Xiaoyan Jin
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View article: Effects of Head-Mounted VR and MR-CAVE in Nursing Laboratory Teaching: A Comparative Study
Effects of Head-Mounted VR and MR-CAVE in Nursing Laboratory Teaching: A Comparative Study Open
Materials and methods: This study involved undergraduate nursing students from a university in China. All participants undertook preclass preparation, which included self-directed learning, knowledge challenges, and desktop VR experiences.…
View article: <i>Edwardsiella piscicida</i> employs C3 derivative to mediate internalization and infection via the teleost-specific receptor
<i>Edwardsiella piscicida</i> employs C3 derivative to mediate internalization and infection via the teleost-specific receptor Open
Edwardsiella piscicida is a prominent fish pathogen, and spreads the infection to humans and mammals. It can resist serum killing and invade the host phagocytic cells. However, the precise mechanisms underlying E. piscicida i…
View article: Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period
Arthrocolin B Impairs Adipogenesis via Delaying Cell Cycle Progression During the Mitotic Clonal Expansion Period Open
Obesity and its related diseases severely threaten people’s health, causing persistently high morbidity and mortality worldwide. The abnormal proliferation and hypertrophy of adipocytes mediate the expansion of adipose tissue, which is the…
View article: Dynamic Changes in Hindlimb Motor Cortex Neurons during Simulated Weightlessness Revealed by Miniature 2-Photon Microscopy
Dynamic Changes in Hindlimb Motor Cortex Neurons during Simulated Weightlessness Revealed by Miniature 2-Photon Microscopy Open
Dysfunction of motor behavior during spaceflight is linked to alterations in neuronal activities. However, the longitudinal functional changes in the motor cortex triggered by simulated weightlessness remain ambiguous. In this study, we ut…
View article: Treatment of Retroperitoneal Well-Differentiated Liposarcoma with Combination of Penpulimab and Anlotinib: A Case Report and Literature Review
Treatment of Retroperitoneal Well-Differentiated Liposarcoma with Combination of Penpulimab and Anlotinib: A Case Report and Literature Review Open
To observe the efficacy of combination therapy with Penpulimab and Anlotinib in the treatment of retroperitoneal well-differentiated liposarcoma. Retrospective analysis of clinical data of a patient with retroperitoneal well-differentiated…
View article: CardioAtlas: deciphering the single-cell transcriptome landscape in cardiovascular tissues and diseases
CardioAtlas: deciphering the single-cell transcriptome landscape in cardiovascular tissues and diseases Open
Increasing scRNA-seq data in cardiovascular research have substantially improved our knowledge on the development of the cardiovascular system and the mechanisms underlying cardiovascular diseases. However, the single-cell transcriptome da…
View article: Lactobacillus rhamnosus GG affects spaceflight-induced helper T cell disorder by modulating the gut microbiota and microbial-derived metabolites
Lactobacillus rhamnosus GG affects spaceflight-induced helper T cell disorder by modulating the gut microbiota and microbial-derived metabolites Open
Spaceflight is physically demanding and has negative effects on the health of astronauts. Previous studies demonstrated that the human gut microbiota and immunity were affected by spaceflight and simulated spaceflight. Changes in the abund…
View article: Targeted axillary dissection using carbon marking for patients with node-positive breast cancer following neoadjuvant therapy (TADCOM): study protocol for a prospective, multicenter, randomized controlled trial
Targeted axillary dissection using carbon marking for patients with node-positive breast cancer following neoadjuvant therapy (TADCOM): study protocol for a prospective, multicenter, randomized controlled trial Open
View article: Abrogating PDK4 activates autophagy-dependent ferroptosis in breast cancer via ASK1/JNK pathway
Abrogating PDK4 activates autophagy-dependent ferroptosis in breast cancer via ASK1/JNK pathway Open
View article: Utility of auto fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions
Utility of auto fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions Open
Fluorescence-guided biopsy can serve as an important adjunct to WLB for the differential diagnosis of lung cancer in patients with bronchial mucosal lesions.
