Explanipedia

Deciphering the role of zingiber officinale phytochemicals for the treatment of prostate cancer: Interactions of phytochemicals with androgen receptor prostate cancer mutant H874Y ligand binding domain Open

Guiyuan Lei, Shuai Yan, Xu Gao, Sireen Abdul Rahim Shilbayeh, Saeed Vohra , et al. · 2025

The results of current in-siico and in-vitro studies are important for gaining an understanding of the mechanisms of how the Zingiber officinale phytochemicals bind to the H874Y mutated ligand binding domain, which is important for the dev…

Induction of ferroptosis in prostate cancer by CCDC719-13 via TRIM21-mediated ubiquitination of SLC7A11 Open

Bisheng Cheng, Qiong Wang, Zean Li, Tianlong Luo, Jiangjiang Xie , et al. · 2025

Prostate cancer is one of the most prevalent malignancies in men, with increasing incidence and mortality largely attributed to treatment resistance and metastasis. The effectiveness of current therapies for advanced cases is hindered by i…

Metabolomic and lipidomic profiling of plasma in kidney stone patients: identification of potential biomarkers and therapeutic targets Open

Ziyu Fang, Shenglan Gong, Ling Li, Shuwei Zhang, Wei He , et al. · 2025

Macrophage Reprogramming: Emerging Molecular Therapeutic Strategies for Nephrolithiasis Open

Shu Meng, Yong Jia, Shuwei Zhang, Bangyu Zou, Zhaoxin Ying , et al. · 2025

Nephrolithiasis, predominantly driven by calcium oxalate (CaOx) crystal deposition, poses a significant global health burden due to its high prevalence and recurrence rates and limited preventive/therapeutic options. Recent research has un…

SerpinE2 promotes M2 polarization in macrophage to accelerate colorectal cancer progression Open

Huilong Liu, Xu Gao, Weifeng Yang, Wanglin Li · 2025

Background Cell-cell crosstalk in the tumor microenvironment (TME) is crucial for cancer development and strongly correlates with clinical outcomes. Interpatient variability in tumor microenvironment composition and function poses ongoing …

Differential impact of spotted fever group rickettsia and anaplasmosis on tick microbial ecology: evidence from multi-species comparative microbiome analysis Open

Jinqi Wang, Yu Tian, Hongyu Qiu, S S Ji, Zhi-qiang Xu , et al. · 2025

Tick-borne diseases (TBDs) pose a significant public health challenge, as their incidence is increasing due to the effects of climate change and ecological shifts. The interplay between tick-borne pathogens and the host microbiome is an em…

Multimodal deep learning model for predicting homologous recombination deficiency in prostate cancer: an international multi-cohort study Open

Zijian Song, Qianwen Zhang, Wenhui Zhang, Na Ta, Yan Zhu , et al. · 2025

Accurate prediction of homologous recombination deficiency (HRD) status is crucial for effective management of prostate cancer (PCa). However, genetic testing is expensive and inaccessible. We propose a multimodal deep learning approach th…

PD-1 regulates the anti-tumor immune function of macrophages through JAK2-STAT3 signaling pathway in colorectal cancer tumor microenvironment Open

Han Jiang, Jingjing Pang, Tengyue Li, Atitso Akofala, Xiaoxi Zhou , et al. · 2025

Analysis of human brain RNA-seq data reveals combined effects of 4 types of RNA modifications and 18 types of programmed cell death on Alzheimer’s disease Open

Ke Ye, Xinyu Han, Maoyi Tian, Lulu Liu, Xu Gao , et al. · 2025

Enhancer transcription profiling reveals an enhancer RNA-driven ferroptosis and new therapeutic opportunities in prostate cancer Open

Sheng Ma, Zixian Wang, Zezhong Xiong, Yue Ge, Mengyao Xu , et al. · 2025

Enhancer RNAs (eRNAs), a subclass of non-coding RNAs transcribed from enhancer regions, have emerged as critical regulators of gene expression; however, their functional roles in prostate cancer remain largely unexplored. In this study, we…

Profiling chimeric RNA in prostate cancer in Chinese cohorts reveals similarities and differences compared to Western populations Open

Qiong Wang, Shunli Yu, Jirong Jie, Justin Elfman, Zhi Xiong , et al. · 2025

Chimeric RNAs from chromosomal rearrangements have long been validated as cancer markers and therapeutic targets for many years. Recently, trans-splicing and cis-splicing between adjacent genes are also shown to generate chimeric RNAs. The…

Optimized graph neural network-multilayer perceptron fusion classifier for metastatic prostate cancer detection in Western and Asian populations Open

Fenglin Han, Xiaohui Fan, P.G. Long, Wenhui Zhang, Qiting Li , et al. · 2025

An Intelligent Temporal Causal Inference Framework for Wwtp Nitrogen Removal: Multi-Stage Spurious Causal Elimination Open

Zhichi Chen, Qiang He, Lu Ao, Q Zhang, Cheng Cheng , et al. · 2025

Immunotherapy in the treatment of rectal invasion by prostate cancer with focal neuroendocrine differentiation: a case report and literature review Open

Huan Chen, Min Qu, Yan Wang, Xu Gao · 2024

This disease entity remains relatively rare in the literature. Accurate differential diagnosis is important. TPE combined with immunotherapy may improve the prognosis. It is of utmost importance to achieve an accurate differential diagnosi…

The significance of pelvic lymph node dissection in radical prostatectomy and its influence on the prognosis of patients with prostate cancer Open

Xianqi Shen, Jialun Li, Zenghui Zhou, Wenhui Zhang, Jin Ji , et al. · 2024

ePLND is recommended for patients with indications of lymphadenectomy, which can significantly optimize the detection rate of positive lymph nodes and provide guidance for subsequent adjuvant therapy.

