Xiaoru Sun
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View article: Case Report: Morbid Obesity and Lithotomy Positioning: A Lethal Triad with GCS Leading to Acute Compartment Syndrome Following Ovarian Cancer Cytoreduction
Case Report: Morbid Obesity and Lithotomy Positioning: A Lethal Triad with GCS Leading to Acute Compartment Syndrome Following Ovarian Cancer Cytoreduction Open
Purpose Venous thromboembolism (VTE) prophylaxis with graduated compression stockings (GCS) is standard in gynecologic oncology surgery; however, contextual risks require attention. Clinical Features: A patient with ovarian carcinoma devel…
View article: High-efficiency likelihood inference of shared proteomic architectures across 50 complex human traits
High-efficiency likelihood inference of shared proteomic architectures across 50 complex human traits Open
Advancements in genetic correlation estimation have elucidated genome-wide pleiotropy’s influence on phenotypic correlations among human complex traits and diseases. However, the role of proteomic domains in these correlations remains unde…
View article: 极端环境对人类睡眠的影响
极端环境对人类睡眠的影响 Open
Recently, with the rapid growth of the global population and the exhaustion of resources, exploration activities in extreme environments such as the polar regions, the outer space, the deep sea, the deep underground and highlands are becom…
View article: Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization Studies
Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization Studies Open
Metabolic disorders (MDs) are a group of medical conditions that impact the metabolism. These complex processes may have common characteristics among various diseases, thereby suggesting the potential of drug repurposing. Employing Mendeli…
View article: Inferring language dispersal patterns with velocity field estimation
Inferring language dispersal patterns with velocity field estimation Open
Reconstructing the spatial evolution of languages can deepen our understanding of the demic diffusion and cultural spread. However, the phylogeographic approach that is frequently used to infer language dispersal patterns has limitations, …
View article: Molecular choreography to acute heat exposure in a simulated extreme high temperature environment
Molecular choreography to acute heat exposure in a simulated extreme high temperature environment Open
Occupational exposure to extreme high temperature and increasing global temperatures require enhanced understanding of how heat exposure impacts human health. However, the molecular changes underlying the response to heat exposure in human…
View article: Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions
Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions Open
Background The relative contributions of genetic and environmental factors versus unavoidable stochastic risk factors to the variation in cancer risk among tissues have become a widely-discussed topic. Some claim that the stochastic effect…
View article: Urine metabolomics analysis of sleep quality in deep-underground miners: A pilot study
Urine metabolomics analysis of sleep quality in deep-underground miners: A pilot study Open
Background In previous questionnaire surveys of miners, sleep disorders were found among underground workers. The influence of the special deep-underground environment and its potential mechanism are still unclear. Therefore, this study in…
View article: Cover Picture: Nanoantidote for repression of acidosis pH promoting COVID‐19 infection (View 4/2022)
Cover Picture: Nanoantidote for repression of acidosis pH promoting COVID‐19 infection (View 4/2022) Open
Acidosis-related pH promotes SARS-CoV-2 pseudovirus infection by increasing cell membrane ACE2 expression. A CaCO3-NPs antacid nanoantidote restored the normal blood related pH 7.4, attenuating the SARS-CoV-2 pseudovirus infection. In arti…
View article: Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients
Incidence and Risk Factors for Hypoxia in Deep Sedation of Propofol for Artificial Abortion Patients Open
Background Respiratory depression is a life-threatening adverse effect of deep sedation. This study aimed to investigate the factors related to hypoxia caused by propofol during intravenous anesthesia. Methods Three hundred and eight patie…
View article: Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods
Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods Open
Nonrandom selection in one-sample Mendelian Randomization (MR) results in biased estimates and inflated type I error rates only when the selection effects are sufficiently large. In two-sample MR, the different selection mechanisms in two …
View article: The Effect of Relaxation Therapy on Hypoxia During Intravenous Propofol Anesthesia in Patients With Pre-operative Anxiety: A Prospective Randomized Controlled Trial
The Effect of Relaxation Therapy on Hypoxia During Intravenous Propofol Anesthesia in Patients With Pre-operative Anxiety: A Prospective Randomized Controlled Trial Open
Background This study aimed to investigate the effect of relaxation therapy on hypoxia during intravenous propofol anesthesia in patients with pre-operative anxiety. Methods Two-hundred and eighty patients were randomly categorized in the …
View article: Additional file 2 of Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions
Additional file 2 of Quantifying substantial carcinogenesis of genetic and environmental factors from measurement error in the number of stem cell divisions Open
Additional file 2: Table S1. Ranked matrix of LCR in global scope and the contribution of the genetic and environmental factors on the variation in cancer risk. Table S2. Ranked matrix of LCR in national-wide of China and the contribution …
View article: Consequence of adjustments for demographic or clinical covariates and a recommended solution in genome-wide association studies
