Xiaorong Pan
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View article: Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons Open
Directed axonal trafficking of mRNA via ribonucleoprotein (RNP) complexes is essential for neuronal function and survival. However, mechanisms governing retrograde RNP transport remain poorly understood. Here, we reveal that Annexin A7 (AN…
View article: The role of prognostic nutrition index in the prognosis of patients with advanced hepatocellular carcinoma who received first-line therapy
The role of prognostic nutrition index in the prognosis of patients with advanced hepatocellular carcinoma who received first-line therapy Open
View article: Actomyosin-II protects axons from degeneration induced by mild mechanical stress
Actomyosin-II protects axons from degeneration induced by mild mechanical stress Open
Whether, to what extent, and how the axons in the central nervous system (CNS) can withstand sudden mechanical impacts remain unclear. By using a microfluidic device to apply controlled transverse mechanical stress to axons, we determined …
View article: Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients
Neutrophil-to-lymphocyte ratio associated with renal function in type 2 diabetic patients Open
BACKGROUND Type 2 diabetes mellitus (T2DM) is a leading risk factor for the development and progression of chronic kidney disease (CKD). However, an accurate and convenient marker for early detection and appropriate management of CKD in in…
View article: Sequential or simultaneous transarterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma within the Milan criteria: A retrospective real‐world study
Sequential or simultaneous transarterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma within the Milan criteria: A retrospective real‐world study Open
Aims Few studies have investigated differences in sequential transarterial chemoembolization (TACE), radiofrequency ablation (RFA), and simultaneous RFA‐TACE for the treatment of hepatocellular carcinoma (HCC) using the Milan criteria. Thi…
View article: Maternal Microchimerism Promotes Tolerance Induction Toward Factor VIII in Severe Haemophilia a Children with Inhibitors
Maternal Microchimerism Promotes Tolerance Induction Toward Factor VIII in Severe Haemophilia a Children with Inhibitors Open
View article: Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress
Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress Open
Summary Pan et al found that actomyosin-II-driven radial contractility underpins the resilience of central axons to mild mechanical stress by suppressing the propagation and firing of injurious Ca 2+ waves. Boosting actomyosin-II activity …
View article: Supplementary figures 1-8 from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Supplementary figures 1-8 from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Supplementary figures 1-8. Supplementary Figure 1. The amino acid sequence of scFv GC33 in the construct of anti-GPC3 CAR. Supplementary Figure 2. The expression of CD64 and CD86 in the artificial antigen-presenting cell aK562-64/86. Suppl…
View article: Supplementary figures 1-8 from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Supplementary figures 1-8 from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Supplementary figures 1-8. Supplementary Figure 1. The amino acid sequence of scFv GC33 in the construct of anti-GPC3 CAR. Supplementary Figure 2. The expression of CD64 and CD86 in the artificial antigen-presenting cell aK562-64/86. Suppl…
View article: Data from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Data from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Purpose: The aim of our study is to elucidate whether T cells expressing GPC3-targeted chimeric antigen receptor (CAR) can efficiently eliminate GPC3-positive HCC cells and their potential in the treatment of HCC.Experimental Des…
View article: Supplementary methods from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Supplementary methods from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Supplementary methods
View article: Supplementary table from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Supplementary table from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Supplementary table. Primer sequences used for construction of the different CARs using the splicing PCR by overlap extension technique.
View article: Data from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Data from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Purpose: The aim of our study is to elucidate whether T cells expressing GPC3-targeted chimeric antigen receptor (CAR) can efficiently eliminate GPC3-positive HCC cells and their potential in the treatment of HCC.Experimental Des…
View article: Supplementary methods from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Supplementary methods from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Supplementary methods
View article: Supplementary table from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma
Supplementary table from Development of T Cells Redirected to Glypican-3 for the Treatment of Hepatocellular Carcinoma Open
Supplementary table. Primer sequences used for construction of the different CARs using the splicing PCR by overlap extension technique.
