Xiaoshan Min
YOU?
Author Swipe
View article: Surgical design and efficacy for restrictive strabismus due to thyroid-associated ophthalmopathy.
Surgical design and efficacy for restrictive strabismus due to thyroid-associated ophthalmopathy. Open
Depending on the degree of extraocular muscle movement restriction in TAO patients, simple muscle recession, Y-split recession, and modified Y-split recession can be employed. These procedures can effectively relieve or improve muscle rest…
View article: Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence–based affinity maturation Open
View article: Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies Open
The heterodimer of ATP-binding cassette transporter ABCG5 and ABCG8 mediates the excretion of sterols from liver and intestine, playing a critical role in cholesterol homeostasis. Here, we present the cryo-EM structure of ABCG5/G8 in compl…
View article: Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile
Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile Open
View article: AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys
AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys Open
Multiple myeloma (MM) is a hematologic malignancy that is characterized by the accumulation of abnormal plasma cells (PCs) in the bone marrow (BM). Patient outcome may be improved with BiTE (bispecific T-cell engager) molecules, which redi…
View article: Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition Open
Details of intestinal sterol absorption and inhibition by cholesterol-lowering drug are uncovered in new protein structures.
View article: Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles
Mechanistic Studies of Cytochrome P450 3A4 Time-Dependent Inhibition Using Two Cysteine-Targeting Electrophiles Open
View article: Discovery of [1,2,4]Triazolo[1,5-<i>a</i>]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists
Discovery of [1,2,4]Triazolo[1,5-<i>a</i>]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists Open
The retinoic acid receptor-related orphan nuclear receptor γt (RORγt), a promising therapeutic target, is a major transcription factor of genes related to psoriasis pathogenesis such as interleukin (IL)-17A, IL-22, and IL-23R. On the basis…
View article: Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor
Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor Open
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharma…
View article: Structure-guided discovery of dual recognition chemibodies
Structure-guided discovery of dual recognition chemibodies Open
Small molecules and antibodies each have advantages and limitations as therapeutics. Here, we present for the first time to our knowledge, the structure-guided design of as small molecule-antibody hybrids that offer dual recognition of a …
View article: Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models Open
Antibody antagonists of the insulinotropic receptor GIPR prevent weight gain in obese animal models, and the effect is enhanced by GLP-1R agonists.
View article: Discovery of Tarantula Venom-Derived Na<sub>V</sub>1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis
Discovery of Tarantula Venom-Derived Na<sub>V</sub>1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis Open
Inhibitors of the voltage-gated sodium channel NaV1.7 are being investigated as pain therapeutics due to compelling human genetics. We previously identified NaV1.7-inhibitory peptides GpTx-1 and JzTx-V from tarantula …
View article: Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions Open
View article: A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling
A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling Open
Endocrine fibroblast growth factors (FGFs) require Klotho transmembrane proteins as necessary co-receptors to activate FGF receptor (FGFR) signaling. In particular, FGF19 and FGF21 function through β-Klotho to regulate glucose and lipid me…
View article: Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2
Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2 Open
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. The R47H TREM2 variant is a significant risk factor for late-onset Alzheim…
View article: Structure-guided Discovery of Dual-recognition Chemibodies
Structure-guided Discovery of Dual-recognition Chemibodies Open
View article: Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2)
Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2) Open