Consequence of adjustments for demographic or clinical covariates and a recommended solution in genome-wide association studies Open
Genome-wide association study (GWAS) is fundamentally designed to detect disease-causing genes. To reduce spurious associations or improve statistical power, about 80% of GWASs arbitrarily adjusted for demographic or clinical covariates. H…
View article: Identification of TNFAIP8 as an Immune-Related Biomarker Associated With Tumorigenesis and Prognosis in Cutaneous Melanoma Patients
Identification of TNFAIP8 as an Immune-Related Biomarker Associated With Tumorigenesis and Prognosis in Cutaneous Melanoma Patients Open
Tumor necrosis factor-α–induced protein 8 (TNFAIP8) is a member of the TIPE/TNFAIP8 family which is associated with inflammation and tumorigenesis. The potential role of TNFAIP8 in a tumor immune microenvironment in skin cutaneous melanoma…
View article: Genetically Predicted Insomnia in Relation to 14 Cardiovascular Conditions and 17 Cardiometabolic Risk Factors: A Mendelian Randomization Study
Genetically Predicted Insomnia in Relation to 14 Cardiovascular Conditions and 17 Cardiometabolic Risk Factors: A Mendelian Randomization Study Open
Background This Mendelian randomization study aims to investigate causal associations between genetically predicted insomnia and 14 cardiovascular diseases (CVDs) as well as the potential mediator role of 17 cardiometabolic risk factors. M…
View article: A Negative Control Outcome Regression Accounting for Unobserved Confounding and Lagged Causal Effects
A Negative Control Outcome Regression Accounting for Unobserved Confounding and Lagged Causal Effects Open
Background: Epidemiologists are increasingly interested in using negative controls to eliminate unobserved confounding. Particularly, difference-in-differences method, which uses pre-exposure outcomes as negative control outcomes, is widel…
View article: Identification of microenvironment related potential biomarkers of biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma
Identification of microenvironment related potential biomarkers of biochemical recurrence at 3 years after prostatectomy in prostate adenocarcinoma Open
Prostate adenocarcinoma is one of the leading adult malignancies. Identification of multiple causative biomarkers is necessary and helpful for determining the occurrence and prognosis of prostate adenocarcinoma. We aimed to identify the po…
View article: Identification of Tumor Microenvironment-Related Prognostic Biomarkers for Ovarian Serous Cancer 3-Year Mortality Using Targeted Maximum Likelihood Estimation: A TCGA Data Mining Study
Identification of Tumor Microenvironment-Related Prognostic Biomarkers for Ovarian Serous Cancer 3-Year Mortality Using Targeted Maximum Likelihood Estimation: A TCGA Data Mining Study Open
Ovarian serous cancer (OSC) is one of the leading causes of death across the world. The role of the tumor microenvironment (TME) in OSC has received increasing attention. Targeted maximum likelihood estimation (TMLE) is developed under a c…
View article: Lipids, Anthropometric Measures, Smoking and Physical Activity Mediate the Causal Pathway from Education to Breast Cancer in Women: A Mendelian Randomization Study
Lipids, Anthropometric Measures, Smoking and Physical Activity Mediate the Causal Pathway from Education to Breast Cancer in Women: A Mendelian Randomization Study Open
Background Our objective is to investigate whether obtaining a higher level of education was causally associated with lower breast cancer risk and to identify the causal mechanism linking them. Methods Firstly, we performed a meta-analysis…
View article: Causal Mediation Analysis with Multiple Causally Ordered and Non-ordered Mediators based on Summarized Genetic Data
Causal Mediation Analysis with Multiple Causally Ordered and Non-ordered Mediators based on Summarized Genetic Data Open
Causal mediation analysis aims to investigate the mechanism linking an exposure and an outcome. Dealing with the impact of unobserved confounders among the exposure, mediator and outcome has always been an issue of great concern. Moreover,…
View article: Lipids, Anthropometric Measures, Smoking and Physical Activity Mediate the Causal Pathway From Education to Breast Cancer in Women: A Mendelian Randomization Study
Lipids, Anthropometric Measures, Smoking and Physical Activity Mediate the Causal Pathway From Education to Breast Cancer in Women: A Mendelian Randomization Study Open
A low level of education is a causal risk factor in the development of breast cancer as it is associated with poor lipid profile, obesity, smoking, and types of physical activity.
View article: A Comprehensive Analysis Identified Hub Genes and Associated Drugs in Alzheimer’s Disease
A Comprehensive Analysis Identified Hub Genes and Associated Drugs in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is the most common neurodegenerative disease among the elderly and has become a growing global health problem causing great concern. However, the pathogenesis of AD is unclear and no specific therapeutics are avail…
View article: Mechanisms of interactions between lung‐origin telocytes and mesenchymal stem cells to treat experimental acute lung injury
Mechanisms of interactions between lung‐origin telocytes and mesenchymal stem cells to treat experimental acute lung injury Open
Acute lung injury is a serious form and major cause of patient death and still needs efficient therapies. The present study evidenced that co‐transplantation of mesenchymal stem cells (MSCs) and telocytes (TCs) improved the severity of exp…
View article: A novel method for controlling unobserved confounding using double confounders
A novel method for controlling unobserved confounding using double confounders Open
Background Controlling unobserved confounding still remains a great challenge in observational studies, and a series of strict assumptions of the existing methods usually may be violated in practice. Therefore, it is urgent to put forward …