneity and clonal evolution analysis of the advanced prostate cancer with castration resistance Open
Background Nowadays, the incidence rate of advanced prostate cancer at the first time of diagnosis grows higher in China yearly. At present, androgen deprivation therapy is the standard first-line treatment of advanced prostate cancer. How…
View article: Exploration of Morphological Features of Clear Cell Renal Cell Carcinoma With <i>PBRM1</i>, <i>SETD2</i>, <i>BAP1</i>, or <i>KDM5C</i> Mutations
Exploration of Morphological Features of Clear Cell Renal Cell Carcinoma With <i>PBRM1</i>, <i>SETD2</i>, <i>BAP1</i>, or <i>KDM5C</i> Mutations Open
The last decade has seen great advances in genomic profiling and prognosis-associated factors of clear cell renal cell carcinoma (RCC), the most common entity in kidney cancer. Following VHL, PBRM1, SETD2, BAP1, and KDM5C have been validat…
View article: Wide morphological spectrums of renal neoplasms with TSC/mTOR, NF2, or monoallelic MUTYH germline mutation
Wide morphological spectrums of renal neoplasms with TSC/mTOR, NF2, or monoallelic MUTYH germline mutation Open
Advances in molecular biology techniques have led to the recognition of more molecularly defined renal entities. However, some molecular-defined renal cell carcinomas (RCC) exhibit heterogeneous morphologies. In recent years, TSC/mTOR and …
View article: Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG
Extensive germline-somatic interplay contributes to prostate cancer progression through HNF1B co-option of TMPRSS2-ERG Open
Genome-wide association studies have identified 270 loci conferring risk for prostate cancer (PCa), yet the underlying biology and clinical impact remain to be investigated. Here we observe an enrichment of transcription factor genes inclu…
View article: WITHDRAWN: SETD2 deficiency promotes the transition from PKD to ccRCC by dysregulation of sphingomyelin metabolism
WITHDRAWN: SETD2 deficiency promotes the transition from PKD to ccRCC by dysregulation of sphingomyelin metabolism Open
Withdrawal Statement bioRxiv has withdrawn this preprint as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as reference for the project. If you have an…
View article: Quantifying the cell morphology and predicting biological behavior of signet ring cell carcinoma using deep learning
Quantifying the cell morphology and predicting biological behavior of signet ring cell carcinoma using deep learning Open
Signet ring cell carcinoma (SRCC) is a malignant tumor of the digestive system. This tumor has long been considered to be poorly differentiated and highly invasive because it has a higher rate of metastasis than well-differentiated adenoca…
View article: Erratum: Evaluation of the clinicopathologic features of diffuse large B cell lymphoma after CD19-targeted CAR T-cell therapy emphasizing the potential diagnostic pitfalls.
Erratum: Evaluation of the clinicopathologic features of diffuse large B cell lymphoma after CD19-targeted CAR T-cell therapy emphasizing the potential diagnostic pitfalls. Open
[This corrects the article on p. 6751 in vol. 12, PMID: 33194070.].
View article: A Combined Technology to Protect the Anatomic Integrity of Distal Urethral Sphincter Complex in Radical Prostatectomy Improves Early Urinary Continence Recovery Without Sacrifice of Oncological Outcomes
A Combined Technology to Protect the Anatomic Integrity of Distal Urethral Sphincter Complex in Radical Prostatectomy Improves Early Urinary Continence Recovery Without Sacrifice of Oncological Outcomes Open
Purpose Our primary aim was to present a combined technique to protect the anatomic integrity of distal urethral sphincter complex (DUSC) during minimally invasive radical prostatectomy (RP) and discuss its impact on urinary continence (UC…
View article: Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma
Case Report: Rare Case of Synchronous Neck Metastasis From Metachronous Bilateral Renal Cell Carcinoma Open
Renal cell carcinoma (RCC) is a malignant tumor that can metastasize easily. Hence, many patients have already developed metastasis when they are diagnosed. It is also one of the most common tumors that metastasize to the head and neck thr…
View article: Quantifying the Cell Morphology and Predicting Biological Behavior of Signet Ring Cell Carcinoma using Deep Learning
Quantifying the Cell Morphology and Predicting Biological Behavior of Signet Ring Cell Carcinoma using Deep Learning Open
Signet ring cell carcinoma(SRCC) is a malignant tumor of the digestive system. This tumor has long been considered to be poorly differentiated and highly invasive because it has a higher rate of metastasis than well-differentiated adenocar…
View article: Primary malignant teratoma of the kidney: a rare case report and literature review
Primary malignant teratoma of the kidney: a rare case report and literature review Open
Teratomas originate from pluripotent cells and can differentiate along one or more embryonic germ lines. Renal teratoma is infrequent and malignant renal teratoma is even rarer. Experience in the diagnosis and treatment of this uncommon ma…
View article: Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma
Epigenome screening highlights that JMJD6 confers an epigenetic vulnerability and mediates sunitinib sensitivity in renal cell carcinoma Open
Aberrant epigenetic reprogramming represents a hallmark of renal cell carcinoma (RCC) tumorigenesis and progression. Whether there existed other epigenetic vulnerabilities that could serve as therapeutic targets remained unclear and promis…