View article: Supplementary Methods, Figures 1 - 6, Tables 1 - 4 from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells
Supplementary Methods, Figures 1 - 6, Tables 1 - 4 from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells Open
PDF file - 734K, Figure S1. EGFRvA is widely expressed in various cancer cell lines and tissues. Figure S2. The upregulation of EGFRvA in glioma tissues compared with paired adjacent non-neoplastic brain tissues and a poor prognosis in pat…
View article: Data from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells
Data from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells Open
As a validated therapeutic target in several human cancers, the EGF receptor (EGFR) provides a focus to gain deeper insights into cancer pathophysiology. In this study, we report the identification of a naturally occurring and widely expre…
View article: Data from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells
Data from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells Open
As a validated therapeutic target in several human cancers, the EGF receptor (EGFR) provides a focus to gain deeper insights into cancer pathophysiology. In this study, we report the identification of a naturally occurring and widely expre…
View article: Supplementary Methods, Figures 1 - 6, Tables 1 - 4 from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells
Supplementary Methods, Figures 1 - 6, Tables 1 - 4 from A Novel EGFR Isoform Confers Increased Invasiveness to Cancer Cells Open
PDF file - 734K, Figure S1. EGFRvA is widely expressed in various cancer cell lines and tissues. Figure S2. The upregulation of EGFRvA in glioma tissues compared with paired adjacent non-neoplastic brain tissues and a poor prognosis in pat…
View article: Simultaneous versus staged major hepatectomy (≥3 liver segments) for outcomes of synchronous colorectal liver metastases: A systematic review and meta‐analysis
Simultaneous versus staged major hepatectomy (≥3 liver segments) for outcomes of synchronous colorectal liver metastases: A systematic review and meta‐analysis Open
Background Hepatectomy is an effective treatment for synchronous colorectal liver metastases (SCLM) patients. However, whether to choose simultaneous hepatectomy (SIH) or staged hepatectomy (STH) is still controversial, especially during m…
View article: Axons-on-a-Chip for Mimicking Non-Disruptive Diffuse Axonal Injury underlying Traumatic Brain Injury
Axons-on-a-Chip for Mimicking Non-Disruptive Diffuse Axonal Injury underlying Traumatic Brain Injury Open
Diffuse axonal injury (DAI) is the most severe pathological feature of traumatic brain injury. However, how primary axonal injury is induced by mechanical stress and whether it could be mitigated remain unknown, largely due to the resoluti…
View article: Machine learning based tissue analysis reveals Brachyury has a diagnosis value in breast cancer
Machine learning based tissue analysis reveals Brachyury has a diagnosis value in breast cancer Open
Background: The aim of the present study was to confirm the role of Brachyury in breast cancer and to verify whether four types of machine learning models can use Brachyury expression to predict the survival of patients. Methods: We conduc…
View article: GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells
GE11 Modified PLGA/TPGS Nanoparticles Targeting Delivery of Salinomycin to Breast Cancer Cells Open
Salinomycin (Sal) is a potent inhibitor with effective anti-breast cancer properties in clinical therapy. The occurrence of various side effect of Sal greatly limits its application. The epidermal growth factor receptor (EGFR) family is a …
View article: Machine Learning based Tissue Analysis Reveals Brachyury has a Diagnosis Value in Breast Cancer
Machine Learning based Tissue Analysis Reveals Brachyury has a Diagnosis Value in Breast Cancer Open
Background The aim of this study was to confirm the role of Brachyury in breast cells and to establish and verify whether four types of machine learning models can use Brachyury expression to predict the survival of patients.Methods We con…
View article: A Protocol for Cancer-Related Mutation Detection on Exosomal DNA in Clinical Application
A Protocol for Cancer-Related Mutation Detection on Exosomal DNA in Clinical Application Open
This study provides some methodological evidences for the selection of the optimal experimental conditions in exosomal DNA analysis. We also suggest a protocol for mutation detection on exosomal DNA, which might be suitable for the clinica…
View article: Proteomic Profiling of Serum Exosomes From Patients With Metastatic Gastric Cancer
Proteomic Profiling of Serum Exosomes From Patients With Metastatic Gastric Cancer Open
Background: Clinical management of metastatic gastric cancer (mGC) remains a major challenge due to a lack of specific biomarkers and effective therapeutic targets. Recently, accumulating evidence has suggested that exosomes play an…
View article: Supplementary Material for: Exploratory Analysis to Identify Candidates Benefitting from Combination Therapy of Transarterial Chemoembolization and Sorafenib for First-Line Treatment of Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Observational Study
Supplementary Material for: Exploratory Analysis to Identify Candidates Benefitting from Combination Therapy of Transarterial Chemoembolization and Sorafenib for First-Line Treatment of Unresectable Hepatocellular Carcinoma: A Multicenter Retrospective Observational Study Open
Introduction: The benefits of combining transarterial chemoembolization (TACE) and sorafenib (TACE-S) over TACE alone for treatment of unresectable hepatocellular carcinoma (HCC) remain controversial. Yet, such populations ar…
View article: KRAS Mutant Allele Fraction in Circulating Cell-Free DNA Correlates With Clinical Stage in Pancreatic Cancer Patients
KRAS Mutant Allele Fraction in Circulating Cell-Free DNA Correlates With Clinical Stage in Pancreatic Cancer Patients Open
Background: The research on circulating tumor DNA (ctDNA) in pancreatic cancer (PC) has emerged recently. Although the detection rate of the KRAS mutation in ctDNA was relatively consistent with that in tumor tissue, whether …
View article: Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts constitutes the hepatocarcinogenesis-associated microenvironment
Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts constitutes the hepatocarcinogenesis-associated microenvironment Open
View article: The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III
The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III Open
Background/Aims: Epidermal growth factor receptor variant III (EGFRvIII), the most frequent EGFR variant, is constitutively activated without binding to EGF and is correlated with a poor prognosis. CH12, a human-mouse chimeric monoclonal a…