UPCARE: Urinary Extracellular Vesicles‐Derived Prostate Cancer Assessment for Risk Evaluation Open

Shaoqin Jiang, Feiting Lu, Jiadi Chen, Yingzhen Jiao, Qingqing Qiu , et al. · 2024

In the quest for efficient tumor diagnosis via liquid biopsy, extracellular vesicles (EVs) have shown promise as a source of potential biomarkers. This study addresses the gap in biomarker efficacy for predicting clinically significant pro…

Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China Open

Wenhui Zhang, Yan Wang, Min Qu, Haoqing Shi, Xin Lü , et al. · 2023

Background The development and expansion of warm autopsy program have important implications in dissecting the heterogeneity during cancer dissemination and resistance. However, in China, the practice of warm autopsy has not yet been offic…

Reviewer #1 (Public Review): Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China Open

Wenhui Zhang, Yan Wang, Min Qu, Haoqing Shi, Xin Lü , et al. · 2023

The development and expansion of warm autopsy program have important implications in dissecting the heterogeneity during cancer dissemination and resistance. However, in China, the practice of warm autopsy has not yet been officially launc…

Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China Open

Wenhui Zhang, Yan Wang, Min Qu, Haoqing Shi, Xin Lü , et al. · 2023

The development and expansion of warm autopsy program have important implications in dissecting the heterogeneity during cancer dissemination and resistance. However, in China, the practice of warm autopsy has not yet been officially launc…

EP10.01-17 Treatment Patterns and Clinical Outcomes among Advanced NSCLC Patients with EGFR exon 20 Insertion Mutations in China Open

Yuyan Wang, Hui‐Ming Lin, Ning Ning, F. Du, Xu Gao , et al. · 2023

Precise and efficient insertion of A673T mutation in APP gene using MSYM Open

Qing Xia, Zijie Liu, Xinyu Yang, Jiaying Xiao, Xue Zhao , et al. · 2023

Genomic and epigenomic evolution of metastatic prostate cancer: the first warm autopsy in China Open

Wenhui Zhang, Yan Wang, Min Qu, Haoqing Shi, Xin Lü , et al. · 2023

Background The development and expansion of warm autopsy program have important implications in dissecting the heterogeneity during cancer dissemination and resistance. However, in China, the practice of warm autopsy has not yet been offic…

Precise and efficient insertion of A673T mutation in APP gene using MSYM Open

Qing Xia, Zijie Liu, Xinyu Yang, Jiaying Xiao, Xue Zhao , et al. · 2023

Alzheimer's Disease is a progressive neurodegenerative disorder characterized by toxic accumulation of amyloid beta peptides and tau neurofibrillary tangles. A673T mutation, as a protective mutation existing in natural people has a huge po…

Multi-Modal Deep Learning Model for Predicting Homologous Recombination Deficiency in Prostate Cancer: An International Multi-Cohort Study Open

Zijian Song, Qianwen Zhang, Wenhui Zhang, Na Ta, Yan Zhu , et al. · 2023

Construction and validation of a novel cuproptosis-related long noncoding RNA signature for predicting the outcome of prostate cancer Open

Shaoqin Jiang, Zhihao Li, Ruiling Dou, Zequn Lin, Jili Zhang , et al. · 2022

Background: Prostate cancer (PCa) is one of the most common tumors of the urinary system. Cuproptosis is a novel mode of controlled cell death that is related to the development of various tumor types. However, the functions of cuproptosis…

Adjuvant radiotherapy in patients with node-positive prostate cancer after radical prostatectomy Open

Huan Chen, Min Qu, Haoqing Shi, Zhenyang Dong, Yan Wang , et al. · 2022

The emerging multifaceted role of <span>PINK1</span> in cancer biology Open

Meng Wang, Shijia Luan, Xiang Fan, Jie Wang, Ju Huang , et al. · 2022

For its various important functions in cells, phosphatase and tensin homolog‐induced kinase 1 (PINK1) has drawn considerable attention for the role it plays in early‐onset Parkinson's disease. In recent years, emerging evidence has support…

The landscape of m6A regulators in multiple brain regions of Alzheimer's Disease Open

ZiJie Liu, Qing Xia, Xue Zhao, Feifei Zheng, Jiaying Xiao , et al. · 2022

Alzheimer's disease is a neurodegenerative disease researched for many years, yet no effective curing methods are found. N6-methyladenosine (m6A) RNA methylation, an essential epitranscriptome regulation mechanism, has been discovered to a…

Extended Focal Ablation of Localized Prostate Cancer With High-Frequency Irreversible Electroporation Open

Haifeng Wang, Wei Xue, Weigang Yan, Lei Yin, Baijun Dong , et al. · 2022

ClinicalTrials.gov Identifier: NCT03838432.

Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer Open

Ziwei Wang, Tao Wang, Danni Hong, Baijun Dong, Yan Wang , et al. · 2022

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