View article: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration
N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration Open
View article: Utility of fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions
Utility of fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions Open
Background: Bronchoscopy is currently the most commontechnique for lung cancer diagnosis. Patients suspected of malignancy often undergo bronchoscopic examination, and biopsy is routinely used in patients with visible bronchial lesions. Ho…
View article: Simulated spaceflight-induced cardiac remodeling is modulated by gut microbial-derived trimethylamine N-oxide
Simulated spaceflight-induced cardiac remodeling is modulated by gut microbial-derived trimethylamine N-oxide Open
View article: HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation
HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation Open
View article: Lycorine suppresses the malignancy of breast carcinoma by modulating epithelial mesenchymal transition and β-catenin signaling
Lycorine suppresses the malignancy of breast carcinoma by modulating epithelial mesenchymal transition and β-catenin signaling Open
Lycorine, an isoquinoline alkaloid can exhibit significant anti-cancer effects. The present study was conducted to illustrate the underlying mechanisms of action of lycorine on breast carcinoma under in vitro and in vivo settings Tandem Ma…
View article: Spaceflight-induced cardiac remodeling simulated by head-down bed rest in rhesus macaques and hindlimb unloading in mice is modulated by gut microbial-derived trimethylamine N-oxide
Spaceflight-induced cardiac remodeling simulated by head-down bed rest in rhesus macaques and hindlimb unloading in mice is modulated by gut microbial-derived trimethylamine N-oxide Open
Background Spaceflight is physically demanding and can negatively affect astronauts’ health. It has been shown that the human gut microbiota and cardiac function are affected by spaceflight and simulated spaceflight. This study investigate…
View article: Utility of fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions
Utility of fluorescence-guided biopsy in suspected lung cancer patients with bronchial mucosal lesions Open
Background: Bronchoscopy is currently the most common technique for lung cancer diagnosis. Patients suspected of malignancy often undergo bronchoscopic examination, and biopsy is routinely used in patients with visible bronchial lesions. H…
View article: Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites
Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites Open
A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent. Its underlying mechanisms of berberine against breast carcinoma under hypoxia have not been elucidated. We focused on the doubt how berberine res…
View article: Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1
Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1 Open
View article: Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancer
Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancer Open
View article: Hydrogen Inhalation Ameliorates Oxidative Stress and Glucose Metabolism Disorder in the Brain of Hindlimb Unloading Rats
Hydrogen Inhalation Ameliorates Oxidative Stress and Glucose Metabolism Disorder in the Brain of Hindlimb Unloading Rats Open
Many studies have shown that spaceflight causes oxidative stress and induces brain disorder in astronauts, but the counter measurements are lacking. Increasing evidence demonstrated that hydrogen can act as a therapeutic antioxidant. In th…
View article: Simulated Spaceflight-Induced Cardiac Remodeling is Modulated by Gut Microbial-Derived Trimethylamine N-Oxide
Simulated Spaceflight-Induced Cardiac Remodeling is Modulated by Gut Microbial-Derived Trimethylamine N-Oxide Open
View article: LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p/IGF2 axis and activating PI3K/AKT/mTOR signaling pathway
LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p/IGF2 axis and activating PI3K/AKT/mTOR signaling pathway Open
View article: A comprehensive comparison of circulating tumor cells and breast imaging modalities as screening tools for breast cancer in Chinese women
A comprehensive comparison of circulating tumor cells and breast imaging modalities as screening tools for breast cancer in Chinese women Open
Background Circulating tumor cells (CTCs) have been recognized as a sensitive biomarker for breast cancer (BC). This study aimed to comprehensively compare CTC with imaging modalities, including ultrasonography, mammography, and contrast-e…
View article: Prognostic implications of the peripheral platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in predicting pathologic complete response after neoadjuvant chemotherapy in breast cancer patients
Prognostic implications of the peripheral platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in predicting pathologic complete response after neoadjuvant chemotherapy in breast cancer patients Open
The PLR may serve as a potential marker of the efficacy of neoadjuvant therapy in breast cancer, enabling oncologists to intervene earlier. Peripheral blood NLR and PLR can reflect the immune status of patients. Indicating that an immunoge…
View article: Factors influencing depression in community-dwelling elderly patients with osteoarthritis of the knee in China: a cross-sectional study
Factors influencing depression in community-dwelling elderly patients with osteoarthritis of the knee in China: a cross-sectional study Open
View article: Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction
Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction Open
Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental importance for osteoclast function. The calcium-activated chloride channel Anoctamin 1 (also known as TMEM16A) is an important chloride channel involved …
View article: Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway
Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway Open
Breast cancer is the most frequent cancer among women and the second highest mortality in female across the world. Recent studies have illustrated that sex-determining region Y (SRY)-box protein (SOX) family plays essential roles in regula…
View article: Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury
Osteoblast Derived Exosomes Alleviate Radiation- Induced Hematopoietic Injury Open
As hematopoietic stem cells can differentiate into all hematopoietic lineages, mitigating the damage to hematopoietic stem cells is important for recovery from overdose radiation injury. Cells in bone marrow microenvironment are essential …
View article: The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention
The mechanosensitive lncRNA Neat1 promotes osteoblast function through paraspeckle-dependent Smurf1 mRNA retention Open